Brahmaiah Bonthagarala

Brahmaiah Bonthagarala
Hindu College of Pharmacy | HCOPGNT · Department of Pharmaceutics and Dept of Drug Regulatory Affairs

M.Pharm,(Ph.d)

About

90
Publications
344,851
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298
Citations
Citations since 2016
23 Research Items
245 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Additional affiliations
October 2016 - present
Hindu college of pharmacy
Position
  • Professor (Assistant)
June 2012 - present
Hindu College of Pharmacy
Position
  • Professor (Assistant)
June 2012 - present
Hindu College of Pharmacy
Position
  • Professor (Assistant)

Publications

Publications (90)
Article
Full-text available
Nano medicine is a revolutionizing field that can benefit both diagnosis and treatment and contribute to a better quality of life. Despite the expected huge benefits, the potential risks on human health are significant as well. This thesis aims to defense a perspective that in case of nascent technologies, where the data are still emerging and scie...
Article
The present research work describes the formulation development of liquisolid compact tablets of pioglitazone for improving its dissolution performance and antidiabetic activity. Using Quality by Design (QbD) approach, a total of nine formulations were prepared as per the central composite design (CCD) by selecting colloidal silicon dioxide and mic...
Article
Full-text available
Aim: The present study revolved around determining the effect of increase in the solubility of these drugs at the absorption site using ritonavir as a drug model. Materials & methods: Ritonavir per-oral tablets were prepared using versatile and nonionic surfactants having high solubilization rate, which were further marked with high rate of dissolu...
Article
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Polymeric drug delivery system can enhance bioavailability, therapeutic efficacy and decrease the side effects of drugs. Past polymer technologies focussed mainly on linear polymers.Currently, highly branched polymers have been found whose properties are diff erent from conventional polymers. Of these polymeric Drug delivery systems, Dendrimers are...
Article
Full-text available
Cosmeceuticals is now commonly used to describe a cosmetic product that exerts a pharmaceutical therapeutic benefit but not necessarily a biologic therapeutic benefit. Cosmetics are products that are used to cleanse and beautify the skin.The aim of this review is to summarize cosmeceutical properties of the various botanicals, vitamins, alpha lipoi...
Article
Full-text available
Solubility is one of the important parameter to achieve desired concentration of drug in systemic for pharmacological respons e to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility....
Article
Full-text available
Cosmeceuticals is now commonly used to describe a cosmetic product that exerts a pharmaceutical therapeutic benefit but not necessarily a biologic therapeutic benefit. Cosmetics are products that are used to cleanse and beautify the skin.The aim of this review is to summarize cosmeceutical properties of the various botanicals, vitamins, alpha lipoi...
Article
Full-text available
The main objective of project is to make clear understanding of current Regulatory requirements for registration of medicines, compilation and submission of dossier in Australia. Therapeutic Goods Administration (TGA) regulates all the medicines in Australia, which is a division or part of Australian Department of Health and Ageing administering. A...
Article
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Abstract: Regulatory affairs (RA) professionals play critical roles in a pharmaceutical industry because it is concern about the healthcare product lifecycle, it provide strategic, tactical and operational direction and support for working within regulations to expedite the development and delivery of safe and effective healthcare products to indiv...
Article
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Abstract: Branded drugs play an important role in medications, but generics are their cost effective alternatives. Generics are similar to branded drugs in terms of purity, efficacy and are perceived to be safer as compared to new drug molecules, as they tend to be older and time tested. Indian pharmaceutical market of generic drugs is increasing d...
Article
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A regulatory process, by which a person/organization/sponsor/innovator gets authorization to launch a drug in the market, is known as drug approval process. In general, a drug approval process comprises of various stages: application to conduct clinical trials, conducting clinical trials, application to marketing authorization of drug and post-mark...
Article
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Organization (CDSCO), headed by the Drug Controller General of India (DCGI), lays down the regulations for the conduct of clinical trials in India. The conduct of trials, regulations in India and quality of data generated may be the cause for this development. It is essential that now all clinical trials conducted in India should as per the Interna...
Article
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Quality is the primordial intention to any industry and its products manufactured. Multiple views on obtaining such quality are the current interest in the pharmaceutical industry. Validation is the art of designing and practicing the designed steps alongside with the documentation. Validation and quality assurance will go hand in hand, ensuring th...
Article
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This study put forth the differences in registration requirements for generics in United States and Canada. Generic drugs in US they are approved under the Abbreviated New Drug Application. Bioavailability and Bioequivalence study data is critical in the generic drug approval process. Generic manufacturers must file an Abbreviated New Drug Submissi...
Article
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ABATRACT The purpose of the study was to compare generic drug registration process and to find out the differences, lacunae among the guidelines. Brazil, Russia, India, China and South Africa are typically rendered as "the BRICS" or "the BRICS economies". The registration process for Brazil and Russia are completely different. Even though India, C...
Article
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The aim of this study was to formulate and investigate the in vitro performance of Lansoprazole press-coated tablets for delayed release. To develop pharmaceutically stable, cost effective and quality improved formulation of Lansoprazole delayed release tablets. To study the effect of various concentrations of different dry polymers for the formula...
Article
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ABSTRACT: The aim of my present study is to Develop and Evaluate Microemulsion for topical application of Aceclofenac by using oleic acid at different ratios for the treatment of pain. Microemulsion was prepared by water trituration method using oleic acid as oil phase, tween-80 as surfactant and polyethylen glycol-400 as co-surfactant. Different o...
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Salicorniabrachiata is a euhalopytic plant belonging to the family Chenopodiaceae. The present study investigates the phytochemistry, characterization and antimitotic activity of ethanolic extract of S.brachiata.Plants popularly known as Sea asparagus are cooked and eaten or pickled. It is also a good fodder for cattle, sheep and goat. Plant materi...
Article
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The purpose of this work is to present an introduction and general overview on process validation of pharmaceutical manufacturing process especially tablet manufacturing process with special reference to the requirements stipulated by the US Food and Drug Administration (FDA).Quality is always an imperative prerequisite when we consider any product...
Article
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Present review highlights the potential of nasal mucosa as an administration route for targeting the centralnervous system, the brain. Targeted drug delivery seeks to concentrate the medication in the tissues ofinterest while reducing the relative concentration of medication in the remaining tissues. Thus improvingefficacy of the drug and reducing...
Article
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The objective of the present study was to prepare nanofibers of Lornoxicam by Electro spinning technique and to increase the drug bioavailability using different polymers such as PMMA, Ethyl Cellulose, Polyethylene oxide, Gelatin. Totally 15 different formulations of Lornoxicam were prepared by Electro spinning technique and prepared nanofibers are...
Article
Full-text available
The aim of this study was to improve the dissolution rate of the poorly soluble drug Clofibrate by delivering the drug as a liquisolid compact. Liquisolid compacts were prepared using propylene glycol as solvent, microcrystalline cellulose as carrier, Starch, Silica and Lactose are used as coating materials. Sodium starch glycolate and Cross carmel...
Article
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The study was carried to formulate and evaluate dispersible tablet dosage form obtaining Nateglinide.Nateglinideis adrugfor the treatment oftype 2 diabetes. The present study is an attempt to select best possible combination of diluents and disintegrates to formulate dispersible tablet of Nateglinide which disintegrates within few minutes thereby r...
Article
Full-text available
ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing compressible powders by blending with selected powder excipents. By using this method dissolution rate and bioavailability of BCS class-II drugs can be increased. About 40-50%drugs available marketed water insoluble...
Article
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Carrier erythrocytes have been evaluated in thousands of drug administration in humans proving safety and efficacy of the treatments. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of dru...
Article
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A reverse phase isocratic HPLC was developed and validated for the determination of levamisole in pure and tablet dosage forms. Method development was carried out on YMCC18isocratic column, (250 mm × 4.6 mm i.d., particle size 5 μm, maintained at ambient temperature), Shimadzu LC–sol 2010 Prominence Liquid Chromatograph. The mobile phase was a mixt...
Article
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Objective: Drugs that have narrow absorption window in the gastrointestinal tract (GIT) will have poor absorption. For these drugs, gastro retentive drug delivery systems offer the advantage in prolonging the gastric emptying time. Atenolol is an antihypertensive drug, which has low elimination half life: 3–4 hrs. The floating tablets of Atenolol w...
Article
Objective: The main aim and objective of the work is to formulate immediate release tablets using different direct compression vehicles (DCV’S) in different ratios. Methods: In the present study, design of oral immediate release tablets of Diltiazem hydrochloride by direct compression technique was carried out. Results: The main motive is to compar...
Article
Full-text available
Oral Disintegrating Tablets (ODTs) may also be used to deliver drugs to the oral cavity, for local action or, in some cases, absorption across the oral mucosa, thereby avoiding first-pass hepatic metabolism and potentially increasing the rate and extent of uptake, and reducing undesirable metabolites. The objectives of the research work was to form...
Article
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The aim of the present research work, Fenofibrate a BCS class II Anti-hyperlipidemic drug belongs to fibrate class was formulated as solid dispersions by using various hydrophilic carriers to enhance the solubility, dissolution rate and oral bioavailability. Kneading technique is used to prepare solid dispersions of fenofibrate. Solid state charact...
Article
Full-text available
The objective of this study is to design and evaluate sustained release matrix tablets of Ozcarbazepine. The effects of various viscosity grades of Eudragit RSPO and HPMC E50LV on the release of Ozcarbazepine have been evaluated. Tablets were evaluated for physical and chemical parameters such as Hardness, Friability, Thickness, Weight variation, D...
Article
Full-text available
Sumatriptan benzoate is a potent and selective 5-HTIB/ID receptor agonist and is effective for the treatment of acute migraine. Sublingual formulation has the advantage of offering fast relief from migraine due to faster drug delivery. The present study involves the formulation and evaluation of fast disintegrating sublingual tablets of Sumatriptan...
Article
Full-text available
The objective of present investigation was to prepare and evaluate a pulsatile drug delivery system of Atenolol. The prepared pulsatile delivery system consists of two different parts: a core tablet, containing the active ingredient, an erodible. The rapid release core tablet (RRCT) was prepared by using superdisintegrants along with active ingredi...
Article
Full-text available
The aim of this research wok is to formulate and evaluate Ciprofloxacin solid dispersions system by using the different techniques. This will increase the solubility of the drug or Ciprofloxacin and give the immediate release of the drug from the formulations. The main objective is to formulate a drug product as immediate release oral solid dosage...
Article
Full-text available
The objective of this study is to design and evaluate sustained release matrix tablets of Ozcarbazepine. The effects of various viscosity grades of Eudragit RSPO and HPMC E50LV on the release of Ozcarbazepine have been evaluated. Tablets were evaluated for physical and chemical parameters such as Hardness, Friability, Thickness, Weight variation, D...
Article
Full-text available
Dihydropyrimidones/ thiones are an important class of heterocyclic compounds reported in 1893 for the first time by P. Biginelli. It possess wide spectrum of biological activities like including anti-tubercular, Anti-malarial, anticancer, anti-HIV activity, analgesic, antiepileptic, CNS activity, anti-inflammatory, antitumor activity. The present r...
Article
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Ultrasonic micro bubbles are the specialized micro spheres containing gas filled contrast agents used for both diagnosis and curative purpose. In general, this is meant for the diagnosis of tumor, cardiac diseases and also in gene therapy. Mainly the ultrasonic micro bubble consists of shell is made up of polymers and gas core which is loaded with...
Article
Full-text available
Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six-membered ring which shows wide range of biological activities. Numerous methods for the synthesis of pyrimidine and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Pyrimidine possess wide spectr...
Article
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An interpenetrating polymer network (IPN) is any material containing two polymers, each in network form. An IPN is a combination of at least two polymers, and IPN can produce synergistic effect by sharing the properties of both the polymers consequently avoiding the limitations of natural as well as synthetic polymers. The present review discusses...
Article
Full-text available
In the present study, design of oral immediate release tablets of Valsartan by direct compression technique was carried out. The main aim and objective of the work is to formulate immediate release tablets using different direct compression vehicles (DCV'S) in different ratios. The main motive is to compare the dissolution profile of these formulat...
Article
Full-text available
The present study was aimed to formulate and evaluate fast dissolving films of Rizatriptan using hydroxyl propyl methyl cellulose. 5 antagonist which is an antimigraine. Hydroxyl propyl methyl cellulose is used as film forming agent. Fast dissolving films are meant to be dissolved in saliva and remain in oral cavity until swallowed. Hence taste mas...
Article
Full-text available
Gas filled microbubbles are well known as ultrasound contrast agents for medical ultrasound imaging and for non-invasive delivery of drugs and genes to different tissues. Microbubbles designate air or gas filled microspheres suspended in a liquid carrier phase which generally results from the introduction of air or gas. The liquid phase contains su...
Article
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This article represents a brief review of new trends along with its principle and instrumentation. It describes about comparative study of new trends in HPLC such as RRLC, UPLC, UFLC & Nano LC. Mainly we discuss in terms of instrumental operating conditions such as column temperature, flow rate, injection volume and also cover the applications and...
Article
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Scientifically validated and technologically standardized botanical products may be explored on a fast track using innovative approaches like reverse pharmacology and systems biology, which are based on traditional medicine knowledge. Traditional medicine communities and individuals continue to discover practices transforming techniques. Many moder...
Article
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The present study was aimed to formulate and evaluate fast dissolving films of Sumatriptan using hydroxyl propyl methyl cellulose. 5-HT 1B and 5-HT 1D antagonist which is an antimigraine. Hydroxyl propyl methyl cellulose is used as film forming agent. Fast dissolving films are meant to be dissolved in saliva and remain in oral cavity until swallowe...
Article
Full-text available
Cosmeceuticals is now commonly used to describe a cosmetic product that exerts a pharmaceutical therapeutic benefit but not necessarily a biologic therapeutic benefit. Cosmetics are products that are used to cleanse and beautify the skin.The aim of this review is to summarize cosmeceutical properties of the various botanicals, vitamins, alpha lipoi...
Article
Full-text available
In addition to the challenge of setting a more development of extremely sensitive and robust analytical methods that can adequately monitor GIs at very low levels is very difficult. Also, the pharmaceutical industry has no long-term experience in the use of these methodologies within the factory setting. Thus, analysts make attempts to determine a...
Article
Full-text available
Rizatriptan benzoate is a potent and selective 5-HTIB/ID receptor agonist and is effective for the treatment of acute migraine. Sublingual formulation has the advantage of offering fast relief from migraine due to faster drug delivery. The present study involves the formulation and evaluation of fast disintegrating sublingual tablets of rizatriptan...
Article
Full-text available
th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India. INTRODUCTION Usually conventional dosage form produce wide ranging fluctuation in drug concentration in the blood stream and tissues with consequent undesirable toxicity and poor efficiency. This factor such as repetitive dosing and unpredictable absorpt...
Article
Full-text available
th Mile, Pulladigunta, Kornepadu (V), Vatticheruk uru (M), Guntur-522017, A ndhra Pradesh, India. ABSTRACT Solubility is one of the important parameter to achieve desired concentration of drug in systemic for pharmacological respons e to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects...
Article
Full-text available
Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India. [E-mail: brahmaiahmph@gmail.com; Tel: +919490921115] The design of the ophthalmic delivery system that enhances the bioavailability and to increase the residence time with improved mechanical properties and mucoadhesive properties has to be prepared in orde...
Article
Full-text available
Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint is the ability of these materials to interact with poorly water soluble drugs and drug candidates water solubility. The cyclodextrins have a wide range of applications in different areas of dr...
Data
Full-text available
The objective of the present study was to prepare and evaluate the mucoadhesive microspheres of Simvastatin. Simvastatin microspheres were prepared by orifice-ionotropic gelation method using polymers such as HPMC (K 100 M), carbopol 940P, sodium CMC, guar gum, sodium alginate, ethyl cellulose, methyl cellulose and xanthan gum. Totally 15 different...
Article
Full-text available
The objective of review article is oral disintegrating films are alternative dosage forms to tablets, capsules and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid-dosage forms. Oral dissolving film technology (ODFT) that can be administered in the buccal cavity for a short period of time in...