C. Monchaud

C. Monchaud
French Institute of Health and Medical Research | Inserm · UMR-1248

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70
Publications
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933
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Publications

Publications (70)
Article
Objectives.- Nirmatrelvir in association with ritonavir (PAXLOVID™, Pfizer) is an antiviral agent targeting the 3-chymotrypsin–like cysteine protease enzyme (3C-like protease or Mpro) which is a key enzyme of the viral cycle of the SARS-CoV-2. This combination with a well-known pharmacokinetic enhancer leads to a high risk for drug-drug interaction...
Article
Background Mycophenolate mofetil (MMF) is theoretically a treatment of choice for Mucous Membrane Pemphigoid (MMP), due to its good long‐term tolerance and efficacy especially in elderly patients. However, no therapeutic monitoring is currently performed despite its large inter‐individual variability. Objectives The aim of this study was to invest...
Article
Le suivi des patients transplantés d’organe solide repose sur la collaboration de tous les professionnels participant à leur prise en charge. La coordination et la communication entre ces acteurs de santé, de ville ou hospitaliers, sont des enjeux importants dans la construction d’un parcours de soins cohérent, structuré et individualisé. Les nombr...
Article
La prise en charge d’un patient transplanté requiert une surveillance clinique et biologique parfois complexe. L’adaptation de la posologie des immunosuppresseurs est fréquente, en particulier en début de greffe. Elle s’appuie notamment sur le suivi thérapeutique pharmacologique, nécessaire pour apprécier la variabilité pharmacocinétique des immuno...
Article
Background: In children with cystic fibrosis (CF), the currently recommended amikacin dose ranges between 30 and 35 mg/kg/d; however, data supporting this dosing efficacy are lacking. In this article, the objectives were to develop a nonparametric pharmacokinetic population model for amikacin in children with CF and investigate the efficacy and to...
Article
Background Tacrolimus has a narrow therapeutic range and requires dose adjustment, usually based on the trough blood concentration but preferably on the area under the concentration–time curve over 12 h post-dose (AUC0–12h). The single-arm, multicentre, clinical study IMPAKT aimed: (i) to develop, in de novo kidney transplant recipients, pharmacoki...
Article
Background: Immunosuppressant Bayesian Dose Adjustment (ISBA) is an online expert system that estimates the area under the curve (AUC) of immunosuppressive drugs through pharmacokinetic modelling and Bayesian estimation to propose dose adjustments to reach predefined exposure targets. The ISBA database was retrospectively analyzed to describe tacr...
Article
Full-text available
Genetic variations in CYP3A4, CYP3A5, and m-TOR could contribute to interpatient variability regarding m-TOR inhibitors pharmacokinetics or cellular effects. The purpose of this study was to evaluate the influence of selected candidate variations in these genes on everolimus pharmacokinetics, efficacy, and toxicity in cancer patients. Thirty-four p...
Article
Full-text available
PurposeThe usual recommended dose for gentamicin is 3 to 7 mg/kg/day for patients with a normal renal function while 1.7 mg/kg/day is recommended for patients undergoing chronic haemodialysis. The objectives of this study were to develop a population pharmacokinetics model (POPPK) for gentamicin, designed for patients undergoing dialysis, and to in...
Article
An 83-year-old man, presenting decreased renal function (estimated glomerular filtration rate 21 mL/min/1.73 m), was treated for a bone and joint infection (on a trans-metatarsal right foot amputation) caused by Klebsiella Pneumonia sensitive to cefepime. The starting dose (1 g bid) was based on recommendations for patients presenting severe infect...
Article
Résumé Tout récemment, la société savante internationale de pharmacologie-toxicologie biologique a émis des recommandations sur le suivi thérapeutique pharmacologique (STP) du tacrolimus. Cette conférence de consensus fait suite à la première du genre, laquelle avait été publiée en 2009. Dans ce document, la place du STP du tacrolimus pour les quat...
Article
Aims: Intravenous mycophenolate mofetil (IV MMF), a prodrug of mycophenolic acid (MPA), is used during non-myeloablative and reduced-intensity conditioning haematopoetic stem cell transplantation (HCT) to improve engraftment and reduce graft-versus-host disease. The aims of this study were to develop population pharmacokinetic models and Bayesian...
Article
Background Scientific data on the psychopharmacological effects of new psychoactive substances (NPSs) are scarce. Web fora contain a wealth of information posted by users as trip reports (TRs), but the reliability of the reports remains questionable because of the nature of the used molecule and the potential for dose inaccuracies. We focused on th...
Article
Full-text available
Objective: Adherence is a dynamic phenomenon and a critical determinant of transplant patients outcome. The objective of this longitudinal study was to explore adherence in kidney transplant patients followed-up for up to three years after transplantation. Methods: Adherence was repeatedly estimated using the Morisky-Green-Levine 4-Item Medication...
Article
Aims: Tacrolimus is a narrow therapeutic range drug that requires fine dose adjustment, for which pharmacokinetic (PK) models have been amply proposed in renal, but not in liver, transplant recipients. This study aimed to build population PK models and Bayesian estimators (BEs) in adult de novo liver transplant patients receiving either the immedia...
Article
Ten years ago, a consensus report on the optimization of tacrolimus was published in this journal. In 2017, the Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicity (IATDMCT) decided to issue an updated consensus report considering the most relevant advances in tacrolimus...
Article
A 67‐year‐old man was admitted to the emergency department about 5 h after deliberate self‐poisoning with 300 mg of Apixaban. The clinical examination did not show any organ dysfunctions or haemorrhagic signs, and the patient's life was not in danger. The first analysis, upon admission, showed a concentration of 2655 μg l−1 of Apixaban. The Cmax wa...
Article
Background: ISBA is an online expert system, routinely used by approximately 140 transplantation centers in the world for the dose adjustment of immunosuppressive drugs in transplant patients. This system determines the drug area-under-the-curve (AUC) by PK modeling and Bayesian estimation. The purpose of this study was to analyze tacrolimus expos...
Article
To the best of our knowledge, no case has been published in the literature that reports an overdose of tiapride, either alone or in combination with other drugs. We report a self-poisoning case in an 18-year-old girl, with approximately 10 times the usual daily dose (ie, 2.5 g). Although the blood concentration was 20/30- fold higher than usually o...
Article
Full-text available
Background Patients’ experiences of immunosuppressive treatment, including their perception of adverse effects, influences their quality of life and may be a trigger for poor adherence. The Medication Experience Scale for Immunosuppressants (MESI) questionnaire was designed in German to evaluate patients’ experiences of immunosuppressive drugs. Ob...
Article
Introduction: Therapeutic drug monitoring (TDM) of everolimus is not performed in oncology and no trough level (C0) target has been yet defined. The aim of this study was to determine everolimus C0 target for toxicity and efficacy. Materials and methods: Clinical, biological and radiologic data from 54 patients were collected. Toxicity event was...
Article
Background and objectives: A new once-daily formulation of tacrolimus (Envarsus(®)) has recently been developed, with alleged different pharmacokinetics from previous tacrolimus formulations. The objectives of this study were to develop population pharmacokinetic models and Bayesian estimators based on limited sampling strategies for Envarsus(®) i...
Conference Paper
Introduction Le mycophénolate mofétil est un immunosuppresseur couramment utilisé pour le traitement de la pemphigoïde cicatricielle (PC). Actuellement, le suivi thérapeutique pharmacologique (STP) n’est pas réalisé pour l’acide mycophénolique (AMP), la forme active alors que tous les arguments pour le STP sont réunis : forte variabilité inter-indi...
Article
Full-text available
Aim: To investigate the potential influence of variants in genes involved in the calcineurin pathway on the efficacy and toxicity of calcineurin inhibitors in renal transplantation. Materials & methods: Twenty-three polymorphisms in thirteen genes were tested in 381 renal transplant recipients receiving ciclosporin (n = 221) or tacrolimus (n = 1...
Article
Unlabelled: We report a case of a pseudo encephalitis presentation of pediatric intoxication - Case report - a 7 year-old girl was admitted to our pediatric emergency unit after she developed sudden agitation, visual and tactile hallucinations. She was febrile (38.3 °C). She had not experienced any recent head trauma, infection or toxic ingestion;...
Article
Every transplant patient will, at least occasionally, miss immunosuppressive drug doses or take them outside the prescribed times. This study aims at quantifying the impact of poor execution on tacrolimus exposure in renal transplant patients. Validated pharmacokinetic tools applied in clinical setting were used to simulate the steady-state pharmac...
Article
Mycophenolic acid (MPA) area under the curve (AUC) has been associated with graft outcome. (1) to develop pharmacokinetic tools to optimize MPA inter-dose AUC estimation in heart transplant patients; and (2) to investigate the relationships between acute allograft rejection and MPA AUC, trough level (C0) or mycophenolate mofetil (MMF) dose. Two ind...
Article
In lung transplantation, diverse clinical events may impact patient outcome. In clinical trials comparing intervention strategies, single primary endpoints require large populations, or long study durations, whereas composite endpoints (CEPs) do not take into account the respective impact of their components on patient survival. The objective of th...
Article
Full-text available
Therapeutic drug monitoring of tacrolimus is a major support to patient management and could help improve the outcome of lung transplant recipients, by minimizing the risk of rejections and infections. However, despite the wide use of tacrolimus as part of maintenance immunosuppressive regimens after lung transplantation, little is known about its...
Article
Full-text available
The immunosuppressive drug mycophenolate mofetil is used to prevent rejection after organ transplantation. In kidney transplant recipients, it has been demonstrated that adjustment of the mycophenolate mofetil dose on the basis of the area under the concentration-time curve (AUC) of mycophenolic acid (MPA), the active moiety of mycophenolate mofeti...
Article
Full-text available
Although immunosuppressive treatments and therapeutic drug monitoring (TDM) have significantly contributed to the increased success of thoracic transplantation, there is currently no consensus on the best immunosuppressive strategies. Maintenance therapy typically consists of a triple-drug regimen including corticosteroids, a calcineurin inhibitor...
Article
Full-text available
Part I of this article, which appeared in the previous issue of the Journal, reviewed calcineurin inhibitors--ciclosporin and tacrolimus. In part II, we review the pharmacokinetics and therapeutic drug monitoring of mycophenolate and mammalian target of rapamycin inhibitors--sirolimus and everolimus--in thoracic transplantation, and we provide an o...
Article
Therapeutic drug monitoring (TDM) of mycophenolate mofetil (MMF) is recommended to guide immunosuppression. High-performance liquid chromatography with ultraviolet (HPLC-UV) or the enzyme-multiplied immunoassay technique (EMIT), used to measure mycophenolic acid (MPA) were compared in an exclusive paediatric renal transplant population. Twenty pati...
Article
A sensitive method of determination of ketamine and norketamine by micro-liquid chromatography/mass spectrometry was developed as part of a clinical trial in a pediatric population. Compounds were extracted from 100 microl plasma samples using solid-phase extraction on Oasis MCX cartridges. Separation was achieved on a C18 micro-column with a mobil...
Article
To demonstrate that injecting drug use is a major risk factor of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection and injecting drug users may be a reservoir of CA-MRSA infection in our community, we conducted a matched case-control study. Cases were CA-MRSA-infected patients at University of California, Davis, M...
Article
Human papilloma virus can cause recurrent respiratory papillomatosis that can degenerate in pulmonary metastasis and eventually, death. A one-year-old child was diagnosed with distal tracheal papillomatosis and treated by cidofovir local injections. Later, pulmonary metastasis were discovered and treatment was switched to continuous infusion of cid...
Conference Paper
Introduction: CA-MRSA is rapidly becoming the predominant cause of SSTI in our community. IDU have a high incidence and prevalence of CA-MRSA SSTI. We previously reported that injection drug use was a risk factor for infection CA-MRSA strain USA300 (OR 4.2, 95% CI 2.4-7.4; IDSA 2005, abstr# 1055). Thus, we further examined the relationship between...
Article
Methicillin-resistant Staphylococcus aureus (MRSA) has long been a common pathogen in healthcare facilities, but in the past decade, it has emerged as a problematic pathogen in the community setting as well. A retrospective case series study of patients from whom MRSA was isolated from December 1, 2003, through May 31, 2004, was conducted at the Un...
Conference Paper
Background: Increasing prevalence of MRSA and emergence of community-acquired MRSA (CA-MRSA) have led to increased clindamycin (CLD) use. CLD treatment failures with clindamycin-susceptible, erythromycin-resistant MRSA (CS/ER-MRSA) infections have been reported, related to iMLSB. However, few studies have described the epidemiology of such MRSA. Me...
Article
The aim of this study was to develop routinely applicable limited sampling strategies for assessing cyclosporin (CsA) AUC(0-12 h), and possibly other exposure indices such as AUC(0-4 h) and C(max), in heart transplant patients over the first year post-transplantation. First, the individual pharmacokinetics (PKs) of 14 adult heart-transplant patient...
Article
The aims of the current study were (1) to study Neoral pharmacokinetics (PK) in stable lung recipients with or without cystic fibrosis (CF), (2) to compare Neoral PK between these two groups, and (3) to design Bayesian estimators for PK forecasting and dose adjustment in these patients using a limited number of blood samples. The individual PK of 1...

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