Bouchareb Fouzia

• Professor
• Enseignante chercheuse at Chadli Bendjedid El Tarf & Badji Mokhtar - Annaba University

Organophosphorus compounds (OPs) are a diverse group of chemical compounds that contain organic moieties directly bonded to phosphorus or through a heteroatom like oxygen, nitrogen, or sulfur. They are ubiquitous in the human environment due to their unique properties and high biological activity. OPs have been widely used in various fields such as...

Traditional chemical synthesis, which involves the use of dangerous protocols, hazardous solvents, and toxic products and catalysts, is considered environmentally inappropriate and harmful to human health. Bearing in mind its numerous drawbacks, it has become crucial to substitute conventional chemistry with green chemistry which is safer, more eco...

In recent years, sulfonamide and N‐acylsulfonamide have emerged as prominent areas of scientific research across multiple fields, including chemistry, biology, and medicine. The large number of drugs and lead compounds reported in recent literature evidences the growing interest in these derivatives. Chemists are increasingly intrigued by these mol...

We have devised a novel one-step approach for synthesizing bis-phosphonamides utilizing primary amines and phenylphosphonic dichloride (PPDC) under ultrasound irradiation. The bis-phosphonamides obtained were used as organophosphorus ligands for the synthesis of new copper (II) complexes with metal ions. The synthesis of these complexes was accompl...

An efficient method for the synthesis of a new series of α-aminophosphonates has been developed in a one-pot Kabachnik-Fields reaction of 4-methylaminophenol with various aldehydes and triethylphosphite under microwave irradiation and neat conditions using ZnO nanoparticles as a reusable and heterogeneous catalyst, with 82-93% yield at 250 Hz withi...

Microbial resistance to drugs currently traded in the market is a serious problem in modern medicine. In this field of research, we synthesized a novel N-acylsulfonamides (NAS) derivatives starting from commercially available compounds; morpholine, isocyanate of chlorosulfonyl and alcohols. The in vitro antimicrobial potential of synthesized compou...

The oxazaphosphinane represent a novel chemical class of synthetic anticancer agents. They exhibits strong activity against a broad range of human cancers and was first discovered in 1958. The oxazaphosphinane ring plays the role of a "carrier" of a pharmacophoric group to a cell through cell membranes. They belong to a wide class of organophosphor...

Cancer is one of the most serious health problems worldwide, affecting individuals from different sexes, ages, and races. However, the most frequent cancer types in the world are lung, prostate, stomach, colorectal, and esophagus in men; and breast, lung, stomach, colorectal and cervical in women. Currently, the search for new active substances use...

We report a rapid, efficient, economic, environmentally benign, and easy to scale-up method for the synthesis of phosphonamide derivatives using ultrasound irradiation, under catalyst and solvent- free conditions starting from the corresponding amine and phenyl phosphonic dichloride. The reaction was achieved in excellent isolated yield in a short...

A series of novel N-acylsulfonamide derivatives were synthesized and characterized by 1H NMR, 13C NMR and HRMS. The N-acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting from chlorosulfonyl isocyanate. These compounds were evaluated in vitro as antimicrobial agents against representativ...

A new series of N, \(N^{\prime }\)-bis-oxazolidinones-sulfone and 5-chloromethylsulfamoyl-oxazolidin-2-ones have been synthesized in three steps (carbamoylation, sulfamoylation and cyclization) starting from 1,3-dichloroporopan-2-ol, chlorosulfonyl isocyanate and primary or secondary amines. Synthesis has been carried out following simple methodolo...

A new series of substituted 1, 3, 2-diazaphospholidine-2,5-diones was synthesized by an efficient method, starting from a primary amines and amino esters. We have established that phenyl phosphonic dichloride is a suitable reagent allowing the introduction a phosphoryl group. We have prepared the phosphoramidates in two steps. These compounds provi...

The oxazolidin-2-ones are key intermediates in the synthesis of various compounds of interest in terms of reactivity. So, several aminoalcohols were prepared from oxazolidinone. The oxazolidinone may also be used as an intermediate in the preparation of peptidosulfonamide similar sulfonated a natural or synthetic peptide

A series of novel sulfonylureas and N-acylsulfonamides derivatives were synthesized and characterized by 1H NMR, 13C NMR and HRMS. These compounds were synthesized efficiently in two steps (carbamoylation-sulfamoylation), using chlorosulfonyl isocyanate (CSI) that was a suitable reagent for allowing the introduction of a sulfonamide moiety. The ant...

The present study describes a convenient method for the synthesis of new N-acylsulfonamides containing phosphonate moiety. The N-acylsulfonamides were prepared starting from Chlorosulfonyl isocyanate (CSI) in four steps (carbamoylation, sulfamoylation, deprotection and acylation). Trimethylphosphite has been used to introduce the phosphonate moiety...

A series of novel N-acylsulfonamides derivatives were synthesized via direct condensation of parent sulfonamide with ethyl lactate as an acylating agent in the presence of tin (IV) chloride (SnCl4) as a Lewis acid catalyst. The sulfonamides were prepared, starting from chlorosulfonyl isocyanate (CSI), in three steps (carbamoylation, sulfamoylation...

A series of modified acyclic sulfamides and cyclic sulfamides were synthesized efficiently, using sulfuryl chloride that is the suitable available reagent allowing the introduction a sulfamide moiety. The cyclosulfamides were prepared in two steps (duplication and cyclization) starting from a primary amines. These compounds were preliminarily teste...