Brent Feske

Georgia Southern University | GSU · College of Science and mathematics

The inside cover picture, provided by Andreas Bommarius, John Woodley, and co‐workers, illustrates how oxygen transfer into an enzyme‐containing solution and enzyme stability are often at odds with each other. A vigorously sparged and stirred tank is best for oxygen transfer but worst for enzyme stability, while a quiescent solution shows the oppos...

We devised a synthetic scheme based on a Horner–Wadsworth–Emmons olefination followed by a stereoselective reduction in the attempt to synthesize a puromycin analog that cannot be metabolized to a known nephrotoxic 3’-aminonucleoside. This procedure allowed the synthesis of a fully protected nucleoside precursor of the target molecule. However, the...

This chapter describes various enzyme-catalyzed reactions for production of amino acids and chiral amines. Enantiomerically pure amino acids can be produced from keto acids via amino acid dehydrogenase (AADH) and transaminase (TA). Enantiomerically pure amines are available from prochiral ketones via catalysis with TA, amine oxidase (AO), and amine...