Cahyana Herry

• Dr. Antonius Herry Cahyana
• Lecturer at University of Indonesia

p> Myristica fragrans is a widely distributed plant that grows well in Indonesia. This plant, also known as nutmeg, has been used in various fields such as food, aromatherapy, and other industries. Research on nutmeg plants has been widely conducted, but most of it discusses the seeds and mace of nutmeg. However, research on nutmeg leaves is still...

Nutmeg (Myristica fragrans) is a plant that grows naturally in Indonesia and widely used in the food and industrial sectors. Nutmeg seeds have been widely studied because they have a variety of compounds with good activities, but research on the leaves still needs to be completed. Therefore, this research compared nutmeg leaves and seed extracts' s...

Molecular hybridization represents a strategic approach in drug design, where two or more pharmacophoric elements from distinct bioactive molecules are integrated into a single hybrid compound. In this study, we synthesized hybrid compounds of chalcone, triazole, and eugenol through straightforward reactions using 4-hydroxyacetophenone as the start...

CoFe2O4 magnetic nanoparticles were successfully synthesized using the green synthesis method with petai peel extract (PPE) as the capping and reducing agent. These nanoparticles were characterized using various techniques, including XRD, VSM, FTIR spectroscopy, UV-DRS, FESEM, EDX, TEM, HR-TEM, and SAED. The synthesized nanoparticles possess cubic...

The utilization of catalysts in organic reactions represents a widely utilized principle within the concept of green chemistry. This study focuses on utilizing hydroxyapatite from green mussel shell waste combined with CoFe2O4 as a heterogeneous catalyst for synthesizing 2-amino-4H-chromene derivative. The green mussel shells were calcined to produ...

Isatin is a unique compound with many bioactivities such as antiviral, anti-HIV, antitumor, anti-inflammatory, anticonvulsant, and antifungal. In this study, isatin derivatives were synthesized with an iodine catalyst and tested for antibacterial and antioxidant activities. Isatin derivatives were conducted through a Knoevenagel condensation reacti...

Utilizing bioresources and renewable materials represents a sustainable approach in chemical reactions. This study aims to harness seafood waste from green mussel shells as a raw material to produce hydroxyapatite (HAp) and employ it as a heterogeneous catalyst for synthesizing spirooxindole compounds. The green mussel shells underwent varying temp...

Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused on green synthesis. Synthesis of spirooxindoles is mainly carried out through multicomponent reactions combined with various green approaches such as...

This study aims to synthesize Fe3O4 nanoparticles using iron rust and evaluate the catalyst's ability in spiropiperidine synthesis. Fe3O4 was synthesized using the thermal decomposition method with palmitic acid as a capping agent. Characterization techniques, including XRD, IR, SEM-EDX, TEM, and PSA confirmed the formation of magnetic Fe3O4 with a...

Saurauia vulcani flora develops certainly in North Sumatra Province, Indonesia. It is normally consumed as an antidiabetic remedy and a treatment related to digestion diseases. This research aims to isolate the major compound from S. vulcani plants and assess the bioactivity of the S. vulcani plant for its anti-colorectal cancer potential. Subseque...

Isatin (1H-indole-2,3‑dione) is a natural heterocyclic compound extracted from various plants and has biological activity as an anticancer agent. Chalcones with the addition of several functional groups (hydroxyl, carboxyl, phenyl, etc.) may become useful templates for the development of new anticancer agents. In this study, we have synthesized Cu/...

Chalcones, with two connected aromatic rings through an α,β-unsaturated carbonyl skeleton, display diverse biological roles like antimalarial, antibacterial, anticancer, and antioxidant activities. This research focuses on crafting azachalcone derivatives from 2-acetylpyridine and aromatic aldehydes using l-proline/Et3N as a catalyst. Refinements e...

The substituted 1,2,3-triazole core is prevalent in numerous commercially available drugs utilized for a wide range of clinical applications. Simultaneously, chalcone represents a privileged framework discovered in natural products exhibiting intriguing bioactivities. In this study, we synthesized triazole-bonded chalcone compounds (4ax-4by), start...

Fathoni A, Hudiyono S, Cahyana AH, Ilyas M, Purnaningsih I, Agusta A. 2023. Anticandidal and antioxidant potencies of endophytic fungi associated with Tinospora crispa. Biodiversitas 24: 2547-2555. Natural products including endophytic fungi, have opportunities for medicinal uses as anticandidal and antioxidant agents. This study aimed to investiga...

Metal ferrite (MFe2O4) is a type of ceramic oxide with magnetoelectric properties. In this review, we have collected and analyzed the research trends of MFe2O4 as a heterogeneous catalyst in multicomponent reactions (MCRs). MFe2O4 could activate specific groups of reactants by increasing their electrophilicity and acting as Lewis acid capable of ac...

The biological activities of extracts and isolated compounds of Macaranga mappa stem bark for antidiabetic herbal medicine, antioxidant, and cytotoxicity activities have been determined. The antidiabetic, antioxidant, and cytotoxicity activities of the sample were carried out by inhibition value of α-glucosidase, DPPH method, and brine shrimp larva...

In the preliminary study, endophytic fungi associated with Tinospora crispa have been reported as antibacterial that assayed by TLC-bioautography. While more comprehensive studies for antibacterial activity using microdilution, total phenolic, flavonoid contents, and their relationship of extracts of fungal endophytes from this plant have never bee...

Isolation, characterization, and bioproduction capacity of (+)-epoxydone produced by Phomopsis sp. TcBt1Bo-6 was performed in this present report. The fungus was cultured in potatoes dextrose broth (PDB) medium. Isolation and purification of (+)-epoxydone using chromatography methods. The metabolite structure elucidation was carried out by using UV...

Isatin is a special heterocyclic compound because of its various biological activities. This research aims to synthesize isatin derivatives catalyzed by iron (III) trifluoromethanesulfonate, Fe(OTf)3. In this study, Fe(OTf)3 catalysts were synthesized using Fe³⁺ ions and Lewis acid and characterized by Fourier transform infrared (FTIR) spectroscopy...

Nitrogen-containing compounds are found in nature and have an essential role in medicine. One of them is a derivative of 2,4,6-triarylpyridines, which has antibacterial, anti-inflammatory, anti-fungal, antioxidant, and anti-malarial activity. The synthesis of 2,4,6-triarylpyridines derivates was successfully carried out with the Multicomponent Reac...

Magnetic Fe3O4 has interesting characteristics such as large surface area, low toxicity, ferromagnetic, and biocompatible. The presence of magnetic properties in Fe3O4 provides an advantage in its application as a heterogeneous catalyst. This study highlights the synthesis of Fe3O4 modified chitosan composite and evaluates the catalytic ability in...

Phenazine derivative compounds are of concern because of their extraordinary activities in medicine. The aim of this study is to synthesize the derivative of benzo[a]pyrano[2,3-c] phenazine compound based on lawsone with caffeine catalyst using the one-pot multicomponent reaction method and test its antioxidant activity. The formation of the target...

Heterocyclic compounds such as spirooxindole, with five rings containing nitrogen, have an important role in the realm of medicine. This study aims to synthesize the spirooxindole derivative compounds using Fe3O4 / graphene oxide (GO) nanocomposite as the catalyst. The GO sample was synthesized by Hummer's method, followed by the insertion of Fe3O4...

Dihydropyrimidine is one of the heterocyclic compounds that has important bioactivity and is well known for its application in medicine. This study aims to test the catalytic ability of l-proline nitrate in the ionic liquids phase for the synthesis of pyrimidine derivatives. The pyrimidine derivatives were synthesized through a one-pot threecompone...

Iron (III) trifluoromethanesulfonate [Fe (OTF)3] has been proven to be an effective catalyst in the synthesis of 2-phenylquinoline-4-carboxylic acid by the Doebner reaction using one-pot pyruvic acid, aniline, and benzaldehyde. This method shows attractive characteristics including concise one-pot conditions, high atom economy, very limited energy...

Multicomponent reactions (MCRs) are an efficient strategy to synthesize various heterocyclic compounds in one pot, and a simple step by combining the reactants in the same flask. In this study, a series of spiro-oxindole substituted chromene rings were synthesized via Knoevenagel and Micheal addition reaction using curcuminoid and chalcone as precu...

Copper ferrite (CuFe2O4) is one of the most popular ferrite spinel semiconductors due to its superparamagnetic properties. In this study, CuFe2O4 nanoparticles were successfully prepared through green synthesis mediated by Morus alba L. leaf extract. Secondary metabolites, such as alkaloids and saponins, in Morus alba L. leaf extract acted as a wea...

Pyranopyrazole is a heterocyclic organic compound in which the skeleton is a pyran ring substituted by pyrazole in the ortho position. Pyranopyrazole can be synthesized using aldehyde, hydrazine, ethyl acetoacetate, and malononitrile as precursors with a multicomponent reaction method. Synthesis of pyranopyrazole is carried out through the Knoevena...

Tagetes erecta flowers contain nematoside compound α-Terthienyl (2,2′:5′,2″-Terthiophene) which are toxic to erythrocytes and human skin. In this study, analysis of the content of α-Terthienyl (2,2′:5′,2″-Terthiophene) in orange and yellow Tagetes erecta flowers originating from several areas in West Java by HPLC and LC-MS/MS have been studied. The...

Pyrazolone derivates are compounds that widely found in biological activity. Thus, this compound commonly used in drugs production and product synthesis. In this study, pyrazolone derivatives were synthesized by Fe3O4 nano magnetic catalyst. The nano-magnetic Fe3O4 catalyst is made from iron rust and used cooking oil. Synthesis of nanomagnetic Fe3O...

In this study, MgFe2O4 nanoparticles were successfully prepared through one-pot synthesis using Cajanus cajan (L.) Millsp. Leaf extract (CLE) as a source of weak bases and stabilizing agents. The optical property, structure, morphology, and particle size of the nanoparticles were analyzed. Several characterizations were performed to investigate the...

Saurauia vulcanii plant has been widely used to treat a variety of diseases suffered by villagers as antidiabetic and digestive problems’ remedy. The Forestry Research and Development Agency has cultivated this plant at Forest Area for Specific Purpose in Northern Sumatra. The aims of this study were to determine the toxicity and total phenolic con...

Endophytic fungi may be a potent source of bioactive compounds and have a vast repertoire of diverse metabolites. One source of endophytic fungi host plants is a medicinal plant such as Brotowali or Tinospora crispa. Research corresponding to the antibacterial activity of endophytic fungi extracts isolated from T.crispa taken from several regions i...

Spirooxindole-pyrrolizidine is an essential compound of concern for researchers, especially in its structure which shows some existing bioactivities in medicine. A novel series of spirooxindole-pyrrolizidine were prepared by a one-pot multicomponent reaction method. The reaction occurred between α, β-carbonyl unsaturated, isatin, and l-proline thro...

A couple of novel Spirooxindole-pyrrolizidine compounds have been synthesized from chalcone derivatives as α, β-unsaturated carbonyl compounds by the help of heterogeneous magnetically separable Fe 3 O 4 -GO catalyst. Four steps involved in this research are synthesis of Fe 3 O 4 -GO catalyst, synthesis of chalcone derivatives from 4-hydroxybenzald...

The simple isolation method of Cannabinol compounds from cannabis plants by maceration combined with ultrasonication assisted extraction, fractionation, separation and purification was carried out to obtain Cannabinol isolates which can be used as a reference standard analysis material. Ultrasonication was proven to shorten the extraction time, whe...

A separable NiFe 2 O 4 nanocrystalline catalyst was synthesized via a simple co-precipitation method. The catalytic activity of this heterogenous catalyst was investigated to synthesize Spiro-oxindole-chromene derivates via Knoevenagel condensation, and Michael addition reaction under conventional heating condition. The catalyst showed a prominent...

Derivatives of 1,8-dioxoacridine and polyhydro-quinoline compounds are active compounds that have several beneficial bioactivities. The purpose of this research is to synthesize 1,8-dioxoacridine and polyhydro-quinoline derivatives supported by SiO2-AA-Glu as the catalyst and test their antioxidant activity. The reaction was conducted at the optimu...

Phenazine is one of the most important organic compounds because of its various biological activities. This study aims to synthesize the phenazine derivatives compound using 2-hydroxy-1,4-naphthoquinone (lawsone) with a one-pot four-component method. Phenazine derivative that had been successfully synthesized was carried out by reacting four reacta...

Pyrimido [4,5-d] pyrimidine is an uracil compound that has similarities to the structure of pteridine and purines and has significant bioactivity. The aim of this research is to synthesize pyrimido [4,5-d] pyrimidine derivatives and test their activity as antioxidant. The reaction was carried out with the support of the iodine catalyst to get an ef...

1,4-dihydropyridine (DHPs) is a class of compounds that are significantly present in a variety of natural products and commercial medicines such as felodipine. This study aims to modify cinnamaldehyde to become derivatives of 1,4-dihydropyridine using NiFe2O4 MNPs as the catalyst. NiFe2O4 MNPs were synthesized by the co-precipitation method using a...

Phenolic compounds are important group of plant-based biologically active compounds that have a particularly antioxidant capacity, which is closely related to the health effects. Based on the beneficial effect of phenolic compounds in humans, it is appropriate to perform the preparation of antioxidant agents by focusing on the structure-activity re...

Cinnamaldehyde is the main compound in the cinnamon (Cinnamomum burmanii) that mostly applied in the essence and aroma industries and can be used as a medicinal product because of its bioactivities. This study aims to modify the cinnamaldehyde compound to 2-hydroxy-1,4-naphthoquinone derivatives containing nitrogen and test their bioactivity as an...

The spiro substances gained a lot of attention in serving as scaffolds in modern drug discovery. Spiro compounds present in natural products such as analgesic morphine, the antibiotic monensin, cannabispirenone A, and alkaloid citrinalin A. In regards to the spiro compound's properties of pharmacological, the synthetic method development which enab...

Abrus precatorius Linn. (Fabaceae), also known as “Saga Rambat”, is commonly found in tropical countries, including Indonesia. The leaves of the plant are widely used commercially in Indonesia to treat cough and sprue. The aim of this research is to segregate and identify the chemical compound of A. precatorius leaf methanolic extract originated fr...

Introduction: Saurauia plant has been widely used to treat a variety of diseases suffered by villagers at various places in the world. These species are widely used traditionally by the community as antidiabetic and digestive problems’ remedy. This paper will present various uses and researches ever carried out by researchers in the world on variou...

We have synthesized two 1,4-dihydropyridine derivatives via one-pot three-component reaction. The reactions were catalyzed by copper(I) iodide nanoparticles with crystallite size of 78.4 nm. Formations of cyclocondensation products were confirmed by Fourier Transform Infrared (FTIR), UV-Vis and Gas Chromatography-Mass Spectrometry (GC-MS) spectra.

Guanidine hydrochloride has been successfully used in one-pot three component assembly of aromatic aldehyde, ethyl acetoacetate and ammonium acetate to produce 1,4-dihydropyridines. Optimization of reaction conditions revealed that 10 mol% guanidine at room temperature for 4 h in ethanol is the best condition for synthesis of compound 4a in 85 % yi...

In this study, we report 3-component combination of 2-naphthol, dimedone and benzaldehyde in 9,9-dimethyl-12-phenyl-9,10-dihydro-8H-benzo[a]xanthen-11(12)-one synthesis using water fraction of Sapindus rarak D.C. fruit extract. This extract promoted an efficient synthesis under mild reaction conditions. The compound structure was confirmed by FT-IR...

Diethyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate, a 1,4-DHP derivative, has been synthesized from benzaldehyde, ethyl acetoacetate and ammonium acetate via a one-pot three component reaction in crude glycerol as solvent. Crude glycerol was obtained from the treatment of waste cooking oil. The product was obtained in 69 % yield wh...

Derivatization of lawsone compound (1) was done by reacting it with ethanolamine to give 2-((2-hydroxyethyl)amino)-1,4-naphthoquinone (2), and then treating with acetic anhydride to produce the desired compound 2-((1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino) ethyl acetate (3). The target compound possesses the antibacterial activity against E. coli...

Our ongoing project regarding to drug discovery based on Indonesian medicinal plants led to the isolation of β-sitosterol from the methanol extract of the leaves of Macaranga magna Turrill. β-sitosterol, a white needle crystals (1) were isolated using serial column chromatographic separation methods. The chemical structure was determined based on s...

A facile heterogeneous synthesis of 1,4-dihydropyridine was effectively conducted using one-pot three component-coupling of an aromatic aldehyde, an active methylene substance, and ammonium acetate in the presence of nanochitosan as a biopolymer catalytic system under solvent-free microwave-irradiation conditions in satisfactory yields. Chitosan na...

Cinnamaldehyde is an essential compound in the cinnamon that have plentiful bioactivities. This research aims to modify cinnamaldehyde to become derivatives of dihydropyrimidine using graphene oxide (GO) as catalyst. GO was synthesized from graphite powder. Afterward, GO was applied in dihydropyrimidine synthesis with one-pot three-component method...

The bioactively rich soursop leaf extract can be encapsulated inside several natural coating materials. The extract of soursop leaf has been found to contain many bioactive compounds such as various phenolic compounds that are beneficial for anticancer, antidiabetic and many other health benefits. However due to the sensitive nature of the bioactiv...

We have prepared a three-component reaction of ethyl acetoacetate, urea and benzaldehyde for synthesis of a pyrimidine derivative, ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate using CuO@SiO2 nanocatalyst. The catalyst was prepared by using glycerol as green solvent, and then it was characterized by FT-IR, EDAX spectrosco...

Acridine derivatives are a class of nitrogen heterocycles which have broad spectrum of important biological properties and pharmaceutical applications. Low-cost eggshells waste material was used as source of CaCO3 to modified magnetic Fe3O4 particles prepared from co-precipitation to serve as reusable heterogeneous catalyst. The synthesized eggshel...

The synthesis of 2-amino-4H-chromenes via Knoevenagel condensation/Michael addition/cyclization reactions under microwave irradiation is reported. Nanoparticle magnetite Fe3O4/camphor with nanospheres structure was developed for utilization as the heterogeneous Bronsted acid in chemical transformation. The synthesis and characterization of camphor...

Preparation of CuO/SiO2 catalyst has been done via sol-gel method using copper nitrate solution and TEOS as precursors. Several instruments such as FT-IR, SEM, EDAX, XRD and particle sizer were employed to characterize the obtained material. Then, CuO/SiO2 catalyst was successfully used in the synthesis of three curcumin derivatives, 4,4'-((1E,1'E)...

The role of free solvent system reaction in environmentally safe and economical technologies, mainly in chemical manufacturing processes and green chemistry is inevitable. Furthermore, the key role of free solvent as condition in the synthesis of heterocycles and other organic compounds is well-known. After completion of reaction, they can easily s...

Nano-Fe3O4 had been synthesized by rapid and green chemistry approach using rust as Fe source and palmitic acid as capped and reductor agent. Liquid parrafin is used as an unexpensive medium of dispersion due to its high boiling point in thermal decomposition. The Fe3O4 was characterisized by FTIR, XRD and TEM-EDS.

Benzaldehyde and cinnamaldehyde were successfully condensed with barbituric acid using samarium(III) chloride in water for 2 h at room temperature. The products were confirmed through FTIR, UV-Vis and GC-MS analysis. © 2018 Oriental Scientific Publishing Company. All rights reserved.

An environment-friendly protocol for the synthesis of bis(phenyl-1H-pyrazol-5-ol) derivatives assisted by a magnetically recoverable catalyst, Fe3O4@SiO2@Sm, has been developed. The catalyst efficiently supports a one-pot, three-component reaction between aromatic aldehydes, phenylhydrazine and ethyl acetoacetate to give corresponding products in m...

The 2,4,5-trisubstituted imidazole derivatives have been synthesized via one-pot condensation of benzil aromatic aldehydes and ammonium acetate catalyzed by CoFe3O4 magnetic catalyst. All products were obtained in good yields. The CoFe3O4 magnetic catalyst can be recycled easily and reused without significant decrease in catalytic ability.

Magnetite – activated chicken eggshell (Fe3O4-ACE) composite has been prepared via co-precipitation method and characterized with FTIR (Fourier Transform Infrared), SEM (Scanning Electron Microscope), XRD (X-Ray Diffraction) and EDS (Electron Dispersive Spectroscopy) instruments. In application, Fe3O4-ACE is successful to catalyze the cross-Aldol c...

A facile technique for the condensation of o-phenylenediamine and aromatic aldehydes to benzimidazole derivatives in the presence of nano-sized Fe3O4 particles has been studied. The reactions were conducted under a mild condition. The compound 3a-c was obtained in high yields, and the catalyst could be readily separated by an ordinary external magn...

Fe3O4@chitosan nanoparticles (size between 6-8 nm) has been prepared by co-precipitation method and characterized by means of FT-IR, XRD and TEM. In application on the condensation of cinnamaldehyde with dimedone, this nanoparticle can catalyze the formation of (E)-5,5-dimethyl-2-(3-phenylallylidene)cyclohexane-1,3-dione in a good yield. The best c...

Catalytic application of copper ferrite nanoparticles in benzo[g]chromene-3-carbonitril synthesis via one-pot, three-component reaction has been explored. The product was obtained in a high yield (60-90%) in the varied conditions. The catalyst can be recovered and reused for five consecutive running without significant decrease in catalytic activit...

Resveratrol derivatives have been reported to have important bioactivities. Synthesis of monomeric resveratrol derivatives has been a challenging topic in both organic and medicinal chemistry. A Synthesis of prenylated resveratrol was developed through prenylation between resveratrol (3,5,4'-trihydroxystilbene) and prenyl bromide (3,3-dimethyl ally...

Peroxidase has been successfully extracted and partially purified from Brassica juncea L. Czern root with protein content and specific activity of 0.747 mg/mL and 0.244 U/mg, respectively. Then, it was applied as biocatalyst for green oxidative coupling reaction of eugenol to produce an orange crystal, dimeric form of eugenol (84% yield). Structure...

The largest clove production contributors in Indonesia are mostly coming from Java and Manado. Different flavor among clove origins is caused by chemical constituents in clove oil. Unfortunately, scientific research and publications about flavor in clove from Indonesia’s origin are still limited. The objective of this research is to determine signi...

The research about post-harvested clove is still limited especially in Indonesia, as the biggest producer of clove in the world. The present study was aimed to investigate the effect of drying process and storage on the composition of essential oil of Indonesian clove originated from Toli-Toli. The essential oil of fresh and dried clove was obtaine...

Clove (Syzygium aromaticum) is native to Indonesia and used as a spice in virtually all of the world’s cuisine. Clove bud oil, a yellow liquid, is obtained from distillation of buds. The quality of oil is influenced by origin, post-harvest processing, pre-treatment before distillation, the distillation method, and post-distillation treatment. The o...

In the present work, 1,8-dioxooctahydroxanthene cannot be obtained from the reaction between cinnamaldehyde and dimedone (ratio 1:2) using samarium(III) chloride as a Lewis acid catalyst. The unexpected product formed is 5,5-dimethyl-2-(3-phenylallylidene)cyclohexane-1,3-dione as a result of 1:1 adduct. The product is obtained in a low to good yiel...

Syzygium aromaticum (clove) are native to Indonesia and have been widely used in food industry due to their flavor. Nonvolatile compounds contribute to flavor, mainly in their taste. Currently, there is very little information available about nonvolatile compounds in clove. Identification of nonvolatile compounds is important to improve clove’s val...

Indonesia is the largest clove producer in the world. In 2012, total world clove production is 113,215 tons where nearly 71 % (79,250 tons) comes from Indonesia. Although Indonesia is a major producer of clove in the world, research and publications about cloves in this country are scarce and hence knowledge about characteristics of difference vari...

A simple preparation of sodium impregnated on activated chicken eggshells (Na-ACE) as a solid base material for substituted chalcones synthesis is presented. After characterization using FTIR, XRD, SEM, EDS and total basicity, the catalyst was applied in Aldol condensation to produce corresponding chalcones 3a-3j. Confirmation of products structure...

Eradicating H. pylori-based infection by using conventional oral dosage form of amoxicillin trihydrate finds difficulties to overcome rapid gastric retention time. Encapsulating amoxicillin trihydrate in floating drug delivery system may solve the problem. In this research, the floating drug delivery system of amoxicillin trihydrate encapsulated in...