Bruno Messina Coimbra

Bruno Messina Coimbra
Universidade Federal de São Paulo | UNIFESP

Researcher

About

23
Publications
2,347
Reads
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199
Citations
Introduction
Psychologist and researcher. My research focuses on stress and accelerated aging, social determinants of health (including racial discrimination), and PTSD related to sexual trauma.
Additional affiliations
May 2013 - present
Universidade Federal de São Paulo
Position
  • Research Associate
Education
January 2014 - December 2016
Universidade Federal de São Paulo
Field of study
  • Psychiatric Genetics

Publications

Publications (23)
Article
Full-text is available: https://authors.elsevier.com/a/1fl2V55vZ61XC Background Sexual violence is a traumatic event that can trigger post-traumatic stress disorder (PTSD) and generate biological responses to stress characterized by inhibiting the hypothalamic-pituitary axis (HPA), altering immune activity, and changing the structure and function...
Article
Some individuals show abnormal reactions to extreme fear and life-threatening situations, including tonic immobility (TI) and peri-traumatic dissociation (PTD). We aimed to investigate the association of TI and PTD with posttraumatic stress disorder (PTSD) in women who experienced sexual violence and the risk factors for PTD occurrence. We compared...
Article
Full-text available
Telomeres are short tandem repeats of “TTAGGG” that protect the chromosome ends from deterioration or fusion of chromosomes. Their repeat length shortens with cell division acting as a biomarker of cellular aging. Traumatic stress events during adulthood or childhood have been associated with posttraumatic stress disorder (PTSD) and short leukocyte...
Article
A growing body of research demonstrates the association between neighborhood context and health. The underlying biological mechanisms of this association are not fully understood. We conducted a systematic review of studies that investigated the association between neighborhood context and telomere length (TL), a DNA-protein complex that shortens a...
Article
Full-text available
The potential mental health consequences of the coronavirus disease 2019 (COVID-19) pandemic are widely acknowledged; however, limited research exists regarding the nature and patterns of stress responses to COVID-19-related potentially traumatic events (PTEs) and the convergence/divergence with responses to other (non-COVID-19-related) PTEs. Netwo...
Article
Full-text available
Background: The mental health impact of the COVID-19 crisis may differ from previously studied stressful events in terms of psychological reactions, specific risk factors, and symptom severity across geographic regions worldwide. Objective: To assess the impact of COVID-19 on a wide range of mental health symptoms, to identify relevant risk factors...
Article
Full-text available
ABSTRACT Background: The mental health impact of the COVID-19 crisis may differ from previously studied stressful events in terms of psychological reactions, specific risk factors, and symptom severity across geographic regions worldwide.Objective: To assess the impact of COVID-19 on a wide range of mental health symptoms, to identify relevant risk...
Article
Full-text available
Background: Most posttraumatic stress disorder (PTSD) sleep disturbances reports have been conducted in male combat veteran populations, usually decades after the disorder’s onset. Given the increase in the prevalence of violence against women and the fact that women are at greater risk for developing PTSD, it is critical to examine sleep abnormali...
Article
Full-text available
Objectives: The aim of this study was to validate CAPS-5 for the Brazilian-Portuguese language on a sample of 128 individuals from two centers (from the cities of São Paulo and Porto Alegre) who have been recently exposed to a traumatic event. Methods: We performed a reliability analysis between interviewers (with a subset of 32 individuals), an in...
Article
Full-text available
Background: Sexual assault is implicated in several adverse psychological and physical health outcomes, including posttraumatic stress disorder (PTSD) and depression. Neurobiological research has shown variations related to the hypothalamic-pituitary-adrenal (HPA) axis, immune alterations, metabolic function, and brain circuitry. Although these me...
Article
Full-text available
Background: Posttraumatic stress disorder (PTSD) is a prevalent, chronic, and severe disorder related to traumatic events. Women are disproportionately affected by PTSD than men and are more at risk in the occurrence of sexual assault victimization. Estimates suggest that 50% of women develop PTSD following sexual assault and successful clinical ma...
Article
Discrimination is unfair treatment against a certain group based on race, age, gender, sexual orientation, or other social identities. Discrimination is pervasive in society, elevates psychosocial stress, and is associated with negative mental and physical health outcomes. However, more research is needed to understand the biological mechanisms und...
Article
Full-text available
Introduction The increase in violence against young women has a high impact on the prevalence of Posttraumatic stress disorder (PTSD). The lifetime prevalence of PTSD is twice as high in women. However, most studies assessing sleep disturbances in PTSD were conducted predominantly in male samples and combat veterans. Objective: To analyze the sleep...
Preprint
BACKGROUND Posttraumatic stress disorder (PTSD) is a prevalent, chronic, and severe disorder related to traumatic events. Women are disproportionately affected by PTSD than men and are more at risk in the occurrence of sexual assault victimization. Estimates suggest that 50% of women develop PTSD following sexual assault and successful clinical man...
Article
Full-text available
Background An estimated 16.9% of adult Brazilian women experience sexual assault in their lifetime. Almost half of women who suffer such trauma develop post-traumatic stress disorder (PTSD). Markowitz et al. (2015) found that an affect-focused non-exposure therapy, Interpersonal Psychotherapy (IPT), adapted to treat PTSD (IPT-PTSD) had similar effi...
Article
Background Posttraumatic Stress Disorder (PTSD) is a clinical condition that occurs after experiencing a traumatic external stressful situation, such as exposure to sexual assault or rape. Previous studies suggested that PTSD may be associated with shortened Leukocyte Telomere Length (LTL), in war veterans. Telomeres are repetitive DNA sequences lo...
Article
Telomeres are repetitive DNA sequences at the ends of chromatids that shorten following each cell replication. Once telomeres reach a critical length, DNA defense mechanisms can direct cells to either a state of arrest (senescence) or apoptosis. Stress induced by adversity is a probable cause of accelerated telomere shortening from an early age. Ho...
Article
Posttraumatic stress disorder (PTSD) is a common psychiatric disorder. The etiology of PTSD is multifactorial, depending on many environmental and genetic risk factors, and the exposure to life or physical integrity-threatening events. Several studies have shown significant correlations of many neurobiological findings with PTSD. Hypothalamic-pitui...
Article
Full-text available
Objective: Associations between parental/caregiver depression and adverse child outcomes are well established and have been described through one or more mechanisms: child psychopathology following exposure to a depressed caregiver, child psychopathology exacerbating a caregiver’s depression, and caregiver and offspring depression sharing the same...
Article
Full-text available
Background Task shifting approaches (rational redistribution of tasks among health workforce teams) to train lay professionals to assist with integrating mental health treatment in primary care has been recommended to close the mental health treatment gap for depression in low- and middle-income countries. This study aims to examine the a new model...

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Projects

Projects (2)
Archived project
To identify the effect of training (training and supervision) on Community Health Agents (ACS) of a Family Health Care Program (PSF) for mental health intervention in the primary network.
Project
Posttraumatic stress disorder is triggered by an external event that threats individual physical integrity, leading to symptoms of reviviscence, avoidance/numbing and hyperarousal. Despite the external adverse event, some predisposing factors are present presupposing multicausality. Once PTSD is installed, it has chronic features leading to important functional impairment. Many biological dysfunctions have been described associated with PTSD, including an altered stress response system suggesting a corresponding increase allostatic load. We hypothesize that this increased allostatic load will lead to neurodegeneration that we will call neuroprogression. We propose to evaluate if there is a correspondence between clinical and neurobiological functioning associated to disease progression. We will evaluate and follow-up 120 female outpatients with PTSD triggered by sexual abuse. We choose the event as it is often in our city, and as it is a high-risk factor for PTSD development. Also, we will have a control group with 120 subjects without history of trauma or abuse and without psychiatric diagnostic paired by socioeconomic status and age. All patients will receive standard treatment for PTSD according to violence program guideline. Many evaluations will be executed including biological markers as: genetics, biochemical, molecular and image. Patients will be enrolled on a head-to-head randomized controlled clinical trial to compare efficacy of two treatments known as effective in PTSD: Sertraline vs Interpersonal therapy (IPT) during 14 weeks.