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Caetano Souto-Maior

Caetano Souto-Maior

M.P.H., Ph.D

About

15
Publications
2,287
Reads
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313
Citations
Citations since 2016
12 Research Items
304 Citations
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2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080

Publications

Publications (15)
Article
Full-text available
Individual variation in susceptibility and exposure is subject to selection by natural infection, accelerating the acquisition of immunity, and reducing herd immunity thresholds and epidemic final sizes. This is a manifestation of a wider population phenomenon known as ”frailty variation”. Despite theoretical understanding, public health policies c...
Preprint
Full-text available
All but the simplest phenotypes are believed to result from interactions between two or more genes forming complex networks of gene regulation. Sleep is a complex trait known to depend on the system of feedback loops of the circadian clock, and on many other genes; however, the main components regulating the phenotype and how they interact remain a...
Article
Full-text available
Sleep is ubiquitous across animal species, but why it persists is not well understood. Here we observe natural selection act on Drosophila sleep by relaxing bi-directional artificial selection for extreme sleep duration for 62 generations. When artificial selection was suspended, sleep increased in populations previously selected for short sleep. L...
Preprint
Full-text available
Individual variation in susceptibility and exposure is subject to selection by natural infection, accelerating the acquisition of immunity, and reducing herd immunity thresholds and epidemic final sizes. This is a manifestation of a wider population phenomenon known as "frailty variation". Despite theoretical understanding, public health policies c...
Preprint
Full-text available
With around 3 billion people at risk, dengue virus is endemic to many parts of the world. In the Brazilian city of Rio de Janeiro, surveillance measures require notification of new dengue virus cases, and are supplemented by serum collection from patients and sequencing of viral RNA. Phylogenetic analyses have been performed for all serotypes circu...
Article
Full-text available
Wolbachia has been introduced into Aedes aegypti mosquitoes to control the spread of arboviruses, such as dengue, chikungunya and Zika. Studies showed that certain Wolbachia strains (such as wMel) reduce replication of dengue viruses in the laboratory, prompting the release of mosquitoes carrying the bacterium into the field, where vectorial capaci...
Article
Full-text available
Infection is a complex and dynamic process involving a population of invading microbes, the host and its responses, aimed at controlling the situation. Depending on the purpose and level of organization, infection at the organism level can be described by a process as simple as a coin toss, or as complex as a multi-factorial dynamic model; the form...
Data
Supplementary file containing the table of mosquitoes challenged and assayed, generalized linear model analysis, an alternate version of viral titer data figure, and the correlations plotted in separate panels. (PDF)
Article
Setting global strategies and targets for d prevention and control often involves mathematical models. Model structure is typically subject to intense scrutiny, such as confrontation with empirical data and alternative formulations, while a less frequently challenged aspect is the widely adopted reduction of parameters to their average values. Focu...
Chapter
Infectious disease has been recognized for a long time as an important evolutionary force: It created the need for and shaped the evolution of immune systems and influenced reproduction as well as behavior of many host species. Infectious agents themselves also evolve and must have adapted to host strategies to evade infection, to multiple external...
Article
Full-text available
Facultative vertically transmitted bacterial symbionts often manipulate its host’s reproductive biology and thus facilitate their persistence. Wolbachia is one such symbiont where frequency-dependent reproductive benefits are opposed by frequency-independent fitness costs leading to bistable dynamics. Introduction of carriers does not assure invasi...
Article
Full-text available
Author Summary While control options for plant, animal, and human pathogens are emerging rapidly, reliable assessment of the effect of interventions in biological systems presents many challenges. A major question is how to connect laboratory experiments and measurements with the relevant process in natural settings, where hosts are subject to path...

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