Burak Tüzün

Burak Tüzün
Sivas Cumhuriyet University · department of chemistry

Prof. Dr. of organic chemistry

About

130
Publications
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Introduction
I am working in the chemistry department of the sivas republic university. I am a theoretical organic chemist. I'm optimizing molecules using the gaussian program. Calculate NMR, IR and UV-vis spectra of molecules using optimized structures. molecules interact with metals. I investigate the corrosion inhibitor properties of molecules.I'm doing a docking calculation to compare biological activity against proteins. I am waiting for your proposals for joint your studies. theburaktuzun@yahoo.com btuzun@cumhuriyet.edu.tr

Publications

Publications (130)
Article
Full-text available
Newly designed nicotinamide derivatives were synthesized and characterized using spectral techniques (IR, ¹H-NMR, ¹³C-NMR, and MS). Moreover, these compounds are investigated computationally. B3LYP/6–31 + G(d,p) level is selected as the calculation level in this study. Experimental and calculated IR spectrum were compared to each other. Electronic...
Article
Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method provided an increase in reaction yields by reducing the reaction time approximately 3-fold. The synthesized compounds were invest...
Article
Full-text available
D614G is one of the most reported mutations in the spike protein of SARS-COV-2 that has altered some crucial characteristics of coronaviruses, such as rate of infection and binding affinities. The binding affinity of different antiviral drugs was evaluated using rigid molecular docking. The reliability of the docking results was evaluated with the...
Article
Full-text available
Spontaneous self-assembly in the supramolecular entity is one of the enthralling synthetic routes. It produces disparate structure crystal complexes after selecting suitable M-L combinations in the pseudohalide sense. In this attempt, a novel cocrystal is synthesized from two independent components (0D + 1D), [PbCd(L¹)(SCN)2]·[PbCd(L¹)(SCN)2]n(1) u...
Conference Paper
Full-text available
Medicinal and aromatic plants are used in many areas such as nutrition, cosmetics and drug production. The use of chemical components of medicinal and aromatic plants, especially in the field of health, makes them important. Green tea obtained from the leaves of the medicinal and aromatic plant Camellia sinensis is a frequently consumed beverage. G...
Article
(A new 4‐oxothiazolidin‐2‐ylidene derivative bearing hydrazone moiety was synthesized via Michael addition between the reaction of 4‐(4‐nitrophenyl)‐3‐thiosemicarbazide and dimethyl acetylenedicarboxylate (DMAD). The structure of synthesized compound was elucidated using various spectral techniques such as FTIR, UV‐spec, 1H NMR and 13C NMR. The str...
Article
Full-text available
Backround: A pyrimidine based Schiff base was examined in this report. Structural and spectral characterizations were done with Gaussian software. Active sites of the compound were determined using molecular electrostatic potential (MEP) maps. Aim: We focused to determine whether pyrimidine based Schiff base would be an inhibitor against Omicron o...
Article
Full-text available
Quinoline‐fused ZnII (ZnPcp/ZnPcnp) and MgII (MgPcp/MgPcnp) phthalocyanines with four 4‐methylquinolin‐2‐ol (1) at non‐peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization of phthalonitrile derivatives (CNp/CNnp) in the presence of zinc (II) and magnesium (II) metal ions in this study. The str...
Article
A new series of imidazolyl hydrazone derivatives IA (1-12) were prepared from a condensation reaction between indoline-2,3-dione (isatin) and 2-benzylidenehydrazinecarboximidamide derivatives. The structure of compounds was elucidated using various spectral techniques including FTIR, ¹H NMR, ¹³C NMR, and HRMS. The proposed structure of IA-2 was det...
Article
Different properties of phthalocyanine compounds can be measured both theoretically and experimentally. In this study, tetra substituted phthalocyanines (H2 (2) and CuII (3) were performed using 4-(4-(4-methoxyphenethyl)-3-benzyl-5-oxo-4,5-dihydro-1,2,4 triazol-1-yl)phthalonitrile (1). The structures of all these original compounds synthesized were...
Chapter
Full-text available
Currently, the eco-friendly corrosion inhibitors are widely used to protect the metallic materials from the corrosion destruction. The eco-friendly corrosion inhibitors are biodegradable, low toxic, low volatile, low cost, good water soluble, good adsorbent, and do not contain heavy metals or other toxic compounds. The plant extracts and natural su...
Conference Paper
Full-text available
Recently, synthetic compounds are regarded as important source for developing the chemotherapeutic agents. The most remarkable advances in medicinal chemistry was made when heterocyclic compounds took a place in regulating biological activities. This study focuses on these three molecules. these molecules are three GAK molecule derivatives. Optimiz...
Article
Lung cancer is the most common cancer worldwide and the leading cause of cancer‐related death. Plant‐derived natural products and compounds are an inspiring source of chemotherapeutic agents. Alzheimer's disease (AD) is linked to the decline of acetylcholine (ACh) effects in the brain, so acetylcholinesterase (AChE) inhibitors are important in the...
Article
Lung cancer is the most common cancer worldwide and the leading cause of cancer-related death. Plant-derived natural products and compounds are an inspiring source of chemo-therapeutic agents. Alzheimer's disease (AD) is linked to the decline of acetylcholine (ACh) effects in the brain, so acetylcholinesterase (AChE) inhibitors are important in the...
Article
Design, synthesis, structural elucidation, and investigation of cytotoxic, antimicrobial, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzyme inhibition activities of isatin-thiosemicarbazone hybrid compounds (1-15) are reported in this study. Hybrid compounds (14 and 15) were synthesized, isolated, and characterized for the first...
Article
In this study, a series of nitrogen‐based novel heterocyclic compounds were synthesized and characterized by elemental analysis, IR and NMR spectra. The novel synthesized nitrogen‐based novel heterocyclic compounds were evaluated against the acetylcholinesterase (AChE) and α‐glycosidase enzymes. These compounds showed IC50 values in range of 0.76–2...
Article
The effect of new compounds containing morpholine moiety including: 3,5-di-tert-butyl-2-(((3-((2-morpholinoethyl)(pyridine-2-ylmethyl)amino)propyl)imino)methyl)phenol (L1) and its reduced form, 3,5-di-tert-butyl-2-(((3-((2-morpholinoethyl)(pyridine-2-ylmethyl)amino)propyl)amino) methyl)phenol (L2) on the corrosion inhibiting of C-steel in 1.0 M HCl...
Article
Full-text available
We serendipitously designed one novel 1D hetero-binuclear Zn(II)-Pb(II) coordination polymer, namely [(Zn)(Pb)(L)(η¹–NCS)(η¹–SCN)]n (1) from Salen ligand (H3L) in the presence of NaSCN. The complex was structurally characterized by elemental, IR, Raman, NMR spectroscopy, Scanning electron microscope, Powder X-ray diffraction, and Single-crystal X-r...
Article
In this study, the corrosion of carbon steel in 1.0 M HCl solutions containing either 1,4-bis(2-(2-hydroxyethyliminomethyl)phenyl)piperazine (1) or its reduced form, 1,4-bis(2-(2-hydroxyethylaminomethyl)phenyl)piperazine (2), as possible corrosion inhibitors, were compared to a solution containing no (1) or (2). The various concentrations of inhibi...
Article
A novel series of purine derivatives containing sulfonamide moiety were synthesized in good yield by the single-step reaction method. The purity of compounds was determined by thin layer chromatography. All the compounds were characterized and confirmed by FT-IR, ¹H NMR, ¹³C NMR, GC/MS, and CHN elemental analysis. The chemical activities of the mol...
Article
Full-text available
A new series of 4-oxothiazolidin-5-ylidene acetates (1-16) containing guanylhydrazone moiety were designed and synthesized by using dimethyl acetylenedicarboxylate (DMAD) as a Michael acceptor. The structure of synthesized compounds was characterized by various spectral techniques including FTIR, ¹H NMR, ¹³C NMR and elemental analysis. Synthesized...
Article
In this study, we report the synthesis and characterization of peripheral alkyl chain-substituted metalophthalocyanines [CuPc (3), ZnPc (4), and CoPc (5)] as optically sensitive substances with antifungal and antibacterial properties. Synthesized compounds were characterized by using common spectroscopic methods such as ¹H-NMR, ¹³C-NMR, FT-IR, MALD...
Article
In this present research work, new 8-hydroxyquinoline derivatives were synthesized and their molecular structures were confirmed by the ¹H-NMR, ¹³C-NMR, IR and elemental analysis. The antioxidant activity of the synthesized compounds is evaluated through their capacity to scavenge 2,2-di-phenyl-1-picrylhydrazyl (DPPH) free radicals. In addition, th...
Article
Full-text available
This study aims to synthesize new pyrrolic compounds derivatives of 8-hydroxyquinoline, explore the structure-activity relationship and the effect of the substituents carried by the pyrrole ring on their antibacterial properties. These compounds were characterized by IR, ¹H, ¹³C NMR and elemental analysis. The NMR predicted chemical shifts were det...
Article
Full-text available
In this study, a series of new Schiff bases, based on a pyrimidine core, were synthesized in two steps. The structures of these newly synthesized Schiff bases were completely characterized. The presence of characteristic -N=CH proton peaks proving the formation of imine supports the structures of the compounds. The cytotoxic activity studies were d...
Article
A comparative investigation of the corrosion inhibition of two ligands, 2-((3-(2-morpholinoethylamino)-N3-((pyridine-2-yl)methyl) propylimino) methyl)pyridine (SB) and N1-(2-morpholinoethyl)-N1,N3-bis(pyridine-2-ylmethyl)propane-1,3-diamine (RSB) for carbon steel in 1.0 M HCl has been carried out. The inhibitor effects on the corrosion behavior of...
Article
Full-text available
One of the deadliest diseases is the SARS-CoV-2 virus, today. The rate of spread of this virus is very high. Momordica Charantia extracts studied for this virus. The inhibitory activities of 96 components in the extract of Momordica Charantia were compared against the SARS-CoV-2 virus. Molecular docking method was initially used for this comparison...
Conference Paper
Full-text available
Cancer, which is increasing in incidence day by day, has become one of the most important diseases that threaten people's lives. In addition to the existing cancer treatment methods, the development of natural herbal treatment facilities has gained great importance in recent years. For this purpose, the effects of medicinal plants, which are tradit...
Conference Paper
Full-text available
Dandelion (Taraxacum officinale) is a perennial, yellow-flowered, herbaceous plant species belonging to the Asteraceae family. Dandelion plant, whose homeland is Europe, North America and Anatolia, grows naturally on the edges of fields, grasslands and roadsides in April and May. Dandelion has been widely used for centuries as a folkloric medicine...
Article
Schiff bases are compounds that have gained importance in the paint industry due to their colorful nature and in the field of chemistry and biochemistry due to their biological activities. Various biological applications of Schiff bases, such as antitumor, antifungal, antibacterial, antioxidant, antituberculosis, and anthelmintic, have been widely...
Conference Paper
Full-text available
Mentha pulegium L. is a pungent, perennial and herbaceous mint species belonging to the Lamiaceae family. This species, which spreads naturally in Europe, North Africa and the Middle East, is commonly called pennyroyal or pennyrile in Europe. The pennyroyal plant, which is known to be very rich in essential oils, has been widely used by people for...
Conference Paper
Full-text available
Saffron (Crocus sativus L.), a member of the Iridaceae family, is a perennial herbaceous plant with bulbous, crocus-like, lilac-purple flowers. Although it is cultivated in many countries due to its economic and commercial importance, it spreads in the Northern hemisphere, tropical and subtropical climate regions. The used organ of the plant is the...
Conference Paper
Full-text available
Helichrysum arenarium (H. arenarium) plant, which grows naturally in almost every region of our country, is locally called golden grass due to the golden yellow color of its flowers. Its homeland is Europe and it is a perennial herbaceous species belonging to the Asteraceae family. Its flowers have many biological activities such as antioxidant, an...
Conference Paper
Full-text available
Medicinal and aromatic plants are used in many fields such as medicine, cosmetics, food and paint. While some of the medicinal plants were collected from nature, some of them were taken into culture. Laurus nobilis L. is one of our most important medicinal and aromatic plants. Laurus nobilis L. are plants in the form of trees or shrubs, especially...
Article
Glioblastoma is the most common and destructive brain tumor with increasing complexity. Flavonoids are versatile natural compounds with the approved anticancer activity, which could be considered as a potential treatment for glioblastoma. A quantitative structure-activity relationship (QSAR) can provide adequate data for understanding the role of f...
Article
In the first step, (4R)-2-(2-hydroxyphenyl)thiazolidine-4-carboxylic acid (c) and 2-(2-(3,4-dicyanophenoxy)phenyl)thiazolidine-4-carboxylic acid (1) were prepared. Then, the peripherally tetra-substituted metallophthalocyanines [ZnPc (2), CuPc (3), and CoPc (4)] were synthesized by using 1. The structures of the obtained compounds were characterize...
Article
β-Amino alcohols (2-4) used in this study were re-synthesized in accordance with our previous study. All compounds were characterized by the combination of NMR, UV-Vis, IR experimental and theoretical spectral data. Then, the cytotoxic activity studies of the molecules on SH-SY5Y and L-929 cell lines showed that compound 2 has the highest activity...
Article
Full-text available
BACKGROUND: Seven dioxaborole compounds are investigated in this study. Structural and spectral characterization is done at M062X/6-31+G(d,p) level in the water. Active sites of these compounds are determined by contour plots of frontier molecular orbital and molecular electrostatic potential (MEP) maps. Electrophilic and nucleophilic attack region...
Article
Full-text available
This study shows the synthesis and characterization of 4,5-bis(4-propionylphenoxy)phthalonitrile (2) and its octa-substituted phthalocyanine derivatives [ZnPc(3), CuPc(4), and CoPc(5)]. A combination of standard spectroscopic techniques has characterized the newly synthesized phthalonitrile derivative and phthalocyanines. The aggregation behaviors...
Article
In this work, two new heterobimetallic Pb(II) complexes, namely [Zn(L¹)(η¹-NCS)Pb(η¹-SCN)] (1) and [Cd(L²)(η¹-NCS)Pb(η¹-SCN)]n (2) integrated from Salen ligands (L¹/L²) in the presence of NaSCN. The title compounds were characterized with microanalytical, spectroscopic techniques, and SC-XRD. SC-XRD divulges a de-protonated form of ligands trapped...
Article
Bicyclic structures were synthesized by LACASA-DA cycloaddition reaction using (S)-BINOL as a chiral inductor. The N-2 pyridazine position was protected; the hydroxyl group was carbonylated to form the new bicyclic structure. The protective group was removed, the double bond dehydroxylated leading to the target compound. Removing of the protective...
Article
Bicyclic structures were synthesized by LACASA-DA cycloaddition reaction using (S)-BINOL as a chiral inductor. The N-2 pyridazine position was protected; the hydroxyl group was carbonylated to form the new bicyclic structure. The protective group was removed, the double bond dehydroxylated leading to the target compound. Removing of the protective...
Conference Paper
Full-text available
Transition metal complexes are playing an important role the field of bioorganic chemistry. it has been attempted to investigate the anti-cancer properties of complexes of oxypropanolamines derivatives formed with various metal atoms [1-2]. In these examinations, biological agents of these derivatives will be compared [3]. The most active ligand wi...
Conference Paper
Full-text available
The metal ions accelerate drug action and efficiency of therapeutic compounds [1]. Metal complexes may inhibit the protein synthesis because of interference in the cellular respiration. Cancer is leading cause of fatality in recent years and remained as a challenge for the world [2-3]. It is known that the formation of transition metal complexes of...
Article
Full-text available
BACKGROUND: Predominant molecules in Peganum harmala leaves were detected using gas chromatography-mass spectrometry (GC-MS). Based on the results of this analysis, most alkaloids, flavonoids and triterpenoids in found P. harmala was compiled from the literature in order to develop and lead the production of effective inhibitor drugs for ACE2, main...
Article
A series of heterocyclic compounds (1-5) were synthesized, characterized and tested towards two human cancer cell lines for learning their in vitro antiproliferative activities. Compound 3 demonstrated the most promising activity in breast cancer cell line with a half maximal inhibitory concentration (IC50) value of 23.73 μM compared to other compo...
Chapter
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Many experts working in the field of corrosion work in laboratories experimentally with long-term procedures and high costs by making changes in the structures of new corrosion inhibitors or existing inhibitors. Advances in computational chemistry and computer software in recent years combine corrosion prevention studies with theoretical chemistry,...
Article
Full-text available
In this study, it was aimed to synthesize novel molecules containing potential biological active phenolic Mannich base moiety and evaluate the inhibition properties against α-glycosidase (α-Gly) and acetylcholinesterase (AChE). For this purpose, phenolic aldehydes (1–3) were synthesized from 4-hydroxy-3-methoxy benzaldehyde (vanillin) according to...
Article
Full-text available
In this study, firstly, (4R)‐2‐(3‐hydroxyphenyl)thiazolidine‐4‐carboxylic acid (1) and (4R)‐2‐(3‐(3,4‐dicyanophenoxy)phenyl)thiazolidine‐4‐carboxylic acid (2) were prepared. Then, the novel type metallophthalocyanines (ZnPc (3), CuPc (4), and CoPc (5)) bearing thiazolidine groups in peripheral positions were synthesized using by compound (2). The s...
Article
In this work, a novel crystal i.e (E)-N'-(4-chlorobenzylidene)-5-phenyl-1H-pyrazole-3-carbohydrazide has been synthesized and characterized using various spectroscopic techniques. The (E)-configuration of the azomethine (N=CH) was confirmed by single crystal X-ray analysis. The molecule crystallizes in the monoclinic space group, P21/c, a = 15.629(...
Article
Given the pharmacological significance of 8-quinolinols and benzimidazoles, in the present paper, two series of new N-Heterocyclic having 8-quinolinol and benzimidazole moieties within a single molecular framework were prepared and characterized by elemental analysis, IR, and 13C/1H NMR techniques. To evaluate the desired compound as DNA-binder 3a,...
Article
Some metabolic enzyme inhibitors can be used as Multi-target-Directed-Ligands (MTDL) in Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are essential. In this study, novel bis-napthoquinone derivatives (5a-o) were synthesized through a multi-component cascade reaction of two molecules of 2-hydroxy-1,4-naphthoqui...
Article
The present study aims to first explore the relationship between the chemical structure of the organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities, as well as the impact of substituent effects on their antibacterial properties. These compounds were synthesized by efficient methods, and their structures confirme...
Article
Various novel heterocyclic compounds containing pyrimidine nuclei 5H-chromeno[4,3-d]pyrimidine (4a–c, e–h, l–r, t) and pyrimidine-5-yl-(2- hydroxyphenyl)methanone (5a, c, d, f–k, m–o, r, s, u) were synthesized from the reaction of guanylhydrazones (2a–u) and 3-formylchromone (3). These compounds were tested against human liver hepatocellular carcin...
Preprint
Full-text available
In this paper, a new benzidine-based azomethine derivate 2 with a proposed new mechanism and its two derivatives 4a-b have been designed, synthesized and characterized by ¹ H, ¹³ C NMR, FT-IR, and HRMS spectroscopic techniques, and their anticancer properties were investigated. The target compounds 2 , 4a-b were obtained with excellent yields (91%...
Article
Full-text available
In this study, in vitro inhibition effects of (E)-1-(4-aminophenyl)-3-(aryl) prop-2-en-1-one (4-amino-chalcones) derivatives (3a-o) on acetylcholinesterase (AChE) enzyme and human erythrocyte carbonic anhydrase I and II isoenzymes (hCA I- II) were investigated. And also, the biological activities of 4-amino-chalcone derivatives against enzymes whic...
Article
BACKGROUND: Seven dioxaborole compounds are investigated in this study. Structural and spectral characterizations are done at the M062X/6-31+G(d,p) level in water. Active sites of these compounds are determined by contour plots of frontier molecular orbital and molecular electrostatic potential (MEP) maps. Electrophilic and nucleophilic attack regi...
Article
In this study, we reported the synthesis of new cobalt and zinc phthalocyanine compounds with ((ethylenediamine-N,N’,N’-triacetic acid-N-2-ethyl)oxy) (ETAEO) substituted groups. Characterization studies and anticancer properties of both synthesized compounds were determined as well. The inhibitory effects of these complexes on some metabolic enzyme...
Article
Quorum sensing (QS) is a system used in the expression of virulence factors by many pathogenic bacteria, and blockage of the system is seen as a new and effective strategy in combating with resistant bacteria. The inhibition effects of two benzimidazolium salts, namely 1-(2-methylbenzonitrile)-3-benzylbenzimidazolium bromide (2) and 1-(N-methylphth...
Article
Syntheses of tetrahydroepoxy, O‐allylic, O‐prenylic, and O‐propargylic tetrafluoronaphthalene derivatives, starting from 1‐bromo‐2,3,4,5,6‐pentafluorobenzene, are reported here for the first time. The O‐substituted tetrafluoronaphthalene derivatives were designed and also synthesized via a one‐pot nucleophilic substitution reaction in excellent yie...
Article
Background: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are sought to prevent the spread of this virus. Azithromycin and clarithromycin are considered for the treatment of the SARS-CoV-2 virus, which has a high similarity to previous c...
Article
Introduction Despite all the efforts to treat COVID-19, no particular cure has been found for this virus. Since developing antiviral drugs is a time-consuming process, the most effective approach is to evaluate the approved and under investigation drugs using in silico methods. Among the different targets within the virus structure, as a vital comp...
Article
Full-text available
Background: Seven dioxaborole compounds are investigated in this study. Structural and spectral characterizations are done at the M062X/6-31+G(d,p) level in water. Active sites of these compounds are determined by contour plots of frontier molecular orbital and molecular electrostatic potential (MEP) maps. Electrophilic and nucleophilic attack reg...
Article
Background: It is the SARS-CoV-2 virus, one of the most significant diseases of today's world. Due to the high transmission of this disease, studies are ongoing to discover an inhibitor drug that can stop this disease. In this study, inhibitory drugs used for many diseases were tried to stop the SARS-CoV-2 virus. Aim: In the calculations made, i...
Article
Full-text available
There are many hormones and molecules in the human body. Many of these take place in different jobs and tasks. Some of these hormones are serotonin (A1), testosterone (A2), dopamine (A3), adrenaline (A4), methylcytosine (A5) and creatine (A6). The anti-oxidant properties of these molecules in both gas and water phases of the HF/6-31++G(d,p) basis s...
Article
Full-text available
There are many hormones and molecules in the human body. Many of these take place in different jobs and tasks. Some of these hormones are serotonin (A1), testosterone (A2), dopamine (A3), adrenaline (A4), methylcytosine (A5) and creatine (A6). The anti-oxidant properties of these molecules in both gas and water phases of the HF/6-31++G(d,p) basis s...
Article
A new class of cyanopyridine derivatives (10a–e and 11a–e) containing the phenylurea unit was synthesized and tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glycosidase (α‐Gly). The new cyanopyridine derivatives showed Ki values in the range of 40.73 ± 6.54 to 87.05 ± 16.98 µM agains...
Article
In recent years, acetylcholinesterase (AChE) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, cancer, and Alzheimer's. In this manner, the preparation and enzyme inhibition activities of peripherally 1,2,3-triazole group sub...