Borislav Spajic

Borislav Spajic
University Clinical Hospital Center "Sestre Milosrdnice" · of urology

M.D., Ph.D. Professor of Urology

About

92
Publications
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Introduction
Borislav Spajic currently works at the of urology, University Clinical Hospital Center "Sestre Milosrdnice". Borislav does research in Urology. Their current project is 'The role of inflammation in pathogenesis and early detection of prostate cancer.'

Publications

Publications (92)
Article
Full-text available
Background Hypofractionated post-prostatectomy radiotherapy is emerging practice, however with no randomized evidence so far to support it’s use. Additionally, patients with persistent PSA after prostatectomy may have aggressive disease and respond less well on standard salvage treatment. Herein we report outcomes for conventionally fractionated (C...
Article
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Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare. endemic nephropathy is a renal disease causing chronic renal failure. it is highly associated with urothelial neoplasm and occurs i...
Article
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The Department of Urology at the Sestre milosrdnice University Hospital Center is the oldest urological institution in the Republic of Croatia and this part of Europe. Today, the Department is a modern tertiary healthcare institution, where the most complex methods of urological practice are performed using modern medical devices and highly sophist...
Article
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The history of Croatian urology clearly shows its affiliation to the medical and civilizational circle of the Western world. The Department of Urology at the Sestre milosrdnice University Hospital Center is the oldest urology institution in the Republic of Croatia. The Department was established in 1894, when the new Sestre milosrdnice Hospital was...
Article
The aim of this study was to determine the incidence of incidental prostate cancer and its clinical significance among patients who underwent transurethral prostate resection or transvesical adenomectomy for benign prostate hyperplasia at the Department of Urology in Sestre milosrdnice University Hospital Center from January 1997 to December 2017....
Article
LMO2 (LIM domain only) is a member of transcription factor family of proteins characterized by their cysteine-rich, zinc-binding LIM domains. Its expression in prostate cancer cells, as well as in adjacent stroma, is described in a study in a cohort of 83 patients treated with radical prostatectomy for clinically localized prostate adenocarcinoma....
Article
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One of the main reasons for the introduction of a new grading system was Gleason sum 7, which differed significantly in the prognosis of the disease depending on the primary Gleason. The aim of this study was to compare grade group 2 and grade group 3, and the impact of cancer percentages in final pathology reports after radical prostatectomy on th...
Article
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Stress urinary incontinence (SUI) continues to present a major complication after radical prostatectomy. Suburethral slings represent one of the less invasive options for postprostatectomy SUI, and a more recent addition is a transobturator sling, the AdVance®. We report our results with the AdVance® sling for the management of postoperative SUI. T...
Conference Paper
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UVOD i CILJEVI: Liječenje lokaliziranog raka prostate radikalnom prostatektomijom (RP) doživjelo je posljednjih dvadesetak godina dramatičan porast. Većina pacijenata postiže zadovoljavajuću kontinenciju unutar godine dana nakon zahvata. Unatoč napretku u kirurškoj tehnici i dalje je prisutan dio bolesnika u kojih perzistira stresna urinarna inkont...
Article
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e551Background: Data on hypofractionated radiotherapy in definitive treatment of prostate cancer are maturing; however, limited information is available for hypofractionated radiotherapy after prostatectomy. We aimed to compare hypofractionated and conventionally fractionated radiotherapy in salvage setting for biochemically recurrent prostate canc...
Article
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Introduction: The interchanged stromal-epithelial relations and altered expression profiles of various extracellular matrix (ECM) proteins creates a suitable microenvironment for cancer development and growth. We support the opinion that remodeling of the extracellular matrix (ECM) plays an important role in the cancer progression. The aim of this...
Data
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PurposeWe are often confronted with patients in the "gray zone" (prostate-specific antigen [PSA]<10 ng/mL) whose biopsies reveal no malignancy but only inflammation. We investigated the relationship between histological inflammation and total PSA (tPSA), free PSA (fPSA), and percentage of free PSA (f/tPSA) levels in patients without prostate cancer...
Article
Full-text available
Unlabelled: Synchronous occurrence of benign and malignant kidney tumours is very rare. We present the case of a 63-year-old female patient who underwent a bilateral partial nephrectomy after being diagnosed with bilateral kidney tumours by ultrasonography and a computed tomography scan. Histopathological analysis of the left kidney tumour mass re...
Article
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Foreign bodies inside the urinary tract are a relatively rare condition in our practice. There are several reports published and in most cases the reason for self insertion of an object is autoerotic stimulation or psychiatric illness. Self treatment by homemade instruments is a rarely seen scenario. A 62 year old man reported to our clinic complai...
Article
Full-text available
Purpose We are often confronted with patients in the "gray zone" (prostate-specific antigen [PSA]<10 ng/mL) whose biopsies reveal no malignancy but only inflammation. We investigated the relationship between histological inflammation and total PSA (tPSA), free PSA (fPSA), and percentage of free PSA (f/tPSA) levels in patients without prostate cance...
Article
Full-text available
A B S T R A C T Herein we present 82-year-old man with leiomyosarcoma arising from the spermatic cord with scalp metastasis, five years after primary surgical treatment. Complete surgical excision is required in such cases, as well as precise evaluation of further therapy. Paratesticular leiomyosarcoma is a rare entity, malignant mesenchimal tumor...
Article
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A specific representative of recurrent urinary tract infections (UTI) called cystitis cystica (CC) was assessed by ultrasound. The aim of the study was to delineate, by means of ultrasound measurement (US) of bladder wall thickness (BWT), the children with mere repeated UTI from those prone to frequent UTI due to CC. Two groups were compared, the c...
Article
Full-text available
ABSTRACT A specific representative of recurrent urinary tract infections (UTI) called cystitis cystica (CC) was assessed by ultrasound. The aim of the study was to delineate, by means of ultrasound measurement (US) of bladder wall thickness (BWT), the children with mere repeated UTI from those prone to frequent UTI due to CC. Two groups were compar...
Article
Full-text available
ABSTRACT Abstract Objective.The aim of this study was to correlate the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) with pathological renal artery changes in patients with renal cell carcinoma (RCC). A further aim was to correlate intratumoral microvessel density (MVD) with VEGF and HIF-1α express...
Article
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The main purpose of this study was to demonstrate positive feedback loop between bladder wall nodules (nodules being one of the key diagnostic factors), bladder wall thickness, and recurrent urinary tract infections. Cystitis cystica was diagnosed in 115 prepubertal girls (mean age 7.79 +/- 3.05 years) by optic examination of bladder mucosal nodule...
Article
Full-text available
Objective: The aim of this study was to correlate the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) with pathological renal artery changes in patients with renal cell carcinoma (RCC). A further aim was to correlate intratumoral microvessel density (MVD) with VEGF and HIF-1α expression and prognost...
Conference Paper
Full-text available
Liječenje lokaliziranog raka prostate radikalnom prostatektomijom doživjelo je posljednjih dvadesetak godina dramatičan porast. Unatoč napretku u kirurškoj tehnici i smanjenju ranih i kasnih postoperativnih komplikacija i dalje je prisutan dio bolesnika u kojih perzistira stresna inkontinencija urina. Većina pacijenata podvrgnutih radikalnoj prost...
Article
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We are presenting a rare case of a spontaneous extensive perirenal hematoma caused by ruptured renal adenocarcinoma in a patient who was on warfarin therapy because she had atrial fibrillation and three myocardial infarctions. A 77-year-old woman was admitted to our department with acute right flank pain and hemorrhagic shock. The anamnestic data r...
Article
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Myelolipoma is a rare, benign, non-functioning tumor most frequently located in the adrenal cortex. It consists of mature fatty tissue with components of hematopoietic tissue in different proportions. There are certain ambiguities related to the diagnosis and therapy of myelolipoma, and it is therefore important to keep in view all the aspects of t...
Article
Objective: To evaluate urinary bladder wall thickness (BWT) assessed by ultrasound as a diagnostic tool for cystitis cystica. Patients and methods: This was a 9-year prospective study comprising 120 prepubertal girls. Sixty subjects of whom half underwent cystoscopy represented cases while the other 60 (those with a single urinary tract infectio...
Article
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Mijelolipom je rijedak, dobroćudan, nefunkcionalni tumor, najčešće smješten u kori nadbubrežne žlijezde. Sastoji se od zrelog masnog tkiva s komponentama hematopoetskog tkiva u različitom omjeru. Postoje stanovite nedoumice vezane uz dijagnosticiranje i liječenje mijelolipoma pa je zbog toga važno sagledati sve aspekte te lezije i okolnosti u kojim...
Article
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Cases of adult renal cell carcinoma with rhabdoid features have been reported in the literature, usually in association with conventional clear cell and papillary tumors. Till date, only one report described chromophobe renal cell carcinoma with rhabdoid differentiation. We report a case of a 47-year-old male patient that underwent a routine medica...
Article
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Primary bilateral iliopsoas abscesses in the elderly are very rare in Europe. We report a case of an elderly male misdiagnosed with rheumatic low back pain. The delay in accurate diagnosis and therapy led to severe worsening of his general condition and septic shock. The diagnosis was established by multi-slice computed tomography (MSCT) and the pa...
Article
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Connexins (Cxs) are a family of transmembrane proteins that build cell-to-cell channels in gap junctions. Gap junctions composed of Cxs have an essential role in intercellular communication, adhesion and cell differentiation. Several studies investigated the role of connexin43 (Cx43) in different carcinomas; however, none investigated its prognosti...
Article
To determine whether the presence and extent of peritumoral retraction artefact could be used to predict biochemical recurrence-free survival in prostatic carcinoma. The study included 162 consecutive patients treated by radical retropubic prostatectomy and bilateral lymphadenectomy for clinically localized prostatic carcinoma. A variable degree of...
Article
Adrenal myelolipoma is a rare benign tumor composed of mature adipose cells and hematopoietic elements. Their mostly small size (<5 cm), unilateral site, and clinical quiescence are accountable for predominantly incidental disclosure. We report a case of a 54-year-old man complaining of gradually aggravating pain in the right hemiabdomen in whom ab...
Article
The distinction between renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC), especially the eosinophilic variant, can often be difficult. Our study has documented for the first time the expression of MAGE-A3/4 and NY-ESO-1 cancer testis antigens (CTAs) in these tumors. A total of 35 patients (17 ROs and 18 ChRCCs) were included in th...
Article
Introduction & objectives: The aim of the study was to determine whether the total percentage of carcinoma in needle core biopsy and localization of carcinoma in the prostate could be used as reliable predictors of biochemical relapse (BCR) in patients treated with radical prostatectomy.
Article
Full-text available
The pathogenesis of recurrent urinary tract infections (UTIs) in preschool children with anatomically correct urinary tract (UT) is rather obscure. In girls, the bladder wall changes of cystitis cystica (CC) may be per se responsible for UTIs recurrence. During the 20-year period, 127 preschool children (125 girls; median age: 6.1 years) with CC, i...
Article
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A 69-year-old man was admitted for resection of rectal adenocarcinoma diagnosed by colonoscopy. Preoperative computed tomography scan and abdominal ultrasonography revealed bilateral renal tumors measuring up to 2 and 2.8 cm in largest diameter, respectively. The patient underwent partial colectomy and bilateral partial nephrectomy. Microscopically...
Article
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The reactive stroma of prostate cancer contains a mixture of myofibroblasts and fibroblasts, while fully differentiated smooth-muscle cells are very rare or absent. In experimental prostate cancer models, prostatic stromal cells promote angiogenesis and stimulate prostate tumorigenesis. The aim of this study is to analyse whether the intensity of s...
Article
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Prostate cancer is the most common visceral tumor in males. It is the second most common cause of death in males due to malignant tumors. It usually appears in persons older than 50 years. It can be detected in asymptomatic patients by a simple and easily accessible procedure that includes prostate specific antigen measurement and needle core biops...
Article
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Both the plasmacytoid and micropapillary types of urothelial carcinoma of the urinary bladder are uncommon, distinct clinical and pathological findings. To date, several reports in the English medical literature have been published on either of these variants. CD138 is commonly used as a marker for tumors of plasma cell origin. However, few authors...
Article
The main puzzle of the pulmonary circulation is how the alveolar spaces remain dry over a wide range of pulmonary vascular pressures and blood flows. Although normal hydrostatic pressure in pulmonary capillaries is probably always below 10 mmHg, well bellow plasma colloid pressure of 25 mmHg, most textbooks state that some fluid filtration through...
Article
Full-text available
Prostate cancer is the most common visceral tumor in males. It is the second most common cause of death in males due to malignant tumors. It usually appears in persons older than 50 years. It can be detected in asymptomatic patients by a simple and easily accessible procedure that includes prostate specific antigen measurement and needle core biops...
Article
Full-text available
The most important differential diagnosis of chromophobe renal cell carcinoma (CRCC) is renal oncocytoma. Due to overlapping morphological characteristics of renal oncocytoma and CRCC, particularly its eosinophilic variant, making a correct diagnosis can be challenging. To date, no data are available on the presence of the tumor fibrous capsule as...
Article
Full-text available
Syndecans are a four-member family of transmembrane heparan sulphate proteoglycans that have different functions in cell signalling, adhesion, cytoskeleton organization, migration, proliferation, and angiogenesis. Several studies investigated the role of syndecan-2 (SDC2) in different carcinomas; however, only one being focused on SDC2 in prostate...
Article
Full-text available
Although prostatitis can contribute to the lack of prostate specific antigen (tPSA) specificity, there is disagreement concerning the effect of histological inflammation on free PSA (fPSA). We investigated the correlation between aggressiveness of histological inflammation and tPSA, fPSA and f/tPSA in patients without detectable prostate cancer (PC...
Article
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Finasteride has been recognized as a drug suitable for the chemoprevention of prostate cancer (PC) by reducing intracellular dihydrotestosterone (DHT) levels. The Prostate Cancer Prevention Trial (PCPT) database on continuous finasteride treatment of almost 19 thousands patients indicated the reduction in cancer prevalence by about 25% . However, i...
Article
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A rare case of posttraumatic high-flow priapism is presented. A 20-year-old man underwent diagnostic procedure with color Doppler sonography and angiography. On color Doppler sonography and selective and supraselective angiographic images, arteriocavernosal fistula and pseudoaneurysm were detected in the proximal part of the right cavernous body. C...
Article
Full-text available
A rare case of posttraumatic high-flow priapism is presented. A 20-year-old man underwent diagnostic procedure with color Doppler sonography and angiography. On color Doppler sonography and selective and supraselective angiographic images, arteriocavernosal fistula and pseudoaneurysm were detected in the proximal part of the right cavernous body. C...
Conference Paper
Full-text available
Introductions and objectives: On transrectal ultrasound (TRUS), prostate cancers are visualized as hypoechoic or isoechoic lesions. Hyperechoic lesions are usually considered as benign, whether benign prostate hyperplasia (BPH), prostatitis or prostate infarction. On TRUS, prostate cancer is visualized as a hypoechoic lesion in 60-70%, and as isoec...
Article
Abstract Introductions and objectives: On transrectal ultrasound (TRUS), prostate cancers are visualized as hypoechoic or isoechoic lesions. Hyperechoic lesions are usually considered as benign, whether benign prostate hyperplasia (BPH), prostatitis or prostate infarction. On TRUS, prostate cancer is visualized as a hypoechoic lesion in 60-70%, an...
Article
Full-text available
An extremely rare case of seminal vesicle cyst associated with ipsilateral renal dysplasia and ectopic ureter is presented. A 36-year-old patient underwent nephroureterovesiculectomy. Considering the clinical and imaging profile of the patient, a diagnosis of ureterocele with megaureter was initially suspected, but intraoperative findings and defin...
Article
We report on a 60-year-old woman with neuroendocrine carcinoma of the left breast metastasizing to renal cell carcinoma (RCC) of the left kidney and to adrenal gland. A yellow, well-circumscribed tumor, 11 cm in largest diameter and limited to the kidney, was found. Histopathology revealed RCC with foci of neuroendocrine differentiation. Solid shee...
Article
Full-text available
An extremely rare case of seminal vesicle cyst associated with ipsilateral renal dysplasia and ectopic ureter is presented. A 36-year-old patient underwent nephroureterovesiculectomy. Considering the clinical and imaging profile of the patient, a diagnosis of ureterocele with megaureter was initially suspected, but intraoperative findings and defin...
Article
Full-text available
We demonstrate the evolution of the clinical presentation and outcomes for patients with clinically localized prostate cancer (PC) treated with radical retropubic prostatectomy (RRP) at our department, emphasizing epidemiologic significance of changes during the 10-year period. We assessed the annual trends for changes in patients age, preoperative...
Article
Full-text available
To estimate the incidence of transrectal ultrasound (TRUS) hyperechoic lesions and of hyperechoic prostate cancer in TRUS-guided biopsy specimens. We prospectively studied 200 patients with total prostate-specific antigen values less than 20 ng/mL and/or positive results on digital rectal examination who had undergone TRUS-guided prostate biopsy. E...
Conference Paper
Full-text available
Introduction & Objectives. Purpose of this report is to evaluate our experience in the management of localized prostate cancer (PC) with radical retropubic prostatectomy (RRP). Changes and advances in patient selection criteria and clinical outcome data are evaluated and discussed emphasizing epidemiologic significance of annual changes over ten ye...
Conference Paper
Full-text available
OBJECTIVE: In clinical practice, we are often confronted with a patient in so called “grey zone” (PSA<10 ng/ml) with a decreased free PSA levels, whose biopsies reveal no malignancy but only inflammation. We investigated the relationship between histological inflammation and total PSA (tPSA), freePSA (fPSA) and percent-free PSA (f/tPSA) levels in p...
Article
Full-text available
Despite the increasing number of patients being detected with a clinically localized (T1,2) prostate cancer, pelvic lymphadenectomy remains a standard in determining the exact histological staging as a reliable prognostic parameter. Extended lymphadenectomy is superior to limited lymphadenectomy, and with the use of appropriate surgical technique d...
Article
The aim of this study was to analyze morphometric parameters of renal arteries (longest diameter and tunica media thickness) in patients with renal cell carcinoma (RCC), to look into their relationship to tumor necrosis and to compare them with morphometric parameters recorded in a control group. We analyzed archival cases of RCC diagnosed in 2003...
Article
Full-text available
Summary Simultaneity of primary renal cell carcinoma (PRCC) and second primary malignant tumors (SPMT) of other organs is considered to be very rare. This study was run in order to determine the incidence of SPMT in patients with PRCC. During the period 1997-2001, 287 patients underwent surgery for PRCC. They included 196 male and 91 female patient...
Article
Full-text available
Asian Journal of Andrology, the top clinical research journal based in China, is a print and online publication that focuses on new basic and clinical (including modern, traditional and epidemiological) research on andrology