Bushra Parveen

• Ph.D. (Pharmaceutical Medicine)
• Jamia Hamdard

Alzheimer's disease (AD) is considered one of the most common neurological conditions associated with memory and cognitive impairment and mainly affects people aged 65 or above. Even with tremendous progress in modern neuroscience, a permanent remedy or cure for this crippling disease is still unattainable. Polyphenols are a group of naturally occu...

The analysis of genome sequences in various plant species has uncovered genes linked to different traits and their inheritance patterns. This exploration has facilitated the mapping of complex traits associated with diverse phenotypes. Recent discoveries demonstrate the utility of DNA barcoding in categorizing unknown specimens, authenticating phyt...

Ethnobotany and medical ethnopharmacology, the interdisciplinary fields, explore the intricate relationship between ancient wisdom and contemporary knowledge. The close relationship between humans and plants has been a cornerstone of cultural, medicinal, and ecological aspects throughout history. This book chapter highlights the rich tapestry of th...

The gut microbiota is a varied population of microorganisms that live in the human gastrointestinal system. Emerging research emphasizes the importance of this microbial ecology in general health and its influence on a variety of disorders. The review explores the synergy between herbal treatment and traditional medicine, emphasizing their cultural...

Artificial Intelligence (AI) has emerged as a powerful tool in various domains, and the field of drug formulation and development is no exception. This review article aims to provide an overview of the applications of AI in drug formulation and development and explore its future prospects. The article begins by introducing the fundamental concepts...

Vitex negundo is a traditional herb known for its medicinal properties in Unani, Ayurveda, Siddha, Chinese, Roman, and other traditional systems of medicine. Traditionally, it is used as anthelminthic, antitoxin, aphrodisiac, contraceptive, antimalarial, analgesic, antiinflamatory, antiasthmatic, vermifuge, etc. All parts of V. negundo contain numb...

In addition to the classical functions of the musculoskeletal system and calcium homeostasis, the function of vitamin D as an immune modulator is well established. The vitamin D receptors and enzymes that metabolize vitamin D are ubiquitously expressed in most cells in the body, including T and B lymphocytes, antigen-presenting cells, monocytes, ma...

Ethnopharmacological relevance Kidney disease (KD) is one of the serious health issues, which causes worrisome morbidity and economic burden. Therapeutic strategies are available however majority of them are associated with severe adverse effects and poor patient compliance and adherence. This explorative article was undertaken to provide a holisti...

Diabetes is a metabolic disorder increasing at an alarming rate in the current era. Medicinal plants and their supplements have shown protective effects against metabolic dysregulation and oxidative damage. The present study is aimed to explore the antidiabetic potential of hydroalcoholic extract of Picrorhiza kurroa (HAE-PK). The UPLC/MS analysis...

The biomedical survey reports edible plant Aegle marmelos has been utilized for centuries by tribal communities in India as a dietary supplement for the management of diabetes. Herein, we have investigated cytotoxicity, cytoprotective and antidiabetic activity of characterized alkaloid-free hydroalcoholic extract of A. marmelos (AFEAM; 200 and 400...

Chronic Kidney Disease (CKD) is a major health problem characterized by kidney dysfunction with progressive segmental glomerulosclerosis to end-stage renal disease (ESRD). Due to lack of scientific data and comprehensive reports, the current systematic review provides an inclusive understanding and prospective associated with phytopharmacology of N...

The cases of COVID-19 are still increasing day-by-day worldwide, even after a year of its first occurrence in Wuhan city of China. The spreading of SARS-CoV-2 infection is very fast and different from other SARS-CoV infections possibly due to structural differences in S proteins. The patients with severe diseases may die due to acute respiratory di...

Ethnopharmacological relevance Synthetic drugs used for cancer treatment have side effects that may be immunosupressive, can cause liver, kidney and cardiac toxicity, and infertility and ovarian failure, among others. Thus, herbal drugs could be used in the cancer treatment as an adjuvant therapy. Andrographis paniculata (Burm.f.) Nees (AP) is one...

The biomedical survey reports edible plant Aegle marmelos has been utilized for centuries by tribal communities in India as a dietary supplement for the management of diabetes. Herein, we have investigated cytotoxicity, cytoprotective and antidiabetic activity of characterized alkaloid-free hydroalcoholic extract of A. marmelos (AFEAM; 200 and 400...

BGR-34 is a polyherbal formulation frequently used to combat diabetes around the globe especially in Asian countries. It provides an attractive treatment option to prediabetics, diabetics, and in metabolic disorders by controlling the altered blood glucose level. The lack of phytopharmacological studies on BGR-34 prompted as to reveal the compounds...

As per the definition approved by the World Health Organization (WHO), the term herbal medicine applies to all those medicines that occur in the form of plants, plant parts (such as roots, rhizomes, stem, bark, wood, leaves, flowers, fruits, seeds or their active ingredients), herbal preparations, or the finished products containing these materials...

Background: Plant-based remedies play a crucial role as powerful health aid worldwide. In recent years, the usage of complementary and alternative medicines has grown rapidly. The objective of the present study was to evaluate the immunomodulatory effects of methanolic extract of Leptadenia arborea leaves in BCG-immunized rats. Materials and Method...

Background: Interest in the antioxidant and antidiabetic activity of natural products are growing vastly in the modern world. Thin layer chromatography-bioautography-mass spectroscopy (TLC-bioautography-MS) plays an important role in chemico-biological screening of natural sources. TLC combined with 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) free radic...

Unani medicine, based largely on herbs, is practiced as a traditional system of medicine in the Indian subcontinent. It owes its origination to the Greek philosopher Hippocrates (460-377 BC) and his associates. However, it progressed and got established under the patronage of Persian and Arab empires and later came to the Indian sub-continent aroun...

Abstract Traditionally, medicinal plants have inhabited an important position in the socio-cultural, spiritual and medicinal domain of rural and tribal lives in Sudan. In the recent years, there is an ever-increasing curiosity in elucidating the role of free radicals in biology, because of their involvement in a diverse range of diseases. Therefore...

Background: Osteoporosis, characterized by compromised bone quality and strength is associated with bone fragility and fracture risk. Biomarkers are crucial for the diagnosis or prognosis of a disease as well as elucidating the mechanism of drug action and improve decision making. Objective: An exhaustive description of traditional markers inclu...

Andrographis paniculata (family: Acanthaceae) is used in the Indian, Thai, and Chinese traditional system of medicines since the ancient times to cure fever, common cold, inflammation, upper respiratory tract infection, pharyngitis, laryngitis, tonsillitis, pneumonia, tuberculosis, hepatic impairment, and pyelonephritis. Andrographolide (a diterpen...

Background The role of dopamine receptor sub-families in the rewarding and reinforcing effects of drugs of abuse has been established in numerous studies. Objectives In view of the extensive role of mesolimbic dopaminergic transmission in rewarding and reinforcing effect of abused drugs including ethanol, the present study evaluated three mechanis...

Background: Antiepileptic drug (AED) therapy has been claimed to deteriorate bone health. Majority of the research was inclined towards vitamin-D deficiency as the patho-mechanism. However, after the role of Wnt in bone metabolism was discovered, it has paved way for investigating the role of Wnt inhibitors in mediating effects on bone accrual. Rec...

Secondary osteoporosis is the major concern associated with long term intake of antiepileptic drugs (AEDs). Women are the vulnerable targets owing to post-menopausal bone loss. In the present work, we evaluated the effect of 10 weeks of treatment with AED therapy (carbamazepine, CBZ, 75 mg/kg; sodium valproate, SVP, 300 mg/kg; levetiracetam, LTM, 1...

Secondary osteoporosis is the major concern associated with long term intake of antiepileptic drugs (AEDs). Women are the vulnerable targets owing to post-menopausal bone loss. In the present work, we evaluated the effect of 10 weeks of treatment with AED therapy (carbamazepine, CBZ, 75 mg/kg; sodium valproate, SVP, 300 mg/kg; levetiracetam, LTM, 1...

Long‐term anti‐epileptic drug (AED) therapy compromises bone health. Though vitamin‐D deficiency is proposed to be involved, it alone is not held responsible. This accounts for investigating other mechanisms in bone accrual. Recent studies have shown modulation of inhibitors of wnt pathway, sclerostin and dickkopf‐1 (DKK‐1), in glucocorticoids‐indu...

Higher plants are the major source of crude drugs used in herbal therapy. Adulteration in crude-drug material has necessitated scientific characterization of plant drugs, which is based primarily on morphological, anatomical and physico-chemical characters studied through microscopy and some analytical techniques. These criteria are helpful in isol...

Tartrate-resistant acid phosphatase (TRACP) is an enzyme abundantly expressed in tissues such as the bone, spleen, liver, lungs, and skin. It has two isoforms, namely, TRACP 5a and TRACP 5b. TRACP 5a is specific for the placenta and lungs, whereas TRACP 5b is exclusive to the bone, spleen, thymus, kidney, colon, and brain. This chapter discusses th...

Tartrate-resistant acid phosphatase (TRACP) is an enzyme abundantly expressed in tissues such as the bone, spleen, liver, lungs, and skin. It has two isoforms, namely, TRACP 5a and TRACP 5b. TRACP 5a is specific for the placenta and lungs, whereas TRACP 5b is exclusive to the bone, spleen, thymus, kidney, colon, and brain. This chapter discusses th...

Unlabelled: Piperine (PIP) is used as anticonvulsant in traditional Chinese medicine. Co-administration of low-dose sodium valproate with PIP has been regarded to have potential anticonvulsant activity. Aim: This study was intended to investigate the effect of PIP on the pharmacokinetics of sodium valproate (SVP) in the plasma samples of rats us...

World Health Organization (WHO) has defined herbal medicines as finished labeled medicinal product that contain an active ingredient, aerial, or underground parts of the plant or other plant material or combinations. According to a report of WHO, about 80% of the world population is reported to rely on traditional medicine for their primary health...