Blas Gil-Extremera

Blas Gil-Extremera
University of Granada | UGR · Department of Medicine

About

228
Publications
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Introduction
Blas Gil-Extremera currently works at the Department of Medicine, University of Granada. Blas does research in Diabetology, Cardiology and Internal Medicine (General Medicine). Their current project is 'Editorial. HYVET Study'.

Publications

Publications (228)
Article
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A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of triterpenes), and a functional olive oil (FOO, 487 ppm of phenolic compounds and enriched with 389 ppm of triterpenes) supplemen...
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Clinical trials are essential tools for the progress of clinical medicine in its diagnostic and therapeutic aspects. Since the first trial in 1948, which related tobacco use with lung cancer, there have been more than 150,000 clinical trials to date in various areas (pediatrics, cardiology, oncology, endocrinology, etc.). This article highlights th...
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Resumen Los ensayos clínicos son una herramienta fundamental para el avance de la medicina clínica en sus vertientes diagnóstica y terapéutica. Desde la aparición del primer ensayo en 1948, que relacionaba el tabaco con el cáncer de pulmón, se han realizado hasta la fecha más de 150.000 en diversas áreas (pediatría, cardiología, oncología, endocrin...
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The DISTINCT study (reDefining Intervention with Studies Testing Innovative Nifedipine GITS-Candesartan Therapy) investigated the efficacy and safety of nifedipine GITS/candesartan cilexetil combinations vs respective monotherapies and placebo in patients with hypertension. This descriptive sub-analysis examined blood pressure (BP)-lowering effects...
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Objectives: DISTINCT (reDefining Intervention with Studies Testing Innovative Nifedipine GITS – Candesartan Therapy) aimed to determine the dose–response and tolerability of nifedipine GITS and/or candesartan cilexetil therapy in participants with hypertension. Methods: In this 8-week, multinational, multicentre, randomized, double-blind, placebo-...
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Importance: Type 2 diabetes mellitus and associated chronic kidney disease (CKD) have become major public health problems. Little is known about the influence of diet on the incidence or progression of CKD among individuals with type 2 diabetes. Objective: To examine the association between (healthy) diet, alcohol, protein, and sodium intake, an...
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Background Blood pressure (BP) has a circardian rhythm. Most of the people presents a BPfall between 10-20% during nighttime hours (dipper condition). Measurement of these circadianvariations is performed by continuous blood pressure ambulatory monitoring. We have studiedthe possible relation between blood pressure nocturnal fall and cardiovascular...
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Datos epidemiológicos señalan que la prevalencia de demencia en España en la población mayor de 65 años puede alcanzar la tasa del 10%. La enfermedad de Alzheimer da cuenta de un mayor número, pero no es despreciable la que se asocia a hipertensión crónica. Las alteraciones cerebrales secundarias a lesiones vasculares generales en los hipertensos,...
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Drug-induced parkinsonism usually resolves after discontinuation of the causative agent. However, it persists in some patients, who actually have subclinical neurodegenerative parkinsonism. Identification of this condition is important because these patients could benefit from therapeutic measures. The objective of this study was to prove whether t...
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Objective: The aim of this paper was to analyse the etiologic, clinical, and therapeutic characteristics of the ischemic stroke in the comarca of Poniente, Almería, Spain. Methods: An observational descriptive study was carried out from June 2005 to June 2006 in the Hospital of Poniente. We studied 243 patients admitted to Internal Medicine Departm...
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This monograph issue of the journal is dedicated to the most frequent cardiovascular disorders in the Western countries: hypertension, mostly in the elderly. In this situation, two patterns can be found: (a) increased systolic and diastolic blood pressure and (b) isolated systolic hypertension.
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The incidence of hypertension is high in the elderly and is present in 2/3 of the patients older than 65 years. Prevalence can reach 90% in patients older than 80 years. The presence of isolated systolic hypertension (ISH) is characteristic of this population. However, the prevalence of hypertension by ambulatory blood pressure monitoring (ABPM) is...
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Lipid disorders are a common clinical challenge in the western countries. In patients with dyslipemia (total cholesterol > 200 mg/dl, HDL cholesterol < 35 mg/dl, LDL cholesterol > 130 mg/dl and triglycerides > 150 mg/dl) it is mandatory to normalize blood pressure (<130/80 mmHg) as well to reduce LDL-C values to normal levels by using drugs to inhi...
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Background. The incidence of hypertension in the Western countries is continuously increasing in the elderly population and remains the leading cause of cardiovascular and morbidity. Methods. we analysed some significant clinical trials in order to present the relevant findings on those hypertensive population. Results. Several studies (SYST-EUR, H...
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To assess if very elderly people with hypertension obtain early benefit from antihypertensive treatment. One year open label active treatment extension of randomised controlled trial (Hypertension in the Very Elderly Trial (HYVET)). Hospital and general practice based centres mainly in eastern and western Europe, China, and Tunisia. People on doubl...
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fractures may have serious implications in an elderly individual, and fracture prevention may include a careful choice of medications. the Hypertension in the Very Elderly Trial (HYVET) was a double-blind placebo-controlled trial of a thiazide-like diuretic (indapamide 1.5 mg SR) with the optional addition of the angiotensin-converting enzyme (ACE)...
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Background: Co-administration of niacin with statin offers the potential for additional lipid management and cardiovascular risk reduction. However, niacin is underutilised because of the side effects of flushing, mediated primarily by prostaglandin D(2) (PGD(2)). A combination tablet containing extended-release niacin and laropiprant (ERN/LRPT),...
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Objective We aimed to study the influence of family history on the age of onset of hypertension. Patients and methods We analyzed 528 (302 women and 226 men; age range, 16-89 years) hypertensive patients in a descriptive cross-sectional study. Results Onset was earlier in men (43.32±11.74 years) than in women (47.84±10.92). Age of onset was signi...
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Background: We compared the lipid-altering effects of ezetimibe/simvastatin (EZE/SIMVA) co-administered with fenofibrate (FENO) in mixed hyperlipidemic patients with (MetS) versus those without MetS. Methods: A total of 611 patients, 20 to 79 years old, with LDL-C 130-220 mg/dL (100-180 mg/dL for patients with type 2 diabetes [T2D]), triglycerid...
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Mixed hyperlipidemia is characterized by elevated low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and TG-rich lipoprotein levels. In a multicenter, randomized, double-blind, placebo-controlled, parallel arm trial, eligible patients were 18 to 79 years of age, with mixed hyperlipidemia (LDL-C 130-220 mg/dL, TG 150-500 mg/dL). Patient...
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The Hypertension Unit, University Hospital San Cecilio of Granada, on fulfilling 15 years and after the experience acquired in this extended period, wants to stress various "facts": 1) the importance of correctly measuring blood pressure, avoiding rounding off "numbers" and making three consecutive measurements, taking the mean value of the last tw...
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The Hypertension Unit, University Hospital San Cecilio of Granada, on fulfilling 15 years and after the experience acquired in this extended period, wants to stress various «facts»: 1) the importance of correctly measuring blood pressure, avoiding rounding off «numbers» and making three consecutive measurements, taking the mean value of the last tw...
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Left ventricular hypertrophy is an important predictor of cardiovascular risk and its detection contributes to risk stratification. However, echocardiography is not a routine procedure and electrocardiography (ECG) underestimates its prevalence. To evaluate the prevalence of echocardiographic left ventricular hypertrophy in low and medium risk non-...
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The selective alpha 1-adrenoceptor antagonist doxazosin in both standard formulation and gastrointestinal therapeutic system (GITS) controlled-release formulation is effective for hypertension without having a negative impact on serum lipids. This study was designed to compare the relative efficacy of these two formulations of doxazosin on clinic a...
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To study the variations lipídicas, antropométricas and of arterial pressure, for age and sex, and its comparison with other national and international studies. The study has removed to end in 380 teenagers and adult young, 220 women and 160 males, with ages between 14-24 years enrolled in school of secondary educations. This one was calculated for...
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Refractory hypertension has a 1% to 3% prevalence and corresponds to the cases that do not respond to drug treatment and general measures: diet, physical exercise and salt intake restriction. Obstructive sleep apnea syndrome (OSAS) occurs in 2%-4% of the hypertensive male and female population respectively. It occurs in about 10% of the population...
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Fixed combinations of calcium channel blockers and angiotensin converting enzyme inhibitors represent an alternative to diuretic-based combination therapy. The aim of the present study was to compare the antihypertensive efficacy of the combination enalapril 10 mg/nitrendipine 20 mg (E/N) vs losartan 50 mg/hydrochlorothiazide 12.5 mg (L/H), assesse...
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This prospective, double-blind, randomised, parallel-group, multicentre study assessed the adjunctive effect of telmisartan monotherapy versus placebo in controlling blood pressure during the last six hours of the 24-hour dosing period. After a two-week run-in phase, 375 patients with essential hypertension uncontrolled on existing therapy were ran...
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Aim To determine the degree of blood pressure (BP) control (optimal < 140/90 mmHg, suboptimal ≤140/ 90 mmHg) in hypertensive patients who attended Primary Health Care centers during the day of November 24, 1999. Design. Descriptive and trasnverse observational study. Study environment. Primary Health Care centers in Granada Subjects Ambulatory pat...
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The risks and benefits of treating hypertension in individuals older than 80 years are uncertain. A meta-analysis has suggested that a reduction in stroke events of 36% may have to be balanced against a 14% increase in total mortality. To report the results of the pilot study of the Hypertension in the Very Elderly Trial (HYVET), which is in progre...
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Telmisartan, an angiotensin II receptor blocker, is an effective once-daily antihypertensive agent available either alone or in fixed-dose combination with hydrochlorothiazide (HCTZ). This multicentre, prospective, randomised, open-label, blinded-endpoint (PROBE) study assessed the efficacy and safety of six weeks' treatment with telmisartan 40 mg/...
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Purpose: The objectives of this trial were to determine the efficacy and safety profiles of 4-mg doxazosin gastrointestinal therapeutic system (DOX GITS) versus 2-mg and 4-mg doses of doxazosin-S (DOX-S) and to evaluate the effect of doxazosin on lipid metabolism.
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It is probable that if we perform an echocardiography to low and medium risk hipertensive subjects, it could modify the category of absolute cardiovascular risk in an important number of them, leading to a redistribution as high risk patients and establishing the indication of pharmacologic treatment. The aim of the study was to evaluate the preval...
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Objective: to compare the 24 hours antihypertensive efficacy of the fixed dose combinations Enalapril 10mg/ Nitrendipine 20mg (E/N) vs Losartan 50mg/ Hidrochlorotiazide 12.5mg (L/H), in mild-to-moderate essential hypertension.
Article
Objective To know clinical, diagnostic, and treatment issues of brucellosis in the Almeria province. Methods Descriptive, epidemiological study from 1,595 disease report cards in the Almeria province during the 1972-1998 period. Issues concerning complications and treatment were reported in 890 cards (57.8%), symptoms, signs and hemograms in 565 (...
Article
The obstructive sleep apnea syndrome (OSAS) occurs in more than 10% of the population aged over 65 years and represents a major risk factor associated with hypertension, obesity, snoring, policytemia, and heart failure (30 %-36 %). Patients with this syndrome typically have diurnal sleepiness, memory loss, irritability, intelectual deterioration an...
Article
To know clinical, diagnostic, and treatment issues of brucellosis in the Almeria province. Descriptive, epidemiological study from 1,595 disease report cards in the Almeria province during the 1972-1998 period. Issues concerning complications and treatment were reported in 890 cards (57.8%), symptoms, signs and hemograms in 565 (35.4%), and other d...
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After the double-blind, placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial ended in February 1997, randomized patients were offered active study medication for a further period of observation. To refine the estimates of the long-term effects of antihypertensive therapy on the incidence of dementia. Eligible patients had no dementia...
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Endothelin has been identified as a potent vasoconstrictor. The aim of this study was to evaluate urinary endothelins and their relation to other markers of renal damage, such as microalbuminuria, creatinine, and N-acetyl-beta-glucosaminidase (NAG), in a group of recently diagnosed (less than 1 year) hypertensive subjects and a control group. We se...
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Despite the importance of hypertension in adults, its effects on child health are poorly understood. This cross-sectional epidemiological study was designed to look for a relationship between elevated blood pressure (BP) in children and 24-h urinary excretion of sodium (Na) and potassium (K), and between BP and dietary salt intake. The study popula...
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The antihypertensive efficacy of nebivolol and amlodipine and their tolerability were compared in a multicentre, randomized, active-controlled, double-blind parallel-group trial in elderly patients with mild to moderate essential arterial hypertension. One hundred and eighty-four subjects aged > or = 65 years were screened. After a run-in phase of...
Article
When blood pressure (BP)-lowering efficacy is assessed by measurements taken in a clinic setting, angiotensin II-receptor antagonists show similar efficacy to angiotensin-converting enzyme inhibitors and better tolerability. A search of MEDLINE to date, however, reveals no randomized, double-blind studies using ambulatory BP monitoring (ABPM) to co...
Article
The objective of the present study was to compare the blood pressure lowering effect of telmisartan 40mg (T40) or 80mg (T80) in combination with hydrochlorothiazide 12.5mg (H) with losartan 50mg (L) plus H using ABPM.Patients with newly diagnosed or inadequately treated mild to moderate hypertension with a mean 24-hour ambulatory DBP (ADBP) >85mmHg...
Article
We describe the case of a 48 year-old married woman, with a family history of hypertension. She presented with a 7 year history of hypertension (stages II-III), without response to all the pharmacological treatments previously administered. The negative results of the laboratory studies in order to confirm a secondary process together with the dram...
Article
A number of trials and meta-analyses have demonstrated clear benefits of blood pressure (BP) reduction in patients aged The Hypertension in the Very Elderly Trial (HYVET) pilot recruited 1283 patients aged ≥80 years and showed the feasibility of performing such a trial in this age group. It was a Prospective Randomised Open Blinded End-Points (PROB...
Article
The aim of the study was to compare 24h-BP reduction and BP control after 12 weeks treatment with irbesartan 150-300 mg o.d. or enalapril 10-20 mg o.d. by means of ABPM in patients with mild-to-moderate essential hypertension. After a 3 week placebo period, 238 patients (48% m, 52±11 years) with daytime-DBP ≥85 were randomized to IRB 150 mg or ENA...
Article
To evaluate the zinc organic concentration in the chronic obstructive pulmonary disease (COPD) in relation to a control group. Also, to analyze if the serum zinc levels are related with zinc concentration in erythrocyte, nail and hair. Forty patients of COPD have been studied, all males, average age 62 +/- 7 years and body mass index (BMI) of 27 +/...
Article
The addition of hydrochlorothiazide (HTZ) to nonresponders patients to losartan (LOS) is commonly used. However, the lack in beneficial effect in vascular risk provided by diuretic may be related to potentially antagonistic metabolic effects on glucose and lipid profile. The aim of this study was to evaluate the efficacy of doxazosin (DOX), once da...