Burcu Yuksel

Burcu Yuksel
Kocaeli University · Kocaeli Health Services Vocational School

PhD

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29
Publications
5,850
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40
Citations

Publications

Publications (29)
Article
Full-text available
Developing new drugs from natural products is important for therapeutic effects to minimise tissue toxicity of drugs used in cancer treatment. Eisenia foetida is a worm with a double transport system consisting of coelomic fluid (ECF) that can be used as alternative medicine. It is important to eliminate or reduce the high cytotoxicity of sodium bu...
Article
Full-text available
Biocides, which are found in nature as persistent pollutants, pose a great danger to the ecosystem. Methylisothiazolinone (MIT), a widely used biocide, reaches plants by mixing with water and soil. Vermicompost tea (VCT), which strengthens the plant defence mechanism and increases its growth and development, is a liquid fertiliser consisting of the...
Article
Full-text available
Earthworms are tube-shaped, segmental worms and have a double transport system consisting of earthworm coelomic fluid (ECF) moving within the fluid-filled colon. As one of the naturally available extracts (NAEs), ECF exerts different biological functions, such as inhibiting the proliferation of cancer cells. Pharmacokinetic limitations in prostate...
Article
Full-text available
Aesthetic and clinical care of the feet includes reducing nail thickness and removing calluses which are perfomed by high-speed nail drill machines. These micromotors diffuse skin material, nail dust, and pathogenic fungi into the air, some of which are then inhaled and causes an occupational risk to workers. This study examines occupational risks...
Article
Full-text available
Amaç: Poly I:C ile indüklenen TLR3 aktivasyonunun iki farklı prostat kanseri hücresinde [PC-3 (hormona duyarsız) ve LNCaP (hormona duyarlı)] oksidatif stres üzerindeki rolünü ilk kez belirlemeyi amaçladık. Bu amaçla lipid peroksidasyonu (MDA), hidrojen peroksit (H2O2) ve prolin miktarlarına, süperoksit dismutaz (SOD) enzim aktivitesine bakılmıştır....
Article
Full-text available
This study aims to evaluate the association of DRD2 gene C957T polymorphism with stuttering within Turkish children who stutter. The sample of the study included 121 children between the ages of 5-16, 44 children with stuttering and 77 typically developing children. The genomic DNA’s were extracted from the saliva of the individuals. The genotyping...
Article
Full-text available
2-methyl-2H-isothiazol-3-one (MIT), widely used in industrial and cosmetic products, is one of the significant representatives of the isothiazolinone group. Due to widespread application fields of MIT, it can be easily mixed with water and soil. Vermicompost (VCT), which has an enriching effect on the properties of the soil, provides nutrients to t...
Article
Full-text available
Oncogenic stimulation shows a rise in reactive oxygen species (ROS), and ROS can eventually induce carcinogenesis by causing DNA damage. In this context, this study aims to evaluate some biochemical and genotoxic changes in the control of cell death caused by NaBu (Sodium butyrate). treatment in breast cancer cells. NaBu’s impact on cell proliferat...
Article
Full-text available
Kathon CG, which has a wide area of usage, is one of the representatives of the isothiazolinone group. Considering the application areas in industrial and cosmetic products, it can be a contaminant to water and soil, and it can be toxic to organisms. Vermicompost, known as the organic matter of worms, has important features in terms of increasing t...
Article
Full-text available
We are grateful to the author of the Letter to the Editor for providing feedback about our manuscript titled “Determination of cytogenetic abnormalities in buccal mucosa of dental laboratory technicians”1 and to the Editors for giving us an opportunity to respond. We believe that our response will be of interest to readers of the Archives of Enviro...
Article
Full-text available
For people working in dental prosthesis laboratories (DPL), metal alloys and methylmethacrylate-based monomers and polymers used in the laboratory can pose occupational risks. These risks can cause occupational health problems and toxic effects on human health. This study purposes of researching the effects of occupational exposure because of denta...
Article
Full-text available
In the current study, it is aimed to investigate the toxic effects of a widely used herbicide Roundup containing active ingredient glyphosate on cucumber (Cucumis sativus) by cytological and molecular investigation. Three different concentrations (0.6%, 1.2% and 2.4%) of Roundup were applied to cucumber for 48 and 72 hours. At the end of the applic...
Article
Full-text available
Nobiletin (NOB) is a polymethoxylated flavone. It has multiple biologic activities that can modulate oxidative stress in many cancer types. However, there is no study in the literature that has examined the effects of NOB on oxidative stress levels in Metastatic Castration-Resistant Prostate Cancer (MCRPC) yet. Motivated from this gap, we investiga...
Article
Full-text available
This study aims to investigate the toxic effects of metals, which dental technicians are exposed to, on the oral mucosa cells in dental prosthesis laboratories (DPL). To monitor cytotoxic effects, mutations of pyknosis, Karyolysis Karyorrhexis, binucleus, micronucleus, and broken-egg were evaluated. Experimental group comprised of a total of 30 vol...
Article
Diş protez laboratuvarlarında (DPL) çalışan kişiler için laboratuvarda kullanılan metal alaşımları ve metilmetakrilat bazlı monomerler ve polimerler mesleki risk oluşturabilmektedir. Bu riskler mesleğe bağlı sağlık problemlerine ve insan sağlığında toksik etkilere sebep olabilir. Bu çalışmanın amacı dental protez üretim operasyonlarına bağlı meslek...
Article
Full-text available
This study examines the genotoxic effects of coumarin (2H-1-benzopyran-2-one) on Lens culinaris Medik cv Sultan in terms of DNA polymorphism and protein quantification. Effective concentration values were calculated according to a probit model, which is a type of regression where the dependent variable can take only two values, i.e., life or death,...
Article
Full-text available
A variety of materials are used in dental prosthesis laboratories (DPL), especially metal alloys and methyl methacrylate (MMA)–based monomers and polymers. These metal alloys contain elements such as cobalt, chromium, nickel, molybdenum, lead, and mercury that can have toxic effects on human health when excessive amounts of exposure occur. This stu...
Article
Full-text available
The aim of this study is to investigate whether neuregulin-1 gene (NRG1) rs6994992 polymorphism has any role in gifted students in Turkish population. This study included 97 gifted students and 99 students with normal development. Genomic DNA was extracted from the oral epithelial cells. Genotyping of the molecular variant was performed by PCR-DNA...
Conference Paper
Full-text available
Oxidative stress has been identified as one of the hallmarks of the development, progression, response to therapy and especially aggressive disease phenotype in metastatic castration resistant prostate cancer. Reactive oxygen species (ROS) production causes DNA damage and increased mutation rate and to balance ROS- induced oxidative damage, cells h...
Article
Full-text available
This study aimed to reveal the effects of coumarin on Lens culinaris Medik. The germinated and ungerminated seed counts of the experimental groups were determined and the EC 50 value was calculated by probit analysis. In biochemical studies, catalase and superoxide dismutase enzyme activities were investigated together with lipid peroxidation and h...
Chapter
Full-text available
Summarizes the use of coumarin, a secondary metabolite, and its derivatives in different aspects of plant growth and formation.
Book
Full-text available
Explore the effects of Arrivo 25 EC (250g/l, Cypermethrin) insecticide applied to Hyacinthus orientalis grown in greenhouse at recommended dosage by manufacturing company and double the recommended dosage were investigated on mitosis in root tip cells and pollen meiosis.
Conference Paper
Full-text available
Özet Teknoloji çağıyla beraber süratli ve büyük ölçekli sanayileşme ile ekonomik gelişme birçok problemi de beraberinde getirmiştir. Bu sorunlardan en önemlilerinden biri ise iklim değişikliğinin neden olduğu ya da olacağı tahmin edilen büyük ölçekli ekonomik ve çevresel problemler olduğu ortaya konulmuştur. Bu çevresel problemlerden en önemlisi is...
Conference Paper
Full-text available
With the era of technology, rapid and large-scale industrialization and economic development have brought many problems. One of the most important of these problems is the large-scale economic and environmental problems which are predicted to be caused or caused by climate change. The most important of these environmental problems is the natural di...
Conference Paper
Full-text available
This study covers the genotoxic effects of coumarin (2H-1-benzopyran-2-one) on Lens culinaris Medik. cv. Sultan in terms total soluble protein content, proline amount and alpha amylase activity. Effective concentration values were calculated according to a probit model, which is a type of regression where the dependent variable can take only two va...
Article
Full-text available
This study examines the cytological effects of coumarin (2H-1-benzopyran-2-one) on Lens culi-naris Medik. cv. Sultan in terms of cell response, mi-totic index, mitotic abnormalities and chromosome aberrations. Effective concentration values were calculated based on a probit model, which is a type of regression where the dependent variable can take...
Chapter
Full-text available
Conference Paper
Full-text available
The cytological effects of coumarin (2H-1-benzopyran-2-one) on Lens culinaris Medik. cv. Sultan in terms of cell response, mitotic index, mitotic abnormalities and chromosome aberrations. Effective concentration values were calculated according to a probit model, which is a type of regression where the dependent variable can only take two values, f...
Article
Full-text available
Two novel proton transfer compounds were prepared between 2,4-dichloro-5-sulphamoylbenzoic acid (lasamide) (Hsba) and ethylenediamine (en), namely ethane-1,2-diaminium 2,4-dichloro-5-sulphamoylbenzoate (1), and also between Hsba and 2-amino-3-methylpyridine (2-amino-3-picoline) (amp), namely 2-amino-3-methylpyridinium 2,4-dichloro-5-sulphamoylbenzo...

Questions

Questions (3)
Question
How can I measure alpha amylase activity by dextrogenic method (620 nm)
Question
I work on lentil.lentil genome size relatively 4.2 Gb. How can I determine if DNA is pure or not after DNA isolation.Thank you very much for your answer
Question
I work on lentil by using rapd pcr. the first band marker. second band sample 3. Band didn't appear 4. Band sample. All of them same pcr condition. do you have any opinion? can I analyze in this form.

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Projects

Projects (3)
Project
Eisenia Foetida Toprak Solucanı Koelomik Sıvısının Prostat Kanseri Hücre Hatları Üzerindeki Potansiyel Genotoksik Ve Apoptotik Etkilerinin Moleküler yöntemlerle Incelenmesi
Project
To determine the effect of surgical smoke on health professsionals and to apply preventive interventions
Project
To investigate the role of vermicompost on plants under stress conditions. Eisenia foetida vermicompost is used to reduce the toxic effects of some heavy metals.