Bulent Yilmaz

Background/aims: There are only a few epidemiological study about inflammatory bowel disease in the last 10 years in Turkey, especially in Western Blacksea region. In our study, we aimed to identify the changes in the incidence and the prevalence of inflammatory bowel disease in Western Blacksea region at the last 10 years. Methods: Totally 223...

With great interest, we read the recent article by Cho et al. (Cho et al. 2015). regarding the high titers of anti-HBs prevent rituximab-related viral reactivation in resolved hepatitis B patient with non-Hodgkin's lymphoma. The authors very clearly determined the predictive factors for rituximab-related HBV reactivation in resolved hepatitis B pat...

Aim : Few data are available regarding the effects of interleukin 28B (IL28B) polymorphisms in chronic hepatitis D (CHD) patients. This study investigated the relationship between IL28B polymorphisms and the response of patients with CHD infections to pegylated interferon (PEG-IFN) therapy. Materials and methods : A total of 101 CHD patients were s...

Hepatocelluler carcinoma (HCC) is one of the most common primary tumors. Extrahepatic metastasis are seen only in 13.5-42% of the patients with HCC (1). The most common sites of metastasis are lung, lymph nodes, bone, adrenal gland and peritoneum. However, spleen metastasis is extremely rare (2-4). In this report, a case of advanced stage HCC with...

Aim: The aim was to develop a high-performance computer-aided diagnosis (CAD) system with image processing and pattern recognition in diagnosing pancreatic cancer by using endosonography images. Materials and methods: On the images, regions of interest (ROI) of three groups of patients (<40, 40-60 and >60) were extracted by experts; features wer...

Amaç: Kronik hastalıklarda, hastaların büyük çoğunluğu hastalığın getirdiği ağrı, yorgunluk ve depresif semptomlarla birlikte sosyal yaşamlarında kısıtlılıklar, fiziksel aktivitelerini gerçekleştirmede güçlükler yaşamaktadır. Buna bağlı yaşam kalitesi etkilenmektedir. Kronik hepatitli hastalarda, hastalığının erken evrelerinde hiçbir semptom bulunm...

Background and objective: Ulcerative colitis is an inflammatory condition of the colon in the gastrointestinal system. Currently, the most potent medications used for ulcerative colitis produce no response in 20-30% of cases. There is a need for more efficient and reliable medications. Tyrosine kinase inhibitors have shown efficacy in some inflamm...

BACKGROUND: Obesity is an epidemic leading to high morbidity, mortality, and therefore health-related costs. Thus, there is a huge need for development of safe and effective treatments. Even though success rates of conservative methods are highly limited, the surgical approaches lead to major complications in as many as 25% of the patients. In this...

Background: The effect of hepatitis B virus (HBV) infection on fatty liver disease is unclear. Objectives: The aim of this study was to investigate the viral and host causes of fatty liver in chronic hepatitis B (CHB) patients. This study included 88 CHB patients of which 17 were not treated. Liver biopsy was performed in each patient. Group 1 i...

Inflammatory bowel disease, a chronic inflammatory disease with unknown etiology, affects the small and large bowel at different levels. It is increasingly considered that innate immune system may have a central position in the pathogenesis of the disease. As a part of the innate immune system, bactericidal permeability increasing protein has an im...

Inflammatory bowel disease is a chronic inflammatory disease of the gastrointestinal system. In some cases, current medications used for inflammatory bowel disease may not enough for remission, creating a need for more potent and reliable medications. There is no study showing the efficacy of fostamatinib, with proven effects on some inflammatory d...

Iatrogenic perforation of the gut during endoscopy remains an uncommon but critical complication with significant morbidity and probable mortality than usual surgical treatment, some authors have already adopted a non-surgical enterprise in chosen cases, first endoclips have been use to close perforation in the stomach, since 1993. The endoscopic p...

Endoscopic retrograde cholangiopancreatography (ERCP) is a state of the art diagnostic and therapeutic procedure for various pancreatic and biliary problems. In spite of the well-established safety of the procedure, there is still a risk of complications such as pancreatitis, cholangitis, bleeding and perforation. Air leak syndrome has rarely been...

There are no validated noninvasive markers of liver fibrosis in autoimmune hepatitis (AIH). An activated renin-angiotensin system (RAS) and its key element angiotensin-converting enzyme (ACE) have been implicated in the pathogenesis of hepatic fibrogenesis. We aimed to study the assumed role of activated RAS in the fibrogenic process and whether th...

Liver transplantation (LT) is a widely-accepted, definitive therapy of irreversible liver diseases including hepatitis C, alcoholic liver disease and metabolic liver disease. After transplantation, patients generally use a variety of immunosuppressive medications for the rest of their lives to prevent rejection of transplanted liver. Mortality afte...

Oxidative stress is increased and anti-oxidant defense mechanisms are impaired in patients with hepatosteatosis. The aim of the present study was to evaluate the serum levels of several oxidant and anti-oxidant markers in patients with nonalcoholic fatty liver disease (NAFLD). Thirty-four patients with NAFLD, and 19 healthy controls were included....

Inflammatory bowel disease is a group of chronic inflammatory conditions affecting gastrointestinal tract. Lots of genes have been identified resulting in susceptibility to inflammatory bowel disease. Any polymorphism leading to functional modifications in tyrosine kinase-2 may precipitate excessive immune response in the intestinal mucosa. The aim...

Inflammatory markers have been studied in ulcerative colitis (UC) for diagnosis, disease activity, and prediction of relapse. Blood neutrophil-to-lymphocyte (N/L) ratio has been used to determine outcomes of some malignancies and coronary artery disease. Blood N/L ratio is a simple sign of clinical inflammation. In this study, we examined N/L ratio...

Aim: Neutrophil-lymphocyte ratio (NLR) has been used as a simple, affordable, and easily accessible marker to predict prognosis in a variety of inflammatory and neoplastic diseases. However, there are few studies investigating their role in patients with hepatitis B. The aim of this study was to investigate the relationship between NLR and liver f...

Aim: To investigate the diagnostic utility of beta 2 microglobulin (B2-M) levels and analyze this correlation with the activity of inflammatory bowel disease (IBD). Methods: Overall, 78 IBD patients and 30 healthy controls were enrolled in the study. We examined B2-M serum levels in 43 ulcerative colitis (UC) patients, 35 with Crohn's disease (C...

Background & aims: Primary biliary cirrhosis (PBC) may present in all decades of life, also in childbearing age. Data on maternal and fetal outcome is limited. We aimed to investigate the impact of pregnancy and childbirth on the disease course and possible effects of PBC on fetal outcome. Methods: Retrospective study of local cases and a compac...

Lung cancer (LC) is the leading reason of death from cancer the world-wide. It is usually silent, and about 50% have extra-thoracic metastasis the initial diagnosis. A 67-year-old man came to our hospital complaining of progressively increasing right-sided chest pain, abdominal pain, anorexia, and weight loss (20kg) since four months. Upper gastroi...

Lesser celandine, also known as Ranunculus ficaria , is a herbaceous perennial plant that commonly utilizes piles and is taken either internally or used externally. The causality assessment of several reports provided evidence for the existence of Greater Celandine hepatotoxicity. However, there hasn't been any case report published thus far, about...

Fascioliasis is a zoonotic infestation caused by the trematode fasciola hepatica. It presents a wide spectrum of clinical pictures ranging from fever and eosinophilia to ambiguous gastrointestinal symptoms in the acute phase. However, it may often be overlooked, especially in the acute phase, because of uncertain symptoms. Fasciola hepatica can hav...

Genome-wide association studies can identify a single nucleotide polymorphism (SNP) that serves as a tag for the causal genomic variants that are responsible for the functional effects, but often not genotyped. The two SNPs, rs12979860 and rs8099917, are, respectively, located 3 and 8kb upstream of the IL28B gene, and encode type III interferon IFN...

Dear Sir, The Budd–Chiari syndrome (BCS) is a clinical condition caused by hepatic venous outflow obstruction and is a rare cause of ascites. Ulcerative colitis is associated with increased risk of venous and arterial thromboembolic events. Hepatic vein thrombosis and BCS are a rare extra intestinal complication of UC. The incidence of venous thro...