Brian PetersonUniversity of Michigan | U-M · Department of Biological Chemistry
Brian Peterson
Biochemistry (BS)
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Citations since 2017
Publications
Publications (4)
![Fig. 5. Effects of test compounds on [ 3 H]E 2 17βG uptake into MRP1...](profile/Surtaj-Iram/publication/335128927/figure/fig3/AS:791181705375744@1565643826298/Effects-of-test-compounds-on-3-HE-2-17bG-uptake-into-MRP1-expressing-membrane_Q320.jpg)
Multidrug resistance protein 1 (MRP1/ABCC1) actively transports a variety of drugs, toxic molecules and important physiological substrates across the plasma membrane. It can confer broad-spectrum multidrug resistance and can decrease the bioavailability of many important drugs. Substrates of MRP1 include anti-cancer agents, antibiotics, antivirals,...
Multidrug resistance protein 1 (MRP1/ABCC1), an integral transmembrane efflux transporter, belongs to the ATP-binding cassette (ABC) protein superfamily. MRP1 governs the absorption and disposition of a wide variety of endogenous and xenobiotic substrates including various drugs across organs and physiological barriers. Additionally, its overexpres...
