Bushra JavedThe University of Manchester · Faculty of Medical and Human Sciences
Bushra Javed
Doctor of Medicine
About
9
Publications
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Publications
Publications (9)
Mandatory labelling of allergenic food ingredients has helped allergic consumer manage their condition, but unintended allergens and precautionary allergen labels (PAL) continue to cause confusion for allergic consumers and the food industry alike. Identifying doses of food protein that are safe for the majority of allergic consumers and test metho...
Quantitative risk assessment (QRA) for allergens exists in many different forms with different requirements placed on the risk assessor depending on the question that needs to be answered. An electronic workshop held in October 2020 and comprising representatives from a wide range of food allergy and allergen stakeholder groups identified that a su...
Background
Eliciting doses (e.g. ED01 or ED05 values, the amount of allergen expected to cause objective symptoms in 1% and 5% of the allergic population) are increasingly used to inform allergen labelling and clinical management. These values are generated from food challenge, but the frequency of anaphylaxis to these low levels of allergen exposu...
Background: Collation of clinical data on IgE-mediated food allergies is essential to provide evidenced-based approaches to managing and treating food allergies and prevent accidental reactions. However, this can be a time consuming and difficult process due to the heterogeneous way in which studies collect such data. In order to facilitate data ha...
Food regulations require that tree nuts and derived ingredients are included on food labels in order to help individuals with IgE-mediated allergies to avoid them. However, there is no consensus regarding which tree nut species should be included in this definition and specified on food labels. Allergen detection methods used for monitoring foods t...
Aims: Food safety authorities recognise food allergy as a significant public health concern and have defined a list of “priority foods” that must be labelled irrespective of their level of inclusion in a recipe. Allergen molecules of those priority foods are the actual hazard for sensitive individuals but data are often lacking regarding their capa...
Background: Allerg-e-Lab is a semantic web service initiative for the documentation and exchange of information related to food allergies. The data dictionary - controlled medical vocabulary is essential to identify and characterise the semantic relationship of variables and is key to interpreting data. This study will analyse and compare existing...
Questions
Questions (8)
The initial plan was to write a thesis in the traditional format. Thesis first draft is already 90% written, of course, need to revisit and make changes or might be restructured.
Now my supervisor suggested the alternative format. which format would be the best?
I am looking to classify participants as "reactive" or "tolerant" based on the clinical symptoms recorded during the oral food challenge. It has been observed, along with clinical symptoms different observations were recorded at the time of food challenge (i.e., pulse rate, respiration, blood pressure and saturation). This challenge data is from the birth cohort and it has been noted that for few infant and young children the observations are not within normal range (e.g. high pulse rate, high respiration rate, etc.). Although these are the vital signs but not the symptoms. Do I need to consider them when interpreting the challenge outcome?
The most frequent question asked by a PhD student is about his/her current or future publications. Publications seems to be an important part of any research. How to evaluate the progress of an individual in today's Science World (impact factor of journals VS total number of publications? I am wondering, what's matter more?
Published literature shows that there are different types of methods used to determine the IgE binding of food allergens.
After Skin Prick Test and Oral Food Challenge, What would be the best method or choice of a researcher among these:
1. Immunoblotting (Western blotting, dot blotting),
2. Immunoassay (e.g. ELISA, RIA, CAP)
3. The Cellular stimulation test (e.g. BAT)
4. Combination of these
5. any other
The general opinion about Systematic review is:
It is time consuming, requires additional training, it is very challenging task and this type of research activity demands group of people (2 or 3 at least) instead of individual student.
Literature review (in first 3 months) is the part of Ph.D. research. I am interested to know, how Systematic Literature Review would be beneficial for a PhD student in first year and how student can defend himself during the viva.
In peer-reviewed articles, mostly authors have mentioned that they have compared the IgE binding ability of a recombinant allergen to the native allergen with allergic patient sera. But I am interested to know how they can find the folding /aggregation pattern of a recombinant allergen. Or IgE binding test is enough to conclude that there were no considerable folding / aggregation occurs during the process.
I am reading some papers, where researchers have used pooled serum along with individual sera to check the IgE reactivity of allergen molecules on immunoblotting. What are the possible reasons for performing this type of experiment?
