Bruce Ian Hutchins

Bruce Ian Hutchins
University of Wisconsin–Madison | UW · Information School

Ph.D.

About

49
Publications
5,386
Reads
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1,327
Citations
Introduction
Ian uses quantitative analysis of information networks to find ways to improve the research enterprise and accelerate biomedical research advances. He previously worked as a data scientist at NIH, where he developed the iCite bibliometrics dashboard, along with many of its quantitative metrics and the NIH Open Citation Collection database. Ian also spearheaded the development of the NIH COVID-19 Portfolio to track and disseminate cutting-edge COVID-19 research in real time.
Additional affiliations
January 2014 - present
National Institutes of Health
Position
  • Instructor
Description
  • Train staff at NIH and other federal/military agencies to conduct portfolio analysis. Classes: - Introduction to Portfolio Analysis - Introduction to Text Mining with IN-SPIRE - Advanced Text Mining with IN-SPIRE
June 2013 - present
National Institutes of Health
Position
  • Data Scientist
January 2010 - June 2013
National Institute of Neurological Disorders and Stroke
Position
  • Pharmacology Research Associate (PRAT) Fellow

Publications

Publications (49)
Article
Full-text available
Author Academic researchers convey their discoveries to the scientific community by publishing papers in scholarly journals. In the biomedical sciences alone, this process now generates more than one million new reports each year. The sheer volume of available information, together with the increasing specialization of many scientists, has contrib...
Article
Full-text available
Despite efforts to promote diversity in the biomedical workforce, there remains a lower rate of funding of National Institutes of Health R01 applications submitted by African-American/black (AA/B) scientists relative to white scientists. To identify underlying causes of this funding gap, we analyzed six stages of the application process from 2011 t...
Article
Full-text available
Fundamental scientific advances can take decades to translate into improvements in human health. Shortening this interval would increase the rate at which scientific discoveries lead to successful treatment of human disease. One way to accomplish this would be to identify which advances in knowledge are most likely to translate into clinical resear...
Article
Full-text available
Citation data have remained hidden behind proprietary, restrictive licensing agreements, which raises barriers to entry for analysts wishing to use the data, increases the expense of performing large-scale analyses, and reduces the robustness and reproducibility of the conclusions. For the past several years, the National Institutes of Health (NIH)...
Preprint
Citation analysis generally assumes that each citation documents causal knowledge transfer that informed the conception, design, or execution of the main experiments. Citations may exist for other reasons. In this paper we identify a subset of citations that are unlikely to represent causal knowledge flow. Using a large, comprehensive feature set o...
Preprint
Full-text available
Adoption of preprints dramatically expanded during the COVID-19 pandemic. Many have expressed concern that the risk of flawed decision-making is increased by relying on preprint data that would not survive peer review. We therefore asked how much the information presented in preprints is expected to change after review. We quantify attrition dynami...
Preprint
Full-text available
Open citation data can improve the transparency and robustness of scientific portfolio analysis, improve science policy decision-making, stimulate downstream commercial activity, and increase the discoverability of scientific articles. Once sparsely populated, public-domain citation databases crossed a threshold of one billion citations in February...
Article
Full-text available
Open citation data can improve the transparency and robustness of scientific portfolio analysis, improve science policy decision-making, stimulate downstream commercial activity, and increase the discoverability of scientific articles. Once sparsely populated, public-domain citation databases crossed a threshold of one billion citations in February...
Data
Data underlying the Fig 1 graphs. (XLSX)
Article
Context: GnRH neurons originate outside the central nervous system in the olfactory placode and migrate into the CNS, becoming integral components of the hypothalamic-pituitary-gonadal axis. Failure of this migration can lead to Idiopathic Hypogonadotropic Hypogonadism (IHH)/Kallmann Syndrome (KS). We have previously shown that CCDC141 knockdown l...
Data
Mean citations accrued each year for 608,058 papers published in 2003 appearing in the same journals as NIH-funded publications. Adding the values for 2003 and 2004 gives a value (2.26 citations per publication per year) close to the mean CPY of the following years (2.36). Although these values may seem low, they are both similar to the global 2013...
Data
Distribution of Faculty of 1000 scores for 2,193 R01-funded papers from 2009. (TIF)
Data
The internal correlation of postpublication peer review scores is similar to the correlation between RCR and review scores. (A) Pearson correlation coefficients (r) of one randomly chosen reviewer score versus the mean of the other two scores for that paper, determined by statistical resampling. Distribution of correlation coefficients determined b...
Data
Frequency distribution of the FCRs of 35,813 R01-funded articles published in 2009, using the standard approach for calculating FCRs (mean, blue) given the JCRs of the articles in the co-citation network or using the median of these JCRs to calculate the FCR (median, orange). (TIF)
Data
Effects on the CPY:FCR ratio of a field with a citation rate that drifts by a factor of 1.5 over the course of 10 y. (XLSX)
Data
Distribution of scores from the STPI survey. (TIF)
Data
Summary of NIH Intramural Research Program (IRP) reviewer responses to postpublication peer review questions. Distribution of ratings to the following questions: (A) rate whether the question being addressed is important to answer; (B) rate whether you agree that the methods are appropriate and the scope of the experiments adequate; (C) rate how ro...
Data
Inferred criteria used by NIH IRP reviewers to rate overall value and impact of a publication. (A) Criteria most strongly linked to assessments of ?overall value,? measured with Random Forest classification. Values indicate the mean decrease in Gini coefficient. (B) Criteria most strongly linked to assessments of ?overall value,? excluding ?likely...
Data
Correlation of the average of different investigators? article RCRs versus the average of the JIFs in which they published. Some investigators published very influential articles (high RCR) in lower-profile venues (low JIF) and vice versa. R2 = 0.23. (TIF)
Data
Using mean versus median values to calculate the RCR denominator. The method for aggregating the JCRs of the articles in the co-citation network was varied and the ACR:FCR ratios compared. (TIF)
Data
Correlation coefficients (r) between the log-transformed RCR values generated with the three different methods for estimating FCRs with co-citation networks. (XLSX)
Data
Correlation between ACR versus ECR. (XLSX)
Data
Regression coefficients (ACR on FCR, through 2012), for OLS linear regression or quantile regression (QR) to the median for papers with concurrent R01 funding. One of the criticisms about impact factor is that it uses the mean, rather than median, of a skewed distribution [78]; for RCR, QR can be used to benchmark articles to the median citation pe...
Data
Summary of investigator-level bibliometric measures and their stability from two 2-y periods spanning a decade (2002?2003 and 2012?2013, PIs with more than five articles in each period). (XLSX)
Data
JIF stability over time. (A) JIFs for 12 selected journals from 2003 to 2011. (B) Pearson correlation coefficients r of the JIFs for these 12 journals in 2003 versus each of their respective impact factors in subsequent years. In each case, r is over 0.9. (TIF)
Data
JIF stability over time for 100 selected journals. (XLSX)
Data
Effects of an attempt to game the denominator by introducing low Impact-Factor articles (40 articles of impact factor 1.0) to the co-citation network to a real article close to the average RCR. (XLSX)
Article
The first mutation in a gene associated with a neuronal migration disorder was identified in patients with Kallmann Syndrome (KS), characterized by hypogonadotropic hypogonadism and anosmia. This pathophysiological association results from a defect in the development of the GnRH and the olfactory system. A recent genetic screening of KS patients re...
Chapter
Cerebral cortex is probably the most complex biological network. Here many millions of individual neurons, the functional units of cortex, are interconnected through a massive yet highly organized pattern of axonal and dendritic wiring. This wiring enables both near and distant cells to coordinate their responses and generate a rich variety of cogn...
Article
Full-text available
Despite their recognized limitations, bibliometric assessments of scientific productivity have been widely adopted. We describe here an improved method that makes novel use of the co-citation network of each article to field-normalize the number of citations it has received. The resulting Relative Citation Ratio is article-level and field-independe...
Article
Full-text available
Microtubules are a critical part of neuronal polarity and leading process extension, thus microtubule movement plays an important role in neuronal migration. However, the dynamics of microtubules during the forward movement of the nucleus into the leading process (nucleokinesis) is unclear and may be dependent on the cell type and mode of migration...
Article
Gonadotropin-releasing hormone (GnRH) neurons originate outside the CNS in the olfactory placode and migrate into the CNS, where they become integral components of the hypothalamic-pituitary-gonadal (HPG) axis. Disruption of this migration results in Kallmann syndrome (KS), which is characterized by anosmia and pubertal failure due to hypogonadotro...
Article
Full-text available
Wnt5a guides cortical axons in vivo by repulsion and in vitro evokes cortical axon outgrowth and repulsion by calcium signaling pathways. Here we examined the role of microtubule (MT) reorganization and dynamics in mediating effects of Wnt5a. Inhibiting MT dynamics with nocodazole and taxol abolished Wnt5a evoked axon outgrowth and repulsion of cul...
Article
Full-text available
Proper assembly of neural circuits requires newly born neurons to migrate from their place of origin to their final location. Little is known about the mechanisms of axophilic neuronal migration, whereby neurons travel along axon pathways to navigate to their destinations. Gonadotropin-releasing hormone (GnRH)-expressing neurons migrate along olfac...
Article
Full-text available
A new technology has emerged that will facilitate the presentation of dynamic or otherwise inaccessible data on posters at scientific meetings. Video, audio, or other digital files hosted on mobile-friendly sites can be linked to through a quick response (QR) code, a two-dimensional barcode that can be scanned by smartphones, which then display the...
Article
Full-text available
Stromal derived growth factor (SDF-1) and Gamma-aminobutyric acid (GABA) are two extracellular cues that regulate the rate of neuronal migration during development and may, in fact, act synergistically. The molecular mechanisms of this interaction are still unclear. Gonadotropin releasing hormone-1 (GnRH) neurons are essential for vertebrate reprod...
Article
Wnt5a gradients guide callosal axons by repulsion through Ryk receptors in vivo. We recently found that Wnt5a repels cortical axons and promotes axon outgrowth through calcium signaling in vitro. Here, using cortical slices, we show that Wnt5a signals through Ryk to guide and promote outgrowth of callosal axons after they cross the midline. Calcium...
Article
Full-text available
Precise wiring of cortical circuits during development depends upon axon extension, guidance, and branching to appropriate targets. Motile growth cones at axon tips navigate through the nervous system by responding to molecular cues, which modulate signaling pathways within axonal growth cones. Intracellular calcium signaling has emerged as a major...
Article
Full-text available
For over 30 years, scientists have focused on the impact of endocrine disrupting chemicals (EDC) on human health. These synthetic or natural compounds can mimic and/or antagonize the action of endogenous hormones. Exposure to EDCs has been linked to reduced fertility, onset of diseases like diabetes, endometriosis, and some cancers (Diamanti-Kandar...
Article
Full-text available
It has been shown in vivo that Wnt5a gradients surround the corpus callosum and guide callosal axons after the midline (postcrossing) by Wnt5a-induced repulsion via Ryk receptors. In dissociated cortical cultures we showed that Wnt5a simultaneously promotes axon outgrowth and repulsion by calcium signaling. Here to test the role of Wnt5a/calcium si...
Article
Wnt5a is thought to propel cortical axons down the corticospinal tract and through the corpus callosum by repulsive mechanisms. We cultured dissociated early postnatal cortical neurons from hamsters and exposed them to a gradient of Wnt5a as a model for studying the mechanism of Wnt5a effects. Turning assays indicated that cortical axons were repel...
Article
Full-text available
During development, competition among undifferentiated neurites results in the growth of one neurite at the expense of the rest. This neurite becomes the axon. A similar competitive mechanism later governs the differential outgrowth of the axon and its branches. A long-range signal between different parts of the neuron is required to mediate this c...
Article
Full-text available
Wnts are morphogens that also function as axon guidance molecules. In vivo Wnt5a gradients via Ryk receptors were found to repel cortical axons into developing callosal and corticospinal pathways. Here, using dissociated cortical cultures, we found that bath-applied Wnt5a increased axon outgrowth. In turning assays, Wnt5a gradients simultaneously i...
Article
Full-text available
During development axon outgrowth and branching are independently regulated such that axons can stall or retract while their interstitial branches extend toward targets. Previous studies have shown that guidance cues and intracellular signaling components can promote branching of cortical axons without affecting axon outgrowth. However, the mechani...

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