Brett Melanson

Brett Melanson

PhD in Psychology + Neuroscience

About

9
Publications
850
Reads
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51
Citations
Citations since 2017
9 Research Items
51 Citations
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Introduction
I am interested in the link between metabolic and mood disorders. My research is centred around the impact of interacting hypoglycemic and psychophysical stressors on behavioural and physiological responses using rodent models. As well, I am interested in mechanisms involved in ketamine's antidepressant effect and its ability to mitigate the negative effects of stress exposure.

Publications

Publications (9)
Article
Full-text available
This study was designed to explore the clinical belief that "set and setting" play an important role in favorable responses to psychedelic agents such as ketamine (KET). In fact, there is evidence in animals that the antidepressant effect of this drug may involve drug-environment interactions in which a context paired with its effects acquires the...
Article
Full-text available
Background There is evidence that post-training exposure to nicotine, cocaine, and their conditioned stimuli (CS), enhance memory consolidation in rats. The present study assessed the effects of blocking noradrenergic and dopaminergic receptors on nicotine and cocaine unconditioned and conditioned memory modulation.Methods Males Sprague–Dawley rats...
Article
Full-text available
There is evidence that hypoglycemic stress can interact with other stressors, and that ketamine can mitigate the impact of these stressors on behavior and physiology. The current study in male Sprague-Dawley rats investigated whether pre-treatment with 0, 10, or 20 mg/kg ketamine could modulate the interaction between hypoglycemia induced by 0 or 3...
Article
Full-text available
RationaleThere is evidence that hypoglycemia, a metabolic stressor, can negatively impact mood and motivation, and can interact with other stressors to potentiate their effects on behavior and physiology.Objectives/methodsThe current study in male Sprague-Dawley rats explored the interaction between impaired glucose metabolism induced by 0, 200, or...
Article
Background: Reverse translating putative biomarkers of depression from patients to animals is complex because Major Depressive Disorder (MDD) is a highly heterogenous condition. This review proposes an approach to reverse translation based on relating relevant bio-behavioural functions in laboratory rodents to MDD symptoms. Methods: This systema...
Article
Full-text available
Rationale Pre-clinical and clinical studies have suggested that the antidepressant efficacy of escitalopram (ESC) can be augmented by co-administration of aripiprazole (ARI). Objective To establish if the effects of ESC + ARI can be altered by modulating the 5-HT1a receptor. Methods Sprague-Dawley male rats received ESC + ARI (10 and 2 mg/kg/day,...
Article
Full-text available
After publication of this paper, the authors determined an error in Fig. 3. Below is the correct Fig. 3.
Article
Puberty is a critical period of development marked by sexual, immune, and neural maturation. Exposure to stress during this period can lead to enduring changes in brain functioning and in behavior; however, the underlying mechanisms and the programming effects of stress during puberty remain unknown. Therefore, the objective of this study was to in...
Article
Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and sex differences in the peripheral and central immune responses, along with...

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Projects

Project (1)
Project
Working to establish the relationship between hypoglycaemia and selection of stress coping styles, and how selection relates to changes in stress and immune physiology.