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PhD-student at the Ghent Research Group on Nanomedicines (Department of Pharmaceutics, Ghent University) under Prof. dr. Koen Raemdonck and Prof. dr. Stefaan De Smedt. Main focus is the development of a lipid nanoparticle platform for cellular delivery of RNA therapeutics
Since the recent clinical approval of siRNA-based drugs and COVID-19 mRNA vaccines, the potential of RNA therapeutics for patient healthcare has become widely accepted. Lipid nanoparticles (LNPs) are currently the most advanced nanocarriers for RNA packaging and delivery. Nevertheless, the intracellular delivery efficiency of state-of-the-art LNPs...
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Due to a lack of effective treatments, patients with metastatic disease have a median survival time of 6-12 months. We recently demonstrated that the SAMMSON long non-coding RNA (lncRNA) is essential for uveal melanoma cell survival and that antisense oligonucleotide (...
RNA interference (RNAi) enables highly specific silencing of potential target genes for treatment of pulmonary pathologies. The intracellular RNAi pathway can be activated by cytosolic delivery of small interfering RNA (siRNA), inducing sequence-specific gene knockdown on the post-transcriptional level. Although siRNA drugs hold many advantages ove...
Small nucleic acid (NA) therapeutics, such as small interfering RNA (siRNA), are generally formulated in nanoparticles (NPs) to overcome the multiple extra- and intracellular barriers upon in vivo administration. Interaction with target cells typically triggers endocytosis and sequesters the NPs in endosomes, thus hampering the pharmacological acti...
In article number 1703658, Yuezhou Zhang, Hongbo Zhang, and co‐workers discuss the biomedical applications of DNA‐based materials. Due to the well understood interactions of four types of nucleotides, which serve as the building blocks of DNA, the programmable and versatile structure is readily achieved and multifaceted functionalities are assigned...
Introduction: In recent years, several types of nanomaterials have been developed as drug delivery systems, allowing to obtain those with the most favourable pharmacological properties for medicinal treatment. Acetalated dextran (Ac-Dex) is an interesting spherical polymer due to its ability to hydrolyse in acidic conditions, while remaining stable...