Breno Satler Diniz

Breno Satler Diniz
UConn Health Center · Department of Psychiatry

M.D., Ph.D.

About

230
Publications
58,428
Reads
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8,257
Citations
Citations since 2016
91 Research Items
6049 Citations
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Introduction
I am Associate Professor of Psychiatry at the University of Connecticut Health Center (UConn Health) and UConn Center on Aging. My main interest research areas are: biomarker development in neurodegenerative and late-life psychiatric disorders and the neurobiological links between aging, psychiatric disorders Alzheimer's disease, and Vascular Dementia.
Additional affiliations
July 2018 - present
University of Toronto
Position
  • Professor (Assistant)
January 2016 - June 2018
University of Texas Health Science Center at Houston
Position
  • Professor (Assistant)
January 2013 - December 2015
Federal University of Minas Gerais
Position
  • Professor (Assistant)
Education
September 2011 - May 2012
University of Pittsburgh
Field of study
  • Clinical Neuroscience and Biomarker Development
January 2008 - May 2011
University of São Paulo
Field of study
  • Clinical Neuroscience and Biomarker Development
February 2007 - January 2008
Independent Researcher
Independent Researcher
Field of study
  • Geriatric Psychiatry

Publications

Publications (230)
Article
Full-text available
Major depressive disorder (MDD) is characterized by psychological and physiological manifestations contributing to the disease severity and outcome. In recent years, several lines of evidence have suggested that individuals with MDD have an elevated risk of age-related adverse outcomes across the lifespan. This review provided evidence of a signifi...
Article
Depression is a complex and multifactorial disease, affecting about 6.5% of the elderly population in what is referred to as late-life depression (LLD). Despite its public health relevance, there is still limited information about the molecular mechanisms of LLD. We analyzed the blood plasma of 50 older adults, 19 with LLD and 31 controls, through...
Article
Full-text available
Late-life depression (LLD) is a risk factor for age-dependent cognitive deterioration. Norepinephrine-related degeneration in the locus coeruleus (LC) may explain this link. To examine the LC norepinephrine system in vivo, we acquired neuromelanin-sensitive MRI (NM-MRI) in a sample of 48 participants, including 25 with LLD (18 women, age 68.08±5.41...
Article
Objective In older adults, major depressive disorder (MDD) is associated with accelerated physiological and cognitive aging, generating interest in uncovering biological pathways that may be targetable by interventions. Growth differentiation factor-15 (GDF-15) plays a significant role in biological aging via multiple biological pathways relevant t...
Preprint
Introduction While aging is the strongest overall risk factor for Alzheimer’s disease (AD), it is unclear whether telomere shortening, a hallmark of accelerated biological aging, plays a role in development of AD. Methods Data from the large prospective UK Biobank cohort (n=435,046) were used to evaluate whether mid-life leukocyte telomere length...
Article
Full-text available
Importance: Many older adults with depression do not experience remission with antidepressant treatment, and markers of cellular senescence in late-life depression (LLD) are associated with greater severity of depression, greater executive dysfunction, and higher medical illness burden. Since these clinical characteristics are associated with remi...
Article
Full-text available
Background: Cognitive impairment and physical frailty are common among older adults and associated with a higher likelihood of adverse health outcomes. These two conditions frequently co-exist in the same individual as cognitive frailty, yet few studies have examined the impact of such comorbidity on clinical outcomes or underlying biological mecha...
Chapter
Due to improvements in general socio-economic conditions, better access to health care, better treatments, we are observing a growing number of individuals with bipolar disorder (BD) reaching the “golden age.” Nonetheless, this population presents with an accelerated aging phenotype, manifested by higher rates of age-related medical problems, cogni...
Conference Paper
Background: Despite the prevalence and public health importance, the biological mechanisms related to neuropsychiatry disorders are not well-defined. Most studies evaluated the molecular abnormalities related to these disorders examined changes in peripheral tissues (e.g., blood or plasma/serum), looking for possible peripheral biomarkers. However,...
Conference Paper
Full-text available
Background: Stress is characterized as a state in which intrinsic or extrinsic stimuli evoke a dynamic and complex repertoire of biological, physiological, and behavioral adaptive responses of the organism. Stress can be either a triggering or aggravating factor for many pathological conditions, including cancer, coronary heart disease, major depre...
Conference Paper
Background: In the past few decades, there is growing evidence that the growth differentiation factor-15 (GDF-15) plays a significant role in aging and multi-system disease development. The GDF-15 has a largely pleotropic effect and has been associated with both the development of cancers, metabolic, inflammatory, and cardiovascular diseases. Emerg...
Article
Background: Mood disorders such as major depressive (MD) and bipolar (BD), are major risk factors for Alzheimer's disease (AD). History of MD and BD can double the risk of developing AD in older adults, and this risk is even higher when depressive symptoms co-occur with mild cognitive impairment. These evidences suggest that mood disorders and AD...
Article
Full-text available
Prevention of major depressive disorder (MDD) is a public health priority. Identifying biomarkers of underlying biological processes that contribute to MDD onset may help address this public health need. This prospective cohort study encompassed 383,131 white British participants from the UK Biobank with no prior history of MDD, with replication in...
Article
Objective To evaluate the circulating cell-free mitochondrial DNA (ccf-mtDNA) levels, a marker of cellular stress and damage, in older adults with late-life depression (LLD) and frailty. We hypothesize that individuals with both frailty and LLD will have higher ccf-mtDNA levels than individuals with either condition in isolation. Methods Fifty-thr...
Article
Full-text available
Objectives Telomeres are structures at the extremity of chromosomes that prevents genomic instability, and its shortening seems to be a hallmark of cellular aging. Past studies have shown contradictory results of telomere length (TL) in major depression, and are a few studies in late-life depression (LLD). This explores the association between TL a...
Preprint
Full-text available
Background Mood disorders, including major depression (MD) and bipolar disorder (BD), are risk factors for Alzheimer’s disease (AD) and possibly share an overlapping genetic architecture. However, few studies have investigated the shared loci and potential pleiotropy among these disorders. Methods We carried out a systematic analytical pipeline us...
Article
Background Oxidative stress (OS) has been implicated in the pathophysiology of late-life depression (LLD). Mitochondria are the primary source of oxidative stress and can be significantly damaged with increased OS. Circulating cell-free mtDNA (ccf-mtDNA) is a marker of cellular stress and mitochondria damage triggered by oxidative stress. Methods:...
Article
The rapid growth of the older adult population poses new challenges in public health, as older adults are more susceptible to certain neurodegenerative and neuropsychiatric conditions. Understanding how the biological changes of aging influence the development of different neuropsychiatric disorders is therefore an important task. In this symposium...
Article
Introduction Major depressive disorder (MDD) and frailty are common disorders in elderly populations. These conditions are associated with a higher rate of negative health outcomes and comorbidity. In previous studies, the measurement of circulating cell-free mtDNA (ccf-mtDNA) has been used as biomarkers for cellular stress from increased oxidative...
Article
Full-text available
Introduction: The biological mechanisms linking mild cognitive impairment (MCI) and major depressive disorder are not well understood. We investigated whether molecular senescence changes in older adults are associated with a history of major depressive disorder (MDD) or MCI. Methods: We included 371 participants: 167 with MCI; 62 cognitively no...
Article
Background DNA oxidative damage is a marker of increased oxidative stress activity. Elevated DNA oxidative damage has been associated with major depressive disorder in young adults, but there is no information about DNA oxidative damage in late-life depression. This study aims to evaluate whether older adults with late-life depression (LLD) has inc...
Article
The root cause of non-inherited Alzheimer's disease (AD) remains unknown despite hundreds of research studies performed to attempt to solve this problem. Since proper prophylaxis remains the best strategy, many scientists have studied risk factors that may affect AD development. There is robust evidence supporting the hypothesis that cardiovascular...
Article
Background We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4). Methods Participants were 30,785 dementia-free individuals aged 55-103 years, from 18 longitudinal cohort studies,...
Article
Full-text available
Objective: To compare mortality in older adults with and without mild or moderate cognitive impairment over 15 years of follow-up in a middle-income country, where little information on this subject is available. Methods: A total of 1,281 community-dwelling older adults were followed-up for a median of 13.3 years. We evaluated their cognitive impa...
Article
Full-text available
Background: Available evidence suggests that adjunctive treatment with immunomodulatory medications may be effective in the treatment of major depressive disorder (MDD). A pilot trial of the tetracycline minocycline as adjunctive treatment in treatment-resistant depression (TRD), produced promising results, however, a larger scale trial is needed...
Article
The rapid growth of the older adult population poses new challenges in public health, as older adults are more susceptible to certain neurodegenerative and neuropsychiatric conditions. Understanding how the biological changes of aging influence the development of different neuropsychiatric disorders is therefore an important task. In this symposium...
Article
Frailty and cognitive impairment are among the 2 most common geriatric syndromes. Their presence poses major risks to the elderly including greater disability, reduced quality of life, and higher morbi-mortality. Recent evidence suggest that frailty can be a risk factor for incident dementia. The opposite is also true since subjects with Alzheimer'...
Article
Biomarkers intersection between depression, diabetes, and cognitive impairment - Volume 32 Issue 1 - Breno S. Diniz
Article
Background: The role of vitamin D is not only limited to bone health and pathogenesis of chronic diseases. Evidence now suggests that it is also involved in the development of various dementias and Alzheimer's disease (AD). Objective: To carry out a systematic review and meta-analysis to evaluate the association between vitamin D levels and incr...
Article
Full-text available
Background Both diabetes and depression increase the mortality risk in the elderly. In this study, we evaluated mortality risk associated with the comorbidity between depression and diabetes. We also assessed the moderating role of inflammation in the mortality risk in this population. Methods We included a total of 1,183 community‐dwelling older...
Article
Full-text available
Recent evidence suggests a significant overlap in biological changes between major depression and aging across the lifespan. We aim to evaluate the impact of a major depressive episode on the Senescence-Associated Secretory Phenotype (SASP) index, a dynamic secretory molecular pattern indicative of cellular senescence. We also tested the potential...
Article
Background: Alzheimer's disease (AD) is the most common neurodegenerative disease causing dementia in the elderly population. Due to the fact that there is still no cure for Alzheimer's dementia and available treatment strategies bring only symptomatic benefits, there is a pressing demand for other effective strategies such as diet. Since the infl...
Article
Full-text available
Abstract Objectives We aim to investigate the association between white matter integrity and accelerated brain aging in late-life depression. Methods We measured senescence-associated secretory phenotype (SASP) index proteins, cognitive performance, and MRI diffusion tensor imaging (DTI) measures of fractional anisotropy and mean diffusivity based...
Article
Full-text available
One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication between the gut and the brain. Scientists suggest that human gut microflora may even act as the “second brain” and be responsible for neurodegenerative disorders like Alzheimer’s disease (AD)....
Article
LLD affects 3% of community-dwelling adults over 60 years old, and 15% of older adults have clinically significant depressive symptoms. LLD increases an older adult's risk of disability by 67-73% over 6 year follow up, causes twice the functional impairment compared to those without LLD, increases mortality in patients with heart disease, and is as...
Article
Epidermal growth factor (EGF) and Fibroblast Growth Factor-2 (FGF-2) are growth factors involved neuronal growth and synaptic plasticity. These markers have been implicated in neuropsychiatric disorders, including major depression. However, no particular studies of EGF and FGF-2 have been conducted in older adults with major depressive disorder (MD...
Chapter
Aging is a complex process associated with significant physiological functions across all body systems, especially the immune system. The age-related changes in the immune system are collectively known as immunosenescence. As a consequence of immunosenescence, advanced age is characterized by a decrease in the ability to cope with stressors. The mu...
Article
Full-text available
Psychosocial factors appear to be associated with increased risk of disability in later life. However, there is a lack of evidence based on long-term longitudinal data from Western low-middle income countries. We investigated whether psychosocial factors at baseline predict new-onset disability in long term in a population-based cohort of older Bra...
Article
Major depressive disorder in the elderly-or late-life depression (LLD)-is one of the most common mental illnesses in the aging population. LLD has several negative effects on health and well-being. Individuals with LLD have an elevated risk of chronic and persistent depressive symptoms as well as high rates of treatment resistance. They also have a...
Article
Full-text available
A growing body of evidence indicates that systemic lupus erythematosus (SLE) is associated with increased risk of cognitive impairment and dementia. However, to date, no studies have been conducted to quantitatively summarize and evaluate the consistency of data. Objective To quantitatively evaluate the relationship of SLE and antiphospholipid ant...
Article
Full-text available
Introduction: Progress in understanding and management of vascular cognitive impairment (VCI) has been hampered by lack of consensus on diagnosis, reflecting the use of multiple different assessment protocols. A large multinational group of clinicians and researchers participated in a two-phase Vascular Impairment of Cognition Classification Conse...
Article
Background: Oxidative stress has been implicated in the pathophysiology of mood disorders in young adults. However, there is few data to support its role in the elderly. The primary aim of this study was to evaluate whether subjects with late-life depression (LLD) presented with changes in oxidative stress response in comparison with the non-depre...
Article
Full-text available
Inflammatory reactions could be both beneficial and detrimental to the brain, depending on strengths of their activation in various stages of neurodegeneration. Mild activation of microglia and astrocytes usually reveals neuroprotective effects and ameliorates early symptoms of neurodegeneration; for instance, released cytokines help maintain synap...
Article
Full-text available
Objective: A consistent body of research has confirmed that patients with major depressive disorder (MDD) have increased concentrations of pro-inflammatory cytokines, including IL-6, TNF-α, IL-1β, the soluble IL-2 receptor, and C-reactive protein, compared to controls; however, there is limited information on IL-17A in MDD. Moreover, information ab...
Article
Full-text available
Objective: To examine associations among substance use disorder (SUD) and measures of length of stay (LOS) and non-psychiatric medical comorbidity (MEDCO) in older-adult inpatients with serious mental illness (SMI), hypothesizing SUD would be related to worse clinical outcomes. Methods: A cross-sectional study analyzed medical records from 2010...
Article
Objective: Depressive symptoms are common among older adults with obesity and diabetes. Nonetheless, the mechanisms for this association are not clear but may involve changes in the insulin cascade signaling. We aimed to investigate the association, and potential mediators, between obesity, insulin resistance, and depressive symptoms among older a...
Article
Aim: Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore, this study was designed to evaluate plasm...
Article
Objective: Impulsivity is a well-established trait of bipolar disorder (BD) that persists across mood phases. It is, however, still unknown whether, in BD, impulsivity remains stable or varies in intensity over the lifespan. This cross-sectional study compared impulsive behavior in older euthymic BD patients and healthy individuals using a range o...
Conference Paper
Full-text available
Introduction: Late-life depression is one of the most common psychiatric diseases among the elderly and may cause or intensify physical disorders. Major depression in older adults can be understood as an interaction of various risk factors such as stressful events, vulnerabilities, genetic factors, cognitive decline and neurobiological changes rela...
Article
OBJECTIVE: To examine associations among substance use disorder (SUD) and measures of length of stay (LOS) and non-psychiatric medical comorbidity (MEDCO) in older-adult inpatients with serious mental illness (SMI), hypothesizing SUD would be related to worse clinical outcomes. METHODS: A cross-sectional study analyzed medical records from 2010 to...
Article
Full-text available
Objective: We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia. Methods: We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of B...