Caglayan Merve Ayaz

Akdeniz University · Faculty of Medicine

The number of older adults undergoing organ transplantation, and waiting lists are increasing. The epidemiological data on infections in older transplant patients are scarce. The objective of the study was to investigate the incidence and distribution of infectious complications in older patients according to post-transplant periods. This retrospec...

In solid organ transplant (SOT) recipients, invasive fungal infections (IFIs) are a significant cause of morbidity and mortality. Thus, the diagnosis, treatment, and management of these infections are of great importance. Eleven different IFIs (five candidemia, three aspergillosis, one cryptococcosis, one intra-abdominal mucormycosis, and one Magnu...

Background The recently used pan-immune-inflammation value (PIV) has not been adequately studied as a predictive marker for mortality in immunosuppressed patients. The aim of this study was to evaluate the usefulness of baseline PIV level as a predictor of 30-day mortality in solid organ transplant (SOT) recipients with gram negative bloodstream in...

Background: The recently used pan-immune-inflammation value (PIV) has not been adequately studied as a predictive marker for mortality in immunosuppressed patients. The aim of this study was to evaluate the usefulness of baseline PIV level as a predictor of 30-day mortality in solid organ transplant (SOT) recipients with gram negative bloodstream i...

We aimed to evaluate the efficacy of adsorption therapy as an extracorporeal blood purification technique in critically ill patients with Coronavirus disease 2019 (COVID-19). A retrospective analysis was performed on 17 adult patients with severe COVID-19, who underwent adsorption therapy using an HA330 cartridge, at Ankara City Hospital. Each adso...

Bu çalışmada, insan immün yetmezlik virüsü [human immundeficency virüs (HIV)] ile yaşayan bir seri erkek bireyde Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis ve Mycoplasma genitalium sıklığının sosyodemografik özellikler ve davranışsal risk faktörleri ile birlikte araştırılması amaçlanmıştır. Tek merkezli, kesitsel bu çalışma...

Aim: Severe complications such as bacteremia and bile duct infection may arise following percutaneous transhepatic biliary drainage (PTBD). The objective of this study was to examine the factors that contribute to mortality and compare the differences between patients with positive blood and biliary drainage cultures following PTBD. Materials and M...

We wanted to evaluate the efficacy of intravenous immunoglobulin (IVIG) treatment in Covid-19 patients in the intensive care unit (ICU). Sixteen (66.7%) male and 8 (33.3%) female adult severe Covid-19 patients who were treated with IVIG in the tertiary ICU between April 2020 and October 2021 at Ankara City Hospital were retrospectively reviewed. Th...

Objective: Altered mental status (AMS) is challenging diagnosis. It was aimed to evaluate the underlying causes, reveal laboratory, microbiological and imaging findings, and determine the infectious process in older patients who presented with AMS. Materials and Methods: This retrospective study was conducted at a training and research hospital. Si...

In the COVID-19 pandemic, due to the difficulties in patients’ applications to health centres, changes have occurred in the places of death of older adults. It is aimed to investigate the change in the places of death of older adults in Turkey, which is one of the countries most affected by the pandemic. Patients admitted to the geriatric outpatien...

We applied adsorption therapy with HA330 cartridge (Jafron©, Zhuhai City, China) as an extracorporeal blood purification technique to critically ill Covid-19 patients in the intensive care unit (ICU). Thereafter, we evaluated the effectiveness of adsorption therapy by investigating the changes in cytokine levels, complete blood count and biochemist...

Bacterial meningitis is a rare infectious disease with high morbidity and mortality. Usually there are facilitating factors such as head trauma or previous head surgery. In this case, extra nodal marginal zone lymphoma was shown as the underlying facilitating factor in a patient who was followed up with the diagnosis of meningitis. Although 1% of a...

Objective: Patients with hematological malignancies (HMs) have a substantial incidence of febrile neutropenic episodes. Gram-negative bacteremia (GNB) is still the major cause of these episodes. We evaluated the factors associated with GNB and mortality of bacteremic patients with HMs in a high-resistance setting. Materials and Methods: We conducte...

Objectives: Diarrhea is a common health problem and may occur for many infectious and non-infectious causes. In this study, it was aimed to investigate the causes, methods used in diagnosis and the results obtained in patients who applied to the gastroenterology clinic with the complaint of diarrhea. Materials and methods: 187 patients who presente...

Materials and Methods: This study was a retrospective cross-sectional survey study. The PLWH were study group and patients without chronic disease were selected as a control group. Results: A total of 326 patients, 163 HIV positive and 163 without chronic disease, were included in the study. Of the patients, 142 (88.1%) were male, and the mean age...

Prosthetic joint infection is not uncommon, but Gardnerella vaginalis has been reported rarely as a causative agent. A 45-year-old patient with no remarkable history was admitted to the hospital ten months after total hip replacement because of loosening of the prosthesis. Initial culture grew S. anginosus. Repeated culture of the debridement mater...

Coronavirus disease 2019 increases transplant recipients' susceptibility to rare opportunistic infections as a consequence of the impairment that COVID-19 can cause in the immune system. Mucormycosis is a rare complication but has a high risk of fatal outcome. A 50-year-old woman who received a kidney transplant 10 years previously was admitted to...

COVID-19 tedavisi konusunda bilimsel araştırmalar halen devam etmektedir. Mevcut veriler semptomu olmayan veya hafif hastalığı olanlarda antiviral tedavi başlanması konusunda tereddütler olduğunu göstermektedir. Ancak erken dönemde başlanan antiviral tedavinin viral yükü azalttığı ve hastalık semptomlarını hafiflettiği belirtilmektedir. Bu bilgiler...

Koronavirüs hastalığı-2019 (COVID-19), hastalarda solunum fonksiyon bozukluğuna neden olan hasar veya sekellerin yanı sıra, fiziksel ve psikolojik işlev bozukluklarına yol açan bulaşıcı bir solunum yolu hastalığıdır. COVID-19 hastalığından iyileşen ancak solunum veya motor fonksiyon bozukluğu devam eden vakalar için uzman fiziyatristlerin gözetimin...

Giriş: Coronavirus hastalığı 2019 (COVID-19), asemptomatik enfeksiyondan ciddi pnömoniye ve sitokin fırtınası gibi ölümcül immünolojik komplikasyonlara kadar değişen hastalık seyri göstermektedir. Sitokin fırtınası gibi immünolojik komplikasyonlar ortaya çıktığında, tek başına anti-viral tedavi yeterli olamamaktadır. Bu durumda, uygulanan tedaviye...

Amaç: Coronavirus hastalığı 2019 (COVID-19) pandemisi tüm dünyada etkisini devam ettirmesine rağmen aşının aktif şekilde uygulanması ile birlikte daha kontrol edilebilir bir hal almıştır (1). COVID- 19’un immünsupresif bireylerde daha ağır seyrettiği bilinmektedir. HIV enfeksiyonu tedavi edilmediğinde ağır immünsupresyona neden olmaktadır (2). Pand...

Giriş-Amaç: Coronavirüs hastalığı 2019 (COVID-19), şiddetli akut solunum sendromu coronavirüs 2’den (SARS-CoV-2) kaynaklanan ve Ekim 2021 itibariyle dünya çapında dört milyonun üzerinde ölüm dahil olmak üzere 240.000.000'dan fazla vakaya neden olan pandemik bir hastalıktır. Bununla birlikte, COVID-19'lu hamile kadınların klinik özellikleri hakkında...

Sexually transmitted diseases are common and preventable causes of morbidity and seri- ous complications. Untreated chlamydial and gonococcal infection may result in pelvic inflammatory dis- ease, which can lead to undesirable complications such as ectopic pregnancy, infertility and chronic pelvic pain. These diseases can also cause negative conseq...

Dietary Supplements and COVID-19

Background: We aimed to analyze the usefulness of a reserved area for the admission of the patients' symptoms suggesting COVID-19 and compare the demographic and clinical characteristics of the patients with COVID-19 and without COVID-19 who were admitted to C1 during the first month of the COVID?19 outbreak in our hospital. Materials and methods...

Background: We aimed to describe the epidemiology, risk factors, and clinical outcomes of co-infections and superinfections in onco-hematological patients with COVID-19. Methods: International, multicentre cohort study of cancer patients with COVID-19. All patients were included in the analysis of co-infections at diagnosis, while only patients...

Objective: To test the hypothesis that the addition of an aminoglycoside to a ß-lactam antibiotic could provide better outcomes than ß-lactam monotherapy for the initial empirical treatment of hematological neutropenic patients with subsequently documented Gram-negative bacilli (GNB) bloodstream infection (BSI). Methods: Multinational, retrospectiv...

Fungemia caused by uncommon Candida species (UCS) (other than C.albicans, C.glabrata, C.parapsilosis, C.tropicalis, C.krusei) is a rare but emerging threat with their potential to exhibit reduced susceptibility or resistance to antifungal agents. We identified 25 patients with UCS fungemia (9 C.kefyr, 8 C.lusitaniae, 4 C.dubliniensis, 2 C.guillierm...

BK VIREMIA EXACERBATION WITH COVID-19 INFECTION IN A KIDNEY TRANSPLANT RECIPIENT INTRODUCTION: Immunocompromised patients with Coronavirus-19 disease (COVID-19) who have previously undergone kidney transplantation should be carefully examined for BK virus, which is a DNA virus from polyoma-virus family and is localized in renal tubular epithelial c...

Ulcerative colitis is a chronic inflammatory bowel disease. Coexistence with autoimmune and inflammatory diseases is common. Incidence is 5.3-63.6/100,000 in Asian race Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) was first described in 1936 during the use of anticonvulsant drugs. Antibiotics causing DRESS syndrome are; vancomycin (39%...

Rhodotorula species are yeasts that are common in the environment,but are not frequently encountered as an infectious agent in humans. Rhodotorula mucilaginosa, Rhodotorula glutinis and Rhodotorula minuta are the species that cause disease in humans. Although its isolation from mucosa is doubtful in terms of the presence of true infection, it is mo...

Background: The number of patients with COVID-19 rapidly increased which resulted in the shortage of hospital beds. An outpatient follow-up plan was developed for COVID-19 patients with stable clinical condition and no concomitant diseases. Methods: The records of COVID-19 first admission clinic were retrospectively reviewed to identify the COVID-1...

Abstract Background: COVID-19 (Coronavirus Disease of 2019) is an infectious disease outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe acute respiratory failure. The clinical studies have shown that advanced age and chronic diseases...

Background While fungemia caused by ≥2 different species of yeasts (mixed fungemia, MF) is infrequent, it might be underestimated. Objectives This study aimed to determine the incidence of MF, clinical characteristics of the patients, and antifungal susceptibility profiles of the isolates with a systematic review of the literature. Data sources P...

Background: Fungemia due to rare yeasts has been recognized as an emerging, clinically relevant, but less investigated condition. Intrinsic resistance or reduced susceptibility of these species to echinocandins or fluconazole remains as a challenge in empirical treatment. Objectives: To describe the clinical characteristics, administered antifun...

Actinomycosis is a granulomatous disease caused by filamentous, gram-positive, anaerobic bacteria. Actinomyces spp. are constituents of the normal flora of mucous membranes. These organisms may cause infection after surgery or damage to the mucosal barrier. Main clinical presentations of actinomycosis are cervicofacial, thoracic, and abdominal form...

Carbapenem resistant Acinetobacter baumannii is a bacterium that causes various hospital acquired infections, primarily ventilator-associated pneumonia and bloodstream infections. The multidrug resistance problem of the bacteria all over the world, is also a problem in our center. As the treatment options are decreasing combination therapies become...