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Camila Renata Correa

Camila Renata Correa

Doctor of Pharmacy

About

181
Publications
31,351
Reads
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1,858
Citations
Education
July 1992 - July 1996
Universidade de Ribeirão Preto
Field of study
  • Oxidative stress and Inflammation and chronic diseases

Publications

Publications (181)
Article
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(1) Background: The bioavailability of nitric oxide (NO) and oxidative stress are important events related to the pathophysiology of preeclampsia (PE). In this present study, we aimed to evaluate the antioxidant effect of glibenclamide (GB) on the NO synthesis, oxidative stress, and antioxidant capacity in endothelial cells incubated with plasma fr...
Article
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Nonalcoholic fatty liver disease (NAFLD) is the main cause of liver disease. The physiopathological processes involved in the disease are metabolic syndrome (MetS) components (central obesity, dyslipidemia, insulin resistance/type 2 diabetes, hypertension), genetic, and dietary factors, including unsaturated fats and sweetened beverages, which are...
Article
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Aim: Evaluate the influence of doxycycline, an anti-inflammatory and matrix metalloproteinase (MMP) inhibitor, on the attenuation of chronic doxorubicin-induced cardiotoxicity in rats. Methods: We allocated male Wistar rats into four groups: control (C), doxorubicin (D), doxycycline (inhibitor of MMP, IM), and Dox + doxycycline (DIM). Groups IM...
Article
Bergamot citrus (Citrus bergamia Risso et Poiteau), have been used as a strategy to prevent or treat comorbidities associated with metabolic syndrome parameters, such as cardiorenal metabolic syndrome (CRMS). The aim was to test the effect of bergamot leaf extract on CRMS and associated pathophysiological factors in rats fed with a high sugar-fat d...
Article
Objectives Non-Alcoholic Fatty Liver Disease (NAFLD) is a silent disease linked to behavioral habits (poor diet and sedentary lifestyle) with inflammatory and oxidative stresses as background, leading to cardiovascular diseases (CVDs) as the worse outcome. These point out to lifestyle modification program(LSMP) as a potential non-pharmacological st...
Article
Objectives Lower muscle mass(sarcopenia) is a contemporary syndrome related to dietary-inadequacy and sedentary lifestyles that might have pro/anti-oxidant balance as major determinant. OBJECTIVE: To determine the role of dietary-associated oxidative stress in the low-muscle mass of free-living adults. Methods A baseline data of 1,218 subjects, bo...
Article
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Clinical trials have shown that sodium glucose co-transporter 2 (SGLT2) inhibitors improve clinical outcomes in diabetes mellitus (DM) patients. As most studies were performed in Type 2 DM, the cardiovascular effects of SGLT2 inhibition still require clarification in Type 1 DM. We analyzed the effects of SGLT2 inhibitor dapagliflozin on cardiac rem...
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Age-related macular degeneration (AMD) is the major cause of irreversible blindness in the elderly and the oxidative stress is considered the main triggering factor of this disease. Several laboratory studies, performed in vitro and in vivo, have demonstrated the beneficial effects of non-enzymatic antioxidants on the reduction of oxidative stress...
Article
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Purpose This study aimed to evaluate the effect of rice bran (RB) supplementation to a high-sugar fat (HSF) diet on cardiac dysfunction in an experimental obesity model. Methods Male Wistar rats were distributed into three groups: control, high-sugar fat, and high-sugar fat supplemented with 11% RB for 20 weeks. Results HSF diet promoted obesity...
Article
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Introduction: Tobacco smoke is associated with oxidative and inflammatory pathways, increasing the risk of chronic-degenerative diseases. Our goal was to evaluate the effects of acute “Pera” and “Moro” orange juice consumption on inflammatory processes and oxidative stress in microRNA (miRNA) expression in plasma from healthy smokers. Methods: This...
Article
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Background/aims: Oxidative stress is associated with cardiometabolic alterations, and the involvement of excess glucose and fatty acids has been demonstrated in this process. Thus, the aim of this study was to investigate the effects of different hypercaloric diets on cardiac oxidative stress. Methods: Wistar rats were randomized into four group...
Article
Background Skeletal muscle is the most important organ for whole-body glucose homeostasis. However, it has been suggested that obesity-related inflammation could be involved in insulin resistance and diabetes mellitus type 2 (DM2) development due several mechanisms, among them, the reduced expression of the glucose transporter type 4 (GLUT-4). Gamm...
Article
The goal of this study was to test if obesity progression can be a risk factor to alter cardiac metabolism and function along the time. Male Wistar rats were randomly divided to receive either chow diet (12.0% calories from fat) [C group] or high-fat diet (49.7% calories from fat) plus sucrose in the drinking water (100% from carbohydrate) [H group...
Article
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Background: As some individuals present resistance to obesity development, experiments have been trying to understand their susceptibility to cardiometabolic diseases. Objective: To evaluate if the cardiac remodeling was related to collagen protein expression change. Methods: Male Wistar rats were randomized into two experimental groups: control di...
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Background: Obesity is a chronic low-grade inflammation condition related to cardiac disorders. However, the mechanism responsible for obesity-related cardiac inflammation is unclear. The toll-like receptor 4 (TLR-4) belongs to a receptor of the transmembrane family responsible for the immune response whose activation stimulates the production of...
Article
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Introduction: The receptor for AGEs (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface receptors expressed in many organs, among them, the kidneys. When activated, RAGE leads to a sequence of signaling that results in inflammation and oxidative stress, both involved in kidney disease pathogenesis. Gamma-oryzanol (γOz)...
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Redox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant women and non-pregnant were studied. Redox markers...
Article
Nonalcoholic steatohepatitis (NASH) is a pathological manifestation with a progressive incidence in response to the epidemic of hepatic steatosis caused primarily by excessive energy intake. The present study unravels affected biological processes and functions by the presence of NASH in rats using a label‐free quantitative proteomic strategy. NASH...
Article
Metabolic syndrome (MetS) include obesity as a critical feature and is strongly associated with risk of cardiovascular disease (CVD). Insights into mechanisms involved in the pathophysiology of these clinical manifestations are essential for the development of therapeutic strategies. Thus, Western diets (WD) have been widely employed in diet-induce...
Article
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The aim of the study is to compare the qualitative and semi-quantitative profile of the polyphenol fraction purified from the leaf (BLPF) and fruit (BFPF) of bergamot (Citrus bergamia), and to evaluate their antioxidant and anti-inflammatory activity. The analytical qualitative profile was carried out by LC-ESI/MS using three different approaches:...
Article
Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this stu...
Article
The literature has reported a higher prevalence of negative clinical outcomes due to Coronavirus disease 19 (COVID-19) in obese individuals. This can be explained by the cytokine storm, result from the cytokine production from both obesity and viral infection. Gamma-oryzanol (γOz) is a compound with anti-inflammatory and antioxidant activities. How...
Article
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Introduction: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The a...
Article
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Considering the importance and lack of data of toxicogenomic approaches on occupational exposure to anaesthetics, we evaluated possible associations between waste anaesthetic gases (WAGs) exposure and biological effects including oxidative stress, DNA damage, inflammation, and transcriptional modulation. The exposed group was constituted by anaesth...
Article
Background Decreased cardiac contractility has been observed in cirrhosis, but the mechanisms that initiate and maintain cardiac dysfunction are not entirely understood. Aim of the study. We test the hypothesis that cirrhotic cardiomyopathy is related to deterioration of myocardial contractility due to alterations in calcium-handling proteins expre...
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Purpose The consumption of products containing fructose is associated with metabolic disorders and nonalcoholic fatty liver disease (NAFLD). Several pathways have been described associating the fructose intake and liver damage, among them the reduced peroxisome proliferator-activated receptor alpha (PPAR-α) expression, insulin resistance, inflammat...
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Background/aims: Considering the importance of inflammation on obesity-related disorders pathogenesis, including cardiac dysfunction, the interest in natural anti-inflammatory therapeutic strategies has emerged. The lycopene is a carotenoid presents in tomato and red fruits that displays anti-inflammatory properties. In this sense, we will evaluat...
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Aims: To test if the level of oxidative stress is different in women with overweight and with metabolic syndrome. Study Design: Cross-sectional. Place and Duration of Study: Endocrinology Clinic of the Botucatu Medical School-UNESP, between March 2013 and March 2014. Methodology: Eighty women (31.15 ± 7.91 years old) attended at the Endocrinology C...
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We have identified the best harvesting periods, related to higher bioactive compound content and post‐harvest quality, for minimally processed sweet potatoes with orange pulp and cream pulp. Quality loss in minimally processed sweet potatoes occurred due to browning in cv. Mãe de Familia and ESAM1 and to whitening in cv. Paraná. Both Mãe de Família...
Article
Cauliflowers are generally associated with healthy diets due to their positive impact on health. This research aims to evaluate the effects of cooking processes (boiling, steaming and microwaving) and different preparation times, on the content of carotenoids and provitamin A and tocopherols, in cauliflowers and to verify the effect of the cooking...
Article
It has been described that the cardiac dysfunction in the obesity model is because of collagen imbalance and that angiotensin II (Ang II) contributes to myocardial fibrosis. However, it remains undefined if changes in collagen I and III metabolism in obesity is due to the renin-angiotensin system (RAS) dysregulation from myocardium or excessive adi...
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The objective of this study was to evaluate Spondias mombin L. (SM) pulp and its influence on cardiac remodelling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: a sham group (animals underwent simulated surgery) that received standard chow (S; n = 20), an infarcted group that received standard chow (MI; n = 24), an...
Chapter
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Diabetes mellitus is a complex disease characterized by glucose, lipid, and protein deregulated metabolism due to insulin deprivation affecting various tissues in the human body. Dysmetabolism in diabetes could lead to oxidative stress, which, in turn, could contribute to pathological processes in the diabetic condition. Natural compounds have been...
Chapter
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Cardiovascular disease is a term for disorders of the heart and blood vessels and its cause is multifactorial, involving behavioral, environmental, and genetic factors. All these causes can be associated with a phenomenon called oxidative stress. In this condition, oxidative stress occurs mainly due to the overproduction of reactive species that ca...
Article
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Solanum paniculatum L. or popularly known as “jurubeba” is an herbal medicinal plant. A few studies have investigated its biological effects; however, research aimed at elucidating the redox balance effects from its fruits has not been reported so far. ROS interplays in various fields of medicine such as chemotherapy. Here, we evaluated antioxidant...
Article
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This cross‐sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollutio...
Article
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We evaluated oxidative stress (OS) and DNA damage in acromegaly patients in a follow-up study at a public tertiary health service. Acromegaly patients in follow up at a public tertiary health service from 2012 to 2013 were enrolled in this study. Healthy volunteers were selected as control group. OS was evaluated in plasma and peripheral lymphocyte...
Article
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The system redox imbalance is one of the pathways related to obesity-related cardiac dysfunction. Lycopene is considered one of the best antioxidants. The aim of this study was to test if the tomato-oleoresin would be able to recovery cardiac function by improving β-adrenergic response due its antioxidant effect. A total of 40 animals were randomly...
Article
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Biogenic amines are important indicators of food quality with recognized antioxidant capacity. Diets that are rich in these compounds promote several benefits for human health, although the consumption in excess may result in food poisoning. This study aims to screen the levels of biogenic amines in four colored cauliflowers, before and after cooki...
Article
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Background: The higher consumption of fat and sugar are associated with obesity development and its related diseases such as non-alcoholic fatty liver disease (NAFLD). Lycopene is an antioxidant whose protective potential on fatty liver degeneration has been investigated. The aim of this study was to present the therapeutic effects of lycopene on N...
Article
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To verify if the bark of Passiflora edulis prevents obesity-related disorders and oxidative stress in db/db mice. Obese male db/db mice (n = 14 animals) were randomly divided into two groups to receive standard chow and water (obese, n = 7 (OB)) or standard chow with bark of Passiflora edulis (BPe) (obese + BPe, n = 7 (OB + BPe)) for 16 weeks. The...
Article
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The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement...
Article
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Rice bran (RB) is a rice milling by-product and an interesting source of fibers and bioactive compounds as γ-oryzanol. These food compounds are capable of prevent and/or improve metabolic disorders associated to chronic diseases. To provide a good source of bioactive compounds and a better destination for RB, the aim of this study was to develop an...
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This work describes the acoustic properties, such as absorption and reflection acoustic coefficients and noise reduction coefficient (NRC), and the mechanical strengthening of a modified asphaltic emulsion concrete. The asphalt emulsion has emulsifying agents, water and 62% asphalt, and has been mixed with styrene butadiene (SB) to 5% in asphalt we...
Article
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Adipose tissue dysfunction is a condition characterized by inflammation and oxidative stress able to lead metabolic disorders. Curcuma longa L. (Cl) is a rhizome commonly used in Indian culinary which presents anti-inflammatory and antioxidant compounds. The aim of this study was to evaluate the effect of in natura Curcuma longa L. on adipose tissu...