Boris Rodenak Kladniew

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Verified

Boris verified their affiliation via an institutional email.

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• PhD
• Research Associate at National University of La Plata

This study presents a novel nanocomposite biomaterial for topical delivery, integrating bacterial cellulose (BC) matrix with Eudragit® (Eu) polymeric nanoparticles (NPs) as an efficient carrier for a bioactive natural extract with hydrophobic properties. BC was produced biotechnologically from Komagataeibacter xylinus, while a propolis extract, kno...

The toxicity and environmental applications of graphene oxide (GO) are largely unknown. The procedures involved in GO synthesis can impact biological responses and toxicity. In this study, the experimental methods involved in the synthesis of lyophilized sonicated graphene oxide (LSGO) followed by 1 h (1 h-LSGO) and 5 h sonication (5 h-LSGO), and t...

Prodigionins is large family of at least 34 pyrrolic compounds including the well‐studied red pigment prodigiosin. Prodigionins are produced by several microorganisms displaying broad biological activities including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities. The present review aims to compile and a...

Background/Objectives: Drug repurposing explores new applications for approved medications, such as simvastatin (SV), a lipid-lowering drug that has shown anticancer potential but is limited by solubility and side effects. This study aims to enhance SV delivery and efficacy against lung cancer cells using bioactive lipid nanoparticles formulated wi...

As part of our efforts to develop novel and more effective metallodrugs, we have synthesized and characterized a new coordination complex between the commercially available drug sunitinib (Sun) and the...

Plant and herbal essential oils (EOs) offer a wide range of pharmacological actions that include anticancer effects. Here, we evaluated the cytotoxic activity of EO from Lippia alba (chemotype linalool), L. alba (chemotype dihydrocarvone, LaDEO), Clinopodium nepeta (L.) Kuntze (CnEO), Eucalyptus globulus, Origanum × paniculatum, Mentha × piperita,...

Geraniol (GOH) is a linear monoterpene alcohol found in essential oils of plants and herbs with multiple pharmacological properties, including anticancer activity. Due to its poor water solubility and volatility, GOH stability, administration, and bioavailability in physiological conditions should be improved to develop efficient carrier systems. T...

3D bioprinting allows creative ideas for 3D scaffold development. Therefore, it enhances the creation of customized dressings for tissue regeneration and the wound healing process. A relevant requirement when employing hydrogels in extrusion-based bioprinting (EBB), is to maintain design fidelity and shape of printed structures. In this work, three...

Violacein (Viol) is a bacterial purple water-insoluble pigment synthesized by Chromobacterium violaceum and other microorganisms that display many beneficial therapeutic properties including anticancer activity. Viol was produced, purified in our laboratory, and encapsulated in a nanostructured lipid carrier (NLC). The NLC is composed of the solid...

Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodig...

BACKGROUND Under scarcity of freshwater, the reuse and low‐cost technological solutions applied to wastewaters seek to reduce contamination to the users and freshwater biota. RESULTS A low‐cost cellulose membrane was doped with silver nanoparticles to filter urban wastewater (UW) from a city in Argentina. The total amount of coliforms and Escheric...

The development of versatile carriers to deliver chemotherapeutic agents to specific targets with establishing drug release kinetics and minimum undesirable side effects is becoming a promising relevant tool in the medical field. Magnetic hybrid nanostructured lipid carriers (NLC) were prepared by incorporation of 1,8-cineole (CN, a monoterpene wit...

Linalool and 1,8-cineole are plant-derived isoprenoids with anticancer activities in lung cancer cells, nevertheless, the cellular and molecular mechanisms of action remain poorly understood. The purpose of this study was to determine the anticancer mechanisms of action of linalool and 1,8-cineole in lung adenocarcinoma A549 cells. Linalool (0–2.0...

Violacein (Viol) is a pigment produced by several Gram-negative bacteria with many bioactivities, such as anticancer, virucide, and antiparasitic. However, violacein is insoluble under physiological conditions preventing its potential therapeutic uses. Surface-active ionic liquids (SAILs) based on the cation 1-alkylimidazolium ([CnHim]) with n = 10...

A nanocomposite based on bacterial cellulose (BC) containing montmorillonite (MMT) modified with silver (BC-MMT-Ag) was developed to be used as potential scaffold for wound healing. Montmorillonite was suspended in silver nitrate solution to incorporate silver in the matrix by ion exchange. The derivative silver clay suspension was used to modify b...

Background and Aims Hypercholesterolemia and oxidative stress are two of the most important risk factors for atherosclerosis. The aim of the present work was to evaluate mandarin (Citrus reticulata) peel oil (MPO) in cholesterol metabolism and lipid synthesis, and its antioxidant capacity. Methods and results Incubation of hepatic HepG2 cells with...

Geraniol (GOH), like other plant-derived natural bioactive compounds, has been found to possess antiproliferative properties that are essential to cope with malignant tumors. However, the mechanisms of molecular action are not fully elucidated. The aim of this study was to evaluate the effect of GOH on some oxidative parameters in human tumor cell...

Aims: 1,8-Cineole is a plant-derived monoterpene and a major constituent of Eucalyptus essential oil. Previously, we demonstrated that 1,8-cineole inhibited hepatocellular carcinoma (HCC) HepG2 cell growth. However, the underlying mechanisms remain unknown. Here, we evaluated the mechanisms of action of 1,8-cineole and the potential benefits of its...

In the global context of an imminent emergence of multidrug-resistant microorganisms, the present work combined the use of nanotechnology and the therapeutic benefits of natural compounds as a strategy to potentiate antimicrobial action of the wide-spectrum antibiotic Ofloxacin (Ofx). Hybrid solid lipid nanoparticles (SLN) were synthesized by incor...

Violacein is a purple pigment member of the indocarbazole family synthesized by Gram(-) bacteria and displays many beneficial activities for human health. However, the medical use of violacein is very limited since the molecule is extremely hydrophobic. An emulsion of violacein and polyoxyethylene sorbitan monolaurate showed high stability in aqueo...

The development of simple, fast and reproducible techniques that provide information about the antioxidant activity (AA) of different compounds is essential to screen and discover new molecules with potential applications in the therapeutic, cosmetic, toxicological and food fields. Here, a novel and simple colorimetric method ("BCB assay") is propo...

Non-small cell lung cancer (NSCLC) accounts for most cases of lung cancer. The peel oil of mandarin Citrus reticulata Blanco cv. Dancy (MPO) is a natural source of essential oils and carotenoids. Volatile and non-volatile lipid compounds were characterized by chromatographic methods. We demonstrate that MPO causes a dose-dependent growth inhibition...

Aims: Linalool is a plant-derived monoterpene with anticancer activity, however its mechanisms of action remain poorly understood. The aim of this work was to elucidate the anticancer mechanisms of action of linalool in hepatocellular carcinoma (HCC) HepG2 cells. Main methods: Cell viability and proliferation were determined by WST-1 assay and B...

Essential oils (EOs) from aromatic plants contain molecules that can interfere with diseases such as cancer and are considered attractive because of their widespread use, good bioavailability, low toxicity and affordable cost. EOs from Lippia alba (LaEOs) manifest intraspecific chemical differences in its composition – defined as chemotypes – and i...

Background: Lipid nanoparticles are considered one of the most promising systems for controlled release of therapeutic molecules highly hydrophobic and with low biodisponibility. Solid lipid nanoparticles and nanostructured lipids carriers are widely seen as the workhorses of drug delivery systems because of low toxicity, enhanced encapsulation ca...

Linalool (LN) is a monoterpene found in essential oils of plants and herbs that produces multiple effects on the mevalonate pathway and interesting antiproliferative activity in cancer cells. However, due to its poor aqueous solubility, an efficient vehicle is needed to improve its administration and bioavailability in physiological media. LN encap...

Aims: Reactive oxygen species (ROS) are generated in the ischaemic myocardium especially during early reperfusion and affect myocardial function and viability. Monoterpenes have been proposed to play beneficial roles in diverse physiological systems; however, the mechanisms of action remain largely unknown. This study aims to assess the effect of...

The essential oils (EOs) of Lippia alba, an herb extensively used as a folk medicine in Latin America, are today promoted as an effective means of eliminating problems caused by hyperlipemia. We hypothesized that L.alba EOs inhibited cholesterol and triacylglycerols synthesis and decreased the intracellular depots of those lipids (lipid droplets),...

Geraniol (G)-a natural compound present in the essential oils of many aromatic plants-has attracted interest for its potential antitumor effects. The molecular mechanisms of the growth inhibition and apoptosis induced by G in cancer cells, however, remain unclear. In this study, we investigated the effects of G on cell proliferation in culture in A...

Monoterpenes are naturally occurring plant hydrocarbons with multiple effects on the mevalonate pathway (MP), while statins competitively inhibit hydroxymethylglutarylcoenzyme-A reductase (HMGCR), the rate-limiting enzyme in the MP. Monoterpenes and statins proved capable of inhibiting both proliferation and cholesterogenesis. In the present study...

Statins are competitive inhibitors of HMG-CoA reductase used in hypercholesterolemic patients. Monoterpenes are non-nutritive dietary components found in the essential oils of many plants with pharmacologic effects on mevalonate metabolism. The study is centered on the effects and action mechanisms of the monoterpene components of essential oils an...

Massive transatlantic immigration starting in 1860 significantly modified the human genetic landscape of Argentina. In an attempt to analyze the genetic composition of the country previous to this radical change, biological samples and genealogical info were obtained from individuals in La Rioja and San Juan cities in central-western Argentina. MtD...