Camelia Mia Hotnog

Camelia Mia Hotnog
Stefan S. Nicolau Institute of Virology (IVN) | IVN · Center of Immunology

PhD

About

28
Publications
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Introduction
Camelia MIA Hotnog currently works at the Center of Immunology, Stefan S. Nicolau Institute of Virology (IVN). Camelia does research in Cancer Research, Molecular Biology and Cell Biology. Their most recent publication is 'Modulation of the interplay between p53, ICAM-1 and VEGF in drug-treated LoVo colon cancer cells'.

Publications

Publications (28)
Article
Full-text available
Berberis vulgaris (L.) has remarkable ethnopharmacological properties and is widely used in traditional medicine. The present study investigated B. vulgaris stem bark (Berberidis cortex) by extraction with 50% ethanol. The main secondary metabolites were quantified, resulting in a polyphenols content of 17.6780 ± 3.9320 mg Eq tannic acid/100 g extr...
Preprint
Full-text available
The present study investigates B. vulgaris stem bark (Berberidis cortex) by extraction with 50% ethanol. The main secondary metabolites were quantified, resulting in a polyphenols content of 17.6780 ± 3.9320 mg Eq Tannic acid / 100 g extract, phenolic acids amount of 3.3886 ± 0.3481 mg Eq Chlorogenic acid / 100 g extract and 78.95 µg/g berberine. T...
Article
Full-text available
Capsicum annuum (L.) is one of the essential spices most frequently used in our daily routine and has remarkable ethnobotanical and pharmacological properties. Its fruits are rich in vitamins, minerals, carotenoids, and numerous other phenolic metabolites with a well-known antioxidant activity. Regular consumption of chili fruits may have a positiv...
Article
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New pyrrolo[1,2-b]pyridazines were synthesized by 3 + 2 cycloaddition reaction between mesoionic oxazolo-pyridazinones and methyl/ethyl propiolate. The mesoionic compounds were generated in situ by action of acetic anhydride on 3(2H)pyridazinone acids obtained from corresponding esters by alkaline hydrolysis followed by acidification. The structure...
Article
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(1) Background: Cutaneous melanoma (CM) originates from melanocytes and causes 90% of skin cancer deaths; therefore, the comparison of different soluble and tissue markers could be valuable in the detection of melanoma progression and therapy monitoring. The present study is focused on the potential correlations between soluble S100B and MIA protei...
Article
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The current study describes the synthesis, physicochemical characterization and cytotoxicity evaluation of a new series of pyrrole derivatives in order to identify new bioactive molecules. The new pyrroles were obtained by reaction of benzimidazolium bromide derivatives with asymmetrical acetylenes in 1,2-epoxybutane under reflux through the Huisge...
Article
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Cisplatin is one of the most effective anticancer agents used to treat colon cancer, which is the third malignancy between the most common human cancers in the world, but the resistance developed represents an obstacle against the full success of chemotherapy. An emerging interest appeared in finding other metallic compounds, such as ruthenium(III)...
Conference Paper
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Background The HER2 gene Ile655Val polymorphism might affect the active conformation of its protein product which would than influence the heterodimerization, signal transduction and the tumor growth. The aim of this work was to investigate the HER2 codon 655 polymorphism and EGFR expression related to proliferative activity of urinary bladder tumo...
Article
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Colorectal cancer is the third of the most common human cancers in the world, and involves genetic alterations, aberrant progression of the cell cycle, resistance to growth inhibition, proliferation without dependence on growth factors, replication without limit, evasion of apoptosis, induction of angiogenesis, and modification of cell adhesion. Du...
Article
Full-text available
Colorectal cancer is the third of the most common human cancers in the world, and involves genetic alterations, aberrant progression of the cell cycle, resistance to growth inhibition, proliferation without dependence on growth factors, replication without limit, evasion of apoptosis, induction of angiogenesis, and modification of cell adhesion. Du...
Chapter
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A big challenge for a successful colon cancer treatment is the lack of eradication of the entire tumour cell population and consequent development of chemoresistance. Control of cell number from tissues and elimination of cells predisposed to malignant transformation, having an aberrant cell cycle or presenting DNA mutations, might be performed by...
Article
Transformation of normal cells, tumor progression and advanced metastasis involve a complex series of events such as genetic alterations, aberrant progression through cell cycle, induction of angiogenesis, inhibition of apoptosis and modification of cell adhesion. One of the most effective anticancer agents used to treat colon cancer is 5-Fluoroura...
Article
Since cancer is a cellular disease, it is essential to identify the development stages and use the information in the prediction, prevention, early detection and design of drug targets. Colon cancer represents a malignancy with high incidence and mortality throughout the world, its etiology involving many genetic, immunological and biochemical fact...

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