Burcu Dogan-Topal

Burcu Dogan-Topal
Ankara University · Division of Analytical Chemistry

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67
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Publications

Publications (67)
Article
Ibrutinib is Bruton’s tyrosine kinase inhibitor that is generally used in the treatment of lymphoma. The investigation of anticancer drug - double-stranded DNA (dsDNA) interaction is a key issue for cancer treatment. In this study, electrochemical and molecular docking studies were realized to explain the interaction mechanism between ibrutinib and...
Article
With the rapid development of the industry, studies on environmental pollution, health, and safety are increasing. Air pollutants, toxic gases, and volatile organic compounds can threaten human health and need sensitive detection of their concentration. Gas sensors are indispensable because of their promising characteristics for detecting these gas...
Article
Full-text available
The screen-printed electrodes have gained increasing importance due to their advantages, such as robustness, portability, and easy handling. The manuscript presents the investigation of the interaction between double-strand deoxyribonucleic acid (dsDNA) and three anthracyclines: epirubicin (EPI), idarubicin (IDA), and doxorubicin (DOX) by different...
Article
In the present work, the first voltammetric method is developed for the detection of pazopanib (PZB), a pharmaceutically active ingredient belonging to the tyrosine kinase inhibitor class, using a modified glassy carbon electrode (GCE). Rod-like CuO nanoparticles synthesized by hydrothermal method and finger-like carbon material obtained from hydro...
Article
Full-text available
In this study, an electrochemical DNA biosensor was developed using a straightforward methodology to investigate the interaction of indinavir with calf thymus double-stranded deoxyribonucleic acid (ct-dsDNA) for the first time. The decrease in the oxidation signals of deoxyguanosine (dGuo) and deoxyadenosine (dAdo), measured by differential pulse v...
Article
An electrochemical dsDNA nanobiosensor was fabricated using amino‐functionalized multi walled carbon nanotubes modified glassy carbon electrode (NH2fMWCNTs/GCE) for the sensitive detection of DNA bases and electrochemical monitoring of drug‐DNA interaction. The influence of functional groups on MWCNT was studied by MWCNT functionalized with NH2 (NH...
Article
A sensitive voltammetric technique has been developed for the determination of Fludarabine using amine‐functionalized multi walled carbon nanotubes modified glassy carbon electrode (NH2‐MWCNTs/GCE). Molecular dynamics simulations, an in silico technique, were employed to examine the properties including chemical differences of Fludarabine‐ function...
Article
Background Nanomaterials have a significant role in improving the performance of electrochemical sensing systems. Unique physical and chemical properties have extended the application of nanomaterials in the fields of engineering, materials and biomedical science. In the last few years, these materials with unique properties have been preferred in...
Article
This study presents evaluation of the possible interaction mechanism between calf thymus dsDNA and three calcium antagonists; nifedipine, lercanidipine and amlodipine. The interactions between Nifedipine-dsDNA and Lercanidipine-dsDNA were investigated by differential pulse voltammetry using two different interaction methods; at the dsDNA-electroche...
Article
A simple voltammetric nanosensor was described for the highly sensitive determination of antiviral drug Tenofovir. The benzalkonium chloride and silver nanoparticles were associated to build a nanosensor on glassy carbon electrode. Surface characterictics were achieved using scanning electron microscopic technique. The voltammetric measurements wer...
Chapter
An estimated 10,000 DNA damage events occur every day in a single cell due to exposure to genotoxic substances that are endogenously produced or are of environmental origin. Mutations play a significant role in the initiation of cancer and in other stages of the carcinogenic process. Oxidative stress, which is the oxidation of biomolecules by react...
Article
Studying the process of interaction between DNA and drugs became widespread in last more than ten years. In this regard, designing electrochemical DNA biosensors contributed to the development of more selective and sensitive electrochemical methods for the detection of specific DNA binding. This paper is based on the researches in the last years (b...
Article
Studying the process of interaction between DNA and drugs became widespread in last more than ten years. In this regard, designing electrochemical DNA biosensors contributed to the development of more selective and sensitive electrochemical methods for the detection of specific DNA binding. This paper is based on the researches in the last years (b...
Article
The kinetics and mechanism for electrochemical oxidation of Nilotinib, a tyrosine kinase inhibitor drug, used in the treatment of chronic myelogenous leukemia, were studied using cyclic and differential pulse voltammetric methods on glassy carbon electrode. The pH-dependent oxidation of Nilotinib was studied within the range of pH 0.3-10.0. Two wel...
Article
Antihypertensive drugs primarily affect systemic vascular resistance through producing vasodilation. This vasodilatory effect is achieved either by interference with sympathetic adrenergic vascular tone or by the blocking of the formation of angiotensin II or its vascular receptors. There are other antihypertensive drugs which have direct arterial...
Article
A voltammetric study of the oxidation of Ceftazidime (CEFT) has been carried out at the glassy carbon electrode by cyclic, differential pulse (DPV) and square wave (SWV) voltammetry. The oxidation of CEFT was irreversible and exhibited diffusion controlled process depending on pH. The oxidation mechanism was proposed and discussed. According to the...
Article
Poly(acridine orange) was electropolymerised on glassy carbon electrodes by potential cycling in phosphate buffer solution at pH 5.5, 6.0, 7.0 and 8.0. Electrochemical behaviour of the modified electrodes was studied by cyclic voltammetry in phosphate buffer solution at various pHs and found that the best polymer film formation was obtained at pH 5.5...
Article
A sensitive electroanalytical method for the determination of anticancer drug etoposide (ETP) using adsorptive stripping differential pulse voltammetry (AdSDPV) at a multi-walled carbon nanotube-modified glassy carbon electrode (MWCNT-modified GCE) is presented. The surface morphology of modified electrode was characterized by scanning electron mic...
Article
The voltammetric behavior of anticancer drug irinotecan (IRT) was investigated at poly (methylene blue)/multi-walled carbon nanotube (PMB/MWCNT) modified glassy carbon electrode (GCE). The modified electrode surface was characterized by a scanning electron microscope (SEM). The PMB/MWCNT modified GCE exhibits a distinct shift of the oxidation poten...
Article
The effect of surface modifications on the electrochemical behavior of the anticancer drug idarubicin was studied at multiwalled carbon nanotubes modified glassy carbon and edge plane pyrolytic graphite electrodes. The surface morphology of the modified electrodes was characterized by scanning electron microscopy. The modified electrodes were const...
Article
Voltammetric, chromatographic, and spectrophotometric methods were developed for the simultaneous determination of bisoprolol fumarate (BIS) and hydrochlorothiazide (HCZ). Differential pulse and square wave voltammetry techniques were used to analyze BIS and HCZ simultaneously by measuring at about 1400 and 1100 mV, respectively. RP-HPLC was the se...
Article
Valganciclovir hydrochloride (VAL) is an antiviral drug active compound which is used for the treatment of the cytomegalovirus infections. The voltammetric oxidation of VAL was investigated at multi-walled carbon nanotubes modified glassy carbon electrode using cyclic and differential pulse voltammetry over a wide pH range. The results revealed tha...
Article
We would like to thank all the authors for their excellent contributions and the editorial board members of Chromatography Research International for their kind invitations to act as guest editors for this special issue.
Article
The mechanism of electrochemical oxidation of trifluoperazine has been proposed on the basis of cyclic and differential pulse voltammetry at a multiwalled carbon nanotube-modified glassy carbon electrode. The modified electrode exhibits catalytic activity, high sensitivity, and stability. The oxidation process exhibited an adsorption-controlled beh...
Article
The electrochemical oxidation of fulvestrant was made on highly boron-doped diamond electrode using differential pulse adsorptive stripping voltammetry. The highest current intensities were obtained by applying ?1.10 V during 150 s for boron-doped diamond electrode. For boron-doped diamond electrode, linear responses were obtained for the concentra...
Article
The interaction of fulvestrant with double-stranded DNA (dsDNA) was studied by means of differential pulse voltammetry (DPV) at dsDNA modified pencil graphite electrode (PGE). The decrease in intensity of the guanine oxidation signals was used as an indicator for the interaction mechanism and sensitive determination of fulvestrant in pH 4.80 acetat...
Article
The electrochemical oxidation of riluzole was investigated using cyclic and linear sweep voltammetry. Under optimized conditions, current and concentration showed linear dependence in Britton Robinson buffer at pH 3.00 for boron doped diamond and pH 3.00 phosphate buffers for glassy carbon electrodes. Differential pulse and square wave voltammetry...
Article
The anticancer drug, leuprolide (LPR) bound to double-stranded fish sperm DNA (dsDNA) which was immobilized onto the surface of an anodically activated pencil graphite electrode (PGE), was employed for designing a sensitive biosensor. The interaction of leuprolide (LPR) with double-stranded DNA (dsDNA) immobilized onto pencil graphite electrode (PG...
Article
Full-text available
The electrooxidation behavior and determination of fulvestrant at a glassy carbon electrode were investigated. The voltammetric study of the model compounds allowed elucidating the possible oxidation mechanism of fulvestrant. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate was determi...
Article
The electrochemical behavior of L-dopa and benserazide at a solid electrode has been investigated using different voltammetric techniques. The anodic voltammetric characteristics of the selected compounds have been studied in aqueous media as a function of pH by cyclic, differential pulse and square wave voltammetric techniques. First derivative of...
Article
Cefaclor (CEF), a second generation cephalosporin antibiotic, possesses various donor sites for interaction with transition metal (II) ions such as Cu(II), Co(II) and Ni(II) to form complexes of the type [M(CEF)(H2O)Cl], with a molar ratio of metal:ligand (M:L) of 1:1. These complexes were prepared and characterized by physicochemical and spectrosc...
Article
The anodic voltammetric behavior and electroanalytical determination of rosiglitazone was studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques on glassy carbon electrode. The oxidation of rosiglitazone was irreversible and exhibited diffusion controlled process depending on pH. Different parameters were tes...
Article
Amlodipine besylate (AML) is a long-acting calcium channel blocker used as an antihypertensive agent. Valsartan (VAL) is also used to treat hypertension, either alone or in combination with other agents. Two-component mixtures of AML and VAL were analyzed by HPLC and the ratio spectra of the first derivative spectrophotometric technique. The spectr...
Article
Compared to other voltammetric techniques a square wave voltammetry (SWV), which is presented in this minireview, has a several advantages such as high speed, increased analytical sensitivity and relative insensitivity to the presence of dissolved oxygen. Also it is an electrochemical technique used in analytical applications and fundamental studie...
Article
The electrochemical behavior of atorvastatin and amlodipine at a glassy carbon electrode has been studied using different voltammetric techniques. First derivative of the ratio voltammetric methods for determination of amlodipine and atorvastatin in tablets in the presence of the other compound has been described. This technique depends on the meas...
Article
A differential pulse (DP) and square wave (SW) voltammetric techniques were developed for the determination of irbesartan. The electrochemical behavior of irbesartan was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) at the hanging mercury drop electrode (HMDE). Different parameters...
Article
Cefotaxime sodium has an antibacterial effect and it is classified as a third-generation broad spectrum cephalosporin antibiotic. It is irreversible, oxidized at the glassy carbon electrode in various buffer systems and at different pH values. The detailed mechanism of the oxidation process is described in this manuscript. Differential pulse and sq...
Article
Cefoperazone sodium is irreversibly oxidized at the glassy carbon electrode in various buffer systems and at different pH values using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. The oxidation of cefoperazone sodium was irreversible and exhibited diffusion controlled process depending on pH. A detailed oxidatio...
Article
The interaction of Efavirenz (EFV) with fish sperm dsDNA immobilized onto pencil graphite electrode (PGE) has been studied by using differential pulse voltammetric technique using an electrochemical DNA biosensor. The guanine signal was lower with (double stranded-DNA) dsDNA-treated PGE than the untreated electrode after the interaction with EFV oc...
Article
Loracarbef has antibacterial activity and is oxidizable at the glassy carbon electrode. The electrochemical oxidation of Loracarbef was investigated using cyclic, linear sweep, differential pulse, and square wave voltammetric techniques. The results obtained from cyclic voltammetry indicate that the oxidation process of Loracarbef is irreversible a...
Article
The electrochemical oxidation of sertindole was investigated using cyclic, linear sweep voltammetry at a glassy carbon and boron-doped diamond electrodes. The aim of this study was to determine sertindole levels in serum and pharmaceutical formulations, by means of electrochemical methods. In cyclic voltammetry, depending on pH values, sertindole s...
Article
The anodic behavior and determination of pefloxacin on boron-doped diamond and glassy carbon electrodes were investigated using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. In cyclic voltammetry, pefloxacin shows one main irreversible oxidation peak and additional one irreversible ill-defined wave depending on p...
Article
Abacavir (I), a drug used in the treatment of HIV, is electrochemically reduced at the dropping mercury electrode in a four-electron process, similar to structurally related adenine (III) and adenosine triphosphate (IV). To undergo the reduction, the species is protonated in the vicinity of the electrode. The protonations take place on the 6-amino...
Article
Boron-doped diamond electrodes have received much attention for electrochemical determination due to their attractive electrochemical properties over other electrodes. The electrooxidation of fluvastatin sodium at boron-doped diamond electrode was investigated using cyclic, differential pulse and square wave voltammetry. The possible mechanism of o...
Article
A rapid, sensitive, and specific reverse phase high performance liquid chromatography with diode array detection procedure for the simultaneous determination of abacavir, efavirenz and valganciclovir in spiked human serum is described. Separation was performed on a 5μm Waters Spherisorb column (250×4.6mm ID) with acetonitrile: methanol:KH2PO4 (at p...
Article
The electrochemical behavior of atorvastatin calcium at glassy carbon and boron-doped diamond electrodes has been studied using voltammetric techniques. The possible mechanism of oxidation was discussed with model compounds. The dependence of the peak current and potentials on pH, concentration, scan rate and nature of the buffer were investigated...
Article
This paper describes the validation of an isocratic high-performance liquid chromatographic method for the assay of valganciclovir in raw materials, tablets and human serum samples. Valganciclovir and fluvastatin (internal standard) were well separated using a reversed phase column and a mobile phase consisting of a mixture of acetonitrile:methanol...
Article
The electrochemical behavior and determination of nabumetone, nonsteroidal anti-inflammatory drug, were studied in aqueous alcohol medium at a glassy carbon electrode using cyclic, differential pulse (DP) and osteryoung square wave (OSW) voltammetric techniques. In pH 3.7 acetate buffer, nabumetone solution presents a well-defined anodic response a...
Article
Indinavir sulfate is an inhibitor of the human immunodeficiency virus (HIV) protease. The aim of this study was to determine indinavir levels in serum and pharmaceuticals, by means of electrochemical methods using the hanging mercury drop electrode (HMDE). Indinavir exhibited irreversible cathodic waves over the pH range 2.00-12.00 in different sup...
Article
The electrooxidative behaviour and determination of quetiapine (QTP), a dibenzothiazepine derivative and antipsychotic agent, on a glassy carbon disc electrode was investigated using cyclic (CV), linear sweep (LSV), differential pulse (DPV) and Osteryoung square wave voltammetry (OSWV). Fully validated DP and SW voltammetric procedures are describe...
Article
Full-text available
Ascorbic acid is the most common electroactive biological compound found in some plant species (e.g., Citrus species, Rosa species). The electrochemical oxidation of ascorbic acid was investigated by cyclic, linear sweep, differential pulse (DPV), and square wave (SWV) voltammetry. For analytical purposes, a very well-resolved diffusion-controlled...
Article
A capillary electrophoretic method was described for the determination of droperidol in pharmaceutical tablets and human serum. Droperidol and internal standard, lansoprazole, were separated on an uncoated fused-silica capillary using a run buffer containing borate (10 mM; pH 9.3) and aqueous methanol (20%, υ/υ). The signals were detected at 210 nm...
Article
Full-text available
Some 2-phenyl indole ( 2PI) derivatives were investigated electroanalytically by voltammetric determination. The electrochemical behaviour of the 2PI derivatives were studied as a function of pH at a glassy carbon and hanging mercury drop electrodes in different buffer media. The characteristics of the corresponding electrode reaction were discusse...
Article
The voltammetric behavior of cefixime was studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques. The oxidation of cefixime was irreversible and exhibited diffusion controlled process depending on pH. The oxidation mechanism was proposed and discussed. Different parameters were tested to optimize the conditio...
Article
The voltammetric behavior of vardenafil was studied on glassy carbon electrode using cyclic, differential pulse (DPV) and Osteryoung square-wave (OSW) voltammetric techniques. Vardenafil exhibited irreversible anodic waves over the pH range 1.00–12.00 in different supporting electrolytes. The current–concentration plot was rectilinear over the rang...
Article
Lamivudine (LAM) is a synthetic nucleoside analogue with activity against human immunodeficiency virus-type 1 (HIV-1) and Hepatitis B virus (HBV). The aim of this study was to determine LAM levels in serum and pharmaceutical formulations, by means of electrochemical methods using hanging mercury drop electrode (HMDE). On this electrode, LAM undergo...
Article
The electrochemical reduction behavior of mefloquine HCl (MEF), the antimalarial drug, was studied in aqueous alcoholic media at a hanging mercury drop electrode. Cyclic voltammetric studies showed one well-defined reduction peak and one ill-defined reduction wave between pH 1.5 and 12.03. The reduction was found as irreversible or quasireversible...
Article
A voltammetric study of the oxidation of fexofenadine HCl (FEXO) has been carried out at the glassy carbon electrode. The electrochemical oxidation of FEXO was investigated by cyclic, linear sweep, differential pulse (DPV), and square wave (SWV) voltammetry using glassy carbon electrode. The oxidation of FEXO was irreversible and exhibited diffusio...
Article
Carvedilol is used in the management of hypertension and angina pectoris and as an adjunct to standard therapy in symptomatic heart failure. The electrochemical oxidation of carvedilol was investigated using cyclic, linear sweep voltammetry at a glassy carbon electrode. In cyclic voltammetry, in all values of pH, the compound shows two irreversible...
Article
A simple and rapid electrochemical method for the determination of ganciclovir in human serum and pharmaceutics was developed. The anodic peak at +1.15 V obtained in a buffer on glassy carbon electrode was used for analysis. The peak current and peak potential depends on pH, scan rate and initial potential. Decrease of the anodic peak with increasi...
Article
Flupenthixol hydrochloride (FLP) has an antipsychotic activity against depression and is irreversible oxidizable at the glassy carbon electrode in various buffer systems and at different pH values. The mechanism of the oxidation process was discussed. According to the linear relation between the peak current and FLP concentration, differential puls...
Article
The electrochemical behaviour of candesartan cilexetil (CND) was investigated in an acetonitrile: supporting electrolyte mixture (30% acetonitrile) in the pH range 1.5-11.00 by cyclic, linear sweep, differential pulse (DPV), adsorptive stripping differential pulse (AdSDPV), square wave (SWV) and adsorptive stripping square wave (AdSSWV) voltammetri...

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