Bo Liu

Guangzhou University of Chinese Medicine · The second affiliated hospital

This work investigates the enhancement on lubrication performances of water lubricants by multilayer graphene via molecular dynamics simulation. It is found that the multilayer graphene shows interlaminar sliding in the commensurate or incommensurate pattern and thus contributes to an ultra-low friction. Such ultra-low friction can be degraded by a...

An attosecond x-ray pulse with known spectrotemporal information is an essential tool for the investigation of ultrafast electron dynamics in quantum systems. Ultrafast free-electron lasers (FELs) have the unique advantage on unprecedented high intensity at x-ray wavelengths. However, no suitable method has been established so far for the spectrote...

Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group (PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is participated in several processes including growth, senescence, immunity, and tissue repair. CBX4 has been shown to have diverse, even opposite functions in different types of tissue and malignancy in previous...

Alzheimer’s disease (AD) urgently needs innovative treatments due to the increasing aging population and lack of effective drugs and therapies. The amyloid fibrosis of AD-associated β-amyloid (Aβ) that could induce a series of cascades, such as oxidative stress and inflammation, is a critical factor in the progression of AD. Recently, peptide-based...

In this Letter, we propose a novel, to the best of our knowledge, technique to generate short-wavelength radiation carrying time-varying orbital angular momentum (OAM) by tailoring relativistic beams in free-electron lasers. To manipulate the temporal properties of OAM beams, two time-delayed seed lasers with different OAM values are used to intera...

Currently, freshwater scarcity is a global challenge, and developing low-cost methods for purifying, desalinating, and distilling seawater is crucial. Natural wood, owing to its advantages of high hydrophilicity, low density, microporous channels, and low thermal conductivity, is widely considered a vehicle for solar evaporation. However, the major...

Innovative therapeutic strategies are urgently needed for Alzheimer's disease (AD) due to the increasing size of the aging population and the lack of effective drug treatment. Here, we report the therapeutic effects of extracellular vesicles (EVs) secreted by microglia, including macrosomes and small EVs, on AD-associated pathology. Macrosomes stro...

Elasticity, as an emerging phenomenon of crystals, endows the newfangled properties on crystals owing to the altered local crystallinity in the deformed state, and hence attracts increasing research endeavors. However, only a few molecular crystals and a limited number of one-dimensional coordination polymer crystals have exhibited such fantastic e...

Attosecond x-ray pulse with known spectro-temporal information is an essential tool for the investigation of ultrafast electron dynamics in quantum systems. Ultrafast free-electron lasers (FELs) have the unique advantage on unprecedented high-intensity at x-ray wavelengths. However, no suitable method has been established so far for the spectro-tem...

Harvesting largely ignored and wasted electromagnetic (EM) energy released by electronic devices and converting it into direct current (DC) electricity is an attractive strategy not only to reduce EM pollution but also address the ever-increasing energy crisis. Here we report the synthesis of nanoparticle-templated graphene with monodisperse and st...

Polyoxometalates (POMs) with multiple redox active sites have been reported as charge sponge for lithium-ion batteries (LIBs). Herein, we for the first time introduce a polyoxovanadate (POV) ionic crystals with macrocations, [Ni(Phen)3][ClV14O34]Cl (NiV14, Phen = 1,10-phenanthroline), as an anode material for LIBs. The existence of macrocation [Ni(...

Background: Evidence for a potential link between air pollution and rheumatoid arthritis (RA) is inconsistent, and the modified effect of genetic susceptibility on the relationship between air pollution and RA has not been well studied. Objective: Using a general population cohort from the UK Biobank, this study aimed to investigate the associat...

Identifying electrocatalysts with functions of easy dissociation of water, rapid transformation of hydroxyl and facile hydrogen-hydrogen bond formation are indispensable while challenge for realizing efficient alkaline hydrogen evolution reaction (HER). Herein, we presented the design of Ni3Sn2-NiSnOx nanocomposites towards addressing this challeng...

Identifying electrocatalysts with functions of easy dissociation of water, rapid transformation of hydroxyl and facile hydrogen‐hydrogen bond formation are indispensable while challenge for realizing efficient alkaline hydrogen evolution reaction (HER). Herein, we presented the design of Ni3Sn2‐NiSnOx nanocomposites towards addressing this challeng...

Natural macrocycles have shown impressive activity to overcome P-glycoprotein (P-gp)-mediated multidrug resistance (MDR). However, the total synthesis and structural modification of natural macrocycles are challenging, which would hamper the deeper investigations of their structure-activity relationship (SAR) and drug likeness. Herein, we describe...

The DNA methyltransferases (DNMTs) were found in mammals to maintain DNA methylation. Among them, DNMT1 was the first identified, and it is an attractive target for tumour chemotherapy. DC_05 and DC_517 have been reported in our previous work, which is non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward...

B-cell lymphoma 6 (BCL6) is a transcriptional repressor that regulates the differentiation of B lymphocytes and mediates the formation of germinal centers (GCs) by recruiting corepressors through the BTB domain of BCL6. Physiological processes regulated by BCL6 involve cell activation, differentiation, DNA damage, and apoptosis. BCL6 is highly expr...

Herein, we describe a practical streamlined two-component dual C–H activation macrocyclization strategy entailing an in situ-generated directing group. The reaction mode is based on Rh(III)-catalyzed three-component coupling involving cascade C(sp³)–H/C(sp²)–H bond dual activation. The process is facilitated by readily obtainable amidation reagents...

Graphitic carbon nitride (GCN) has drawn widespread interests in solar hydrogen production. However, the difficult exfoliation and the intrinsic shortcomings greatly restrict the hydrogen production efficiency. Herein, we report a chlorine-mediated strategy to synthesize ultrathin wavy-structured GCN nanosheets for enhancing photocatalytic activity...

Membranes composed of two-dimensional (2D) materials suffer from low stability and structural swelling and are usually restricted to applications in aqueous systems. Among various 2D materials, graphitic phase carbon nitride (GCN, g-C3N4) has shown great application potential owing to its structural tunability. Herein, we develop a coordination-ass...

This work studies the thermal conductivity of Na-ion intercalated carbon honeycomb (CHC) via the combination of first-principles calculation and molecular dynamics simulation. The effects of ion concentration, ion charge, temperature, and strain are explored. The simulation results show that the thermal conductivity of CHC presents a nonmonotonic d...

Concerns are growing about the adverse health effects of ambient temperature and ambient temperature changes. However, the association between ambient temperature and ambient temperature changes on the risk of warts outpatient visits is poorly understood. Our study used the distributed lag non-linear model (DLNM) aimed to evaluate the association b...

The Shanghai soft X-ray free-electron laser (SXFEL) user facility project started in 2016 and is expected to be open to users by 2022. It aims to deliver ultra-intense coherent femtosecond X-ray pulses to five endstations covering a range of 100–620 eV for ultrafast X-ray science. Two undulator lines are designed and constructed, based on different...

Fluorescent materials have achieved a great success in the fields of biomedicine, photonic devices, light-emitting diodes and others; however, millions of fluorescent materials lose their emission properties owing to aggregation-caused quenching (ACQ) effect, especially in solid state. Herein, we report the enhanced fluorescence of Melem-based poly...

Shanghai Soft X-ray Free-Electron Laser (SXFEL) is the first X-ray free-electron laser facility in China. The initial commissioning of the beamline was carried out in May 2021. Herein, we present a status report and the first experimental results obtained during the early commissioning of Kirkpatrick-Baez (KB) mirrors for the Coherent Scattering an...

We proposed a simple method based on the seeded free-electron laser (FEL) to generate fully coherent X-ray pulses with durations at dozens of attosecond level. The echo-enabled harmonic generation technique is utilized to generate the fully coherent laser pulse covering the water-window range. A wavefront rotation laser is adopted as the seed to ta...

Polymeric carbon nitride (CN) as a metal-free photocatalyst holds great promise to produce high-value chemicals and H2 fuel utilizing clean solar energy. However, the wider deployment of pristine CN is critically hampered by the poor charge carrier transport and high recombination. Herein, we develop a facile salt template-assisted interfacial poly...

Semiconductor materials were adopted in their solid states for photovoltaic applications owing to their nonsolubility and/or breaking of the photogenerated carrier transfer pathway in solution. The liquid-state photovoltaic device fills in a gap between currently prevailing full-solid-state and solid-liquid-state solar cells; however, reports on th...

Background A large body of evidence has linked air pollution and temperature with chronic kidney disease (CKD) prevalence and hospitalizations. However, most studies have focused on the influence of heat stress on CKD prevalence, and the potential effect modification of temperature on the association between air pollution and CKD has not been well-...

The eyes are highly susceptible to the oxidative stress induced by ultraviolet B (UVB, wavelength between 280 ∼ 320 nm), which could cause severe damage to the cornea. Fullerenols are effective antioxidants to alleviate UVB-induced injury, while their application for the eyes is still rare. In present study, we investigated the protective performan...

Due to its periodic porous structure and high mechanical strength, carbon honeycomb (CHC), a new carbon allotrope, possesses a high energy absorption capability and thus great potential for the design and fabrication of advanced impact-resistant materials. In this work, the propagation and attenuation of shock waves in CHC are investigated for the...

[This corrects the article DOI: 10.3389/fphar.2021.727874.].

Carbon honeycomb (CHC) is a novel carbon allotrope with excellent mechanical and physical properties and has great potentials for various energy and environmental applications. In this work, the tensile response of the CHC nanostructure is re-examined via molecular dynamics simulation to provide an atomistic understanding of its anisotropic mechani...

In this work, the Al2O3 tritium permeate barriers (TPBs) with controllable α/γ phase ratios were prepared by supersonic atmospheric plasma spraying. A comparative study was carried out to explore micro-structure, irradiation tolerance, corrosion property and mechanical properties in the Al2O3 coatings with different α phase ratios (77.6 ± 3.9% and...

Prion diseases are fatal neurodegenerative diseases that can cause severe dementia. The misfolding and accumulation of the prion peptide (PrP)106-126 is crucial, and this process is closely relevant to biological membranes. However, how PrP106-126 aggregation is affected by the molecular chirality of phospholipid membrane is unknown. Thus, in this...

Copper is one of the most promising components in CO2 hydrogenation reactions, however, it still seriously suffers from the lower capability in CO2 activity, as well as poor durability. Herein, a novel copper‐cerium mixed metal oxide is fabricated via a controllable surface deposition route, showing excellent catalytic performance in CO2 hydrogenat...

In recent years, there have been many studies on photocatalytic water splitting, but there are still few high-efficiency photocatalysts for photocatalytic seawater splitting. In this study, a series of hollow Co sulphide-supported CdS catalyst (H–CoS/CdS) composite photocatalysts were prepared by loading CdS onto the surface of H–CoS, which can be...

Background: The aging process and declining estradiol levels are two important factors that cause structural brain alterations. Many prior studies have investigated these two elements and revealed controversial results in menopausal women. Here, a cross-sectional study was designed to individually evaluate estradiol-related structural changes in th...

To generate optical vortex with multiple topological charges, a simple scheme based on the phase mask shaping technique is proposed and applied in a seeded free electron laser. With a tailored phase mask, an extreme-ultraviolet (EUV) vortex with multiple topological charges can be produced. To prove the feasibility of this method, an eight-step pha...

Blockade of immune checkpoint PD-1/PD-L1 has been a promising anticancer strategy; however, clinically available PD-1/PD-L1 small-molecule inhibitors are lacking. In view of the high potency of compound 2 (BMS-1002), structural fine tuning of the methoxy linkage together with diverse modification in the solvent interaction region was conducted. A s...

Purpose. To delineate the clinical and genetic characteristics of Chinese patients with RPGRIP1-associated Leber congenital amaurosis 6 (LCA6). Methods. After screening 352 unrelated families with clinically diagnosed RP, five LCA6 patients with RPGRIP1 variations from unrelated Chinese families were identified. Full ophthalmology examinations, inc...

The practical deployment of promising NiFe‐based oxygen evolution reaction (OER) electrocatalysts is heavily limited due to the constrain in both stability and activity under industrial conditions. Herein, a 3D free‐standing NiFe(oxy)hydroxide‐based electrode with Schottky junction is constructed, in which NiFe(oxy)hydroxide (NiFe(OH)x) nanosheets...

Excellent friction properties of graphene are degraded by the presence of various defects. Such degradation may be suppressed with the help of element passivation. This work investigates the effect of hydrogen (H)-passivation on the friction behavior of graphene containing vacancy defects under strain engineering by molecular dynamics simulations....

The synchronization between the ultrashort electron beam and external seed laser is essential for seeded FELs, especially for a multi-stage one. In this paper, we demonstrate a simple method to obtain the correlations between the pulse energy and relative timing jitter for evaluating the corresponding effects. In this method, the sensitivity of the...

A large fraction of energy, including solar energy, is dissipated into ambient atmosphere as low‐grade waste heat. Efficient utilization of such energy is critical to address current energy crisis and global warming issue. Herein, we report the efficient NIR‐photothermal, thermoelectric and thus photo‐thermo‐electric conversion of polyoxovanadate c...

Insert abstract text here. One of the most pressing challenges in single‐atom catalysis is the manipulation of the coordination environment of the central metals to maximize catalyst performance. Herein, we fabricated a high‐performance catalyst (Co‐SNC) by introducing S into the neighboring position of the Co–N4 coordination. The developed ball‐mi...

S,N co-doped carbon immobilized Co single atoms exhibit superior performance in amine self-coupling reaction, which can be attributed to the superiorities of such dual-site catalysts in boosting O2 activation and amine adsorption, simultaneously. Abstract One of the most pressing challenges in single-atom catalysis is the manipulation of the coord...

Graphene has great potential in the application as supercapacitor electrode materials owing to its unique properties. However, it is challenging to find a facile and cost‐efficient method using cheap raw materials for large‐scale synthesis. Herein, we demonstrate a simple method for converting printing paper to graphene via one‐step pyrolysis follo...

Plane‐oriented mesopore formation and closure in microporous MOFs were demonstrated mimicking the surgical operation but at molecular level. The established strategy enables formation of hierarchical MOF with tunable porosity. The anisotropic nature of the MOF lattice planes enabled not only engineering the mesopore size and volume, but also contro...

The receptor tyrosine kinase Axl plays important roles in promoting cancer progression, metastasis, and drug resistance and has been identified as a promising target for anticancer therapeutics. We used molecular modeling-assisted structural optimization starting with the low micromolar potency compound 9 to discover compound 13c, a highly potent a...

The spectroscopic techniques for time-resolved fine analysis of matter require coherent x-ray radiation with femtosecond duration and high average brightness. Seeded free-electron lasers (FELs), which use the frequency up-conversion of an external seed laser to improve temporal coherence, are ideal for providing fully coherent soft x-ray pulses. Ho...

External seeded free-electron lasers (FELs) hold promising prospects for producing intense coherent radiation at high harmonics of a conventional laser. The practical harmonic up-conversion efficiencies of current seeding techniques are limited by various three-dimensional effects on the electron beam. In this paper, a novel method is proposed to e...

Chromobox 4 (CBX4) is a core component of polycomb-repressive complex 1 with important roles in cancer biology and tissue homeostasis. Aberrant expression of CBX4 has been implicated in several human malignancies. However, its role and underlying mechanisms in the tumorigenesis of lung adenocarcinoma (LUAD) have not been defined in vivo. Here, we f...

In this study, molecular dynamics simulation is used to investigate the effect of metal atom in Zeolitic imidazolate frameworks (ZIFs) on capacitive deionization (CDI) desalination using the same organic linker but with four different metal atoms as the surface of the electrodes in CDI desalination to simultaneously remove both salty and Cr(VI) ion...

Graphene is a good candidate for solid lubricants due to its unique atomic structure. Its lubrication properties are sensitive to chemical modifications such as hydrogenations. Here, an investigation on the lubrication behavior of hydrogenated graphene on a substrate of diamond-like carbon films is performed via molecular dynamics simulations. Hydr...

Metal–organic frameworks (MOFs) are a new type of porous crystal materials that have been widely used in various fields. Owing to their adjustable porous structure, MOF photocatalysts with high catalytic activity have become a research hotspot. In this study, NH2-MIL-125/CoSx samples were investigated as a novel visible light-responsive catalyst fo...

The graphene oxide (GO) membrane has recently emerged as a promising material for nanofiltration. However, its application in seawater desalination is limited because of the comparatively low ion rejection performance. The ionisation of the functional groups such as carboxylic acid results in a negative charge on the GO sheet. In this study, molecu...

In this work, a new porous Li4SiO4 bulk breeder was prepared by a novel synthesis method of compression molding-sintering technique based on organic binder. This process results in a denser bulk configuration breeder with an interconnected channel structure for tritium release, following prefabricated in mold the organic binder is removed by volati...

The hydrogenated diamond-like carbon (H-DLC) films were deposited by Plasma Enhanced Chemical Vapor Deposition (PECVD) technique and implanted with 60 keV He ion (He+) over a wide dose ranges. A two-steep model for the evolution of tribological properties of H-DLC films after irradiation has been proposed and discussed. Firstly, at the He+ doses ra...

We introduce a novel stainless equiatomic FeCrNi medium entropy alloy (MEA) with improved tensile properties and corrosion resistance. This alloy exhibits superior tensile properties with yield strength of 644 MPa, ultimate tensile strength of ~1.03 GPa and ductility of ~54 %, mainly owing to the multiple deformation mechanisms including nanotwinni...