C. Bellecci

C. Bellecci
University of Rome Tor Vergata | UNIROMA2 · Department of mechanical engineering

full professor of phisics

About

216
Publications
29,322
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2,651
Citations

Publications

Publications (216)
Article
Full-text available
The Omicron variant of concern (VOC) has a peculiar spectrum of mutations characterized by the acquisition of mutations or deletions rarely detected in previously identified variants, particularly in the spike glycoprotein. Such mutations, mostly residing in the receptor-binding domain, could play a pivotal role in enhancing severe acute respirator...
Article
Full-text available
Herein, we report a case of an Italian male infected by Delta sublineage AY.4 harboring an atypical deletion, leading to a N gene target failure (NGTF) by a commercial molecular assay for SARS-CoV-2 diagnosis (AllplexTM SARS-CoV-2 Assay, Seegene). A 59-year-old unvaccinated patient was hospitalized for pulmonary embolism, with first negative result...
Article
Background The impact of drug resistance mutational load and APOBEC editing in heavily treatment-experienced (HTE) people living with multidrug-resistant HIV has not been investigated. Material and Methods We explored the HIV-DNA and HIV-RNA mutational load of drug resistance and APOBEC-related mutations through next-generation sequencing (NGS, Il...
Article
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Since the emergence of SARS-CoV-2, several recurrent mutations, particularly in the spike protein, arose during human-to-human transmission or spillover events between humans and animals, generating distinct worrisome variants of concern (VOCs) or of interest (VOIs), designated as such due to their clinical and diagnostic impacts. Characterizing th...
Article
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A growing number of emerging SARS-CoV-2 variants is being identified worldwide, potentially impacting the effectiveness of current vaccines. We report the data obtained in several Italian regions involved in the SARS-CoV-2 variant monitoring from the beginning of the epidemic and spanning the period from October 2020 to March 2021.
Article
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Background: If analytical antiretroviral-treatment (ART) interruption (ATI) might significantly impact quantitative or qualitative peripheral-total HIV-DNA is still debated. Methods: Six chronically HIV-1 infected patients enrolled in APACHE-study were analysed for peripheral-total HIV-DNA and residual viremia, major-resistance-mutations (MRMs)...
Article
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Our study aimed to investigate the kinetics of SARS-CoV-2 RNA in bile and in different body fluids of two SARS-CoV-2 positive patients with acute cholecystitis by innovative droplet digital PCR (ddPCR) assays. For each patient, nasopharyngeal-and rectal swabs, bile, urine, and plasma samples were collected at different time points for SARS-CoV-2 RN...
Chapter
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The world has changed. The global crisis related to the reduction of energy fossil resources, the reduction of potable water resources and the war for the control of energy sources are part of the causes which can lead to an intentional CBRNe (Chemical, Biological, Radiological, Nuclear, and explosive) event together with the potential misuse of CB...
Article
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Background: The aim of the study was to investigate the intra-host variability through next-generation-sequencing (NGS) of the NS5A-gene in nosocomial transmission-clusters observed in two Italian hospitals among hepatitis C virus (HCV)-genotype-1b infected patients. Methods: HCV-sequencing was performed by Sanger-sequencing (NS3 + NS5A + NS5B) and...
Article
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Background & aims: We investigated the HCV-RNA amount, variability and prevalence of resistance-associated substitutions (RASs), in plasma, hepatic tumoral and non-tumoral tissue samples in patients undergoing liver-transplant/hepatic-resection (LT/HR), because of hepatocellular carcinoma and/or cirrhosis. Methods: Eighteen HCV-infected patients...
Article
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The biology of HIV is rather complex due to high rate of replication, frequent recombination, and introduction of mutations. This gives rise to a number of distinct variants referred as quasispecies. In addition, the latency within reservoir allows the periodic reactivation of virus replication. The rapid replication of HIV allows immune response e...
Article
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With limited and low-genetic barrier drugs used for the prevention of mother-to-child transmission (PMTCT) of HIV in sub-Saharan Africa, vertically transmitted HIV-1 drug-resistance (HIVDR) is concerning and might prompt optimal pediatric strategies. The aim of this study was to ascertain HIVDR and viral-tropism in majority and minority populations...
Article
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In recent years, the publication of the studies on the transmissibility in mammals of the H5N1 influenza virus and synthetic genomes has triggered heated and concerned debate within the community of scientists on biological dual-use research; these papers have raised the awareness that, in some cases, fundamental research could be directed to harmf...
Article
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Background: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. Methods: This study included 128 chronically HBV-infected patients: 23 with HCC (73.9% D; 26.1% A...
Article
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Background & aims: Despite the excellent efficacy of direct-acting antivirals (DAA) reported in clinical trials, virological failures can occur, often associated with the development of resistance-associated substitutions (RASs). This study aimed to characterize the presence of clinically relevant RASs to all classes in real-life DAA failures. Me...
Article
Nowadays the intentional diffusion in air (both in open and confined environments) of chemical contaminants is a dramatic source of risk for the public health worldwide. The needs of a high-tech networks composed by software, diagnostics, decision support systems and cyber security tools are urging all the stakeholders (military, public, research &...
Article
Full-text available
Nowadays Toxic Industrial Components (TICs) and Toxic Industrial Materials (TIMs) are one of the most dangerous and diffuse vehicle of contamination in urban and industrial areas. The academic world together with the industrial and military one are working on innovative solutions to monitor the diffusion in atmosphere of such pollutants. In this ph...
Article
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Chemical or biological contamination, due to natural or man-made disasters, represents a severe concern for safety and security of people, and of the environment. Chemical agents (CAs) and biological agents (BAs) are commonly used for a number of civilian and military applications, and can be deployed as a weapon with terroristic purposes. Therefor...
Article
A laboratory worker was infected with human immunodeficiency virus (HIV) type 1 in a biosafety level 2 containment facility, without any apparent breach. Through full-genome sequencing and phylogenetic analyses, we could identify the source of infection in a replication-competent clone that unknowingly contaminated a safe experiment. Mode of transm...
Article
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Urban air pollution causes deleterious effects on human health and the environment. To meet stringent standards imposed by the European Commission, advanced measurement methods are required. Remote sensing techniques, such as light detection and ranging (LiDAR), can be a valuable option for evaluating particulate matter (PM), emitted by vehicles in...
Article
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CBRNe events that occur in a geographic location can have consequences on human health and/or infrastructures, even in places very far away from that where the event happened. Thus, the effects of such events often have an influence on the response systems of various countries, from a socioeconomic point of view, from where the event had its origin...
Article
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The choice of materials for the future nuclear fusion reactors is a crucial issue. In the fusion reactors, the combination of very high temperatures, high radiation levels, intense production of transmuting elements and high thermomechanical loads requires very high-performance materials. Erosion of PFCs (Plasma Facing Components) determines their...
Conference Paper
A Table Top Exercise (TTX) gap analysis tool was developed with the aim to provide a complete, systematic and objective evaluation of TTXs organized in safety and security fields. A TTX consists in a discussion-based emergency management exercise, organized in a simulated emergency scenario, involving groups of players who are subjected to a set of...
Conference Paper
Chemical or biological contamination, due to natural or man-made disasters, represents a severe concern for safety and security of people and of the environment. Chemical Agents (CAs) and Biological Agents (BAs) are commonly used for a number of civilian and military applications, and of course, can be deployed as a weapon with terroristic purposes...
Article
Full-text available
Accidents in spent nuclear fuel reprocessing plants are a critical issue for the safety of people, of operators and the environment, as well as for the security of the plants. The purpose of this work is to demonstrate the possibility to use a free license code to simulate radiological diffusion after an accident in these particular plants, in orde...
Conference Paper
Nowadays the intentional diffusion in air (both in open and closed environments) of chemical and biological contaminants presents a dramatic risk for the health of the public worldwide. The needs of a high-tech network composed by diagnostics, software, decision support systems and cyber security tools are urging all the stakeholders (military, pub...
Article
Full-text available
Background: To characterize HBV RT and HBsAg quasispecies heterogeneity in acute HBV-infected (AHB) patients and to define their clinical value. Methods: 62 patients with AHB (44 genotype-D and 18 genotype-A) were enrolled from 2000 to 2010. Plasma-samples obtained at first observation were analyzed by Ultra-deep-pyrosequencing (UDPS). Extent of...
Article
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CFD (Computational Fluid Dynamics) simulations are widely used nowadays to predict the behaviour of fluids in pure research and in industrial applications. This approach makes it possible to get quantitatively meaningful results, often in good agreement with the experimental ones. The aim of this paper is to show how CFD calculations can help to un...
Article
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The use of weapons of mass destruction for military purposes is a problem that has its origins in the early history of humanity. Many substances were used as weapon but the chemical ones were the first to be used in history. The first use of chemical agents dates back to 7th century B.C. during the siege of Cirrha, a Greek city. In the literature o...
Article
Anthrax endospores were used in the past to attempt to the life of civilians, just think about the failed attack in Tokyo in 1993 or the 22 cases, including five deaths, occurred in USA in 2001. Because of the high case-fatality rate (CFR around 50% for respiratory form of anthrax), to the strong resistance to environmental adverse conditions and t...
Article
The history of the serious efforts to achieve chemical disarmament that culminated in the conclusion of the Chemical Weapons Convention (CWC) began more than a century ago. Although toxic chemicals have been used as a method of warfare throughout the ages, it is clear from some of the earliest recorded incidents that such weapons have always been v...
Article
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The problem of dust resuspension in case of Loss Of Vacuum Accident (LOVA) in a nuclear fusion plant (ITER or DEMO like) is an important issue for the safety of workers and the security of environment. The Quantum Electronics and Plasma Physics Research Group has implemented an optical set-up to track dust during a LOVA reproduction inside the expe...
Article
Mathematical modelling is an important tool for understanding the dynamics of the spread of infectious diseases, which could be the result of a natural outbreak or of the intentional release of pathogenic biological agents. Decision makers and policymakers responsible for strategies to contain disease, prevent epidemics and fight possible bioterror...
Article
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Smoke agents contained chlorinated compounds with a high environmental impact such carbon tetrachloride and hexachloroethane have been used for a long time by North Atlantic Treaty Organization (NATO). The aim of this paper is to present an analytical method for the determination of these organochlorinated compounds based on Solid Phase Microextrac...
Article
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It's well known that air pollution due to anthropogenic sources can have adverse effects on humans and the ecosystem. Therefore, in the last years, surveying large regions of the atmosphere in an automatic way has become a strategic objective of various public health organizations for early detection of pollutant sources in urban and industrial are...
Poster
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The long-term experience of Quantum Electronics and Plasma Physics Research group in laser techniques like LIDAR (Light Detection and Ranging) and DIAL (Differential Absorption of Light) is evident by improve of four experimental demonstrator (TAEMS, SAI, COLI and TELEMACO) developed by the group itself. SAI and COLI are two mobile LIDAR systems fo...
Conference Paper
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Ebola, Armi di Distruzioni di Massa, Terrorismo, ISIS, Fukushima e minacce globali. I media ci aggiornano quotidianamente sui danni causati dal rilascio e la diffusione accidentale/naturale o volontaria di agenti pericolosi per l’uomo e l’ambiente circostante. È ben noto che la risoluzione degli eventi critici causati da tali fenomeni comportano im...
Conference Paper
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Chemical Warfare Agents, Biological Warfare Agents, Toxic Industrial Materials, Toxic Industrial Components. In questi anni il gruppo di ricerca di Elettronica Quantistica e Plasmi dell’Università di Tor Vergata ha realizzato dei dimostratori per la rivelazione ed identificazione delle sostanze chimiche sopra citate. Inoltre, sta mettendo a punto u...
Article
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The Ebola virus epidemic burst in West Africa in late 2013, started in Guinea, reached in a few months an alarming diffusion, actually involving several countries (Liberia, Sierra Leone, Nigeria, Senegal, and Mali). Guinea and Liberia, the first nations affected by the outbreak, have put in place measures to contain the spread, supported by interna...
Article
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Analytical chemistry in CBRNe (Chemical Biological Radiological Nuclear explosive) context requires not only high quality data; quickness, ruggedness and robustness are also mandatory. In this work, three samples preparation methods were compared using several organophosphorus pesticides as test compounds, used as simulants of nerve CWA (Chemical W...
Article
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Biohazards represent an important issue in the field of security, both for the destructive potential and the psychological, economic and social impact that the use of biological agents for biowarfare could have on populations. Early identification of an intentional biological event is essential to ensure correct management and response to the emerg...
Article
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The decontamination of sensible surfaces contaminated by chemical agents is a key issue for the safety of population and security of structures. SX34 is an innovative decontamination product developed for sensible surfaces decontamination from biological and chemical agents. In this work the authors present the effects of SX34 on contaminated surfa...
Article
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Forensic microbiology came into the spotlight after the anthrax attack in September 2001 in the US. It is a new discipline that is able to trace the origin of a biological agent using a range of biological analyses, and it is based on the fast and accurate detection and identification of microorganisms found at a biological crime scene. In this pap...
Article
The used first generation protease inhibitors may be hampered by virological failure in partially interferon-sensitive patients. To investigate early hepatitis C virus (HCV)-RNA decay and quasispecies modifications, and disclose viral dynamics underlying failure. Viraemia decay at early time-points during telaprevir treatment was modelled according...
Article
Full-text available
Development of new technologies for Biological Warfare Agents (BWA) stand-off detection implies several safeties, logistic and economic drawbacks that involve production of different highly virulent bacteria and viruses, their isolation and characterization under adequate bio-containment and sample preparation for each agent to evaluate the testing...
Article
Unlabelled: Hepatitis B virus (HBV) reactivation during immunosuppression can lead to severe acute hepatitis, fulminant liver failure, and death. Here, we investigated hepatitis B surface antigen (HBsAg) genetic features underlying this phenomenon by analyzing 93 patients: 29 developing HBV reactivation and 64 consecutive patients with chronic HBV...
Article
Full-text available
The large volume vacuum systems are used in many industrial operations and research laboratories. Accidents in these systems should have a relevant economical and safety impact. A loss of vacuum accident (LOVA) due to a failure of the main vacuum vessel can result in a fast pressurization of the vessel and consequent mobilization dispersion of haza...
Conference Paper
Full-text available
In the last years, surveying large regions of the atmosphere in an automatic way, for early detection of pollutant sources in urban and industrial areas, has become a strategic objective of various public health organizations. The Lidar/Dial technique has become a well-established laser remote sensing method for atmosphere monitoring. It is often u...
Chapter
Full-text available
In many industrial and research fields the vacuum technologies are routinely used. In some applications the macroscopic erosion of hazardous materials (radioactive, toxic or explosive) and consequent accumulation of dust represents a risk for the workers and the population especially if this dust is mobilized during a loss of vacuum due to an accid...
Article
Full-text available
Abstract In a CBRNe (Chemical, Biological, Radiological, Nuclear and explosive) scenario, biological agents hardly allow efficient detection/identification because of the incubation time that provides a lag in symptoms outbreak following their dissemination. The detection of atmospheric dispersion of biological agents (i.e.: toxins, viruses, bacter...
Article
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Self-cleaning building materials is a form of passive safety technology that is used to provide increased resistance against chemical, biological, radiological and nuclear (CBRN) incidents. This paper is aimed at evaluating the effectiveness of a self-cleaning coating based on a dispersion in ethanol of titanium dioxide (TiO 2) powder at 0.5 gr/L d...
Article
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In a globalised world, the potential for crisis in the exchange of goods through sea routes continues to increase due to its low costs and technological progress. The worldwide terrorist threat has increasingly identified transports as a main target, showing several gaps in the field of security to which international conventions and organisations...