Brice Faraut

Brice Faraut
Paris Descartes, CPSC | Paris 5 · EA 7330 VIFASOM Sommeil-Vigilance-Fatigue et Santé Publique. Centre du Sommeil et de la Vigilance

PhD, HDR

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51
Publications
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Publications

Publications (51)
Article
Full-text available
Objectives We aimed to examine the effects of circadian and sleep rhythm disruptions on immune biomarkers among hospital healthcare professionals working night shifts and rotating day shifts. Methods Hospital nurses working either as permanent night shifters (n=95) or as day shifters rotating between morning and afternoon shifts (n=96) kept a dail...
Article
Full-text available
Background: Telemonitoring of circadian and sleep cycles could identify shift workers at increased risk of poor health, including cancer and cardiovascular diseases, thus supporting personalized prevention. Methods: The Circadiem cross-sectional study aimed at determining early warning signals of risk of health alteration in hospital nightshifte...
Article
Objectif Comparer l’efficacité de la TCCi de groupe pratiquée en distanciel ou en présentiel, et sur 2 ans autour du pic de la pandémie COVID-19. Méthodes Il s’agit d’une étude clinique rétrospective chez des patients atteints d’insomnie chronique et pris en charge au centre du sommeil et de la vigilance de l’Hôtel-Dieu. Les analyses portent sur t...
Article
Objectif La sieste est habituellement peu recommandée chez les insomniaques afin de préserver la « pression » de sommeil le soir. Quel intérêt pour l’observance à la TCC de la pratique de courtes siestes quand la somnolence induite par la restriction du temps passé au lit potentialise la baisse de vigilance normalement observée en début d’après-mid...
Article
Full-text available
Background: Persons living with HIV (PLWH) frequently report sleep complaints, but objective measurements are still lacking regarding sleep continuity, total sleep time per 24 h, and the links with both prospective memory performance and HIV infection parameters. Methods: PLWH (n = 96) and control (n = 96) groups (balanced for gender and age) were...
Article
Introduction Short total sleep time (TST < 6 hours) is a strong major health determinant that correlates with numerous metabolic, cardiovascular and mental comorbidities, as well as accidents. Our aim was to better understand, at a population level, how adults adapt their TST during the week, and how short sleepers and those with sleep debt and sle...
Article
Full-text available
Sleep debt is becoming a better acknowledged cause of physiological stress and neurobehavioral deficits with major public-health concerns. We investigated whether exposure to blue light during daytime could be an efficient countermeasure to limit sleep restriction’s impact on relevant behavioral (stress, sleepiness, sustained attention, and memory...
Article
Full-text available
Objective: The aim of the present study was to assess the optimal length of actigraphic recordings in patients with narcolepsy type 1. Methods: A secondary analysis was carried out with the previously collected data in eleven patients with narcolepsy type 1. Ten of the 11 patients were medicated at the time of actigraphic recording. Each patient...
Article
Objectif L’actimétrie est un outil sous-estimé en clinique capable de différencier des patients atteints de narcolepsie de type 1 (NT1), d’insomnie primaire (IP) ou des bons dormeurs, grâce à une combinaison de paramètres actimétriques nocturnes et diurnes. Méthodes Nous avons cherché à tester cette fonction discriminante (DS ou score discriminant...
Article
Full-text available
Short and long sleep durations have been associated with inflammation and chronic diseases. To study the association between sleep duration/quality and HIV disease severity, a cross-sectional study was conducted in patients living with HIV (PLWHs) using self-administered questionnaires assessing total sleep time, insomnia (ICSD-3 criteria), and poo...
Article
Objective/background: It has been shown that actigraphy may have a discriminant function (DS) for the diagnosis of narcolepsy type 1 patients (NT1), based on a combination of nighttime and daytime parameters. Here, we aimed to test those findings using another actigraph model with a different clinical sample as control (ie, primary insomniacs, PI)...
Article
Full-text available
Objective To investigate the role of night work in prostate cancer based on data from the EPICAP Study. Methods EPICAP is a French population-based case-control study including 818 incident prostate cancer cases and 875 frequency-matched controls that have been interviewed face to face on several potential risk factors including lifetime occupatio...
Article
Objectif La narcolepsie est une hypersomnie rare caractérisée par des accès de sommeil brutaux, invincibles et récurrents. L’objectif principal de l’étude, soutenue par la fondation maladies rares, est de mieux comprendre et décrire le parcours professionnel de ces personnes en période de formation, de recherche d’emploi ou en activité professionne...
Article
Objectif Nous avons souhaité tester la pertinence de plusieurs paramètres biologiques salivaires comme marqueurs potentiels de la privation de sommeil. Méthodes Étude monocentrique avec 17 jeunes hommes sains, soumis à 2 nuits de restriction à 3 heures de sommeil, avec 4 mesures salivaires répétées de l’alpha-amylase, du cortisol, de l’IL-6 et de...
Article
Objectif Un temps de sommeil total trop court ou trop long a ete souvent retrouve comme associe a un statut pro-inflammatoire et a des maladies chroniques. Mais on connait peu l’association entre temps de sommeil et la severite de la maladie VIH. Methodes Etude mono-centrique avec auto-questionnaires proposes systematiquement aux patients VIH perme...
Article
Objectif Les modifications immunitaires et neuroendocriniennes liées à la restriction de sommeil sont impliquées dans les conséquences cardiovasculaires délétères associées au mauvais sommeil. Les effets de la sieste sur la vigilance sont bien admis mais l’impact de la sieste sur les réponses immunitaires et neuroendocriniennes sont mal connues. M...
Article
Objectif L’etude du syndrome de l’epuisement professionnel (SEP) est complexe. La litterature scientifique montre qu’une approche bio-psychometrique est interessante. L’objectif est d’etudier le sommeil et les modifications des taux sanguins de variables biologiques sur un groupe de salaries en epuisement professionnel. Methodes Nous avons realise...
Article
Sleep specialists have proposed measures to counteract the negative short- and long-term consequences of sleep debt, and some have suggested the nap as a potential and powerful “public health tool”. Here, we address this countermeasure aspect of napping viewed as an action against sleep deprivation rather than an action associated with poor health....
Article
La loi du 17 août 2015 relative au dialogue social et à l’emploi impose à chaque entreprise de « prévenir la pénibilité au travail ». Cette dernière est caractérisée par « une exposition, au-delà de certains seuils, à un ou plusieurs facteurs de risques professionnels pouvant laisser des traces durables, identifiables et irréversibles sur la santé...
Article
Objectif Nous avons voulu évaluer si la sieste pouvait être une contre-mesure efficace aux effets délétères de la restriction de sommeil sur la sensibilité à la douleur. Méthodes Nous avons étudié les effets d’une nuit de restriction à 2 heures de sommeil et les effets d’une sieste de 30 minutes en début de matinée et d’après-midi après la restric...
Article
Full-text available
Total sleep deprivation (TSD) in humans is associated with altered hormonal levels which may have clinical relevance. Less is known about the effect of an extended sleep period before TSD on these hormonal changes. Fourteen subjects participated in two experimental counterbalanced conditions (randomized cross-over design): extended sleep (21:00 - 0...
Article
Full-text available
Sleep loss may induce endothelial dysfunction, a key factor in cardiovascular risk. We examined the endothelial function during one week of sleep restriction and a recovery period (from 3-to-13days) in healthy subjects, and its link to autonomic, inflammatory and/or endocrine responses. 12 men were followed at baseline (B1, 8-h sleep), after 2 (SR2...
Article
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To investigate pain sensitivity after sleep restriction and the restorative effect of napping. A strictly controlled randomized crossover study with continuous polysomnography monitoring was performed. Laboratory-based study. 11 healthy male volunteers. Volunteers attended two three-day sessions: "sleep restriction" alone and "sleep restriction and...
Article
Full-text available
Context: Neuroendocrine and immune stresses imposed by chronic sleep restriction are known to be involved in the harmful cardiovascular effects associated with poor sleep. Objectives: Despite a well-known beneficial effect of napping on alertness, its effects on neuroendocrine stress and immune responses after sleep restriction are largely unkno...
Article
Full-text available
Background: A significant U-shaped association between sleep duration and several morbidity (obesity, diabetes or cardiovascular disease) and mortality risks has been regularly reported. However, although the physiological pathways and risks associated with ‘‘too short sleep’’ (,5 hours/day) have been well demonstrated, little is known about ‘‘too...
Article
Full-text available
Background A significant U-shaped association between sleep duration and several morbidity (obesity, diabetes or cardiovascular disease) and mortality risks has been regularly reported. However, although the physiological pathways and risks associated with “too short sleep” (<5 hours/day) have been well demonstrated, little is known about “too much...
Article
The link between sleepiness and the risk of motor vehicle accidents is well known, but little is understood regarding the risk of home, work and car accidents of subjects with insomnia. An international cross-sectional survey was conducted across 10 countries in a population of subjects with sleep disturbances. Primary care physicians administered...
Article
Full-text available
Shift work is commonly associated with disturbed life rhythms, resulting in chronic exposure to circadian desynchronization and sleep restriction. Epidemiological data have shown that shift workers are at an increased risk of cardiovascular disease and breast cancer. In this review, we will explore how observed increases in neuroendocrine stress, n...
Article
Compelling evidence from laboratory-based and population-based studies link sleep loss to negative cardiovascular health outcomes. However, little is known about the association between sleep duration and hypertension in primary care health settings, independently of other well controlled clinical and biochemical characteristics. We investigated th...
Data
Sleep architecture at 3rd baseline night and during sleep restricted and recovery nights. Values are shown as medians (25%–75% range). Baseline 3 (the 3rd baseline night) was used as control and other nights as the comparative groups. Data comparisons with baseline 3 were performed using a Friedman Repeated Measures Analysis of Variance on Ranks an...
Data
Immune and inflammatory blood markers after the 3rd baseline night and during sleep restriction and recovery periods. Values are shown as medians (25%–75% range). Baseline 3 (the 3rd baseline day) was used as control and other days as the comparative groups. Data comparisons with baseline 3 were performed using a Friedman Repeated Measures Analysis...
Article
Full-text available
Many studies have evaluated the ways in which sleep disturbances may influence inflammation and the possible links of this effect to cardiovascular risk. Our objective was to investigate the effects of chronic sleep restriction and recovery on several blood cardiovascular biomarkers. Nine healthy male non-smokers, aged 22-29 years, were admitted to...
Article
Full-text available
Understanding the interactions between sleep and the immune system may offer insight into why short sleep duration has been linked to negative health outcomes. We, therefore, investigated the effects of napping and extended recovery sleep after sleep restriction on the immune and inflammatory systems and sleepiness. After a baseline night, healthy...
Article
Neuropeptide Y (NPY), a 36-amino-acid peptide from the pancreatic polypeptide family, is one of the more abundant peptides in the central nervous system. It acts as a neurohormone and as a neuromodulator. NPY is widely distributed in the brain, particularly the hypothalamus, the amygdala, the locus coeruleus and the cerebral cortex. At least six NP...
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The involvement of skeletal muscle mitochondrial uncoupling protein-3 (UCP3) in the control of energy expenditure in skeletal muscle and at the whole-body level is still a matter of debate. We previously reported that UCP3 downregulation is linked to an enhanced mitochondrial energy metabolism in rat skeletal muscle as a result of acute capsiate tr...
Article
Our 24 h society promotes wakefulness to the detriment of sleep. Many people reduce their sleep time voluntary or by obligation. The effects of sleep restriction on performances and on vigilance are becoming to be recognized. However, the effects of chronic sleep loss on health and disease, particularly cardiovascular disease, are less documented....
Article
Full-text available
This study examines the effects of sleep restricted to four hours for three consecutive nights on blood parameters, known to be associated with cardiovascular risk, in young healthy men. Eight young healthy men (age 24.5 +/- 3.3 years) were studied in the sleep restricted group. Nine young healthy men (age 24 +/- 2 years) were included in the contr...
Article
Full-text available
Although it has been suggested that the skeletal muscle mitochondrial uncoupling protein-3 (UCP3) is involved in regulating energy expenditure, its role is still poorly understood. In the present study, we aimed at investigating noninvasively, using magnetic resonance techniques, metabolic changes occurring in exercising muscle as a result of capsi...
Article
Congenital myasthenic syndromes (CMS) are rare genetic diseases affecting the neuromuscular junction (NMJ) and characterized by a dysfunction of the neurotransmission. They are heterogeneous at the pathophysiological level and can be classified in three categories according to their origin: presynaptic, synaptic or postsynaptic. The strategy for th...
Article
Congenital myasthenic syndromes (CMS) are rare genetic diseases affecting the neuromuscular junction (NMJ) and are characterized by a dysfunction of the neurotransmission. They are heterogeneous at their pathophysiological level and can be classified in three categories according to their presynaptic, synaptic and postsynaptic origins. We report he...
Article
Full-text available
We report the first case of a human neuromuscular transmission dysfunction due to mutations in the gene encoding the muscle-specific receptor tyrosine kinase (MuSK). Gene analysis identified two heteroallelic mutations, a frameshift mutation (c.220insC) and a missense mutation (V790M). The muscle biopsy showed dramatic pre- and postsynaptic structu...
Article
In the course of studies on thrombin and its inhibitor(s) in synaptic plasticity, we addressed the question of their roles in the formation of neuromuscular junctions (NMJ) and used a model of rat neuron-myotube cocultures. We report that the size of acetylcholinesterase (AChE) patches used as a marker of neuromuscular contacts was decreased in the...
Article
Regulation of thrombin activity may be required during skeletal muscle differentiation since the thrombin tissue inhibitor protease nexin-1 appears at the myotube stage before being localized at the neuromuscular synapse. Here, we have used a model of rat fetal myotube primary cultures to study the effect of thrombin on acetylcholine receptor (AChR...

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