Camerron Crowder

Camerron Crowder
University of Alabama at Birmingham | UAB · Hugh Kaul Precision Medicine Institution & Department of Neurobiology

Doctor of Philosophy

About

20
Publications
5,248
Reads
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290
Citations
Introduction
My research interests involve using molecular, cellular, and pharmacological approaches to better understand cellular development and signaling associated with healthy and diseased states. I aim to understand how genetic mutations lead to disease mechanisms associated with rare-neurological disorders. To examine this I use artificial intelligence and gene editing approaches to develop disease models that can be used to screen therapeutics to identify drugs for clinical trial.
Additional affiliations
August 2021 - present
University of Alabama at Birmingham
Position
  • Professor (Assistant)
October 2019 - present
Hugh Kaul Precision Medicine Institute
Position
  • Managing Director
July 2018 - January 2019
University of Alabama at Birmingham
Position
  • PostDoc Position

Publications

Publications (20)
Preprint
The recent emergence of a novel coronavirus, SARS-CoV-2, has led to the global pandemic of the severe disease COVID-19 in humans. While efforts to quickly identify effective antiviral therapies have focused largely on repurposing existing drugs 1–4 , the current standard of care, remdesivir, remains the only authorized antiviral intervention of COV...
Article
Full-text available
Estrogens regulate vertebrate development and function through binding to nuclear estrogen receptors alpha and beta (ERα, ERβ) and the G protein-coupled estrogen receptor (GPER). Studies in mutant animal models demonstrated that ERα and ERβ are required for normal ovary development and function. However, the degree to which GPER signaling contribut...
Preprint
Full-text available
Estrogens regulate vertebrate development and function through binding to nuclear estrogen receptors alpha and beta (ERα, ERβ) and the G protein-coupled estrogen receptor (GPER). Studies in mutant animal models demonstrated that ERα and ERβ are required for normal ovary development and function. However, the degree to which GPER signaling contribut...
Article
Full-text available
Androgens act through the nuclear androgen receptor (AR) to regulate gonad differentiation and development. In mice, AR is required for spermatogenesis, testis development and formation of external genitalia in males and oocyte maturation in females. However, the extent to which these phenotypes are conserved in non-mammalian vertebrates is not wel...
Article
Full-text available
Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a role for NF-κB in immunity and disease on a broader evolutionary scale we have characterized NF-κB in a sea anemone (Exaiptasia pallida; called Aiptasia herein) model for cnidarian symbiosis...
Article
Full-text available
The relationship between reef-building corals and phototrophic dinoflagellates of the genus Symbiodinium is fundamental to the functioning of coral reef ecosystems. It has been suggested that reef corals may adapt to climate change by changing their dominant symbiont type to a more thermally tolerant one, although the capacity for such a community...
Preprint
Full-text available
Androgens act through the nuclear androgen receptor (AR) to regulate gonad differentiation and development. In mice, AR is required for spermatogenesis, testis development and formation of external genitalia in males and oocyte maturation in females. However, the extent to which these phenotypes are conserved in nonmammalian vertebrates is not well...
Article
Full-text available
Reproductive timing in brooding corals has been correlated to temperature and lunar irradiance, but the mechanisms by which corals transduce these environmental variables into molecular signals is unknown. To gain insight into these processes, global gene expression profiles in the coral Pocillopora damicornis were examined (via RNA-Seq) across lun...
Article
Full-text available
Many non-model species exemplify important biological questions but lack the sequence resources required to study the genes and genomic regions underlying traits of interest. Reef-building corals are famously sensitive to rising seawater temperatures, motivating ongoing research into their stress responses and long-term prospects in a changing clim...
Article
Full-text available
Reproductive timing in corals is associated with environmental variables including temperature, lunar periodicity, and seasonality. Although it is clear that these variables are interrelated, it remains unknown if one variable in particular acts as the proximate signaler for gamete and or larval release. Furthermore, in an era of global warming, th...

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Projects

Projects (4)
Project
At the Hugh Kaul Precision Medicine Institute, we use bioinformatics and artificial intelligence tools to focus on finding therapeutic options for patients with rare genetic disorders. In collaboration with Dr. Summer Thyme, my research focus on using CRISPR/Cas9 mutagenesis to develop zebrafish models of genetic disorders associated with neuropsychiatric disease.
Project
To determine the role of GPER signaling in gonad sex determination, development and gametogenesis in zebrafish.