Brenna R. Pugliese

Brenna R. Pugliese
North Carolina State University | NCSU · Department of Clinical Sciences

Doctor of Veterinary Medicine

About

16
Publications
973
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154
Citations
Introduction
Brenna is a veterinarian and PhD student at NC State University. She completed her DVM and Master of Comparative Biomedical Sciences at Cummings School of Veterinary Medicine at Tufts University. Thereafter she pursued a clinical equine internship, followed by a Veterinary Research Fellowship at the AO Research Institute. Brenna completed a Large Animal Surgery Residency at Cornell University in 2023. Her research focuses on regenerative therapies for musculoskeletal disease in horses.
Additional affiliations
July 2019 - July 2020
AO Foundation
Position
  • Veterinary Research Fellow
Education
August 2013 - May 2018
Tufts University
Field of study
  • Veterinary Medicine
August 2009 - May 2013
Worcester Polytechnic Institute
Field of study
  • Biology & Biotechnology

Publications

Publications (16)
Article
Full-text available
Objective We aimed to study the antimicrobial and pro‐healing potential of equine mesenchymal stromal cell secreted products (i.e. secretome), collected as conditioned media (mesenchymal stromal cell‐conditioned media, MSC CM), in a novel in vivo model of methicillin‐resistant Staphylococcus aureus (MRSA)‐inoculated equine thorax wounds. Study des...
Article
A 20‐year‐old Warmblood broodmare was admitted to evaluate bilateral nasal discharge (primarily left) and difficulty masticating grain, without weight loss. During oral endoscopy, thick purulent discharge (pus) was seen along the palatal gingival attachment of the left maxillary third and fourth premolars (207, 208 Triadan). Nasal endoscopy encount...
Article
Full-text available
Simple Summary Equine castration is a commonly performed veterinary surgical procedure in young colts. The procedure involves surgical removal of both testicles by transection of the spermatic cord. One complication of the procedure includes persistent hemorrhage from blood vessels within the spermatic cord and surrounding tissues. In severe cases,...
Article
Objective: To describe the successful restoration of superior eyelid function in a horse following traumatic avulsion using an advancement flap blepharoplasty and subdermal hyaluronic acid filler. Animal studied: A 21-year-old American Paint Horse stallion who was attacked by a fellow stallion resulting in numerous traumatic injuries including a...
Article
Full-text available
Articular cartilage has limited healing capacity and no drugs are available that can prevent or slow the development of osteoarthritis (OA) after joint injury. Mesenchymal stromal cell (MSC)-based regenerative therapies for OA are increasingly common, but questions regarding their mechanisms of action remain. Our group recently reported that althou...
Preprint
A 20-year-old Warmblood broodmare was presented to the primary veterinarian for bilateral nasal discharge, which had been treated with sulfamethoxazole without complete resolution. The mare was referred to Cornell’s Equine Hospital after she began dropping feed without losing weight. Oral exam, radiography, computed tomography (CT) of the head, and...
Article
Full-text available
Cartilage and other skeletal soft tissues heal poorly after injury, in part due to their lack of vascularity and low metabolic rate. No pharmacologic approaches have proven effective in preventing chronic degenerative disease after joint injury. Mesenchymal stromal cells (MSCs) have been investigated for their ability to treat pain associated with...
Article
Orthopedic device‐related infection (ODRI) preclinical models are widely used in translational research. Most ODRI models require induction of general anesthesia, which frequently results in hypothermia in rodents. This study aimed to evaluate the impact of peri‐anesthetic hypothermia in rodents on outcomes in preclinical ODRI studies. A retrospect...
Article
Objective: To determine the influence of screw head diameter on equine condylar fracture fixation with 5.5 mm cortical screws. Study design: Ex vivo, biomechanical study, blinded, matched-pair design. Sample population: Fifteen pairs of equine third metacarpal (MC3) bones. Methods: Lateral condylar fractures were simulated by parasagittal os...
Article
Full-text available
Short-chain fatty acids (SCFAs) produced by the gut microbiota have previously been demonstrated to play a role in numerous chronic inflammatory diseases and to be key mediators in the gut-bone signaling axis. However, the role of SCFAs in bone fracture healing and its impact on systemic inflammation during the regeneration process has not been ext...
Article
Full-text available
OBJECTIVE To investigate the effects of novel legwear designed to limit metacarpophalangeal joint (MCPJ) extension and redirect loading forces from the flexor apparatus through analyses of 2-D kinematic and kinetic data. ANIMALS 6 adult horses without musculoskeletal disease. PROCEDURES Horses were subjected to 4 treatments: control (no legwear), i...
Article
Full-text available
OBJECTIVE To evaluate the ability of novel legwear designed to limit extension of the metacarpophalangeal joint (MCPJ) to redirect loading forces from the flexor apparatus during walk, trot, and canter on a treadmill and during unrestrained and restrained activity in a stall. ANIMALS 6 adult horses without musculoskeletal disease. PROCEDURES Legwea...
Article
The objective was to validate a scientific method for characterizing equine metacarpophalangeal joint (MCPJ) motion in the nonfatigued and fatigued states using a single horse at trot, slow canter, and fast canter. One healthy Thoroughbred gelding exercised on a treadmill to exhaustion (fatigued state) (heart rate >190 BPM and blood lactate >10 mmo...
Article
X-ray reconstruction of moving morphology (XROMM) uses biplanar videoradiography and computed tomography (CT) scanning to capture three-dimensional (3D) bone motion. In XROMM, morphologically accurate 3D bone models derived from CT are animated with motion from videoradiography, yielding a highly accurate and precise reconstruction of skeletal kine...
Article
Full-text available
Background: Inflammatory airway disease (IAD) in horses, similar to asthma in humans, is a common cause of chronic poor respiratory health and exercise intolerance due to airway inflammation and exaggerated airway constrictive responses. Human rhinovirus is an important trigger for the development of asthma; a similar role for viral respiratory di...

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