Burcu Uner

• PhD
• Postdoctoral researcher at University of Health Sciences and Pharmacy

This study introduces advanced nanoparticle-based drug delivery systems (NDDS) designed for targeted colorectal cancer treatment. We developed and characterized three distinct formulations: Bevacizumab-loaded chitosan nanoparticles (BEV-CHI-NP), polymeric micelles (BEV-PM), and BEV-conjugated exosomes enriched with AS1411 and N1-methyladenosine (AP...

Leigh syndrome (LS), a severe neurometabolic disorder caused by mitochondrial dysfunction, is often linked to coenzyme Q10 (CoQ10) deficiency. This study investigated using dequalinium chloride to create CoQ10-loaded DQAsomes (liposome-like vesicles) to improve CoQ10 solubility and delivery to mitochondria. DQAsomes were characterized for size, cha...

Properties of pH‐responsive electrospun nanofibers incorporated with biocompatible/degradable Carbopol, commonly used in pharmaceuticals and personal care products, are reported. Sonication of Carbopol dispersions prior to electrospinning leads to uniform incorporation into fibers of the host polymer polyvinylpyrrolidone. The hydration behavior is...

Recently developed nanoparticles and nanofibers present new brain‐specific treatment strategies, especially for Alzheimer's disease treatment. In this study, donepezil (DO)‐loaded PLGA nanoparticles (DNP) are embedded in PVA/PEG nanofibers (DNPF) produced by pressurized gyration for sublingual administration. SEM images showed produced drug‐loaded...

This study describes the synthesis and characterization of a series of novel hydrazide‐hydrazone derivatives containing a 1,2,4‐triazole ring. The compounds were characterized using various spectroscopic techniques, such as FT‐IR, ¹ H‐NMR, ¹³ C‐NMR, HRMS, and elemental analysis. The antiproliferative activity of the synthesized compounds was evalua...

Aim: Thiocolchicoside (THC) is a drug under the category of BCS III. Due to its high molecular weight, it has poor oral bioavailability and low skin permeability. This study aims to find an alternative delivery method for THC that enhances its bioavailability through nasal application approach. In situ gels containing plain or liposomal THC with d...

Loteprednol etabonate (LE) is a topical corticosteroid for the symptomatic management of ocular conditions, encompassing both allergic and infectious etiologies. Owing to the dynamic and static barriers of the eye, LE exhibits significantly low bioavailability, necessitating an increase in the frequency of drug administration. The objective of this...

Quality by Design (QbD) is a systematic approach that focuses on understanding and controlling product quality through the integration of scientific principles, risk management, and regulatory requirements. This abstract provides a comprehensive overview of the application of QbD principles in the development of parenteral drug formulations, which...

Pharmaceutical companies are currently investing a significant amount of their resources in developing advanced carrier systems. These systems are designed to deliver drugs over an extended period with minimal side effects, which improves patient compliance and decreases variability that is often associated with intermittent dosing. The utilization...

The focus of the research was to overcome the limitations of metoclopramide (MTC) when administered intranasally. The aim was to improve its bioavailability, increase patient compliance, and prolong its residence time in the nasal cavity. MTC-loaded liposomes were prepared by applying the film hydration method. A study was conducted to determine ho...

Although SGLT-2i initially acquired prominence for usage in diabetes, they later emerged as the top medication class in both cardiovascular diseases and disorders. However, they still do not have the proper bioavailability (50–70%); therefore, it has different options such as using either a higher dose amount or dose frequency. The aim of this revi...

This research primarily focuses on the development of innovative topical nanoemulsions for etodolac, aimed at surmounting its inherent limitations. The preparation of etodolac nanoemulsions is accomplished through a combination of high shear homogenization and ultrasonication methods. The optimization of the formulation components is systematically...

The purpose of this study was to conduct the kinetic assessment of iontophoretic delivery of niosomal tetracycline-HCl formulated in an electroconductive gel. Tween-80 and Span-80 were used to obtain tetracycline-HCl niosomes with an average diameter of 101.9 ± 3.3 nm, a polydispersity index of 0.247 ± 0.004, a zeta potential of − 34.1 mV, and an e...

Addressing obesity is a critical health concern of the century, necessitating urgent attention. L-carnitine (LC), an essential water-soluble compound, plays a pivotal role in lipid breakdown via β-oxidation and facilitates the transport of long-chain fatty acids across mitochondrial membranes. However, LC’s high hydrophilicity poses challenges to i...

Ocular drug delivery methods are highly favored for boosting bioavailability, patient compliance, and lower adverse effects and dose frequency. In addition to preventing adverse effects from the active ingredient, the parts of drug delivery systems must be nontoxic and nonallergic as well. Mitochondrial toxicity test (MTT) and Hen's egg chorioallan...

Leigh syndrome (LS), a rare hereditary neurometabolic disorder caused by mitochondrial dysfunction, results from genetic mutations affecting the central nervous system. Endogenous bioactive antioxidant Coenzyme Q10 (CoQ10) deficiency is associated with LS and contributes to various clinical symptoms. Dequalinium chloride (DQA) is a bolalipid with m...

Obesity is considered one of the most crucial health problems of the century. Therefore, reducing obesity is critically important. Caffeine (CF) and chlorogenic acid (CLA), which are substantial components in green bean coffee which maximize thermogenesis in brown adipose tissue. In our study, we have prepared CF, CLA, and CF + CLA loaded-solid lip...

Phenylketonuria (PKU) is a rare inherited metabolic disease characterized by phenylalanine hydroxylase enzyme deficiency. In PKU patients, coenzyme Q10 (CoQ10) levels were found low. Therefore, we focused on the modification of CoQ10 to load the micelles and increase entry of micelles into the cell and mitochondria, and it is taking a part in ATP t...

Coenzyme Q10 (CoQ10) is a fat-soluble vitamin-with a benzoquinone-like structure. CoQ10 plays a role in membrane stability, energy conversion, and ATP production. It is also one of the important antioxidants in the body. The bioavailability of exogenous CoQ10 is extremely low due to its poor aqueous solubility and large molecular mass. In this stud...

Background: Eplerenone is a member of antihypertensives used individually or in combination with other medicines. Eplerenone exhibits poor solubility and is considered a class II drug. Objective: Increasing the solubility of eplerenone by using both liquid and solid self-emulsifying drug delivery system as an alternative to its marketed tablet p...

The beta-adrenoceptor blocker timolol maleate (TML) is a commonly used pharmaceutical agent for the management of glaucoma. Conventional eye drops have limitations due to biological or pharmaceutical factors. Therefore, TML-loaded ethosomes have been designed to mitigate these restrictions and give a viable solution for reducing elevated intraocula...

Ulcerative colitis is an inflammatory condition with ulcerations throughout the colon. The existing remedies have some limitations such as drug inactivation, poor absorption, and adverse reactions. The present study aimed to design novel microsponge formulations to enhance remission of the dexamethasone (as a model pharmaceutical ingredient) in the...

Loteprednol etabonate (LE) is a topical corticosteroid that uses inflammatory conditions of the eye. It has a low ocular bioavailability and side effects such as corneal disorder, eye discharge, and ocular discomfort. Therefore, it was decided to select the delivery systems, which are solid lipid nanoparticles (SLN), nanostructured lipid carriers (...

As in other fields of science, medical sciences are rapidly developing and being updated. Today, due to the direct and indirect relations of science fields, the scientific importance of multidisciplinary and even interdisciplinary applications is increasing. Recently, serious discussions have been made on scientific platforms and scientific congres...

The objectives of the current research were to produce fast dissolving oral films (FDOFs) containing standardiszed freeze-dried ginseng root extract (FDG) and to exploit and evaluate the effect of pullulan on the fast-dissolving oral films to impart desirable features to the drug formulation, such as rapid drug release, high release rates and impro...

Objectives: This study constructed dorzolamide (DRZ)-loaded ophthalmic implants for extended drug delivery and increased drug retention. Materials and methods: Carboxymethyl cellulose (CMC) and chitosan (CHI) were used to describe the ophthalmic implants. The implants were prepared by the solvent casting technique in presence of polyethylene gly...

Anthocyanins are pigments in the polyphenol class, which are found in high amounts especially in dark colored fruits and have high antioxidant properties, but Vaccinium fruit extract has low oral bioavailability and chemical instability. The purpose of this study was to develop a fast dissolving orodispersible film (FDOF) formulation containing ant...

Aim: Loteprednol etabonate (LE) is a new generation corticosteroid that is used for the treatment of inflammatory and allergic conditions of the eye. Therefore, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were attempted to improve for transdermal LE delivery for the first time. Methods: SLN and NLC were produced by ho...

Viburnum opulus L. fruits have been used in traditional medicine in the Turkish population for kidney problems, hypoglycemic and cough relaxant activities. This study aimed to prepare V. opulus extract-loaded orally disintegrating films (ODFs) to enhance oral absorption and improve patient compliance. ODF formulations were prepared using the solven...

Purpose Loteprednol etabonate (LE) is a new generation corticosteroid that is used for the treatment of inflammatory and allergic conditions of the eye, and management of seasonal allergic rhinitis nasally. LE which is a poorly soluble drug with insufficient bioavailability, has a high binding affinity to steroid receptors. Sophisticated colloidal...

Essential oils have a high volatility that leads to evaporation and loss of their pharmacological effect when exposed to the environment. The objectives of the present work were to prepare microcapsules with oregano essential oil by extrusion using sodium alginate as a shell material and non-ionic surfactant polysorbate 80 as an emulsifier to stabi...

Nanocrystals are a feasible system to improve the aqueous solubility of poorly soluble compounds. Orodispersible films (ODFs) offer a rapid release of the drug in the mouth and are preferred for patients with dysphagia or paediatrics. The objective of the current study was to develop resveratrol (RES) nanocrystal-loaded ODFs. RES nanocrystals were...