Bulteau Samuel

Bulteau Samuel
Centre Hospitalier Universitaire de Nantes | CHU Nantes

MD, PhD

About

101
Publications
19,598
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880
Citations
Citations since 2017
67 Research Items
847 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Additional affiliations
October 2016 - present
University of Nantes
Position
  • PhD Student

Publications

Publications (101)
Article
La réalisation pratique d’un traitement par stimulation magnétique transcrânienne (rTMS) est aujourd’hui peu intégrée dans les habitudes de soin en France. De fait, si les connaissances théoriques et scientifiques sont maintenant répandues, les considérations pratiques peuvent demeurer obscures pour les psychiatres qui ne pratiquent pas eux-mêmes l...
Article
At a time when innovations in psychiatry are booming, particularly in the field of medical devices, we thought it necessary, as members of French Society for Biological Psychiatry and Neuropsychopharmacology (AFPBN), to reconsider one of the oldest medical devices in psychiatry: the ECT apparatus. First, we recall the regulatory aspects of ECT. Nat...
Article
Full-text available
Introduction: The perinatal period is an at-risk period for the emergence or decompensation of psychiatric disorders. Transcranial electrical stimulation (tES) is an effective and safe treatment for many psychiatric disorders. Given the reluctance to use pharmacological treatments during pregnancy or breastfeeding, tES may be an interesting treatme...
Article
Psychological flexibility is a key process in mental health, both in a psychopathological approach and from a quality of life and well-being perspective. The notion seems to suffer from a conceptual vagueness with multiple definitions, stemming from different conceptual propositions, with a frequent opposition between a “neuropsychological” approac...
Presentation
Introduction Le trouble dépressif majeur est le plus prévalent de tous les troubles psychiatriques et peut affecter la référence à soi. La plupart des stratégies thérapeutiques de la dépression visent à modifier le processus de référence à soi pour rectifier le biais cognitif négatif du patient. L'efficacité de ces traitements est souvent mesurée a...
Article
Full-text available
Background Recently intermittent theta burst stimulation (iTBS) proved to be non-inferior to conventional repetitive transcranial magnetic stimulation (10 Hz rTMS) in unipolar depression after failure of one antidepressant trial, but to date no randomized control trial assessed the ability of iTBS to improve depression level and quality of life in...
Article
Aim: Deep brain stimulation (DBS) has proven to be an effective therapy of some treatment-resistant psychiatric disorders and movement disorders. Comorbid depressive symptoms are common and difficult to manage. Treatment with electroconvulsive therapy (ECT) may be required. There are few published cases describing the safety and efficacy of ECT fo...
Article
Background Electroconvulsive therapy (ECT) is the most effective non-pharmacological treatment for treatment-resistant depression (TRD) but can expose to transient cognitive impairments. Understanding factors underlying these cognitive side effects is important. This study investigated the impact of anticholinergic treatments on cognitive performan...
Article
Full-text available
Background: Transcranial Direct Current Stimulation (tDCS) and Virtual Reality Exposure Therapy (VRET) are individually increasingly used in psychiatric research. Objective/hypothesis: Our study aimed to investigate the feasibility of combining tDCS and wireless 360° full immersive active and embodied VRET to reduce height-induced anxiety. Meth...
Article
Recent evidence suggests an association between benzodiazepines (BZDs) use and lower brain amyloid load, a hallmark of AD pathophysiology. Other AD-related markers include hippocampal atrophy, but the effect of BZDs on hippocampal volume remains unclear. We aimed at 1) replicating findings on BZDs use and brain amyloid load and 2) investigating ass...
Article
Objectives: Depression as well as a treatment by antidepressant are factors that may interfere with sexuality. Due to this complex relationship between depression, antidepressant and sexuality, it is difficult to incontestably establish the exclusive accountability of a treatment or of a psychiatric disorder on sexual dysfunctions. The main purpos...
Article
Résumé Les traitements de la dépression comprennent un mode de vie adapté, l’activité physique, les psychothérapies, les médicaments antidépresseurs et thymorégulateurs, la neuromodulation, les chronothérapies et les cures thermales. Les traitements médicamenteux utilisés dans le traitement de l’EDC sont les traitements antidépresseurs et les thymo...
Article
Introduction Le trouble dépressif majeur est le plus prévalent de tous les troubles psychiatriques et peut affecter la référence à soi. La plupart des stratégies thérapeutiques de la dépression visent à modifier le processus de référence à soi pour rectifier le biais cognitif négatif du patient. L’efficacité de ces traitements est souvent mesurée a...
Preprint
BACKGROUND In neuropsychology, fully-immersive virtual reality has been spotlighted as a promising tool. It is considered that not only overcome existing limitation of neuropsychological tests, but also appropriate for treating executive functions within daily living tasks due to its high ecological validity. While fully-immersive virtual reality o...
Article
Full-text available
Background Although clozapine is the most effective antipsychotic drug for treatment-resistant schizophrenia, it leads to a poor or partial response in 40 to 70% of patients. Augmentation of clozapine with electroconvulsive therapy (ECT) is a highly effective and relatively safe treatment for these clozapine-resistant patients. However, parameters...
Article
Full-text available
Objective: The aim of the study was to identify clinical variables associated with changes in specific domains of self-reported depression during treatment by antidepressant and/or repetitive Transcranial Magnetic Stimulation (rTMS) in patients with Major Depressive Disorder (MDD). Methods: Data from a trial involving 170 patients with MDD receivin...
Article
Background: Nearly 3% of the general population is treated by antipsychotic. The aim of this study was to assess the conformity of monitoring with the minimal screening recommended by guidelines to prevent Metabolic Syndrome. Research design and method: A cohort study was conducted using SNIIRAM data (2013 to 2017). The analysis included patients w...
Article
Some studies have suggested that postural balance improved after a single session of transcranial direct current stimulation (tDCS), whereas others have found minimal, if any, effects on postural performance. To address the issue of replication in tDCS studies, we re-tested the anodal tDCS effects of left dorsolateral prefrontal cortex while perfor...
Article
Objectives: Relapses and recurrence remain the greatest risks posed by patients with severe mood disorders after discontinuation of electroconvulsive therapy (ECT). To date, despite a wide range of literature on ECT, little is known about the rate of recurrence of depression after maintenance ECT (mECT) discontinuation specifically. This study sou...
Article
Full-text available
Résumé La pandémie du COVID-19 a des conséquences majeures sur l’organisation des soins. En France et dans le monde, les centres pratiquant l’électroconvulsivothérapie (ECT) ont vu leur activité diminuer, voire s’arrêter, pour de diverses raisons. Dans ce contexte, le maintien ou la reprise de cette activité thérapeutique essentielle pour de nombre...
Article
Full-text available
Background: Depression is a debilitating and costly disease for our society, especially in the case of treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy in treatment-resistant unipolar and non-psychotic depression. It can be applied according to two therapeutic strategies aft...
Article
RÉSUMÉ Objectifs: La pandémie de la maladie à coronavirus (COVID-19) a provoqué une crise sanitaire majeure et mis en quarantaine la moitié de la population planétaire. En France, elle a provoqué une réorganisation en urgence de l’offre de soins mobilisant les soignants dans un climat d’incertitude. L'objectif du présent article est de faire le poi...
Article
Full-text available
Résumé La pandémie récente de COVID-19 a entraîné des changements organisationnels majeurs dans les lieux de soins et notamment en hospitalisation en psychiatrie. Pour évaluer l’évolution de l’activité des différents centres pratiquant l’ECT, une enquête nationale en ligne a été réalisée. 65 réponses de toute la France ont été analysées. Plus de 90...
Article
Background: ECT is the most effective treatment of major depressive episode (MDE) but remains a neglected treatment. The French Society for Biological Psychiatry and Neuropsychopharmacology aimed to determine whether prescribing practice of ECT followed guidelines recommendations. Methods: This multicenter, retrospective study included adult pat...
Article
Introduction Depression is among the most widespread psychiatric disorders in France. Psychiatric disorders are associated with considerable social costs, amounting to €22.6 billion for treatment and psychotropic medication in 2011. Treatment as usual (TAU), mainly consisting of pharmacotherapy and psychotherapy, is effective for only a third of pa...
Article
Full-text available
Introduction Depression is among the most widespread psychiatric disorders in France. Psychiatric disorders are associated with considerable social costs, amounting to €22.6 billion for treatment and psychotropic medication in 2011. Treatment as usual (TAU), mainly consisting of pharmacotherapy and psychotherapy, is effective for only a third of pa...
Article
Les ECT sont un traitement de référence pour les troubles de l’humeur avec des taux d’efficacité encore inégalés pour les dépression sévères ou résistantes. Les recommandations officielles de l’ANAES concernant l’ECT ont maintenant plus de 20 ans (1997), et peu d’études ont tenté depuis de décrire ses modalités d’utilisation dans notre pays. Or le...
Poster
Introduction Le burnout peut être défini comme un syndrome psychologique associant un épuisement émotionnel, une dépersonnalisation et une baisse de l’accomplissement personnel [1]. Le burnout affecte en particulier les professionnels d’aide à la personne, comme les sapeurs-pompiers. Les conséquences du burnout sont nombreuses, allant de la baisse...
Article
Introduction La dépression est un trouble psychiatrique répandu, qui entraîne des coûts sociaux considérables. Le traitement usuel (TU), associant généralement antidépresseurs et psychothérapie, n’est efficace que pour un tiers des patients. La stimulation transcrânienne à courant continu (tDCS) est un traitement non invasif, peu coûteux, et bien t...
Article
La prévalence des états dépressifs caractérisés chez les sujets âgés de plus de 65 ans est estimée environ à 30 % en institution et 10 % à domicile. Sur le plan cognitif, les états dépressifs sont marqués principalement par une détérioration des capacités attentionnelles, de la vitesse de traitement de l’information et des fonctions exécutives. Ces...
Article
Full-text available
Objective: The current study aimed to examine whether specific features of psychomotor retardation (PMR) and cognitive functioning established different profiles in unipolar (UD) and bipolar depression (BD). Methods: Two groups of age-matched patients with UD (n=54) and BD (n=20) completed the Montgomery-Asberg Depression Rating Scale (MADRS/60)...
Article
The safety and efficacy of neuronavigated intermittent theta burst stimulation (iTBS) in patients with bipolar depression has not yet been investigated. We hypothesized the superiority of active iTBS over sham. Twenty-six patients were randomly allocated to receive either active (n=12) or sham (n=14) iTBS. Response and remission rates according to...
Article
Introduction The proven effectiveness of neuromodulation and stimulation techniques for the management of psychiatric disorders has brought strongly needed innovation in psychiatry, given the high prevalence and high costs of treatment resistance. Although evidence-based guidelines in neuromodulation have been implemented to improve the clinical ef...
Article
Major depression (MD) is a debilitating condition associated with huge personal, social, and economic costs, as well as excessive mortality and disability. A large proportion of subjects doesn’t reach adequate clinical improvements with psychosocial and pharmacologic interventions and are exposed to side effects. In recent years, novel neuromodulat...
Article
Introduction Transcranial Direct Current Stimulation (tDCS), a medical device, has Grade B evidence-based efficacy for treatment-naive depressive patients, or with treatment, and no resistance. Its ease of use, its good tolerance and its cost of acquisition, lower than transcranial magnetic stimulation and electroconvulsive therapy, make it a good...
Article
Résumé La stimulation magnétique transcrânienne répétée (rTMS) est un outil thérapeutique d’utilisation encore récente en psychiatrie. Cet article a pour objectif d’actualiser l’état des connaissances sur la rTMS dans le traitement des troubles de l’humeur. La rTMS possède une efficacité certaine (niveau de preuve de grade 1) dans le traitement ini...
Article
Background: Nitrous oxide (N2O) is used worldwide for analgesia and anesthesia. It is also used for recreational purposes by some people. N2O can have major side effects (myeloneuropathy, delusions, emphysema) when used to excess. In France, N2O is available as an equimolar mixture of oxygen and nitrous oxide (EMONO). Its substance use disorder pot...
Article
Full-text available
Background: Many studies were conducted to assess the benefit/risk of equimolar mixture of oxygen and nitrous oxide (EMONO), but evaluating the appetite associated to its use is now getting very little attention in the literature. The purpose of this study was to investigate the effects present, felt, and sought during care by the child related wit...
Article
Objectives: Due to its ease of use, tolerance, and cost of acquisition, transcranial direct current stimulation (tDCS) could constitute a credible therapeutic option for non-resistant depression in primary care, when combined with drug management. This indication has yet to receive official recognition in France. The objective of this study is to e...
Article
Les traitements des épisodes dépressifs caractérisés (EDC) sont essentiellement médicamenteux et psychothérapiques. Une rémission clinique est atteinte dans seulement 30 % des cas après une première ligne de traitement antidépresseur bien conduite [1]. La majorité des patients dépressifs (63 %) auraient une faible observance médicamenteuse, due à u...
Article
Introduction: Co-occurring pain impairs depression’s prognosis. Selective serotonin reuptake inhibitors or serotonin and norepinephrine reuptake inhibitors are first-line pharmacotherapies for depression and inhibit many cytochrome 2D6 enzymes. Codeine is a first-line treatment for pain and needs to be metabolized into morphine by cytochrome 2D6 to...
Article
Full-text available
Objective Therapeutic observance is one of the cornerstones of bipolar disease prognosis. Nostalgia of previous manic phase has been described as a cause of treatment retrieval in bipolar disorder. But to date no systematic study has examined manic episode remembering stories. Our aim was to describe manic experience from the patient’s point of vie...
Article
The proven effectiveness of neuromodulation and stimulation techniques for the management of psychiatric disorders has brought strongly needed innovation in psychiatry, given the high prevalence and high costs of treatment resistance. Although evidence-based guidelines in neuromodulation have been implemented to improve the clinical efficacy, safet...
Article
Full-text available
Background Craving is a core symptom of addictive disorders, such as pathological gambling for example. Over the last decade, several studies have assessed the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the addiction field, which triggers the dorsolateral prefrontal cortex (DLPFC) to decrease craving. The STIMJEU study inves...
Article
Introduction L’isotrétinoïne est le médicament de choix des acnés sévères. Cependant, le lien entre ce médicament et la survenue de complications psychiatriques est controversé. Il est difficile à évaluer car l’acné en elle-même a un impact sur la qualité de vie et peut parfois induire une anxiété, une dépression ou des idées suicidaires. L’objecti...
Article
Full-text available
The administration of dopaminergic medication to treat the symptoms of Parkinson’s disease (PD) is associated with addictive behaviors and impulse control disorders. Little is known, however, on how PD patients differ from other patients seeking treatments for behavioral addictions. The aim of this study was to compare the characteristics of behavi...
Article
Aim: Poppers have become legal in France since June 2013. Is their liberalisation associated with an increase of severe side effects observed? Methods: To identify elevated methaemoglobinaemia related to poppers abuse, we reviewed all methaemoglobin concentrations measured in Nantes university hospital, during 12 months. Results: Methaemoglobi...
Article
Full-text available
Catatonia can lead to severe complications and may be lethal but is often underdiagnosed. The clinical presentation can be similar to coma. In these situations, electroconvulsive therapy (ECT) can be used as first-line treatment to enable extubation, recovery of autonomy, and rapid discharge from intensive care. We report 4 cases of patients hospit...
Article
Full-text available
The current study supported the idea that postural control variables, particularly the center-of-pressure velocity-based parameters, could be a relevant hallmark of depression-related psychomotor retardation (PMR). The purposes were twofold: first, it aimed to clearly look at the interplay between the subjective PMR scores and the postural performa...
Article
Full-text available
Depression-related psychomotor retardation (PMR) is often misinterpreted as the age-related slowing, playing down the importance of depression in aging population. Thus we tested the PMR-related cognitive flexibility by assessing the verbal fluency performance in healthy older controls (n = 18; mean age: 61.7 ± 9.23 years) and in age-matched patien...
Article
Background: The link between isotretinoin, treatment of a severe form of acne, and psychiatric disorders remains controversial, as acne itself could explain the occurrence of psychiatric disorders. This study aims at assessing the disproportionality of psychiatric adverse events reported with isotretinoin in the French National PharmacoVigilance Da...
Article
The question of the association between isotretinoin and the development of psychiatric disorders has been debated for the past 20 years. Some authors have argued that similar psychiatric symptoms or disorders could also be induced by other systemic retinoids(1) . However, few reports have included a formal assessment of the causal link between sys...
Article
We report a case of a 32-year-old male patient who suffered from bipolar depression complicated by severe alcohol dependence and chronic cannabis abuse. No medication could help him to control a strong craving leading to frequent relapse until off-label treatment by baclofen at high dosage (300 mg/day). The subject became completely abstinent in al...
Article
Aims: In the literature, psychomotor retardation (PMR) is increasingly highlighted as a relevant marker for depression. Currently, we chose to focus on the fluency capacities as an evaluation of the frontal lobes functioning to reach a better understanding of cognitive and neurobiological mechanisms involved in PMR in depression. The aims of this...
Article
Résumé La qualité de vie subjective des patients diabétiques peut être déterminée par une interaction des facteurs biologiques, sociaux et psychologiques. Cette conception de l’individu est reconnue dans la pratique clinique, mais peu de travaux ont étudié ses bénéfices de manière quantitative. Dans une approche locale, on examine l’influence de ch...
Article
Full-text available
Non-invasive brain stimulation (NIBS) might be a new approach to treat substance use disorders (SUD). A systematic review and critical analysis was performed to identify potential therapeutic effects of NIBS on addictions. A search of the Medline database was conducted for randomized sham-controlled trials using NIBS in the field of addiction and p...
Article
Full-text available
Background: The treatment of depression remains a challenge since at least 40% of patients do not respond to initial antidepressant therapy and 20% present chronic symptoms (more than 2 years despite standard treatment administered correctly). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy but still not ideal....
Article
Purpose: There are differences between recommendations and practice in the pharmacological treatment of acute mania. Objective: The objective was to assess conformity of the anti-manic prescription between national recommendations (Haute Autorité de santé [French health authority, HAS] and "résumé des caractéristiques du produit" [product charac...
Article
This study examined whether postural control variables, particularly the center-of-pressure (COP) velocity-based parameters, could be a relevant hallmark of depression-related psychomotor retardation (PMR). We first aimed at investigating the interplay between the PMR scores and the COP performance in patients with major depressive disorder (MDD),...
Article
Objective: To our knowledge, no studies have been conducted in France on benzodiazepine (BZD) dependence among outpatients with alcohol use disorders (AUD). Some international studies have been conducted on the consumption of BZD in this specific population, but the comparisons among them are difficult. We aimed to assess the current prevalence of...
Article
L’intérêt des antidépresseurs dans le traitement curatif de la dépression bipolaire est très controversé. Cependant ils représentent la première classe médicamenteuse prescrite dans cette indication. La persistance de cet usage important peut être expliquée par leur relative bonne place dans les guidelines. Cependant, il existe un manque d’études a...
Article
L’épisode dépressif majeur est une pathologie dont la fréquence et la gravité ont un impact socioéconomique important. Les antidépresseurs validés dans cette indication, basés sur l’hypothèse tri-mono-aminergique, ont une efficience globale limitée par leur latence d’action et le taux de patients répondeurs ou en rémission. Les données scientifique...
Article
Le lithium est un traitement de première intention dans les troubles de l’humeur et pourtant son usage décline, sans doute par crainte des effets secondaires et des contraintes de surveillance. Le monitoring plasmatique est essentiel pour la tolérance et l’observance. Nous avons donc comparé cette surveillance en pratique clinique avec les recomman...
Article
Full-text available
Introduction: Trading and gambling appear to share some similarities. Indeed, traders can get professionally involved in high-risk types of trading as if it were gambling. This research explores whether excessive trading can be conceptualized as a subset of gambling disorders. Objective: To better acknowledge the existence of an addictive-like t...
Article
Full-text available
Background: The diagnosis of behavioral variant of frontotemporal dementia (bvFTD) relies primarily on clinical features and remains challenging. The specificity of the recently revised criteria can be disappointing, justifying development of new clinical tools. Objective: We produced a behavioral inventory named DAPHNE. This scale (adapted from...
Article
Full-text available
This pilot study investigated the feasibility of a comprehensive battery of tests assessing psychomotor retardation after a 3-week protocol of repetitive transcranial magnetic stimulation for depression. In addition to the beneficial effect of this treatment on depression, the results showed positive changes in psychomotor retardation.
Article
Full-text available
Objectives: Behavioral addictions (BA) are complex disorders for which pharmacological and psychotherapeutic treatments have shown their limits. Non-invasive brain stimulation, among which transcranial direct current stimulation (tDCS), has opened up new perspectives in addiction treatment. The purpose of this work is to conduct a critical and syst...