Brandon M Lehrich

Brandon M Lehrich
University of Pittsburgh | Pitt · School of Medicine

Bachelor of Science

About

66
Publications
6,280
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393
Citations

Publications

Publications (66)
Article
Purpose: To present rectal toxicity rates in patients administered a polyethylene glycol (PEG) hydrogel rectal spacer in conjunction with combination high-dose-rate brachytherapy and external beam radiotherapy. Methods and materials: Between February 2010 and April 2015, 326 prostate carcinoma patients underwent combination high-dose-rate brachy...
Article
Full-text available
It is known that culture media (CM) promotes cellular growth, adhesion, and protects explanted primary brain cells from in vitro stresses. The fetal bovine serum (FBS) supplement used in most CM, however, contains significant quantities of extracellular vesicles (EVs) that confound quantitative and qualitative analyses from the EVs produced by the...
Article
Full-text available
Background: The novel coronavirus disease 2019 (COVID-19) pandemic is an urgent public health crisis, with epidemiologic models predicting severe consequences, including high death rates, if the virus is permitted to run its course without any intervention or response. Contact tracing using smartphone technology is a powerful tool that may be emplo...
Article
Objectives/Hypothesis There exists a lack of consensus on the optimal sequence of treatment for many sinonasal malignancies (SNMs). This study compares the overall survival (OS) outcomes for primary surgery (PS) versus salvage surgery (SS) in SNM patients across stage, histology, and primary site. Study Design Retrospective database review. Metho...
Article
Objective: Pain control is an important topic that has not been extensively studied in patients undergoing endoscopic skull base surgery (ESBS). The purpose of this study is to identify opioid requirements after ESBS and the risk factors predictive of increased use. Methods: This study was a retrospective review of all patients undergoing ESBS a...
Article
Long‐term survival and recurrence patterns of squamous cell carcinoma arising from inverted papilloma (IP‐SCC) have not been thoroughly investigated. Four electronic databases were searched and primary studies describing overall survival (OS), recurrence, and mean time to recurrence of patients with IP‐SCC were included for review. Our search yield...
Article
Objectives Skull base chordomas are locally aggressive malignant tumors derived from the notochord remnant. There are limited large-scale studies examining the role and extent of surgery and radiation therapy. Design Analysis of the National Cancer Database (NCDB) was performed to evaluate the survival outcomes of various treatments, and to assess...
Article
Background No study to date has analyzed the progression of sinonasal symptoms over time in COVID-19 patients. The purpose of this study is to analyze the progression of sinonasal symptoms and risk factors for olfactory dysfunction in the mild severity COVID-19 patient. Methods An internet survey was used to assess sinonasal symptoms in patients w...
Article
Objective Chondrosarcomas of the skull base are rare tumors most commonly treated surgically with or without adjuvant radiation therapy. Using the National Cancer Database (NCDB), we analyzed overall survival (OS), treatment modalities, and prognosticators. Methods The NCDB was queried for all cases of histologically confirmed skull base chondrosa...
Article
Full-text available
Objective Pituitary adenomas in the pediatric population are extremely rare, resulting in limited information in the literature on these patients. In this study, data from the National Cancer Database (NCDB) to compare pituitary adenoma clinical presentations, treatment management patterns, and overall survival between pediatric and adult patients....
Article
The objective of this study is to evaluate the impact of preoperative frailty on short-term outcomes following intradural resection of skull base lesions. The 2005–2017 ACS-NSQIP database was queried for 30-day post-operative outcomes of patients undergoing intradural resection of the skull base, extracted by CPT codes 61601, 61606, 61608, and 6161...
Article
Full-text available
Objective To examine neurotologists' 2013 to 2016 Medicare Part-D data and evaluate commonly prescribed medications, longitudinal changes in prescribing patterns, presumed associated pathologies, and cost distribution across United States. Methods Comprehensive prescription data of Part-D-participating neurotologists was quiered from the 2013 to 2...
Article
Objectives/Hypothesis To identify prognosticators and determine the efficacies of surgery with adjuvant radiotherapy (SR) and surgery with immunotherapy (SI) of head and neck mucosal melanoma (HNMM). Study Design Retrospective database study. Methods The 2004 to 2017 National Cancer Database was queried for HNMM patients. Cox proportional hazards...
Article
Objective To review overall survival (OS), recurrence patterns, and prognostic factors of de novo sinonasal squamous cell carcinoma (DN-SCC). Data Sources PubMed, Scopus, OVID Medline, and Cochrane databases from 2006 to December 23, 2020. Review Methods The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PR...
Conference Paper
Full-text available
Background: Tranexamic acid (TXA) is an antifibrinolytic agent associated with reduced blood loss and mortality in a wide range of procedures including spine surgery, traumatic brain injury (TBI), and craniosynostosis. Despite this, the safety and efficacy of TXA in spine surgery has been considered controversial due to a relative scarcity of liter...
Article
Full-text available
PurposeLess than 5% of chordomas occur in pediatric patients. While many studies have explored the treatment and outcomes of skull base chordomas, few have focused on the differences between pediatric and adult populations. The aim of this study is to analyze the epidemiological variables and clinical outcomes between pediatric and adult skull base...
Article
The emerging literature regarding the novel coronavirus disease 2019 (COVID-19) suggests that patients with olfactory dysfunction (OD) have a milder disease course with improved clinical symptomatology and outcomes. This study utilized the National Library of Medicine’s PubMed/MEDLINE database to query for articles describing major outcomes in pati...
Article
Background This study evaluates the influence of facility case‐volume on nasopharyngeal carcinoma (NPC) treatments and overall survival (OS). Methods The 2004–2015 National Cancer Database was queried for patients with NPC receiving definitive treatment. Results A total of 8260 patients (5‐year OS: 63.4%) were included. The 1114 unique facilities...
Article
Objectives To evaluate the impact of preoperative frailty on short-term outcomes following complex head and neck surgeries (HNSs). Study Design Cross-sectional database analysis. Setting American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Methods The 2005 to 2017 ACS-NSQIP was queried for patients und...
Article
Full-text available
Purpose This study uses a large-population national database to describe the presenting clinical, sociodemographic, treatment, and clinical outcome differences between pediatric and adult craniopharyngiomas. Methods This study utilized the 2004–2015 National Cancer Database and was queried for all cases of craniopharyngioma. Multivariate Cox propo...
Article
Objective Osteosarcomas of the skull base are rare and aggressive tumors that are most commonly treated with primary surgical resection and adjuvant chemoradiation. Using the National Cancer Database (NCDB), we analyzed demographic and clinical prognosticators for overall survival (OS). Methods The NCDB was queried for cases of histologically conf...
Article
Full-text available
Extracellular vesicles (EVs) are released by many cell types and distributed within various biofluids. EVs have a lipid membrane‐confined structure that allows for carrying unique molecular information originating from their parent cells. The species and quantity of EV cargo molecules, including nucleic acids, proteins, lipids, and metabolites, may...
Article
Objectives/hypothesis: This study utilizes a large population national database to comprehensively analyze prognosticators and overall survival (OS) outcomes of varying treatment modalities in a large cohort of sinonasal diffuse large B-cell lymphoma (SN-DLBCL) patients. Study design: Retrospective database study. Methods: The National Cancer Dat...
Article
Background Esthesioneuroblastoma (ENB) is an uncommon sinonasal malignancy and is even less common in the pediatric population. Objective The purpose of this study is to compare characteristics and outcomes of ENB between adult and pediatric patients. Methods The National Cancer Database was queried for patients with histologically proven ENB of...
Conference Paper
Introduction: There are currently no large-sample studies assessing the clinical outcomes of pituitary adenomas (PA) patients undergoing active surveillance (AS) versus definitive treatment (DT). This population-based analysis aims to identify clinical and sociodemographic predictors of undergoing AS and compare clinical outcomes of PA patients und...
Conference Paper
Introduction: There remain controversies regarding whether elderly patients are predisposed to more complications following pituitary adenoma (PA) surgical resection. This study utilizes a large-population national database to compare clinical outcomes between young and elderly patients receiving either endoscopic surgery (ES) or nonendoscopic surg...
Conference Paper
Full-text available
INTRODUCTION: Advancing age and greater number of medical comorbidities are well-known risk factors for higher rates of surgical complications and undesirable outcomes. METHODS: We identified 107 patients who underwent DBS for PD at our institution from 2008-2018. Patients' records were retrospectively reviewed and divided into three groups based o...
Article
Background Recently, there has been increased interest in patient satisfaction measures such as Press Ganey and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys. This systematic review aims to analyze the available spine surgery literature to evaluate factors predictive of patient satisfaction as measured by these s...
Article
Introduction The short-term adverse events and predictors of morbidity in surgical resection of esthesioneuroblastoma (ENB) are largely unknown, and investigating these variables can help direct planning for at-risk patients. Methods The 2005–2017 National Surgical Quality Improvement Program database was queried to identify patients with a diagno...
Article
Objectives To comprehensively investigate nasopharyngeal carcinoma (NPC) treatment, overall survival (OS), and the influence of clinical/sociodemographic factors on outcome. Study Design Retrospective database study. Setting National Cancer Database. Methods The 2004-2015 National Cancer Database was queried for all patients with NPC receiving d...
Article
Background Achieving functional repair after peripheral nerve injury (PNI) remains problematic despite considerable advances in surgical technique. Therein, questions lie regarding the variable capacity of peripheral nerves to regenerate based on environmental influence. In-depth analyses of multiple therapeutic strategies have ensued to overcome t...
Article
Full-text available
Objective: Frailty is a clinical state of increased vulnerability due to age-associated decline and has been well established as a perioperative risk factor. Geriatric patients have a higher risk of frailty, higher incidence of brain cancer, and increased postoperative complication rates compared to nongeriatric patients. Yet, literature describin...
Article
Full-text available
Despite the peripheral nervous system's (PNS) capacity to regenerate, functional restoration is highly variable following peripheral nerve injury (PNI), oftentimes leading to persistent functional deficits. In the preclinical arena, advances in the therapeutic use of exogenous neurotrophic factors and synthetic neural scaffold technology hold promi...
Article
Introduction: The emergence of popular online rating websites, social media platforms, and public databases for industry payments and scholarly outputs provide a complete physician online presence which may guide choice and satisfaction. Methods: Websites of all U.S. otolaryngology academic institutions were queried for fellowship-trained rhinol...
Article
Objectives: Esthesioneuroblastoma (ENB) is a rare sinonasal malignancy arising from olfactory neuroepithelium. Recurrence typically occurs locoregionally at the primary site or in the form of cervical metastasis. Delayed local recurrence away from the initial primary site is exceedingly rare. Methods: Retrospective review of four patients with h...
Article
Full-text available
Dr. James Tait Goodrich was an internationally renowned pediatric neurosurgeon who pioneered the neurosurgical procedures for the multistage separation of craniopagus twins. As of March 2020, 59 craniopagus separations had been performed in the world, with Goodrich having performed 7 of these operations. He was the single most experienced surgeon i...
Article
Full-text available
Much of the published literature regarding the novel corona-virus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, including chemosensory and/or sinonasal dysfunction. This study utilized the National Library of Medi...
Preprint
Full-text available
BACKGROUND The novel coronavirus disease 2019 (COVID-19) pandemic is an urgent public health crisis, with epidemiologic models predicting severe consequences, including high death rates, if the virus is permitted to run its course without any intervention or response. Contact tracing using smartphone technology is a powerful tool that may be employ...
Article
Objective The influence of graft type (non-autologous versus autologous) on surgical outcomes in endoscopic anterior skull base (EASB) reconstruction is not well-understood. This review systematically evaluated rates of post-operative complications of EASB repairs that utilized autologous or non-autologous grafts. Methods Original studies reportin...
Article
Objective: For symptomatic nonsecreting pituitary adenomas (PAs), resection remains a critical option for treatment. In this study, the authors used a large-population national database to compare endoscopic surgery (ES) to nonendoscopic surgery (NES) for the surgical management of PA. Methods: The National Cancer Database was queried for all pa...
Article
Background: Sinonasal undifferentiated carcinoma (SNUC) is an uncommon malignancy of the nasal cavity and accessory sinuses with limited available studies evaluating role of induction chemotherapy (IC), demographics, and socioeconomic factors on overall survival (OS). Methods: The 2004-2015 National Cancer Database was queried for patients with...
Article
Full-text available
Purpose We report on the long-term clinical outcomes of clinically localized prostate carcinoma (PCa) patients treated with external beam radiotherapy (EBRT) in combination with high-dose-rate brachytherapy boost (HDR-B). Material and methods Between 2002 and 2015, 538 prostate carcinoma patients underwent combined HDR-B (Ir-192) of 16 Gy over 4 f...
Research
Comments regarding publication: DriedonksTAP,NijenTwilhaarMK,Nolte-‘THoenENM. Technical approaches to reduce interference of Fetal calf serum derived RNA in the analysis of extracellular vesicle RNA from cultured cells. J Extracell Vesicles. 2019;8 (1):1552059. Please note above author's response to our Letter to the editor: Tom A.P. Driedonks & E...
Article
Objective: To assess the risk recall of complications among patients who underwent different vestibular schwannoma (VS) treatments. Study design: Patients with VS completed a voluntary and anonymous survey. Setting: Survey links were distributed via the Acoustic Neuroma Association (ANA) website, Facebook, and email list. Subjects and methods...
Article
Full-text available
Objective This study reports on the 5-year biochemical-relapse free survival (bRFS), and late gastrointestinal (GI) and genitourinary (GU) toxicities of patients who underwent a prostatectomy and received high dose (> 72 Gy) radiation therapy with an absorbable polyethylene glycol (PEG) rectal spacer implant. Methods From January 2010 to October 2...
Article
Objectives: To analyze medical malpractice lawsuit trends pertaining to cases of vestibular schwannomas (VS). Methods: Two major computerized legal databases (LexisNexis and WestLaw) were queried and reviewed for evaluation of all the US state and federal court records from civil trials alleging malpractice between 1976 and 2016. Results: A to...
Article
Objectives: To assess and characterize patients' online ratings and comments of neurotologists and determine factors that correlate with higher ratings. Methods: All the American Neurotology Society members were queried on Healthgrades, Vitals, RateMDs, Yelp, and Google from March to June 2018. All ratings were normalized for comparison on a fiv...
Code
Research Project for Pooya Khosravi, Department of Information and Computer Sciences and Brandon M. Lehrich, Department of Biomedical Engineering, for Bio199. BPM ExoPlot is a MATLAB (needs 2017b or above) application that allows the user to load multiple sample replicates of the ZetaVIEW (Particle-Metrix) .txt file acquisition measurements via des...
Code
Description: Research Project for Brandon M. Lehrich, Department of Biomedical Engineering, for Bio199, and Pooya Khosravi, Department of Information and Computer Sciences. BPM Plot: A MATLAB® application that allows the user to load multiple sample replicates of the ZetaVIEW® (Particle-Metrix) .txt file acquisition measurements via designated fold...
Article
Background: To report 3-year outcomes of patients treated with combination high-dose-rate (HDR) brachytherapy with intensity modulated radiation therapy (IMRT) for prostate carcinoma. Methods: Between 2002 and 2014, 324 prostate carcinoma patients received combination HDR brachytherapy [Iridium-192 (Ir-192)] and external beam IMRT. A total of 16 Gr...

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