Boubker Nasser

Boubker Nasser
Université Hassan 1er · Department of Biomedical Sciences

Ph.D

About

62
Publications
16,330
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907
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April 1994 - March 2017
Université Hassan 1er
Position
  • Head of Department

Publications

Publications (62)
Article
Full-text available
Coronavirus illness (COVID-19) is an infectious pathology generated by intense severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This infectious disease has emerged in 2019. The COVID-19-associated pandemic has considerably affected the way of life and the economy in the world. It is consequently crucial to find solutions allowing remedying o...
Article
Full-text available
Citation: Brahmi, F.; Vejux, A.; Ghzaiel, I.; Ksila, M.; Zarrouk, A.; Ghrairi, T.; Essadek, S.; Mandard, S.; Leoni, V.; Poli, G.; et al. Role of Diet and Nutrients in SARS-CoV-2
Article
Age-related diseases for which there are no effective treatments include cardiovascular diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as cataract and age-related macular degeneration; and, more recently, Severe Acute Respiratory Syndrome (SARS-CoV-2). These diseases are associated with plasma and/or tissue inc...
Article
Ethnopharmacological relevance The genus Ziziphus (Rhamnaceae) contains 58 accepted species that are extensively used by local people and medicinal practitioners in arid and semi-arid regions for the treatment of diarrhoea, dysentery, cholera, diabetic, hypertension, inflammation, intestinal spasm, liver, malaria and other diseases. Aims of this r...
Article
Ethnopharmacological relevance The genus Ziziphus (Rhamnaceae) contains 58 accepted species that are extensively used by local people and medicinal practitioners in arid and semi-arid regions for the treatment of diarrhoea, dysentery, cholera, diabetic, hypertension, inflammation, intestinal spasm, liver, malaria and other diseases. Aims of this re...
Article
Full-text available
Vegetables from the genus Ziziphus (Rhamnaceae) have been identified as one of the main dietary antioxidants, especially phenolic compounds. However, their chemical composition varies according to the specie or the part of the plant. Mineral composition (potassium, magnesium, calcium, sodium, iron, and zinc), polyphenolic content (Flavan-3-ol, Proa...
Article
Full-text available
Background The effects of vegetable oils on human health depends on their components. Therefore, their profiles of lipid nutrients were determined. Objective To establish and compare the fatty acid, tocopherol, phytosterol and polyphenol profiles of Mediterranean oils: cosmetic and dietary argan oils (AO; Morocco: Agadir, Berkane); olive oils (OO;...
Article
Full-text available
Tetrahymena pyriformis (protozoa) is intensely investigated as a model organism, offering numerous advantages in comprehensive and multidisciplinary studies using morphologic or molecular methods. Since DNA extraction is a vital step of any molecular experiment, here a new mixed surfactant (Sodium dodecyl sulfate (SDS) 20%/Triton X-100) was adopted...
Article
Mitochondrial dysfunction and oxidative stress are involved in neurodegenerative diseases associated with an enhancement of lipid peroxidation products such as 7β- hydroxycholesterol (7β-OHC). It is therefore important to study the ability of 7β-OHC to trigger mitochondrial defects, oxidative stress, metabolic dysfunctions and cell death, which are...
Poster
Full-text available
En élevage ovin, la rentabilité d’une exploitation est fortement dépendante des performances de reproduction du troupeau Pour ce, il est nécessaire d’améliorer la fertilité et la prolificité des brebis et augmenter la fréquence de l’agnelage, ainsi que suivre l’alimentation des brebis au cours des périodes de gestation et lactation. Au cours de ces...
Article
Acyl-CoA oxidase 1 (ACOX1) deficiency is a rare and severe peroxisomal leukodystrophy associated with a very long-chain fatty acid (VLCFA) β–oxidation defect. This neurodegenerative disease lacks relevant cell models to further decipher the pathomechanisms in order to identify novel therapeutic targets. Since peroxisomal defects in microglia appear...
Article
Full-text available
Cholesterol oxidation products, also named oxysterols, can be formed either by cholesterol auto-oxidation, enzymatically or both. Among these oxysterols, 7-ketocholesterol (7KC) is mainly formed during radical attacks that take place on the carbon 7 of cholesterol. As increased levels of 7KC have been found in the tissues, plasma and/or cerebrospin...
Article
Full-text available
The aim of the present work was to study the effect of age (2.5 years vs 6 years) and extender (skim milk vs tris egg yolk) on the storage of liquid semen at 5°C. Semen was collected weekly from Boujaâd rams and extended to a final concentration of 0.8 x 109 spermatozoa/ml. Sperm quality assessment included total and progressive motility, viability...
Article
Full-text available
The aim of the present work was to study the effect of age (2.5 years vs 6 years) and extender (skim milk vs tris egg yolk) on the storage of liquid semen at 5°C. Semen was collected weekly from Boujaâd rams and extended to a final concentration of 0.8 x 10 9 spermatozao/ml. Sperm quality assessment included total and progressive motility, viabilit...
Poster
Full-text available
The objective of this study was to evaluate the effect of aqueous saffron extract addition (ASE) (6%) to skim milk and tris on the Boujaâd rams (3-4 years) sperm liquid storage. To achieve this goal, this work was divided into two steps; step 1: Boujaâd ram semen was extended in skim milk based extender supplemented or not with 6% of ASE and stored...
Article
The purpose of this investigation was to evaluate the effect of cactus seed oil (CSO) on ram semen quality parameters during liquid storage. Semen samples collected from five adult fertile Boujaâd rams were pooled and diluted to a final concentration of 0.8 × 10⁹ spermatozoa/ml in Tris egg yolk (TEY) and skim milk (SM) extenders supplemented with C...
Article
Full-text available
For their colony needs, bees harvest honey, honeydew, pollen and water from the environment, which contain natural products and various chemical contaminants. Most of the latters can be found in products consumed by humans and, consequently, may constitute a risk to public health. Honey product could be considered a bio-indicator of environmental p...
Article
Full-text available
For their colony needs, bees harvest honey, honeydew, pollen and water from the environment, which contain natural products and various chemical contaminants. Most of the latters can be found in products consumed by humans and, consequently, may constitute a risk to public health. Honey product could be considered a bio-indicator of environmental p...
Article
Full-text available
In this study, we aimed to evaluate the antioxidant and anti-inflammatory properties of Opuntia ficus-indica cactus cladode extracts in microglia BV-2 cells. Inflammation associated with microglia activation in neuronal injury can be achieved by LPS exposure. Using four different structurally and biologically well-characterized LPS serotypes, we re...
Article
Full-text available
Opuntia ficus-indica cladode growing in Settat region of Morocco was freshly consumed and traditionally used in folk medicine for health benefits by the local people. The antioxidant activity and the chemical compounds of it were studied using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and spectrophotometric techniques. The antioxida...
Poster
Full-text available
La réussite de l’insémination artificielle (IA) est influencée par la qualité de la semence qui peut varier selon l’âge du bélier et la saison. La race Boujaâd est considérée comme une race à faible effectif ce qui impose sa conservation in et ex situ. L’objectif principal de ce travail est d’étudier l’effet de la saison et de l’âge des béliers sur...
Article
The present study aimed to assess the phenolic composition of the acetone extract from Opuntia ficus indica cladodes (ACTEX) and its effects on ram semen variables, lipid peroxidation and DNA fragmentation during liquid storage at 5 °C for up to 72 h in skim milk and Tris egg yolk extenders. Semen samples from five rams were pooled extended with Tr...
Article
Full-text available
In patients with sepsis, liver metabolism and its capacity to provide other organs with energetic substrates are impaired. This and many other pathophysiological changes seen in human patients are reproduced in mice injected with purified endotoxin (lipopolysaccharide, LPS). In the present study, down-regulation of genes involved in hepatic fatty a...
Article
We have described the flowering and fruiting phenology of 14 accessions of six Opuntia species grown in Morocco: O. ficus-indica, O. robusta, O. aequatorialis, O. dillenii, O. leucotricha, and O. stricta. We also determined the physicochemical characteristics of their cladodes. For each accession, we used four-to-20 plants. Two systems were used to...
Article
Full-text available
In patients with sepsis, liver metabolism and its capacity to provide other organs with energetic substrates are impaired. This and many other pathophysiological changes seen in human patients are reproduced in mice injected with purified endotoxin (lipopolysaccharide, LPS). In the present study, down-regulation of genes involved in hepatic fatty a...
Article
Full-text available
The purpose of the present study was to investigate the distribution of PON1 Q192R and L55M polymorphisms and activities in a North African population and to determine their association with cardiovascular complications. The prevalence of the QQ, QR, RR, LL, LM, and MM genotypes in the study population was 55.4%, 34.09%, 9.83%, 41.97%, 48.20%, and...
Article
The present work was carried out to determine the concentrations of trace elements (copper and zinc) and heavy metals (cadmium and lead) in the different organs of camels slaughtered in municipal slaughterhouse of Casablanca, which is the main source of consumption of camel meat in the study area. The samples of meat, liver, lungs, heart and kidney...
Article
Full-text available
Opuntia ficus-indica, commonly referred to as prickly pear or nopal cactus, is a dicotyledonous angiosperm plant. It belongs to the Cactaceae family and is characterized by its remarkable adaptation to arid and semi-arid climates in tropical and subtropical regions of the globe. In the last decade, compelling evidence for the nutritional and health...
Article
Full-text available
Objective: The functionality of HDL has been suggested as an important factor in the prevention of cardiovascular and coronary artery diseases. The objective of the present study was to investigate the functionality of HDL and the factors that may affect the anti-atherogenic properties of HDL in ACS patients. Methods and results: One hundred hea...
Article
Full-text available
Two species of Mayetiola (Cecidomyiidae), Mayetiola destructor (Say) and Mayetiola hordei Keiffer are the most destructive insect pests of wheat and barley, respectively, in Morocco. Infested plants are stunted, will stop growing, and eventually die. The objective of the present study was to understand mechanisms of cereals' responses to induced st...
Article
This work is mainly devoted to the study of trace elements concentrations, copper and zinc, in different organs of 50 cattle, 50 sheep, 30 camels and 40 equines slaughtered in municipal slaughterhouse of Casablanca, which is the main source of consumption meat in the study area. The organs that have been studied were the liver, lung, skeletal muscl...
Book
Full-text available
8. Seminar of the FAO-CIHEAM Sub-Network on Production Systems, 2013/06/11-13, Tangier (Morocco)
Data
Full-text available
Pseudo-neonatal adrenoleukodystrophy (P-NALD) is a neurodegenerative disorder caused by acyl-CoA oxidase 1 (ACOX1) deficiency with subse-quent impairment of peroxisomal fatty acid β-oxidation, accumulation of very long chain fatty acids (VLCFAs) and strong reduction in perox-isome abundance. Increase in peroxisome num-ber has been previously sugges...
Article
Full-text available
Pseudo-neonatal adrenoleukodystrophy (P-NALD) is a neurodegenerative disorder caused by acyl-CoA oxidase 1 (ACOX1) deficiency with subse-quent impairment of peroxisomal fatty acid β-oxidation, accumulation of very long chain fatty acids (VLCFAs) and strong reduction in perox-isome abundance. Increase in peroxisome num-ber has been previously sugges...
Article
Mussels may concentrate pollutants, with possibly significant side effects on human health. Therefore, mussels (Mytilus galloprovincialis) from two sites of the Moroccan Atlantic coast (Jorf Lasfar [JL], an industrial site, and Oualidia [OL], a vegetable-growing area), were subjected to biochemical analyses to quantify the presence of heavy metals...
Article
The previously suggested mechanism of the condensation–rearrangement reaction of a Reissert compound hydrofluoroborate salt with reactive olefins was reexamined in the case of methyl methacrylate, itaconate, citraconate, and mesaconate. Addition of triethylamine to the reaction medium leads to the isolation of a presumed intermediate 8. Spectrometr...
Article
Precursors of phospholipids or ether lipids were synthesized from D-mannitol, i.e., 1-O-myristoyl-2-O-benzyl-sn-glycerol 11 and 1-O-hexadecyl-2-O-benzyl-sn-glycerol 13. The chemical pathways involved sequential protection reactions using allyl, triphenylmethyl, or benzyl groups via 3-O-allyl-sn-glycerol. Eleven intermediates were isolated and for t...
Article
Modern codes contain application rules based essentially on monotonic tests that allow the design of welded connections between a profile with H section and a plate or a beam flange without transverse stiffeners in the H section. The validity of such designs has been tested in cyclic plastic conditions on 5 specimens. The results indicate that the...
Article
Industrial processing of phosphates generates chemical wastes which are, without any treatment, discharged directly into the Atlantic Ocean at Jorf Lasfar (JL), located 120 km south of Casablanca (Morocco) were shellfish are also collected by people without any control. Marine bivalves concentrate these pollutants by filtration and serve as vectors...
Article
Atlantic coast in mice. Preliminary studies showed that seawater contains heavy metals from domestic, agricultural and industrial wastes. Marine bivalves concentrate these pollutants by filtration and serve as vectors in human exposure. The objective of this study was to determine the concentration of heavy metals; cadmium (Cd); chromium (Cr), and...
Article
Preliminary studies showed that seawater contains heavy metals from domestic, agricultural and industrial wastes. Marine bivalves concentrate these pollutants by filtration and serve as vectors in human exposure. The objective of this study was to determine the concentration of heavy metals; cadmium (Cd); chromium (Cr), and lead (Pb) in mussels (My...
Article
Full-text available
This work was aimed at evaluating the possibility of using bromophenol blue as an indicator for detecting the presence of Sclerotinia sclerotiorum in the seeds of dry-beans (Phaseolus vulgaris) and soybean (Glycine max), through incubation of the seeds on an agar medium and "blotter" substrates. The seeds were artificially inoculated with four S. s...
Article
D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30), a membrane enzyme, has been purified to homogeneity from dromedary (Camelus dromedarius) liver mitochondria. Our new purification method consisted of the solubilization of mitochondrial membranes by Triton X 100 and purification of BDH by two steps: DEAE-Sephacel and Phenyl-Sepharose. The mo...
Article
Full-text available
The distribution profiles of individual trans- as well as cis-18:1 isomers from the fat prepared from the hump adipose tissue and the milk from Camelus dromedarius (the single-humped Arabian species) are described. Gas-liquid chromatography on two capillary columns with different polarities and lengths were used for this purpose in combination with...
Article
D-3-Hydroxybutyrate dehydrogenase (BDH), an inner mitochondrial protein, is a well-known phospholipid dependent enzyme. It is a primary dehydrogenase of the oxidative phosphorylation system and is involved in the redox balance of the NAD+/NADH pool. The preparation of fluorescent phospholipids and newly synthesized bifunctional phospholipid analogu...
Article
D-3-hydroxybutyrate dehydrogenase, an inner-mitochondrial enzyme responsible for the interconversion of two ketone bodies, is a well known phospholipid dependent enzyme. Newly synthesized phospholipid analogues were used to study the structural requirement for lipid activation of the purified enzyme. A positive charge on the polar head is required...
Article
D-3-Hydroxybutyrate dehydrogenase (BDH) is an NAD(+)-dependent dehydrogenase of the mitochondrial inner membrane involved in the energetic balance between the liver and peripheral organs in mammals. It allows the conversion of ketone bodies (acetoacetate and D-3-hydroxybutyrate) and it is one of the best documented lipid-requiring enzymes with a de...
Article
The structural requirements of lecithins analogs for purified D-beta-hydroxybutyrate dehydrogenase activation have been studied with chemically defined phospholipids. It appears that the trimethylamine group of choline can be changed by a pyridinium group. On the other hand, the decrease of density of the positive charges on the liposomes surface o...
Article
Laboratoire de mécanique de structures et stabilités de constructions (LM2SC) .Université des sciences et de la technologie d'Oran.. BP 1505 Oran El-Ménouar Algérie. E-mail : nasser54dz@yahoo.fr **Ecole Normale d'Enseignement Technique d'Oran BP1523 Oran El Ménouar Algérie. RESUME:Avec l'évolution des méthodes de dimensionnement en Construction Mét...

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