C. Leconte

C. Leconte
Paris Descartes, CPSC | Paris 5 · EA4475 - Pharmacology lab

PhD

About

22
Publications
3,847
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462
Citations

Publications

Publications (22)
Article
Full-text available
Substance use disorders (SUD) may emerge from an individual’s attempt to limit negative affective states and symptoms linked to stress. Indeed, SUD is highly comorbid with chronic stress, traumatic stress, or post-traumatic stress disorder (PTSD), and treatments approved for each pathology individually often failed to have a therapeutic efficiency...
Article
Traumatic brain injury (TBI) is a chronic pathology, inducing long term deficits that remains understudied in preclinical studies. In this context, exploration, anxiety-like behavior, cognitive flexibility and motor coordination were assessed until 5 and 10 months after an experimental TBI in the adult mouse, using two cohorts. In order to differen...
Article
Full-text available
Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm-born infants is associated with permanent neurological sequelae in 9 million infants every year. Investigating the regulators of microgl...
Article
Mild traumatic brain injury (TBI) is a major risk factor for post-traumatic stress disorder (PTSD), and both disorders share common symptoms and neurobiological defects. Relapse after successful treatment, known as long-term fear resurgence, is common in PTSD patients and a major therapeutic hurdle. We induced a mild focal TBI by controlled cortica...
Preprint
Full-text available
Microglia of the developing brain have unique functional properties but how their activation states is regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm born infants is associated with permanent neurological sequelae in 9 million infants every year. Investigating the regulators of microgli...
Article
Neonatal acute ischemic stroke is a cause of neonatal brain injury that occurs more frequently in males, resulting in associated neurobehavioral disorders. The bases for these sex differences are poorly understood but might include the number, morphology and activation of microglia in the developing brain when subjected to stroke. Interestingly, po...
Article
Full-text available
Traumatic brain injury (TBI) results in white matter injury (WMI) that is associated with neu-rological deficits. Neuroinflammation originating from microglial activation may participate in WMI and associated disorders. To date, there is little information on the time courses of these events after mild TBI. Therefore we investigated (i) neuroinflam...
Data
Time course of spatial learning and cognitive flexibility, evaluated by the number of errors, after mild TBI. The number of errors was obtained during the Barnes maze test, performed on unoperated, sham-operated and TBI mice at (A) 15 days, (B) 1 month, (C) 2 months and (D) 3 months post-injury. Data were expressed as means ± S.E.M. Differences wer...
Data
Time course of spatial learning and cognitive flexibility, evaluated by the escape latency, after mild TBI. The escape latency was obtained during the Barnes maze test, performed on unoperated, sham-operated and TBI mice at (A) 15 days, (B) 1 month, (C) 2 months and (D) 3 months post-injury. Data were expressed as means ± S.E.M. Differences were an...
Article
Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is currently the only approved pharmacological strategy for acute ischemic stroke. However, rt-PA exhibits vascular toxicity mainly due to endothelial damage. To investigate the mechanisms underlying rt-PA-induced endothelial alterations, we assessed the role of rt-PA in the generat...
Article
Whereas severe hypoxia is known to contribute to neuronal death and to lead to neurological disturbances, mild hypoxia can also induce beneficial effects through endogenous adaptive responses. The aim of this study was to investigate the effects of mild hypoxia (8% O(2)) on cognitive and emotional behavior in the adult mouse. To this end, mice were...
Article
Erythropoietin (EPO), a well known haematopoietic growth factor, possesses neuroprotective and neurotrophic effects which have been recently reported to improve cognition and to modulate emotional processing. We investigated the effects of EPO and of its non-erythropoietic carbamylated derivative (CEPO) on memory- and emotion-related behaviour in t...
Article
Inspired from preconditioning studies, ischemic postconditioning, consisting of the application of intermittent interruptions of blood flow shortly after reperfusion, has been described in cardiac ischemia and recently in stroke. It is well known that ischemic tolerance can be achieved in the brain not only by ischemic preconditioning, but also by...
Article
Full-text available
Distal occlusion of the middle cerebral artery (dMCAo), which closely mimics human stroke, is one of the most used animal models. However, although assessment of histological and functional outcome is increasingly recommended for preclinical studies, the latter is often excluded because of the high difficulties to estimate, especially in mice, beha...
Article
The understanding of mechanisms involved in ischaemic brain tolerance may provide new therapeutical targets for stroke. In vivo genomic studies revealed an up-regulation of adrenomedullin expression by hypoxic pre-conditioning. Furthermore, adrenomedullin reduced ischaemia-induced brain damage in rodents. However, whether adrenomedullin is involved...

Questions

Question (1)
Question
I try the black-gold II staining on 12 months old brains and the red stain can't be seen with the naked eye, whereas the intensity staining is high and clearly visible on 7 months old brains. Do the age of animals affects brain permeability?
Thank you for your answers,
Claire Leconte

Projects

Project (1)
Project
Traumatic Brain Injury (TBI) induces a neuroinflammation that might participate to white matter injury (WMI) evidenced by demyelination, that persists months and years after the insult and are responsible for psychiatric diseases. As only few preclinical data are available, the objective of this study was to evaluate WMI and its consequences on cognitive and emotionnal behavior at long term after TBI.