Brett CohenInstitute for Advanced GABA Studies · Research and Development
Brett Cohen
Ph.D. Chemistry
About
151
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Introduction
Dr. Brett Cohen currently conducts Research and Development at The Institute for Advanced GABA Studies. His most recent publication are RISING AUTISM RATES AND THE LINK WITH EPIGENETICS (Nexus), UNRAVELLING THE MYSTERY OF AUTISM AS A MALE DISORDER (Nexus), Current Research Indicates the Root Cause of Autism is GABA-Transaminase: A Chemical Perspective (Scientific India) and Autism: a Chemical Perspective- Current Research Indicates the Root Cause of Autism is GABA-Transaminase (Nexus).
Publications
Publications (151)
In his book The Giza Power Plant: Technologies of Ancient Egypt (Dunn
1998), Christopher Dunn proposes a very intriguing theory regarding
the function of the Queen’s Chamber. He suggests that it was an engine
of a great power plant, where hydrogen (H2) gas was used to create
piezoelectric or electromagnetic energy. A detailed chemical approach...
World's Strongest Permanent Magnet’ (Neodymium-Iron-Boron): A Chemical Perspective. Dr. Brett I. Cohen Ph.D. takes a look at the phenomenon of magnetism, but from a chemical perspective.
With the recent trade wars
between China and The
United States of America,
there has been increasing
interest in rare-earth metals and how
China trade could effec...
The Strangest Solid on Earth, Lighter than Air: A Chemical Perspective.
By: Dr. Brett I. Cohen, Ph.D.
One of the most unique and supernatural materials on Planet Earth is a solid called Aerogels. This strange synthetic material is straight out of science fiction. Aerogel is a synthetic porous ultralight solid, which was created by American scient...
Autism is a complex genetic disorder that is characterised by significant disturbances in social, communicative and behavioural functioning. An autistic subject can have disturbances that include serious impairment of social relationships, delayed or deviant language development, and repetitive and/or ritualistic play and interests. Onset of autism...
Abstract
Charles Dellschau was an American artist who created drawings, collages and watercolors of airplanes and airship. Dellschau was also involved in the recording of the activities of the Sonora Aero Club (a group of flight enthusiasts). According to Dellschau, one of the members (Peter Mennis, an inventor and pilot) had discovered a formula f...
The Niacin 2013 Crop Circle: A Chemical Perspective.
By: Brett I. Cohen, Ph.D.
E-mail: ebicbis@aol.com
A crop circle or crop formation is a pattern created by flattening a crop found in a field (Thomas, 2015). The crops are usually composed of a cereal in structure. In order to appreciate or recognize the full worth of a crop circle formation, it...
Charles Dellschau was an American artist who created drawings, collages and watercolors of airplanes and airship. Dellschau was also involved in the recording of the activities of the Sonora Aero Club (a group of flight enthusiasts). According to Dellschau, one of the members (Peter Mennis, an inventor and pilot) had discovered a formula for an ant...
A crop circle or crop formation is a pattern created by flattening a crop. The number of crop circles around the world has substantially increased from the 1970's to today. There have been very few scientific studies (mainstream studies) of crop circles throughout the world. Very close to Wiltshire, United Kingdom near Stonehenge on August 1, 2013,...
The Holocaust (which occurred during World War II) involved systematic murder and was the deadliest genocide in history where Nazi Germany erected concentration camps (also called "death camps") that were equipped with gas chambers. Uses of Zyklon B (Hydrogen cyanide gas [HCN]) included delousing clothing, disinfecting ships, warehouses and was als...
There are a number of blue holes that are found around the world in the ocean and sea waters. A blue hole is a large marine sinkhole (a depression and/or hole in the ground caused by some form of collapse of the surface layer) or cavern (a natural void in the ground). A blue hole can develop in a bank or island and the structure of the blue hole is...
With the recent trade wars between China and The United States of America, there has been increasing interest in rare-earth metals and how China trade could effect the economy of the United States, if the trade of these rare-earth metals between China and The United States of America are halted. As of 2017, China produced approximately 80% of the w...
Located in Java (between Banyuwangi Regency and Bondowoso Regency), Indonesia is a group of composite volcanoes called the Ijen volcano complex. Within one of these volcanoes is a lake which is recognised as the largest, most acidic crater lake in the world. This lake is found inside a large caldera Ijen. A caldera is a large volcanic crater, it is...
Autism is a complex genetic disorder that is characterised by significant disturbances in social, communicative and behavioural functioning. An autistic subject can have disturbances that include serious impairment of social relationships, delayed or deviant language development, and repetitive and/or ritualistic play and interests. Onset of autism...
One of the most unique and supernatural materials on Planet Earth is a solid called Aerogels. This strange synthetic material is straight out of science fiction. Aerogel is a synthetic porous ultralight solid, which was created by American scientist Samuel Stephens Kistler in 1931. Chemically, Kistler replaced the liquid in jellies (gels) with gas...
Autism rates are rising alarmingly and may be linked to a transgenerational response to environmental factors that switch off key genes affecting a specific chromosome. High plasma GABA levels, resulting in abnormal axonal development in the corpus callosum, are implicated in autism.
by Brett I. Cohen, PhD © 2015
Email: ebicbis@aol.com
OCTOBER – N...
The corpus callosum in the centre of the brain has lower fibre density in males than in females. High plasma GABA levels found in autism inhibit signalling in the corpus callosum. These findings may explain why males are more susceptible to autism.
by Brett I. Cohen, PhD © February 2016
Email: ebicbis@aol.com
In conclusion, it has been demonstrated that Neanderthals (found at archaeological sites throughout their world of Europe and Asia utilied a chemical process known as dry distillation to affix (with the use of tar as a glue or adhesive) stone sharpened tips to their spear halts and this chemical process represents the earliest use of chemistry on P...
Strangely, a few crop circles discovered in the United Kingdom are found to be chemical molecules. In a time span from 2011 to 2013, three different molecular crop circle structures were observed. On July 23, 2011, a crop circle in Wiltshire, United Kingdom (a county in South West England with an area of approximately 1,300 square miles) of melaton...
A crop circle or crop formation is a pattern created by flattening a crop. The number of crop circles around the world has substantially increased from the 1970's to today. There have been very few scientific studies (mainstream studies) of crop circles throughout the world. Very close to Wiltshire, United Kingdom near Stonehenge on August 1, 2013,...
Science and its study of the nature of physical reality can be seen as a window into the nature of spiritual reality. Edgar Cayce (born March 18, 1877; death January 3, 1945 also known as “The Sleeping Prophet”) , the most documented psychic of the 20th century, expressed in his readings how the One becomes the many. One of the most frequently ment...
The Iron Pillar of Delhi is located at Mehrauli, Delhi (India) and is most notable for its rust-resistance iron metal composition. The pillar has intrigued archaeologists and scientists over centuries because of its unique high chemical resistance to corrosion in spite of the local climate in Delhi, India. The Iron Pillar of Delhi has been continuo...
The Dogon people are an ethnic group that live in the central plateau region in Mali, West Africa. They are best known for their religious traditions. The Dogon are believed to be of Egyptian decent (Egypt is located in Northeast Africa and is in close proximity to Mali, West Africa) and the Dogon astronomical myths and lore goes back thousands of...
Recently, it was illustrated that the classical optical experiment of white light passing through a prism (where a prism is a metaphor or a representation for "ego" consciousness) to produce a spectrum of different colored lights (violet, blue, green, yellow, orange, and red) can be seen as a physical representation of spiritual reality (Cohen & Co...
This article will illustrate that the classical optical experiment of white light passing through a prism to produce a spectrum of different colored lights (violet, blue, green, yellow, orange, and red) can be seen as a physical representation of a spiritual reality. In which the divine One Light passes through the ego or separate self to produce t...
Damascus steel swords were used in the Near East and composed of a type of steel Books New Book Kindle called wootz steel. This type of steel was first pioneered in India as well as Sri Lanka in the sixth century B.C. and then exported globally. Swords made from this steel were tough, resistant to shattering and capable of being honed to a very s...
This article will discuss the differences and similarities between non-dualism and autism. While non-dualism is not a genetic or neurological disorder (where autism is a genetic and neurological disorder), there are many similar characteristics regarding these seemingly different phenomena. These similarities (between non-dualism and autism) are di...
In the year Ca. 256 A.D., the siege of the Roman fortress-city of Dura (now DuraEuropos) in the eastern Syrian desert by the invading Sassanid (Persian) army took place under Shapur I (The first) (James, 2011, Mayor 2003). The fortress-city of Dura backs up against the Euphrates River and was a Roman military base, well-fortified with high-thick wa...
An incendiary weapon used by the Byzantine Empire (Eastern Roman Empire) was "Greek Fire". During the Byzantine Empire "Greek Fire" was typically used in naval battles and gave the Byzantines great technological advantages and was responsible for many key military victories. The Byzantines would apply "Greek Fire" using a pressurized nozzle or siph...
Charles August Dellschau was born on June 4, 1830 in Brandenburg, Prussia and he died on April 20, 1923 in Texas (in the United States). He was an American artist who created drawings, collages and watercolors of airplanes and airship (resulting in twelve large, hand-bound books with more than 2,500 drawings) that were discovered decades after his...
The Holocaust (which occurred during World War II) involved systematic murder and was the deadliest genocide in history where Nazi Germany erected concentration camps (also called "death camps") that were equipped with gas chambers. Uses of Zyklon B (Hydrogen cyanide gas (HCN)) included delousing clothing, disinfecting ships, warehouses and was als...
The Fibonacci Sequence in mathematics involves the following number sequence where two consecutive numbers (in the sequence) are added together to give the next number in the sequence (i.e. 1+1= 2, 1+ 2= 3, 2+3= 5, 3+5= 8, and so on). The Fibonacci Sequence (or Fibonacci numbers) are 1, 1, 2, 3, 5, 8, 13, 21, 34, 55, etc. The Italian mathematician...
Dragons from European culture are part of folklore and mythology and they overlap as part of its culture. A very special type of dragon depicted in European mythology and folklore is the fire-breathing dragon. Interestingly, the Bible (King James Version (KJV), Job 41) also describes a creature called the Leviathan. Leviathan is a fire-breathing mo...
The first known description in history for the invention of flexible glass or unbreakable glass (vitrum flexile) was during the reign of the Roman Emperor Tiberius Caesar (from 14 A.D. to 37 A.D.). Saint Isidore of Seville recounted the stories by Petronius (ca. 27 A.D.–66 A.D) and Pliny the Elder (23 A.D.–79 A.D) of an unknown inventor who brought...
In his book, The Giza Power Plant: Technologies of Ancient Egypt1, Christopher Dunn proposes a very intriguing theory regarding the function of the Queen's Chamber in which the chemical Hydrochloric acid (HCl) found in the southern shaft was mixed with the northern shaft chemical hydrated Zinc Chloride (ZnCl2) to produce Hydrogen (H2) gas. He sugge...
Bob Lazar in the 1980s claimed to have worked with the super heavy element 115 (Ununpentium (Uup)). His theory was that Uup served as the fuel and propulsion system for alien aircraft. In this paper, a chemical perspective of Uup is described where Uup is a highly radioactive element, all of the stable isotopes of Uup have very short half lives (wi...
In the book The Giza Power Plant: Technologies of Ancient Egypt, it is proposed that a very intriguing theory regarding the function of the Queen's Chamber found in the Great Pyramid. He suggests that it was an engine of a great power plant, where hydrogen (H2) gas was used to create piezoelectric or electromagnetic energy. A detailed chemical appr...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
This article determines the compressive and diametral tensile strength of two titanium-reinforced composites (Bis-GMA-based), Ti-Core and Flexi-Flow cem with titanium and compares their strengths to dentin and commercially available core materials and cements. In addition scanning electron microscope (SEM) photographs were taken of Ti-Core and Flex...
SUMMARY Advantages of a new post design, Flexi-Flage® are described. It incorporates a split-shank parallel threaded post with a flange that seats into an occlusal countersunk dentine space. This case report desecribes placement of three Flexi-Flange posts in a first bicuspid, canine and central incisor. The Flexi-Flange system was designed to offe...
This in vitro study was designed to determine if enlarging a canal with a holmium: YAG (Ho:YAG) laser (using six different-sized fiber-optic tips) would increase the change in temperature at the root surface and if fiber-optic tips spaced more closely would enlarge the canal more efficiently and consistently.
The in vitro study measured the time required to instrument and shape canals by conventional reamers and files compared with a newly introduced reamer and file system. This experiment was divided into four groups with 10 block samples for each group. The results of instrumentation time demonstrate that the noninterrupted flat-sided design (EZ-Fill...
The basics for the sound restoration of endodontically treated teeth have not changed despite the advent of new materials and techniques. Adequate retention for posts and crowns, resistance to cyclic shearing forces, minimal insertional stresses, and even distribution of functional stresses are prime requirements that cannot be compromised without...
It has been reported in the literature that after lasing dentin the dentin surface has a glassy or globular appearance. Many authors believe this to be recrystallized hydroxyapatite. The purpose of this elemental analysis was to see if any of the silica fiber optic was melted and deposited as these globular structures on the canal wall. Two teeth w...
Simplified Endodontic Techniques (SET), along with EZ-Fill, a bidirectional spiral and epoxy root canal cement, have been used for more than 2 1/2 years. This particular sequence of instrumentation and obturation provides the dentist with predictable and easily attained success. Periapical areas demonstrate healing, and excess EZ-Fill cement is res...
Cohen has illustrated that extremely high Gamma-aminobutyric acid (GABA) levels in the urine and blood and high plasma ammonia were observed for an autistic male child diagnosed with infantile autism. GABA is a major inhibitory neurotransmitter of the mammalian brain and the enzyme responsible for catabolism is GABA-Transaminase (GABA-T). Elevated...
This paper describes the use of a GABA-transaminase agonist for the treatment of infantile autism. An approximate one third reduction of GABA and ammonia levels for an autistic patient with noticeable improvement of verbal/language skills and a reduction of repetitious ritualistic self-stimulatory behavior (stimming) was observed. A reduction of th...
The compatibility of different dental materials (root canal sealer and composite core build-up restoratives) is an important factor for a successful restoration. The aim of this in vitro study was to determine the effects on compressive and diametral tensile strength of a classical chemical cure composite resin (Henry Schein Composite Anterior-Post...
Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter of the mammalian brain and the enzyme responsible for catabolism (breakdown in the liver during regulation) is GABA-Transaminase (GABA-T). Recently, Cohen has shown that extremely high GABA levels in the urine and blood were observed for an autistic child. The finding that elevat...
Artificial cores replace missing tooth structure and contribute to the retention and stability of the subsequent restoration. The post is the anchoring mechanism for the core, which supports the final restoration. Stability of the post and core is the most important factor concerning the long-term success of the post-and-core restoration. The amoun...
This study calculated the flexural strength for six reinforced restorative materials and demonstrated that flexural strength values can be determined simply by using physical parameters (diametral tensile strength and Young's modulus values) that are easily determined experimentally. A one-way ANOVA analysis demonstrated a statistically significant...
The use of dental amalgam as a direct restorative material has been a subject of controversy for many years. The potential safety of amalgam has been questioned because of leakage of elements such as mercury, copper, tin, and silver.
This study evaluated the elemental leaching from Tytin dental amalgam placed in deionized water for 2 months. Both m...
The evolution of endodontic treatments has included the introduction of rotary crown-down nickel-titanium instrumentation and the use of thermoplasticized gutta percha to obturate canals. Although these techniques have provided dentists with solutions to problems encountered with earlier generation endodontic procedures, they have also presented de...
There are no studies analyzing the effects of a crown in relationship to torsional resistance for a titanium-reinforced core material supported by a post.
This study investigated the effects of post design on the torsional resistance of a crown supported by a titanium-reinforced composite core material (Ti-Core) and 3 endodontic posts (AccessPost,...
There are few studies on the retention of core build-up materials to prefabricated post head designs, especially for a new ceramic post design.
This in vitro study compared the retention of 2 types of core build-up materials (Ti-Core titanium-reinforced composite and a GC Miracle Mix silver-reinforced glass ionomer) supported by 3 post head designs...
Retention was compared of an active post system (Flexi-Flange), a metal passive prefabicated post system (ParaPost), a passive prefabricated burnout post system (ExactaCast) with and without grooved dentin walls, and a zirconium oxide ceramic post design (Cerapost). The Flexi-Flange with Flexi-Flow Natural cement obtained the highest retentive valu...
The purpose of this in vitro study was to determine the cytotoxicity of two root canal sealing materials (AH26 and AH-Plus). This cytotoxicity test (agar diffusion test) was conducted based on the procedures described in the International Organization for Standardization. The biological reactivity of a mammalian monolayer, L929 mouse fibroblast cel...
This pilot study concerned the cyclic fatigue of five different endodontic post systems (AccessPost(R), Flexi-Flange(R), Flexi-Post(R), ParaPost(R), and Vlock(R)) with four different core materials (Tytin(R) Silver amalgam, Ti-Core(R), Ketac-Silver(R) and G-C Miracle Mix(R)). In vitro cyclic fatigue was performed using a fatigue machine that simula...
Using a simplified step-back sequence, which consists of traditional .02 tapered stainless-steel hand reamers, the No. 2 peeso reamer, and four manual nickel-titanium instruments, a dentist can easily, safely, and economically create a continuously tapered canal shape. This article discusses the complete coating of canal walls with EZ-Fill epoxy-re...
There are few research studies concerning prefabricated posts overdenture attachment systems using multiple pull cycles.
This study tested 6 prefabricated post overdenture attachment systems (AccessPost Overdenture, ERA white and ERA grey, Flexi-Overdenture, O-SO and ZAAG) measured to simulate wear over a 2000 pull cycle and compared the in vitro r...
There are no studies analyzing the effects of a bonding agent on torsional resistance for a titanium-reinforced core material bonded with a multistep bonding system.
This pilot study investigated the effects of multistep bonding agents on torsional resistance of a titanium-reinforced composite core material (Ti-Core core material).
A total of 40 re...
There are no studies that have investigated the effects of bonding agents on the resistance to torque of a composite core supported by a prefabricated post.
This study investigated the ability of bonding agents to resist rational forces applied to titanium-reinforced composite cores supported by 2 post designs.
Two post designs (AccessPost and Para...
This in vitro study compared the retention and photoelastic stress patterns from two loading conditions, vertical (133.2 N, 30 pounds) and oblique at a 26 degrees angle (133.2 N, 30 pounds) for two prefabricated post systems. The post studied were: (1) Flexi-Post (a split-shank threaded post) and (2) C-Post (a carbon fibre bound in an epoxy resin,...
The purpose of this study was to measure the amount of formaldehyde released from three types of endodontic sealing cement (AH-Plus, EZ-Fill, and AH-26). Formaldehyde release was analyzed using High Performance Liquid Chromatography, which could detect as low as 0.25 ppm. The data was tabulated after two runs. The two paste system of AH-Plus endodo...
A sequence of steps constituting an innovative way of cleansing, shaping and obturating a root canal system is described. The advantages of this sequence over other instrumentation and obturation techniques are discussed.
The aim of this study was to determine if there is an increase in temperature at the root surface as the canal is enlarged when using a Holmium:YAG laser. An increase might be expected because, as the canal is enlarged, there is less dentin between the canal walls and the outer cementum surface of the root to absorb the heat. Sixty single-rooted hu...
Canals shaped to wider tapers, specifically .06 mm and .08 mm, have traditionally been associated with thermoplastic fills. However, the canals shaped to .06 mm and .08 mm tapers correlate very closely to the shape of fine-medium and medium gutta-percha points, respectively. Combining the placement of these single-point fills with the patented EZ-F...
This study evaluated the apical leakage for three endodontic systems: (1) lateral condensation with Essential Dental System's epoxy adhesive: (2) Thermafil with Thermaseal adhesive; and (3) EZ-Fill Bi-directional spiral with EDS' epoxy adhesive. Five groups of 10 recently extracted single-rooted human teeth were used. Results showed that lateral co...
Recently introduced single-step bonding agents reduce the number of steps involved in the bonding process. Nevertheless, there are few studies on the bond strengths obtained with these new systems.
This in vitro study evaluated the shear bond strength of a titanium-reinforced cores bonded with 5 multistep bonding systems (ScotchBond Multi-Purpose,...
The purpose of this investigation was to examine the tear strength of four irreversible hydrocolloid (alginate) impression materials (Tare-Free Alg, Jeltrate, Identic, and Kromopan).
Eighty specimens, 20 for each alginate tested, were according to the manufacturers' instructions. A cutting die described in American Standard Test and Material docume...
The retention of a post is believed to be a major factor in restoration survival. Therefore the cement with the greatest in vitro retention property should give the best performance for a restoration.
This study compared retentive values of three posts (Flexi-Post, AccessPost, and ParaPost) cemented with five cements (Flexi-Flow, zinc phosphate, Ad...
The purpose of this study was to record the fluoride released measured in parts per million of four fluoride composite resins for five years.
Four fluoridated composites were separated into four groups. Two composite resins with high viscosity were core materials, Ti-Core with titanium (group 1) and Ti-Core Natural (group 2) and the other two resin...
The aim of this study was to compare the fracture strengths of three restorative materials, a lanthanide reinforced composite (Ti-Core Natural), a silver amalgam (Tytin), and a hybrid glass ionomer (Advance), supported by either a multitiered, threaded split-shank post (Flexi-Flange) or with a dentin spur without a post.
A total of 60 recently extr...
This pilot study examined the cyclic fatigue of five endodontic post systems (AccessPost, Flexi-Flange, Flexi-Post, ParaPost, and Vlock) with four core materials (Tytin silver amalgam, Ti-Core, Ketac-Silver and G-C Miracle Mix).
In vitro cyclic fatigue was performed with a machine designed to simulate masticatory fatigue forces. An instantaneous fo...
Restoration of the endodontically treated tooth is a common occurrence in everyday dental practice. Unfortunately, clinical posthole preparation seems to be a random technique. Even for a prefabricated post supplied with matching drills, the task is often difficult or not straightforward. Some questions inevitably arise. How long should the posthol...
The purpose of this in vitro study was to determine the fractural load of four core materials supported by five post designs. This study was divided into 20 groups with 10 samples per group. Specimens were placed in a special jig at a 45-degree angle, and the fracture load values, in pounds, were obtained with the use of a universal testing machine...
The aim of this study was to determine the maximum amount of power, in watts, that a Holmium YAG laser could deliver via a 245-micron fiberoptic to the canal surface and still not raise the temperature (delta T) of the cementum by > 5 degrees C. Sixty single-rooted teeth were divided into three groups according to power selection (0.50, 0.75, and 1...
This pilot study compared stress distribution using photoelastic blocks for both vertical loading and oblique loading (26 degrees angle) for four groups of post systems (Flexi-Post, Flexi-Flange, ParaPost and AccessPost dowels). For each group, three test blocks of photoelastic material were prepared with simulated endodontic canals, and the specim...
The surgical microscope, today used almost exclusively by endodontists, will eventually be used by general dentists as well. This will give them the ability to perform a myriad of tasks and achieve superior results.