Bojana Andrejic Visnjic

University of Novi Sad · Department of Histology and Embriology

1 Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Odeljenje za nefrologiju 2 Medicinski fakultet Novi Sad, Univerzitet u Novom Sadu 3 Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Odeljenje za laboratorijsku dijagnostiku 4 Klinički centar Vojvodine, Centar za histologiju i patologiju 5 Institut za zdravstvenu zaštitu dece i...

Silymarin, derived from Silybum marianum, has been used in traditional medicine for various ailments. In this study, the cardioprotective and hepatoprotective effects of silymarin against paracetamol-induced oxidative stress were examined in 28 male Swiss Webster mice, divided into four groups and treated for 7 days (via the oral route) with (a) sa...

Background/Aim. To date, most of the scientific attention has been aimed at the morphometric analysis of the nephrogenic zone (NZ) of the fetal renal cortex, while the quantification and analysis of the maturation zone (MZ) and other indicators of renal maturity were missing. The aim of the study was to examine the characteristics of fetal kidney c...

Dyslipidemia and obesity are recognized as two of the major global health issues and main risk factors for coronary heart disease and cerebrovascular disease. In recent years, carob has shown certain antioxidant and anti-dyslipidemic potential. In this study, Wistar rats were fed with a standard and cholesterol-enriched diet and treated orally with...

Objective: The aim of this study was to investigate the hypolipidemic effects of carnosine and a commercial carnosine supplement on lipid status, liver and kidney function, and inflammation associated with dyslipidemia in rats with high-fat diet-induced hyperlipidemia. Materials and methods: The study was conducted on adult male Wistar rats, div...

Doxorubicin (DOX) is one of the drugs necessary for the treatment of the 10 most common types of cancer. The leading adverse effect limiting clinical use of DOX is cardiotoxicity. Given that literature data indicate a protective role of carotenoids in doxorubicin-induced toxicity, in our study we compared the cardioprotective effect of a mixture of...

Acrylamide (AA) is a widely used chemical and an important monomer in various industrial and laboratory processes. In addition, AA is formed during processing of starchy food at high temperature. The aim of our study was to examine effects of subchronic AA treatment on adult rat liver using histological, stereological and biochemical methods. Adult...

Leg length inequality (LLI) affects gait - primarily pelvic and torso movements. LLI is present in around 40-70 % of the healthy population. Due to LLI’s significant impact on the body, as well as the possible occurrence of a variety of associated health problems, the aim of this research is to determine whether there is a significant difference in...

Metakognicija, shvaćena kao znanje o sopstvenim kognitivnim procesima, pri čemu se odnosi, između ostalog, i na aktivno praćenje i posledično regulisanje ovih procesa, uključena je u različite aktivnosti tokom procesa učenja (obrazovanja). Sastoji se iz dva različita, međusobno povezana dela, metakognitivno znanje, koje je svest o svom razmišljanju...

To examine antioxidant capacity and the hepatoprotective effect of carob pulp flour, microwave-assisted extraction was performed. The influence of ethanol concentration (0–40% w/w), extraction time (5–25 min) and irradiation power (400–800 W) on DPPH, FRAP and ABTS antioxidant activity of carob pulp flour extract was evaluated. The strongest influe...

Introduction: Carotenoids are liposoluble plant pigments. The most common in the human diet are a-carotene, b-carotene, b-cryptoxanthin, lycopene, lutein, and zeaxanthin. Methods: This article provides an overview of the findings on carotenoids to date, their depots in body, recommended daily doses and mechanisms of protective action. We searched P...

Statins inhibit cholesterol synthesis, but also have other pleiotropic effects. There are indications that they affect macrophage survival trough the regulation of apoptosis. We analyzed 50 samples of aortic wall, selected based on statins in patients’ therapy (n=25, Th-S group) or statin-free therapy (n=25, Th-nonS group). Each group had 5 samples...

Introduction: Doxorubicin is an antibiotic from the anthracycline group, with clinical use limited by adverse reactions, primarily cardiotoxicity. Material and Methods: This article provides an overview of therapeutic and toxic doses of doxorubicin, the mechanism of side effects, markers for early detection as well as currently available preparatio...

The group of primary renal tumours with granular-oncocytic cytoplasm is a very heterogeneous group, in its histological origin and biological behavior resulting in many diagnostic problems. In this study 57 renal epithelial tumours with granular oncocytic cells were analyzed using fluorescence in situ hybridisation (FISH), array comparative genomic...

The choice of the anti-HER2 agent depends on country-specific availability, the specific, previously administered anti-HER2 therapy and the relapse-free interval, although there is not much published data on the use of lapatinib after progression on pertuzumab and/or T-DM1. The aim of this research is to determine efficacy of lapatinib in this sett...

Acrylamide is a toxic chemical substance with wide implementation in chemical industry. In 2002 the presence of acrylamide was discovered in foods rich in starch which are prepared at high temperatures. The aim of this study was to investigate the histopathological changes in the gastric tissue in Wistar rats induced with injection of oral acrylami...

The choroid plexus (ChP) is essential for brain homeostasis by regulating the secretion of the cerebrospinal fluid (CSF). Despite a substantial body of work on the pathologically alterations of the ChP, there is lack of data concerning the naturally occurring morphological changes asso-ciated with ageing. In this study, we investigated 30 human ChP...

Adenocarcinoma of the prostate is occasionally associated with pulmonary embolism, occurring as a result of secondary hypercoagulable states or cancer-associated emboli. The objective of this study was to provide a review of clinical, histopathological and immunohistochemical features of poorly differentiated prostatic adenocarcinoma, emphasizing t...

Background/Aim. Human papilloma virus (HPV) infection is the main etiological factor for the development of cervical precancerous dysplastic squamous intraepithelial lesions (SIL). The virus oncoproteins affect several proteins included in cell proliferation. The aim of this study was to evaluate application of immunohistochemical markers related t...

Background/Aim. Adenocarcinoma of the lung is the most common histological type of lung cancer. The most reliable method in detecting epidermal growth factor receptor (EGFR) mutations is real-time polymerase chain reaction (PCR). It is recommended to sample three to five biopsy samples with a minimum of 200?400 preserved tumor cells. We analyzed th...

Background/Aim. Calcification is a frequent change in aortic cusps and the most frequent cause for the occurrence of aortic valve stenosis. Recent studies have shown that the process of aortic calcification is often active and closely related to the formation of bone tissue in calcific aortic stenosis. The aim was to analyze the demographic charact...

Background/Aim. Ultrastructural analysis of tumours has shown many common characteristics of certain neoplasms, as well as their specificities. Primary renal epithelial tumours with granular oncocytic cytoplasm is a very heterogeneous group in their histological origin and biological behaviour, which results in a difference in treatment and prognos...

Introduction. Through androgen receptors, androgens regulate prostate cellular growth and function, proliferation, differentiation, apoptosis, lipid metabolism and secretory activity, as well as development and progression of prostate cancer. Prostate cancer, and its primary glandular tissue are influenced by hormones, and it is used for therapeuti...

Introduction. The rarity of primary extraneural ependymomas (EnEs), its great variations in morphology and rare occurrence of metastasis, increase chances of misdiagnosis, particularly if they are found in paraovarian localization. Case report. The presented patient was diagnosed with malignant mesothelioma 14 years ago, after right salpingo-oophor...

Both histology and pathology as a scientific fields and as an educational subjects have always relied on technology. In the 19th century a major breakthrough happened in certain areas related to histotechnology, so histology and pathology were rapidly developing. Technological revolution has lead to modernization of histology and pathology teaching...

Objective: The bioengineering of the small intestine due to impairment of the intestinal epithelium is becoming an attractive field of research. We explored the possibility of the multiplication of the enterocyte mass using the serosal patch technique and growth stimulators. Methods: Sixty Mill Hill rats were divided in 4 groups of 15 animals. In t...

Benign, especially polypoid, lesions of the cervix are common in everyday work. Rare tumors of this region are vascular ones, particularly capillary and/or cavernous hemangiomas. Cervical hemangiomas are especially rare, usually asymptomatic and only one third of the cases is clinically manifested as vaginal bleeding, polyps, etc. We reported a 54-...

Damage to the small intestine and impairment of the intestinal epithelium occur in various diseases, resulting in a need for new epithelium. Therefore, bioengineering of the small intestine is becoming an attractive field of research where all contributions are highly appreciated. The purpose of this study was to determine the possibility of the mu...

There are opposite hypotheses on the effect of saccharin. Our aim was reviewing the influence of chronically ingested saccharin on the function and histological structure of liver and pancreas and all this in light of gender differences. The rats were divided into control group - (Group C) and saccharin-treated group - (Group S) which was given a n...

Lipoma is a benign tumor of adipose tissue, the most common tumor of the human body soft tissues. As such, it can be found almost anywhere in the human body including the gastrointestinal system (incidence below 0.5%), but rarely in the sigmoid colon. This is a case report on symptomatic polyp of the sigmoid colon, which after one year, at control...

A 59-year old patient was admited to the Gastroenterology Clinic with the signs of gastrointestinal bleeding. Computerized tomography (CT) and a barium-meal radiography revealed a circumferential nodular wall narrowing and incomplete stricture at the D2 part of the duodenum. CT also showed a poorly demarcated mass in the upper and lower poles of th...

Apart from assessing the nutrition status, the diagnosis of obesity also includes the assessment of mass and distribution of adipose tissue which provides revealing of latent types of obesity that hold higher health risks. The aim of our study was to assess the nutritional status and to analyze the prevalence of normal weight obesity and abdominal...

Lipomas are rare benign tumors in the gastrointestinal system. Within the gastrointestinal system, 65% of the lipomas are located in the colon (sigmoid part of the colon or rectum) and rarely in the stomach and esophagus. The paper presents two gastrointestinal lipomas. First is the case of lipoma of the sigmoid colon and the other one is gastric l...

Gastrointestinal tract xanthomas are non tumor, well demarcated mucosal lesions that consist of foamy histiocytes, most commonly diagnosed in the stomach. The histologic appearance of xanthomas can resemble certain malignant lesions. After retrospective data base search, we have encountered only 2 cases of xanthomas, both in the antral part of the...

Hilar cholangiocarcinomas involving the bifurcation of the hepatic duct are called Klatskin tumors. A resected specimen of the hilar hepatic region with Klatskin tumor was analyzed. The lining epithelium of major biliary ducts was regular, while the majority of epithelial cells lining the excretory ducts of peribiliary glands (PBGs) exhibited malig...

Cystic fibrosis or mucoviscidosis is a genetically caused disease. The intensity of disease and histopathological changes grow throughout the life. According to the literature, pathological changes characteristic of cystic fibrosis become noticeable around the sixth month of life. After amniocentesis of a 5-lunar month-old fetus had been done, whic...

Introduction: Sebaceous glands are spread almost all over the skin. The spectrum of changes with sebaceous differentiation involves numerous entities including sebaceous carcinoma as a rare malignant tumour. Sebaceous carcinoma makes 1% of skin cancer, and it can be ocular and extraocular. Extraocular sebaceous carcinoma makes a quarter of this num...

Th ere are opposite hypotheses on the eff ect of saccharin. Our aim was reviewing the infl uence of chronically ingested saccharin on the function and histological structure of liver and pancreas and all this in light of gender diff erences. Th e rats were divided into control group – (Group C) and saccharin-treated group – (Group S) which was give...