Björn L.D.M. Brücher

4open

Background Carcinogenesis is widely thought to originate from somatic mutations and an inhibition of growth suppressors, followed by cell proliferation, tissue invasion, and risk of metastasis. Fewer than 10% of all cancers are hereditary; the ratio in gastric (1%), colorectal (3-5%) and breast (8%) cancers is even less. Cancers caused by infectio...

The delineation of key molecular pathways has enhanced our knowledge of the biology of tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell-cell communication and the possibilities for modulation provide new opportunities for treating cancers. Cells communicate by direct and indirect signaling. Direct cell-cell...

Hysteron proteron reverses both temporal and logical order and this syllogism occurs in carcinogenesis and the somatic mutation theory (SMT): the first (somatic mutation) occurs only after the second (onset of cancer) and, therefore, observed somatic mutations in most cancers appear well after the early cues of carcinogenesis are in place. It is no...

Background/Aims: Many questions in cancer biology remain unanswered. Perhaps the most important issues remaining to be addressed focus on the molecular basis of carcinogenesis. Today’s cancer focus lies on genetics and gene expression, which is unlikely to explain the true cause of most cancers or lead to a cure. Methods: Earlier, we provided a p...

„Leben mit Krebs – Digitalisierung, Künstliche Intelligenz in Medizin und Tumormedizin“

Background/aims: Many questions in cancer biology remain unanswered. Perhaps the most important issues remaining to be addressed focus on the molecular basis of carcinogenesis. Today's cancer focus lies on genetics and gene expression, which is unlikely to explain the true cause of most cancers or lead to a cure. Methods: Earlier, we provided a...

A 44-year-old athletic man presented in 2009 with severe low back pain. Dual-energy x-ray absorptiometry revealed severe osteoporosis; serum testosterone was 189 ng/dL while serum estradiol (E2) measured by liquid chromatography/mass spectrometry was 8 pg/mL. DNA was extracted and sequenced from a blood sample from the patient since his maternal fi...

Supplementary Material to Physics Essentials Enable Deeper Understanding in Signaling and Crosstalk of the Carcinogenesis Paradigm “Epistemology of the Origin of Cancer”

Radioactivity and radiation-induced mutations are believed to be primary causal examples of cancer-initiating events (stimulus). The assumption that an increase in cancer risk develops from any amount of radiation gave rise to the linear no-threshold model. This also led to the assumption that cancer is caused by somatic mutations as described by t...

Editorial There is a perception that meta-analyses can provide neat and concise conclusions which can then be used for clinical treatment guidelines or in public health as in the ongoing Coronavirus disease 2019 (COVID-19) pandemic. The widespread popularity of meta-analyses also presents a risk in that inconclusive results in the original individu...

Science should not stigmatize in regard to origin, citizenship, gender, religion or color and many aspects are of importance in this regard. We at the 4open Life Sciences – Medicine Editorial Board care primarily about science, and distance ourselves from war, and support humanitarian initiatives, but reject any attempt at alienating anyone (gover...

- to improve education, training & research o with its knowledge & expertise o in any area of science and medicine - to stimulate critical thinking - for broad audiences from students to senior professor - by delivering online lectures of high quality - without regard on on marketing, fame or pride

CITATIONS 0 READS 129 60 authors, including: Some of the authors of this publication are also working on these related projects: SafeConsume View project O perfil epidemiológico e demográfico dos pacientes com tumor da cabeça e pescoço HPV16+ numa instituição oncológica em Portugal View project

Theodor-Billroth-Academy® (TBA®), and its International Consortium of Research Excellence (INCORE), announces realization of next step of our conception - creation of a foundation - starting in the US - on May 5 - Sacramento Big Day of Giving Cancer Metastases Research Fund (CMRF) - 501 c (3) non-profit organization - founded in the US - to...

4open, its Editorial Board, scientists, and the network of the Theodor-Billroth-Academy and its International Consortium of Research Excellence (INCORE) are aware of the current dire situation for Ukrainian scientists and students. After the unprovoked attack on Ukraine on February 24, 2022, our colleagues in Ukraine are now in fear for their fam...

4open, its Editorial Board, scientists, and the network of the Theodor-Billroth-Academy and its International Consortium of Research Excellence (INCORE) are aware of the current dire situation for Ukrainian scientists and students. After the unprovoked attack on Ukraine on February 24, 2022, our colleagues in Ukraine are now in fear for their famil...

Purpose: The local health department (in German: Gesundheitsamt) ordered a shutdown of a teaching hospital due to the severe acute respiratory syndrome coronavirus (SARS-CoV-2) outbreak – one index patient and five infected healthcare workers – and put it under quarantine. For the first time, all patients plus all employees of one German hospital (...

Cited in @WHO report An awesome #Teamwork by 35 #scientists from 15 #countries #Australia #Austria #Brazil #Ecuador #Germany #Guatemala #Iran #Israel #Italy #Philippines #Poland #Portugal #Spain #Turkey & #USA #Openaccess article “COVID-19: Pandemic surgery guidance” has been cited in @WHO report https://bit.ly/3mtd6ri Check out interview ht...

As the COVID-19 pandemic endures, an interview to understand the process behind the creation of pandemic surgery guidance, published openaccess by 35 scientists and clinicians from 15 countries. Find out more: http://bit.ly/3cMHNPP

The World Health Organization (WHO) stated at Mar 11th, 2020, in its Situation Report -51, the Coronavirus disease 2019 (COVID-19) as a pandemic. In early April 2020, a teaching hospital underwent shutdown and quarantine due to an outbreak of infection in accordance with Section 6 of the Infection Protection Act (patient index and 5 infected nursin...

Anfang April 2020 wurde für ein Lehrkrankenhaus aufgrund eines COVID-19-Ausbruchs (Indexpatient und fünf infizierte Pflegekräfte) die Betriebsunterbrechung und Quarantäne gemäß § 6 Infektionsschutzgesetz angeordnet. Das komplette Personal (Ärzte, Pflegekräfte und nichtmedizinisches Personal [NMP]) wurde auf COVID-19 getestet. Die kumulierte Infekti...

Based on high quality surgery and scientific data, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues circumstances related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, the authors used the B...

Based on high quality surgery and scientific data, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues circumstances related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, the authors used the B...

Abstract Despite the high quality of science and surgery, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, surgeons and scientists used...

Despite the high quality of science and surgery, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, surgeons and scientists used the Briti...

Remembering Jan 29, 1881 including being aware - everything in #medicine #surgery #cancersurgery #science needs #teamwork It’s always Team Work - 139th anniversary day (Jan 29, 1881) Christian Albert Theodor Billroth (1829-1894) performed the first successful distal gastrectomy for gastric cancer within 90 min 

Abstract It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect. Here, decades of thinking based on incorrect assumptions has resulted in an incorrect hypothesis on the origin of cancer. Ma...

The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with incessant inflammation. This persistent inflammation, when unresolved, induces fibrosis with consequent...

Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex. TFs thus support or suppress the recruitment of the corresponding RNA polymerase. In general, TFs are classified by structure or function. The T...

The microbiome, the relationship between environmental factors, a high-fat diet, morbid obesity, and host response have been associated with cancer, only a small fraction of which (<10%) are genetically triggered. This nongenetic association is underpinned by a worldwide increase in morbid obesity, which is associated with both insulin resistance a...

The role of ubiquitous proteins (UPs) and their corresponding enzymes have been underestimated in carcinogenesis as the focus of much research revolved around measuring mutations and/or other genetic epiphenomena as surrogate markers of cancer and cancer progression. Over the past three decades, the scientific community has come to realize that the...

Fibroblasts are actively involved in the creation of the stroma and the extracellular matrix which are important for cell adhesion, cell-cell communication, and tissue metabolism. The role of fibrosis in carcinogenesis can be examined by analogy to tissues of various cancers. The orchestration of letters in the interplay of manifold components with...

A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease. Chronic inflammation involves many cell types with numerous cytokines and signaling pathways, the release of different components by the cells, and the crosstalk provo...

The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this review shows the multiplicity of its effects on interdicting signaling and crosstalk, anti-infl...

Inflammation is the body's reaction to pathogenic (biological or chemical) stimuli and covers a burgeoning list of compounds and pathways that act in concert to maintain the health of the organism. Eicosanoids and related fatty acid derivatives can be formed from arachidonic acid and other polyenoic fatty acids via the cyclooxygenase and lipoxygena...

The vast majority of anticancer strategies are symptomatic but in order to achieve some tangible progress, we need to identify the cause(s) of the majority of cancers. There is a kind of zeitgeist that findings in genetics, namely somatic mutations, are reflexively viewed as being causative for carcinogenesis, although some 80% of all cancers are p...

The shortage of nursing staff in Germany compromises public healthcare in deference to profits explaining why this is on the daily political and media agenda. In Germany, over a 22 year period, significant savings were achieved by decreases in: (1) hospital beds by À29.3% saving 119 000 beds, (2) patient care and treatment days by À23% saving 43.1...

HMCs were isolated from human greater omentum. Fluorescence-labeled tumor cells (SKOV-3, OvCar-29, OAW42, FraWü; ovarian/HT29; colorectal) were incubated on confluent mesothelial monolayers with 10 µM simvastatin for 48 h. Adhesion was quantified using a fluorescence reader. Expression of the adhesion molecules VCAM-1, ICAM-1 and β1 integrin chain...

HMCs were isolated from human greater omentum. Fluorescence-labeled tumor cells (SKOV-3, OvCar-29, OAW42, FraWü; ovarian/HT29; colorectal) were incubated on confluent mesothelial monolayers with 10 µM simvastatin for 48 h. Adhesion was quantified using a fluorescence reader. Expression of the adhesion molecules VCAM-1, ICAM-1 and β1 integrin chain...

influence of PGK1 on CXCR4 and β-catenin was assessed as well as the invasiveness of PGK1 overexpressing cancer cells published here by Zieker et al. Int J Cancer 2010 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811232/

A metastatic nude mouse model simulating human gastric cancer behavior by orthotopic tumor implantation was established. Mice were divided into one control group (n=5) and two experimental groups (n=30) divided by half in animals baring tumors from MKN45-cells and MKN45-cells with plasmid-mediated overexpression of PGK1. In the course of tumor grow...

The vast majority of anticancer strategies are symptomatic but in order to achieve some tangible progress, we need to identify the cause(s) of the majority of cancers. There is a kind of zeitgeist that findings in genetics, namely somatic mutations, are reflexively viewed as being causative for carcinogenesis, although some 80% of all cancers are p...

Purpose: We retrospectively investigated the postoperative pancreatic fistula (PF) rate in patients (pts) undergone pancreatico-duodenectomy (PD) measured by positive amylase in accordance to International Study Group definition and grading compared to the occurrence of preoperative biliary stenting. Methods: Patients between June 2014 and October...

In the first article published in 4open, the journal’s Editor-in-Chief, Björn LDM Brücher discusses several important aspects relating to scientific publishing in a modern, digital world.

One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables with an outcome-oriented approach. Such an approach, in a multimodal therapy setting, could identify those patients (1) who should undergo a de...

Um Diagnose und Therapie von Krebserkrankungen weiter zu verbessern, ist es entscheidend, bereits vorhandenes Wissen in Patienten- und Tumor-spezifische Ansätze zu integrieren. Dabei sollen zukünftig molekularbiologische Informationen einen multimodalen Diagnose- und Therapieansatz ermöglichen, um Patienten zu identifizieren, die nach den festgeleg...

Der globale weltweite Biotechnologie Markt wird Ende des Jahrzehnts voraussichtlich 500 Milliarden US Dollar betragen mit kalkulierten monatlichen Steigerungsraten von ca. 11% pro Jahr. Hoffnung besteht mittels zu erarbeitender molekularbiologischer Daten reale personalisierte und individualisierte Diagnose-und Behandlungsstrategien zu verschiedene...

Hysteron proteron reverses both temporal and logical order and this syllogism occurs in carcinogenesis and the somatic mutation theory (SMT): the first (somatic mutation) occurs only after the second (onset of cancer) and, therefore, observed somatic mutations in most cancers appear well after the early cues of carcinogenesis are in place. It is no...

Not the development of a new cancer hypothesis, but the desire to understand and characterize carcinogenesis is of importance. The approach proved to be successful: not only did a new theory emerge that fundamentally questions the previous hypotheses, but also a new, outcome-oriented cancer strategy. In an interview with “Monitor Healthcare Resea...

Background: The somatic mutation theory as the origin of cancer (carcinogenesis) was born some 100 years ago, when Theodor Boveri 1914 suggested that a combination of chromosomal defects may result in cancer. This was followed by Karl-Heinrich Bauer in 1928 suggesting that mutations could cause cancer. Subsequently, in 1953 Carl Nordling proposed t...

Background: The somatic mutation theory as the origin of cancer (carcinogenesis) was born some 100 years ago, when Theodor Boveri 1914 suggested that a combination of chromosomal defects may result in cancer. This was followed by Karl-Heinrich Bauer in 1928 suggesting that mutations could cause cancer. Subsequently, in 1953 Carl Nordling proposed t...

The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the distinction between adenocarcinomas above, below, or within the gastroesophageal junction; combined modality therapy; tumor markers for use in personalized medicine; PET-CT and endoscopic biopsies in the evaluation of response to neoadjuvant c...

Global economies and their health systems face a huge challenge from cancer: 1 in 3 women and 1 in 2 men will develop cancer in their lifetime. In the less developed countries, the volume of cancer patients will overwhelm the existing healthcare systems. Even in developed regions, patients with upper gastrointestinal (GI) cancer usually present wit...

Die Autoren sind der Auffassung, dass nur eine klar definierte personalisierte und individualisierte Antikrebs-Strategie langfristig in eine reale präzisierte Tumor-Therapie und Strategie resultieren kann. Es besteht Hoffnung, dass dies es ermöglicht, die Mikro- und Makro-Interaktionen von Tumoren und ihrer Umgebung (Microenvironment) besser zu ver...

Appropriate pain therapy prior to diagnosis in patients with acute abdominal pain remains controversial. Several recent studies have demonstrated that pain therapy does not negatively influence either the diagnosis or subsequent treatment of these patients; however, current practice patterns continue to favour withholding pain medication prior to d...

The delineation of key molecular pathways has enhanced our knowledge of the biology of tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell-cell communication and the possibilities for modulation provide new opportunities for treating cancers. Cells communicate by direct and indirect signaling. Direct cell-cell...

Background Carcinogenesis is widely thought to originate from somatic mutations and an inhibition of growth suppressors, followed by cell proliferation, tissue invasion, and risk of metastasis. Fewer than 10% of all cancers are hereditary; the ratio in gastric (1%), colorectal (3-5%) and breast (8%) cancers is even less. Cancers caused by infection...

e14500 Background: Unanswered questions remain regarding treatment efficacy in colon cancer (CC), especially those determining high-risk node-negative cohorts that may benefit from adjuvant therapy. We sought to evaluate the use of machine learning and classification modeling to estimate survival and recurrence in CC. Methods: We used the Departmen...

Unanswered questions remain in determining which high-risk node-negative colon cancer (CC) cohorts benefit from adjuvant therapy and how it may differ in an equal access population. Machine-learned Bayesian Belief Networks (ml-BBNs) accurately estimate outcomes in CC, providing clinicians with Clinical Decision Support System (CDSS) tools to facili...

Unanswered questions remain in determining which high-risk node-negative colon cancer (CC) cohorts benefit from adjuvant therapy and how it may differ in an equal access population. Machine-learned Bayesian Belief Networks (ml-BBNs) accurately estimate outcomes in CC, providing clinicians with Clinical Decision Support System (CDSS) tools to facili...

Surgical resection remains a mainstay of treatment and is highly effective for localized colorectal cancer. However, ~30-40% of patients develop recurrence following surgery and 40-50% of recurrences are apparent within the first few years after initial surgical resection. Several variables factor into the ultimate outcome of these patients, includ...

Despite advances in neoadjuvant and adjuvant therapy, attention to proper surgical technique, and improved pathological staging for both the primary and metastatic lesions, almost half of all colorectal cancer patients will develop recurrent disease. More concerning, this includes ~25% of patients with theoretically curable node-negative, non-metas...

Since the "War on Cancer" was declared in 1971, the United States alone has expended some $300 billion on research, with a heavy focus on the role of genomics in anticancer therapy. Voluminous data have been collected and analyzed. However, in hindsight, any achievements made have not been realized in clinical practice in terms of overall survival...

Peritoneal surface malignancy (PSM) is a heterogeneous form of cancer. A paradigm shift has occurred in the past 50 years; operative intervention in selected patients with limited peritoneal carcinomatosis (PC) is now undertaken with curative intent. Approximately 150,000 patients are diagnosed with colorectal cancer (CRC) in 2012 in the USA and on...

Advanced gastric cancer (GC) has been recognized as lethal disease when peritoneal metastases (PM) occurred. There is no standard treatment for advanced GC with PM. Until 1980s, the therapeutic arena for these patients had remained stagnant, with no therapeutic approach having shown a survival gain in GC with PM. However, cytoreductive surgery (CRS...