Biswaranjan Paital

Odisha University of AGriculture and Texchnology

Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI disorders, including IBD, that are driven by oxida...

Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially on fish. Fish is a staple and affordable food source, rich in animal protein, along with various vitamins, essential amino acids, and minerals. Exposure of fish to microplastics, pesticides, and various nanop...

The recent emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease (COVID-19) has become a global public health crisis, and a crucial need exists for rapid identification and development of novel therapeutic interventions. In this study, a recurrent neural network (RNN) is trained and optimize...

The oxidative stress (OS) condition and antioxidant level as a function of pH, few major elements, temperature, turbidity, organic carbon, sediment, and water salinity are vital to understanding the redox homeostasis of inhabiting animals. These parameters are also used to monitor environmental health. A spatiotemporal redox antioxidant system, fol...

The water of the mangrove ecosystem and surrounding coastal areas are gradually shrinking due to the intense destruction. Therefore, the effects of the physicochemical properties of the habitat water on the in-habitant species must be studied. Scylla sp. is involved in the food chain and bioturbation structure formation in mangrove forests. Five ma...

Medical-grade oxygen is the basic need for all medical complications, especially in respiratory-based discomforts. There was a drastic increase in the demand for medical-grade oxygen during the current pandemic. The non-availability of medical-grade oxygen led to several complications, including death. The oxygen concentrator was only the last hope...

Mycoplasma sp. comprises cell wall-less bacteria with reduced genome size and can infect mammals, reptiles, birds, and plants. Avian mycoplasmosis, particularly in chickens, is primarily caused by Mycoplasma gallisepticum (MG) and Mycoplasma synoviae. It causes infection and pathology mainly in the respiratory, reproductive, and musculoskeletal sys...

Studies on oxidative stress on organisms especially on invertebrates are widely used as biomarkers in relation to the redox regulatory system to assess the freshwater environment. Despite broad availability of Indian apple snail Pila globosa, no data on its antioxidant and oxidative stress status are available. Therefore, determination of tissue-sp...

The extensive use of plastics in daily life has led to the generation of huge amounts of plastic waste, which causes an enormous burden on the environment. More than half of the plastic waste ends up in the landfill, and about one-fifth of waste is managed by incineration. Only about one-tenth of plastic waste is recycled, and the rest, about one-f...

Salinity is a decisive abiotic factor that modulates the physiology of aquatic organisms. Salinity itself is modulated by various factors—most notably by anthropogenic factors. In coastal regions, increasing salinity is observed mostly due to the elevated rate of evaporation under high temperatures, especially under global warming. In addition, man...

Type 2 diabetes mellitus is a metabolic disorder resulting from impaired insulin secretion and resistance. Dipeptidyl peptidase (DPP)-IV is an enzyme known to trigger the catalysis of insulinotropic hormones, further abating the endogenous insulin levels and elevating the glucose levels in blood plasma. In the field of drug development, DPP-IV inhi...

Type 2 diabetes mellitus is a metabolic disorder resulting from impaired insulin secretion and resistance. Dipeptidyl peptidase (DPP)-IV is an enzyme known to trigger the catalysis of insulinotropic hormones, further abating the endogenous insulin levels and elevating the glucose levels in blood plasma. In the field of drug development, DPP-IV inhi...

The semi-sessile, ectothermic, amphibious mollusc Pila globosa receives less attention for studying its environmental aspects. Its ecological role, ecotoxic and physiological responses to environmental factors including pollution and during dormant periods such as hibernation and estivation to understand key information about many cellular metaboli...

Background The carbon family nanoparticles are less reviewed for their impact on organisms associated with oxidative stress physiology. Methods This review was carried out after collecting literature on the above topic from various sources, including PubMed and Google Scholar. Results The carbon family nanoparticles have tissue-specific impacts o...

Studies on oxidative stress physiology on molluscs to monitor the aquatic environment, influenced by pollutants and stressors are very limited in general and in Indian apple snails, P. globosa in particular. The main focus of the present study was to establish the baseline data on a redox regulatory system in P. globosa sampled across the Indian su...

Studies on the synergetic effects of soil and water parameters on Oxidative Stress (OS) physiology systems of the edible mud crab Scylla serrata sampled from different parts of East India are unknown. This study aimed to evaluate the effects of soil Ca, Mg, and organic carbon load and water physicochemical stressors induced spatio-temporal variatio...

The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. Medicinal plants are universally acknowledged as t...

Information on the oxidative stress physiology parameters (OSPP) in general and as a function of the fluctuation of Mg, Ca and organic carbon present in soil and aquatic physico-chemical factors such as pH, temperature and salinity in particular are scanty in the amphibious snail Pila globosa. A spatio-temporal analysis of redox metabolism (as OSPP...

In addition to the numerous health effects caused by the COVID-19 pandemic, the scientific community have considered other emerging effects such as water-related impacts worthy of deep investigation. In this regard, the transmission cycle of the SARS-CoV-2 virus from fecal, vomiting, and sputum routes to sewage has led health authorities to diagnos...

Background: Coronavirus disease-2019 (COVID-19

A major threat that has surrounded human civilization since the beginning of the year 2020 is the outbreak of coronavirus disease 2019 (COVID-19). It has been declared a pandemic by the World Health Organization and significantly affected populations globally, causing medical and economic despair. Healthcare chains across the globe have been under...

respectively. Similarly, dissolved oxygen and pH were elevated by 26 and 7%, respectively. Water temperature , conductivity and total dissolved solute levels were reduced by 7, 46 and 15%, respectively, which were again elevated during post-lockdowns during 2021 as observed from the Landsat-8 OLI satellite data. Air NO 2 , SO 2 , NH 3 , PM 2.5 , PM...

In the present study, water deprived condition (WPC, up to 18 h) induced hypoxia and altered oxidative stress (OS) physiology along with responses of respiratory chain enzyme in Heteropneustes fossilis are described . The body O2 saturation level in the fish was declined with respect to air exposure. Higher levels of lipid peroxidation and protein...

Although vaccines are successfully developed against Severe Acute Respiratory Syndrome Coronavirus-19 (COVID-19), and many anticancer, anti-malarial, antibiotic drugs have been repurposed against the disease, it has been just impossible to save valuable human lives in specific conditions. Therefore, medical care has been developed against COVID-19...

Background: Coronavirus disease-2019 (COVID-19) has become a pandemic around the globe due to the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), a new variant of the Coronavirus (CoV) family. The rapid transmission of the infectious disease, 135,646,617 positive cases from which 2,930,732 mortality cases were recorded until 11 Apri...

Corona virus disease (COVID-19) is one of the largest pandemics that the world is experiencing now. The disease has infected about 52.44 million people out of which about 1.29 million people have died as on 12th November 2020 and still the counting is on. Although around 36.67 million people have recovered from the disease, still all 220 countries,...

The current pandemic caused by the deadly Coronavirus (SARS-CoV-2) is called as Coronavirus Disease (COVID-19). Rolling data indicate that it has affected 222 countries, areas or territories with cases, infected 77,862,704 individuals out of which 1,712,010 have died. Although, the virus has catastrophic effects, it has also indirectly nourished th...

Small cell lung cancer (SCLC) is known for its rapid growth with high metastatic spread. Its treatment remains a major challenge for oncologists due to the high mutation rate and other clinical disadvantages. The survival rate of these patients is very poor but there is no significant progress over the last few decades in the treatment protocols. H...

Getting a sufficient quantity of sleep is an important aspect of maintaining a healthy sleep pattern. A good night-sleep is the natural cure for all health problems. Sleeping disorders affect people of all ages, although adults (18-60) are the most common sufferers these days. If a person does not get enough sleep during the day, he or she may deve...

Background Although the apple snail Pila globosa is used as indicator species for human consumption locally and as fish feed, research on it in general is very scanty. It is used in food industry, in aquaculture as fish bait and used as food in many regions of India and many other countries, but research on it has been started in the 1970s. Only 40...

A heterogeneous mixture of small rock particles/debris and organic materials/humus is called soil. It is usually produced over the surface of the earth and helps in the sustenance of autotrophic life in plant. India is an agriculture based country in which West Bengal, Uttar Pradesh, Punjab, Haryana, Madhya Pradesh, Chhattisgarh, Odisha, Andhra Pra...

A positive association between oxidative stress and hyper-thyroid conditions is well established. Vitamin E (VIT-E) and curcumin (CRM) are considered as potent antioxidant small molecules. Nuclear factor erythroid 2–related factor 2(NRF-2) is known to bind with antioxidant response element and subsequently activate expression of antioxidant enzymes...

Apple snails are one of the most survived fresh water invasive species that causes massive economic loss to vegetations, especially to the rice fields. They survive against many environmental stressors and are considered as a major pest in water-lodged cultivated area due to their intrusiveness, adaptation mechanisms and survivability. Therefore, t...

Specific areas in many countries such as Italy, India, China, Brazil, Germany and the USA have witnessed that air pollution increases the risk of COVID-19 severity as particulate matters transmit the virus SARS-CoV-2 and causes high expression of ACE2, the receptor for spike protein of the virus, especially under exposure to NO2, SO2 and NOx emissi...

Wastewater-based epidemiology (WBE) has a long history of identifying a variety of viruses from poliovirus to coronaviruses, including novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The presence and detection of SARS-CoV-2 in human feces and its passage into the water bodies are significant public health challenges. Hence, the...

Molecular network-based studies have gained tremendous importance in biomedical research. Several such advanced technologies in molecular biology have evolved in the past decade and have contributed to building up enormous molecular data. These molecular networks gained much significance among researchers triggering widespread use of experimental a...

The World Health Organization (WHO) has recently pronounced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a serious pandemic. It is, therefore, mandatory for public health authorities to have an environmental health management plan against COVID-19. This chapter summarizes articles and official reports related to environmental hea...

Accumulation of heavy metals in zooplanktons is used as an essential tool for the evaluation of health of an ecosystem. Such data are used to set further monitoring strategies especially in (coastal) water bodies. In the present study, seasonal bioaccumulation of heavy metals such as Cu, Zn, Pb, Cd and Hg, organic loads such as nitrite and phosphat...

The groundwater in coastal and abiding zones is experiencing alarmingly growing levels of salinity that might be small in absolute terms. Several reasons may contribute for retrogression of groundwater quality and the most concerning issue is they can critically distress the inhabitants. This notion encouraged us to comprehensively investigate the...

The disease COVID-19 caused by SARS-CoV-2 is the third highly infectious human Coronavirus epidemic in the 21s⁢t century due to its high transmission rate and quick evolution of its pathogenicity. Genomic studies indicate that it is zoonotic from bats. The COVID-19 has led to significant loss of lives and a tremendous economic decline in the world....

Molecular network-based studies have gained tremendous importance in biomedical research. Several such advanced technologies in molecular biology have evolved in the past decade and have contributed to build- ing up enormous molecular data. These molecular net- works gained much significance among researchers trig- gering widespread use of experime...

The disease COVID-19 caused by SARS-CoV-2 is the third highly infectious human Coronavirus epidemic in the 21st century due to its high transmission rate and quick evolution of its pathogenicity. Genomic studies indicate that it is zoonotic from bats. The COVID-19 has led to significant loss of lives and a tremendous economic decline in the world....

Objectives Science is the erudite methodical systematic practises to study the structure and behaviour of natural objects and/or phenomena. It clearly unknot about the fact that science is a human (society) need based process that starts with social affairs, for example, need to exchange emotion and cognitive processes (psychology), feelings (liter...

The outbreak of COVID-19 has made a global catastrophic situation that caused 1,039,406 deaths out of 35,347,404 infections, and it will also cause significant socio-economic losses with poverty increasing from 17.1 to 25.9%. Although the spreading rate of COVID19 is very high on October 6, 2020, the death rate is still less than 2.94%. Nonetheless...

Exposure to a variety of environmental factors such as temperature, pH, oxygen and salinity may influence the oxidative status in aquatic organisms. The present review article focuses on the modulation of oxidative stress with reference to the generation of reactive oxygen species (ROS) in aquatic animals from different phyla. The focus of the revi...

Introduction: After the outbreak from Wuhan City of China, COVID-19, caused by SARS-CoV-2, has become a pandemic worldwide in a very short span of time. The high transmission rate and pathogenicity of this virus have made COVID-19 a major public health concern globally. Basically, the emergence of SARS-CoV-2 is the third introduction of a highly i...

Introduction: The coronavirus disease (COVID-19) has been found to influence almost all sectors starting from socio-religious to educational and environmental levels. However, the systematically planned or unplanned implementation of sudden lockdown across the globe, including India, has pushed the migrant workers into huge troubles. Without savin...

The COVID-19 induced lockdowns have many positive effects on the environment. However, a preplanned experiment explaining the impacts of such lockdowns on environmental markers and appearance of fish species is lacking. We hypothesize that spotting the fish Aplocheilus panchax along the industrial belt of Mahanadi River near Cuttack in a never seen...

Many major cities that witnessed heavy air pollution by nitrogen dioxide (NO2) and particulate matter (PM) have experienced a high rate of infection and severity of the coronavirus disease pandemic (COVID-19). This phenomenon could be explained by the overexpression of the angiotensin converting enzyme 2 (ACE-2) on epithelial cell surfaces of the r...

The disease caused by Coronavirus (CoV) is called as Coronavirus Disease (COVID-19). It became pandemic in 210 countries and rolling data indicate that 2,606,635individuals are infected with the deadly pandemic disease and 713,812 have recovered, while, 182,114 have lost their lives. Although, few drugs namely Chloroquine, Hydr oxychl or oqui ne an...

Background: Obesity is one of the most common contributors to ill health, mortality and the reduced quality of life. Prevalence is increasing across the world especially in developed countries but now a days it is also increasingly noticed in developing countries including India due to change in life styles of the people. Garcinia cambogia (GC) is...

Removal of superoxide radical from industrial and biological samples as well as in-vitro condition is a biomedical important prerequisite. Therefore, a novel water soluble heterometallic compound 2 consisting of Cu(II) and Pd(II) centre with superoxide dismutase (SOD) mimicking character has been synthesized for possible use as mentioned above. Com...

Infection by coronavirus (CoV-19) has led to emergence of a pandemic called as Coronavirus Disease (COVID-19) that has so far affected about 210 countries. The dynamic data indicate that the pandemic by CoV-19 so far has infected 2,403,963 individuals, and among these 624,698 have recovered while, it has been fatal for 165,229. Without much experie...

Coronavirus Disease (COVID-19) has become the largest pandemic that has affected 210 countries. Rolling data indicate that 257,3605 people are infected by the disease, from which 701,838 have recovered and 178,562 have died. No specific medicine or vaccine is available yet to control the disease, hence, social distancing via lockdown is widely adop...

Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging and cancer. In human cancers, epigenetic changes such as DNA methylation, histone modifications, micro RNAs and nucleosome remodelling all control gene expression. The link between the genetics and epigenetics in cancer is further shown by existence of aberra...

The Bulletin of Medical and Clinical Research (BMCR) is one of the new advanced Book series which focused on the new issues and developments in all aspects of general & scientific medical research and clinical practice. This volume is a welcome contribution to the all areas of Medical and Clinical Research. It is concise and accessible, yet covers...