Bradley Kossmann

Bradley Kossmann
Georgia State University | GSU · Department of Chemistry

BS Chemistry

About

14
Publications
1,810
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80
Citations
Education
January 2012 - April 2017
Georgia State University
Field of study
  • Computational Biophysical Chemistry
August 2008 - January 2012

Publications

Publications (14)
Article
Full-text available
Tyrosyl-DNA phosphodiesterase 2 (TDP2) processes protein/DNA adducts resulting from abortive DNA topoisomerase II (Top2) activity. TDP2 inhibition could provide synergism with the Top2 poison class of chemotherapeutics. By virtual screening of the NCI diversity small molecule database, we identified selective TDP2 inhibitors and experimentally veri...
Article
Full-text available
Replicative DNA polymerases (Pols) frequently possess two distinct DNA processing activities - DNA synthesis (polymerization) and proofreading (3'-5' exonuclease activity). The polymerase and exonuclease reactions are performed alternately and are spatially separated in different protein domains. Thus, the growing DNA primer terminus has to undergo...
Data
PolB domains are colored as follows: N-terminal domain in light blue; exonuclease domain in green; palm domain in cyan; fingers domain in gold and thumb domain in red. PCNA and DNA are shown in grey and black.
Data
PolB domains are colored as follows: N-terminal domain in light blue; exonuclease domain in green; palm domain in cyan; fingers domain in gold and thumb domain in red. PCNA and DNA are shown in grey and black. The hinge region is highlighted in yellow.
Data
Contact residues are explicitly shown in ball and stick representation. Contact types are colored as follows: Salt-bridges in light blue and red; persistent hydrogen bonds (other than salt bridges) in cyan and dark blue; hydrophobic interaction in green and purple.
Data
Contact residues are explicitly shown in ball and stick representation. Contact types are colored as follows: Salt-bridges in light blue and red; persistent hydrogen bonds (other than salt bridges) in cyan and dark blue; hydrophobic interaction in green and purple.
Article
Full-text available
Many genomes contain families of paralogs—proteins with divergent function that evolved from a common ancestral gene after a duplication event. To understand how paralogous transcription factors evolve divergent DNA specificities, we examined how the glucocorticoid receptor and its paralogs evolved to bind activating response elements [(+)GREs] and...
Article
Full-text available
Phospholipids (PLs) are unusual signaling hormones sensed by the nuclear receptor liver receptor homolog 1 (LRH 1), which has evolved a novel allosteric pathway to support appropriate interaction with coregulators depending on ligand status. LRH-1 plays an important role in controlling lipid and cholesterol homeostasis and is a potential target for...
Article
Full-text available
Author Summary DNA repair efficiency is critically dependent on the function of DNA glycosylases. These versatile enzymes perform a remarkably discriminating search for DNA lesions, followed by damage-specific base extrusion into to the enzyme's active site and removal of the damaged bases. Our work elucidates the mechanism of Bacillus cereus AlkD,...