Bryan A. Whitson

Bryan A. Whitson
The Ohio State University | OSU · Division of Cardiac Surgery

MD, PhD, FACS

About

375
Publications
20,653
Reads
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5,095
Citations
Additional affiliations
June 2016 - present
The Ohio State University
Position
  • Associate Professor of Surgery, Co-Director COPPER Laboratory
July 2012 - June 2016
The Ohio State University
Position
  • Research Assistant
July 2012 - June 2016
The Ohio State University
Position
  • Research Assistant

Publications

Publications (375)
Article
Background Because body mass index (BMI) is generally used clinically to define obesity and to estimate body adiposity, BMI likely is positively correlated with epicardial adipose tissue (EAT) level. Based on echocardiography, previous outcomes on this matter have varied from almost absent to rather strong correlations between BMI and EAT. The purp...
Article
We sought to assess the impact of temporary preoperative mechanical circulatory support (TPMCS) on heart transplantation outcomes. A total of 4,060 adult heart transplants from June 1, 2006, to December 31, 2019, were identified in the Scientific Registry of Transplant Recipients database as having TPMCS. Recipients were divided into groups based o...
Article
Full-text available
Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on beta-myosin heavy chain (b-MHC) in normal and failing human heart tissues. We report six acetylated lysines and t...
Article
Objective For some individuals, chronic allograft failure is best treated with retransplantation. We sought to determine if time to retransplantation (TTR) impacts short and long-term outcomes for heart or lung retransplant recipients with a TTR > 1 year. Methods The UNOS/OPTN STAR file was queried for all adult, first time heart (6/1/06-9/30/20)...
Article
Full-text available
The relationship between hypothyroidism and the occurrence and progression of heart failure (HF) has had increased interest over the past years. The low T3 syndrome, a reduced T3 in the presence of normal thyroid stimulating hormone (TSH), and free T4 concentration, is a strong predictor of all-cause mortality in HF patients. Still, the impact of h...
Article
Full-text available
Background: Use of lungs donated after circulatory death (DCD) has expanded, but changes in donor/recipient characteristics and comparison to brain dead donors (DBD) has not been studied. We examined the evolution of the use of DCD lungs for transplantation and compare outcomes to DBD lungs. Methods: The SRTR database was used to construct three 5-...
Article
Purpose Ex vivo lung perfusion (EVLP) allows re-evaluation of extended criteria/marginal donor lungs. This can increase the number of lung transplants. However, the long-term outcomes of transplanting EVLP-screened lungs in a multicenter setting are unknown. We proposed to evaluate the short- and long-term outcomes of EVLP performed at multiple cen...
Article
Purpose Heart failure (HF) related deaths in Southern United States (SUS), where majority of the African American (AA) population lives, is 202.5/100,000 of population, and is significantly higher than median of 189.5 deaths for rest of US. We sought to investigate the heart transplant (HTX) trends and post-transplant outcomes in the AA population...
Article
Purpose The purpose of this study was to evaluate the effect of education on survival after orthotopic heart transplantation. Few studies have explored the impact of education from quality of life and adherence to medication and follow-up, thus a paucity of literature exists in understanding education and its impact on survival. Methods We evaluat...
Article
A 59-year-old male with past medical history significant for hypertension, coronary artery disease, atrial fibrillation, hyperlipidemia, obesity, obstructive sleep apnea and deep vein thrombosis developed severe COVID19 pneumonia. His clinical course was noted for progressive respiratory failure that subsequently resulted in bilateral lung transpla...
Article
Objectives The effects of stroke and delirium on post-discharge cognition and patient-centered health outcomes after surgical aortic valve replacement (SAVR) are not well characterized. Here we assess the impact of post-operative stroke and delirium on these health outcomes in SAVR patients at 90 days. Methods Patients (N=383) undergoing SAVR (41%...
Article
Ex vivo lung perfusion (EVLP) increases the pool of suitable organs for transplant by facilitating assessment and repair at normothermia, thereby improving identification of quality of marginal organs. However, there exists no current objective approach for assessing total organ edema. We sought to evaluate the use of electrical impedance as a metr...
Article
Background: Advanced age is considered a risk factor for lung transplantation (LTX). We sought to evaluate the long-term outcomes of LTX in the septuagenarian. Methods: LTX recipients in the UNOS transplant registry (May 1, 2005-June 12, 2020) were stratified into 18-59, 60-69, and > = 70 years of age. Recipient and transplant characteristics we...
Article
Full-text available
Pulmonary arterial dissection (PAD) is a rare and often lethal complication of chronic pulmonary arterial hypertension (PAH), which may occurs in patients with idiopathic pulmonary arterial hypertension (IPAH) and potentially in those with connective tissue disorders. While rare, sudden death often occurs secondary to acute cardiac tamponade, as th...
Article
The worldwide pandemic caused by COVID-19, resulting from the infection by betacoronarvirus SARS-CoV-2, has dramatically altered healthcare worldwide. Due to the highly contagious nature of SARS-CoV2, coupled with hospitals and intensive care units being overwhelmed, numerous transplant programs either slowed or shut down completely. While there ha...
Article
Background Acute kidney injury (AKI) is a common complication after lung transplantation (LT) and is associated with higher cost and mortality. We sought to evaluate the incidence of postoperative AKI, defined as AKI within 14 days of transplant, and identify associated perioperative factors. Methods We conducted a single-center, retrospective rev...
Preprint
Full-text available
Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on beta-myosin heavy chain (β-MHC) in normal and failing human heart tissues. We report six acetylated lysines and t...
Article
Introduction: Aging is associated with chronic oxidative stress and inflammation that affect the tissue repair and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell membrane injury in a redox-dependent manner. However, it is not clear how MG53 regulates cardiac inflammation during aging. Hypothesis: We hypothesize...
Article
Full-text available
Nitrogen mustard (NM) is an alkylating vesicant that causes severe pulmonary injury. Currently there are no effective means to counteract vesicant-induced lung injury. MG53 is a vital component of cell membrane repair and lung protection. Here we show that mice with ablation of MG53 are more susceptible to NM-induced lung injury than the wild type...
Article
Full-text available
Aging is associated with chronic oxidative stress and inflammation that impact the tissue repair and regeneration capacity. MG53 is a TRIM family protein that facilitates repair of cell membrane injury in a redox-dependent manner. Here we demonstrate that the expression of MG53 is reduced in failing human heart and aging mouse heart, concomitant wi...
Article
From its identification as a distinct disease entity, understanding and management of pulmonary hypertension has continuously evolved. Diagnostic and therapeutic interventions have greatly improved the prognostic implications of this devastating disease, previously rapidly and uniformly fatal to one chronically managed by multi-disciplinary teams....
Article
There is limited evidence comparing direct oral anticoagulants (DOACs) and warfarin in solid organ transplant recipients. We performed a pooled analysis to study the safety and efficacy of DOACS in this patient population. We searched PubMed, Embase, and Scopus databases using the search terms “heart transplant” or “lung transplant” or “liver trans...
Article
Background Survival rates for out-of-hospital cardiac arrest (OOHCA) are extremely low and neurologic recovery is poor. Extracorporeal cardiopulmonary resuscitation (ECPR), which combines extracorporeal membrane oxygenation (ECMO) with cardiopulmonary resuscitation (CPR), has emerged as a viable strategy to improve outcomes in OOHCA. A collaborativ...
Article
Full-text available
Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction, which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations are associated with HF progression. However, the transcriptome of HF human SAN, and its role in HF-associated remodeling of ion channels, transporters, and receptors respon...
Article
The novel severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 (coronavirus Disease 19 (COVID-19)) was identified as the causative agent of viral pneumonias in Wuhan, China in December 2019, and has emerged as a pandemic causing acute respiratory distress syndrome (ARDS) and multiple organ dysfunction. Interim guidance by the World Health Or...
Article
Sarcomeric proteins have been shown to be a target of post-translational modifications (PTMs). Phosphorylation and acetylation of several sarcomeric proteins have been reported to be important for fine-tuning of myocardial contractility. Given the emerging importance of understanding the potential role of PTMs on cardiac muscle performance in healt...
Article
Over 6 million Americans suffer from heart failure (HF) while the 5-year mortality rate following first admission for HF is over 40%. Cardiac fibrosis is a clinical hallmark of HF, regardless of the initiating pathology and is thought to contribute to disease progression. Using an epigenomics discovery approach, we uncovered a nuclear protein, Sert...
Article
Through stress and injury to tissues, the cell membrane is damaged and can lead to cell death and a cascade of inflammatory events. Soluble factors that mitigate and repair membrane injury are important to normal homeostasis and are a potential therapeutic intervention for regenerative medicine. A myokine is a type of naturally occurring factors th...
Article
Full-text available
Background The opioid epidemic has seen a drastic increase in the incidence of drug-associated infective endocarditis (IE). No clinical tool exists to predict operative morbidity and mortality in patients undergoing surgery. Methods A multi-institutional database was reviewed between 2011 and 2018. Multivariate logistic regression was fitted in an...
Article
Introduction Traditionally, implantation of Left Ventricular Assist Devices (LVADs) is performed via median sternotomy. Recently, less invasive thoracotomy approaches are growing in popularity as they involve less surgical trauma, potentially less bleeding, and may preserve right ventricular function. We hypothesized implantation of LVADs via thora...
Article
Background: Up to fifty percent of the adult human sinoatrial node (SAN), is composed of dense connective tissue. Cardiac diseases including heart failure (HF) may further increase fibrosis within the SAN pacemaker complex, leading to impaired automaticity and conduction of electrical activity to the atria. However, unlike the role of cardiac fibro...
Conference Paper
Full-text available
Introduction Pleural effusions after lung transplant (LT) are common and use of chest tubes is routine. Chronic pleural effusion post-LT, can impede attainment of best pulmonary function. Therapeutic interventions may include tube thoracostomy, pleural decortication, and pleurodesis. Due to concerns related to immunosuppression and fears of infecti...
Conference Paper
Full-text available
Purpose Lung transplantation (LT) is an effective treatment of end-stage lung disease. Despite recommendations for optimal referral for LT, some patients still present in distress seeking emergent rescue LT. Traditionally, these patients have been considered too ill to benefit from LT. Clinical outcomes for this population remain uncertain. Here, w...
Article
Full-text available
Purpose Patients with advanced hypertrophic cardiomyopathy (HCM) have high waitlist (WL) mortality. The United Network of Organ Sharing (UNOS) heart allocation system from 10/18/2018 provides greater emphasis and clarity for status exceptions for HCM patients. We analyzed the effect of allocation policy change on the WL and post-transplant outcomes...
Conference Paper
Full-text available
Purpose Concomitant heart and lung donation may adversely affect outcomes in lung transplant recipients. In this study we characterized donor characteristics and examined the outcomes of lung transplantation from donors with concomitant heart donation. Methods This retrospective cohort study used the UNOS SRTR database and identified donors as lun...
Article
Purpose Transplant program assessment by short term survival is inherently limited. We defined a “textbook outcome” (TO) for heart transplant recipients without complication and examined association with survival. Methods We identified all primary, isolated adult heart transplants in the SRTR database from 6/06-12/19. TO was defined as: No mortali...
Article
Full-text available
Purpose In 2018, United Network of Organ Sharing (UNOS) changed the heart allocation system to better stratify higher acuity patients and provide more equitable geographic distribution. However, they did not prioritize recipient allosensitization which can be a barrier to organ access. We analyzed outcomes based on sensitization in the modern era a...
Article
Purpose There is limited evidence comparing direct oral anticoagulants (DOACs) and warfarin in solid organ transplant recipients. We performed a pooled analysis to study the safety of DOACS in this patient population. Methods We searched PubMed, Embase, and Scopus databases from their inception to July 31, 2020 using the search terms “heart transp...
Conference Paper
Full-text available
Purpose Lung transplantation (LTX) is generally reserved for the young due to perioperative complications & organ utilization. We sought to evaluate the long-term outcomes of LTX in the septuagenarian. Methods Retrospectively, LTX recipients in the UNOS transplant registry (May 1, 2005 to June 12, 2020) were stratified into 18-59, 60-69, and >=70...
Article
For ex vivo lung perfusion (EVLP), there is often inadequate pulmonary artery for effective EVLP. Creation of a neopulmonary artery conduit with donor aorta alleviates this shortcoming. This technique will become of more importance and need as there are more donation after circulatory death donor (DCD) heart procurements as this is a common source...
Article
Objective In 2018, the heart allocation system changed status classifications and broadened geographic distribution. We examined this change at a national level based on the immediate pre and post change periods. Methods Utilizing the Scientific Registry of Transplant Recipients database, we identified all adult primary, isolated heart transplants...
Article
Background Heart failure (HF) is associated with highly significant morbidity, mortality, and health care costs. Despite the significant advances in therapies and prevention, HF remains associated with poor clinical outcomes. Understanding the contractile force and kinetic changes at the level of cardiac muscle during end-stage HF in consideration...
Article
Rationale: Cardiac hypertrophy, a major risk factor for heart failure, occurs when cardiomyocytes remodel in response to complex signaling induced by injury or cell stress. Although cardiomyocytes are the ultimate effectors of cardiac hypertrophy, non-myocyte populations play a large yet understudied role in determining how cardiomyocytes respond t...
Article
Regulation of gene expression plays a fundamental role in cardiac stress-responses. Modification of coding transcripts by adenosine methylation (m⁶A) has recently emerged as a critical post-transcriptional mechanism underlying heart disease. Thousands of mammalian mRNAs are known to be m⁶A-modified, suggesting that remodeling of the m⁶A landscape m...
Article
Full-text available
Introduction Lung injury has several inciting etiologies ranging from trauma (contusion and hemorrhage) to ischemia reperfusion injury. Reflective of the injury, tissue and cellular injury increases proportionally with the injury stress and is an area of potential intervention to mitigate the injury. This study aims to evaluate the therapeutic bene...
Article
Full-text available
Under natural conditions, injured cells can be repaired rapidly through inherent biological processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy, and other degenerative conditions, the natural repair process is impaired. Repair of injury to the cell membrane is an important aspect of physiology. Inadequate membran...
Conference Paper
Full-text available
Background Lung transplant recipients are at increased risk for infection in the early post-operative phase. Perioperative antibiotic (POA) practices are variable among transplant centers with sparse data regarding optimal antibiotic prophylaxis duration. This study aimed to evaluate the efficacy of short course (SC) (≤10 days) vs long course (LC)...
Article
Background New or worsened mitral regurgitation (MR) is an uncommon yet serious complication after surgical aortic valve replacement (SAVR). While there have been numerous reports of its occurrence, there is little consensus regarding its presentation and management. This systematic review summarizes the evidence in the current literature surroundi...
Article
Lung transplant recipients are at increased risk for infection in the early postoperative phase, thus perioperative antibiotics are employed. This retrospective study evaluated the efficacy of short‐ vs long‐course perioperative antibiotics in lung transplant patients. Lung transplant patients with donor positive cultures between August 2013 and Se...
Article
Introduction: It remains unclear if body mass index (BMI) is correlated to the amount of cardiac adipose tissue in humans. Echocardiography is typically utilized to measure epicardial fat in live patients, but has yielded inconclusive results, as it is difficult to measure cardiac adipose tissue levels from a single location on a 1-dimensional imag...
Article
Introduction: Atrial fibrillation (AF) is not effectively treated in clinics due to a lack of adequate tools for identifying AF drivers as targets in ablation treatment. Recent studies revealed that 30-50% of patients with persistent AF have drivers not only in the left atrium (LA) but also in the right atrium (RA). However, the precise substrate u...
Article
Introduction: Conventional multielectrode mapping is not sufficient to reveal subsurface intramural activation. Thus, atrial fibrillation (AF) driver identification remains challenging. To overcome these limitations we utilized machine learning (ML) to identify AF drivers based on the combination of electrogram (EGM) and 3D structural magnetic reso...
Article
Introduction: Anthracyclines are used effectively to treat many cancers. However, cumulative and irreversible cardiotoxicity can limit anthracyclines’ clinical benefit. Mechanisms of cardiotoxicity have been assessed in murine models, but no studies directly assess human heart contractility. Our objective was to assess left ventricular contractile...
Article
Due to complex 3D human atrial structure, atrial fibrillation (AF) mapping with multielectrode arrays (MEA) mostly represents surface activation. Therefore, MEA may not properly visualize patient specific AF mechanisms, which impairs ablation outcomes. Conversely, near-infrared optical mapping (NIOM) visualizes subsurface intramural activation and...
Article
Introduction: Dense fibrous connective tissue is inherently found in the human sinoatrial node (hSAN), which further increases in heart failure (HF) leading to sinoatrial node dysfunction (SND). While several factors contribute to cardiac fibrosis, it is unknown if long non-coding RNAs (lncRNA), a novel class of RNA known to affect cardiac fibrosis...
Article
Full-text available
Background Atrial fibrillation (AF) driver mechanisms are obscured to clinical multielectrode mapping approaches that provide partial, surface‐only visualization of unstable 3‐dimensional atrial conduction. We hypothesized that transient modulation of refractoriness by pharmacologic challenge during multielectrode mapping improves visualization of...
Chapter
In the field of lung transplantation, extracorporeal membrane oxygenation (ECMO) can be used in multiple phases of perioperative care including pre-operatively as a bridge to transplantation, intraoperative support, and post-operative support for delayed graft function. ECMO is safe for use in patients with end-stage lung disease who experience rap...
Chapter
For patients with end-stage lung disease, there is no cure though lung transplantation is an effective treatment. Unfortunately, the number of viable donor lung allografts is woefully low and does not meet the need for clinical lung transplantation. Furthermore,donor lung utilization rates are less than 20%. Ex-vivo lung perfusion is a technique th...
Chapter
Medical and surgical managementManagement in lung transplantationLung Transplantation has evolved over the past 30 years with significant improvements in short- and long-term survival. For non-suppurative interstitial and obstructive lung diseases, there is the option of either single or bilateral lung transplantationLung Transplantation. However,...