Bradley S Duerstock

Bradley S Duerstock
Purdue University | Purdue · Weldon School of Biomedical Engineering

PhD

About

53
Publications
7,260
Reads
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765
Citations
Citations since 2016
16 Research Items
425 Citations
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20162017201820192020202120220204060
Introduction
Bradley S Duerstock currently works at the Weldon School of Biomedical Engineering and School of Industrial Engineering Purdue University. Bradley does research in Biomedical Engineering, Industrial Engineering and Rehabilitation Medicine. Their most recent publication is 'Multimodal Perception of Histological Images for Persons Who Are Blind or Visually Impaired'.
Additional affiliations
August 2010 - present
Purdue University
Position
  • courtesy appointment

Publications

Publications (53)
Article
Full-text available
Feature selection plays a crucial role in the development of machine learning algorithms. Understanding the impact of the features on a model, and their physiological relevance can improve the performance. This is particularly helpful in the healthcare domain wherein disease states need to be identified with relatively small quantities of data. Aut...
Chapter
The goal of this project was to use ergonomic design principles to evaluate a 3-dimensional computer simulation of a manikin in a clinical laboratory setting for individuals with lower limb disabilities. The first step was to use the University of Michigan 3D Static Strength Prediction Program (3D SSPP) to determine biomechanical challenges from th...
Article
Full-text available
Objective The goal of this review is to investigate the relationship between indirect physiological measurements and direct measures of situation awareness (SA). Background Assessments of SA are often performed using techniques designed specifically to directly measure SA, such as SA global assessment technique (SAGAT), situation present assessmen...
Article
Full-text available
Objective: Autonomic Dysreflexia (AD) is a potentially life-threatening syndrome which occurs in individuals with higher level spinal cord injuries (SCI). AD is caused by triggers which can lead to rapid escalation of pathophysiological responses and if the trigger is not removed, AD can be fatal. There is currently no objective, non-invasive and...
Chapter
Typical exergames used for rehabilitative therapy can be either too difficult to play or monotonous leading to a lack of adherence. Adapting exergames by tuning various gameplay parameters based on the individual’s physiological ability maintains a constant challenge to improve a participant’s level of engagement and to encourage the physical perfo...
Article
Individuals who are blind adopt multiple procedures to tactually explore images. Automatically recognizing and classifying users' exploration behaviors is the first step towards the development of an intelligent system that could assist users to explore images more efficiently. In this paper, a computational framework was developed to classify diff...
Conference Paper
We present a method to extract workspace comfort areas for ergonomic placement of assistive technologies for persons with upper extremity mobility impairments Currently, areas of comfort are determined using multiple physical prototypes over several iterations which is expensive and time consuming. Our method utilizes a virtual reality exergame to...
Article
Lack of suitable substitute assistive technology is a roadblock for students and scientists who are blind or visually impaired (BVI) from advancing in careers in science, technology, engineering, and mathematics (STEM) fields. It is challenging for persons who are BVI to interpret real-time visual scientific data which is commonly generated during...
Article
Gesture-based interfaces have become an effective control modality within the human computer interaction realm to assist individuals with mobility impairments in accessing technologies for daily living to entertainment. Recent studies have shown that gesture-based interfaces in tandem with gaming consoles are being used to complement physical thera...
Article
This paper presents a multiple-sensors, 3D vision-based, autonomous wheelchair-mounted robotic manipulator (WMRM). Two 3D sensors were employed: one for object recognition, and the other for recognizing body parts (face and hands). The goal is to recognize everyday items and automatically interact with them in an assistive fashion. For example, whe...
Article
Hand gesture-based interfaces have become increasingly popular as a form to interact with computing devices. Unfortunately, standard gesture interfaces are not very usable by individuals with upper limb motor impairments, including quadriplegics due to spinal cord injury (SCI). The objective of this paper is to convert an existing interface to be u...
Conference Paper
Full-text available
Approximately 30-50% of all persons with a spinal cord injury (SCI) are rehospitalized every year due to secondary health complications. One of the more common post-SCI health conditions is Autonomic Dysreflexia (AD). Key physiological indicators in the detection of AD are paroxysmal increase of blood pressure and sweating above the spinal cord inj...
Article
Multiple biochemical and immunohistochemical tests were performed to elucidate the role of oxidative stress during ascending-descending (A-D) myelomalacia by comparing dogs with this progressive terminal condition to dogs with chronic, focal spinal cord injuries (SCIs) and controls without SCI. Dogs with A-D myelomalacia exhibited increased biochem...
Article
With the advent of new gaming technologies, hand gestures are gaining popularity as an effective communication channel for human computer interaction (HCI). This is particularly relevant for patients recovering from mobilityrelated injuries or debilitating conditions who use gesture-based gaming for rehabilitation therapy. Unfortunately, most gestu...
Article
Purpose – The purpose of this paper is to develop an integrated, computer vision-based system to operate a commercial wheelchair-mounted robotic manipulator (WMRM). In addition, a gesture recognition interface system was developed specially for individuals with upper-level spinal cord injuries including object tracking and face recognition to funct...
Article
A machine vision-based gestural interface was developed to provide individuals with upper extremity physical impairments an alternative way to perform laboratory tasks that require physical manipulation of components. A color and depth based 3-D particle filter framework was constructed with unique descriptive features for face and hands representa...
Article
Acrolein, an α,β-unsaturated aldehyde and a reactive product of lipid peroxidation, has been suggested as a key factor in neural post-traumatic secondary injury in SCI, mainly based on in vitro and ex vivo evidence. Here we demonstrate an increase of acrolein up to 300%; the elevation lasted at least two weeks in a rat SCI model. More importantly,...
Article
Full-text available
Speech recognition (SR) technologies were evaluated in different classroom environments to assist students to automatically convert oral lectures into text. Two distinct methods of SR-mediated lecture acquisition (SR-mLA), real-time captioning (RTC) and postlecture transcription (PLT), were evaluated in situ life and social sciences lecture courses...
Article
An integrated, computer vision-based system was developed to operate a commercial wheelchair-mounted robotic manipulator (WMRM). In this paper, a gesture recognition interface system developed specifically for individuals with upper-level spinal cord injuries (SCIs) was combined with object tracking and face recognition systems to be an efficient,...
Article
An innovative 3D joystick was developed to enable quadriplegics due to spinal cord injuries (SCIs) to more independently and efficiently operate a robotic arm as an assistive device. The 3D joystick was compared to two different manual input modalities, a keyboard control and a traditional joystick, in performing experimental robotic arm tasks by b...
Article
This paper presents a hand gesture-based interface to facilitate interaction with individuals with upper-level spinal cord injuries, and offers an alternative way to perform “hands-on” laboratory tasks. The presented system consists of four modules: hand detection, tracking, trajectory recognition, and actuated device control. A 3D particle filter...
Conference Paper
A gesture recognition based interface was developed to facilitate people with upper extremity physical impairments as an alternative way to perform laboratory experiments that require ‘physical’ manipulation of components. A color, depth and spatial information based particle filter framework was constructed with unique descriptive features for fac...
Article
Full-text available
A web-based application was developed to remotely view slide specimens and control all functions of a research-level light microscopy workstation, called AccessScope. Students and scientists with upper limb mobility and visual impairments are often unable to use a light microscope by themselves and must depend on others in its operation. Users with...
Article
An electromechanical video camera coupler was developed to rotate a light microscope field of view (FOV) in real time without the need to physically rotate the stage or specimen. The device, referred to as the Camera Thetarotator, rotated microscopical views 240 degrees to assist microscopists to orient specimens within the FOV prior to image captu...
Article
The sitting posture of power wheelchair (WC) users greatly limits their overall visibility Without the ability to stand or lean forward, WC users are prevented from peering over most obstacles and into deep containers A vision cad to raise or extend forward the line of sight of power WC users would be useful in many daily living educational. and oc...
Article
We have previously shown that acrolein, a lipid peroxidation byproduct, is significantly increased following spinal cord injury in vivo, and that exposure to neuronal cells results in oxidative stress, mitochondrial dysfunction, increased membrane permeability, impaired axonal conductivity, and eventually cell death. Acrolein thus may be a key play...
Article
An integrated accessible microscopy workstation was designed and developed to allow persons with mobility impairments to control all aspects of light microscopy with minimal human assistance. This system, named AccessScope, is capable of performing brightfield and fluorescence microscopy, image analysis, and tissue morphometry requisite for undergr...
Article
Full-text available
We have tested the effectiveness of polyethylene glycol (PEG) to restore the integrity of neuronal membranes after mechanical damage secondary to severe traumatic brain injury (TBI) produced by a standardized head injury model in rats. We provide additional detail on the standardization of this model, particularly the use and storage of foam beddin...
Article
Neuroimaging using fluorescent markers is an effective technique to study specific structures and functions in the brain. However, it is very challenging to register the fluorescent image series. This is because the problem involves complex factors such significant noise, non-uniform slice thickness, and inhomogeneous deformation. In this paper, we...
Article
A method of double labeling a set of serial histological sections was performed to produce multiple three-dimensional (3D) reconstructions from the same segment of injured spinal cord. Alternate groups of consecutive histological sections were stained with Luxol fast blue with cresyl violet and Mallory's trichrome in order to reconstruct two differ...
Article
We have studied the ability of nonionic detergents and hydrophilic polymers to seal permeabilized membranes of damaged cells, rescuing them from progressive dissolution, degeneration, and death. We report that a single subcutaneous injection of the tri-block copolymer, Poloxamer 188 (P188) 6 hr after a severe compression of the adult guinea pig spi...
Article
We evaluated the accuracy of estimating the volume of biological soft tissues from their three-dimensional (3D) computer wireframe models, reconstructed from histological data sets obtained from guinea-pig spinal cords. We compared quantification from two methods of three-dimensional surface reconstruction to standard quantitative techniques, Caval...
Article
Full-text available
We are developing a novel means of restoring function after severe acute spinal cord injury. This involves a brief application of polyethylene glycol (PEG) to the site of injury. In the companion paper, we have shown that a delayed application of PEG can produce strikingly significant physiological and behavioral recovery in 90-100 % of spinal-cord...
Article
Three-dimensional (3D) computer reconstruction is an ideal tool for evaluating the centralized pathology of mammalian spinal cord injury (SCI) where multiple anatomical features are embedded within each other. Here, we evaluate three different reconstruction algorithms to three-dimensionally visualize SCIs. We also show for the first time, that det...
Article
We have evaluated three-week-old compression lesions of the rat spinal cord using two-dimensional and three-dimensional morphometry, reconstruction, and visualization techniques. We offer a new computer assisted method to determine the number and density of macrophages within the spinal lesion using the macrophage specific monoclonal label ED1. We...
Article
Immediately following amputation of the limb in salamanders, a strong, steady, and polarized flow of ionic current is produced by the injury. Current flows in a proximodistal direction within the limb stump and is associated with a fall in electrical potential of about 50 mV/mm near the stump's end. This current is electrogenically driven by the Na...
Article
Full-text available
We are interested in three-dimensionally visualizing soft tissues and their internal structures through a process of computer image reconstruction from serial histological sections. We demonstrated that three-dimensional (3D) reconstruction permits a level of anatomical evaluation not possible with conventional histology. Three-dimensional imaging...

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