Bishnu Marasini

Bishnu Marasini
Tribhuvan University · Central Department of Microbiology (Institute of Science and Technology)

21.1
 · 
PhD

About

25
Publications
6,415
Reads
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184
Citations
Research Experience
December 2014 - present
Motherland Hospital
Position
  • Adviser
December 2014 - present
PNM Health Institute
Position
  • Instructor
December 2014 - present
Lumbini Center for Sustainability
Position
  • CEO

Publications

Publications (25)
Article
Full-text available
Urinary Tract Infection (UTI) is one of the most common infectious diseases and people of all age-groups and geographical locations are affected. The impact of disease is even worst in low-resource developing countries due to unaware of the UTIs caused by multidrug-resistant (MDR) pathogens and the possibility of transfer of MDR traits between them...
Article
Full-text available
Article
Full-text available
The worldwide increase of multidrug resistance in both community- and health-care associated bacterial infections has impaired the current antimicrobial therapy, warranting the search for other alternatives. We aimed to find the in vitro antibacterial activity of ethanolic extracts of 16 different traditionally used medicinal plants of Nepal agains...
Article
Prevalence of Alzheimer’s disease (AD) is significantly high in developed countries where life expectancy is relatively higher and its incidence is expected to increase over years. Etiology of this disease is complex; however, in a subtype called Early Onset Alzheimer’s Disease (EOAD) which manifests at age below 65 years, genes are the sole cause...
Article
Full-text available
Streptomyces are widely used for the production of secondary metabolites with diverse biological activities, including antibiotics. The necessity of alternative antimicrobial agents against multidrug-resistant pathogens is indispensable. However, the production of new therapeutics is delayed in recent days. Thus, the isolation of new Streptomyces s...
Preprint
Full-text available
Metabolic enzymes are often targeted for drug development programs of metabolic diseases such as diabetes and its complications. Many secondary metabolites isolated from natural products have shown therapeutic action against these enzymes. However, some commercially available synthetic drugs have shown unfriendly impacts with various side effects....
Article
Full-text available
Background α-Amylase catalyses the hydrolysis of starch and ultimately producing glucose. Controlling the catalytic activity of this enzyme reduces glucose production in the postprandial stage, which could be a therapeutic benefit for people with diabetes. This study was conducted to evaluate α-amylase inhibition for utilizing the crude extracts of...
Article
Full-text available
Ameliorating the sustainable and eco-accommodating routes for the procurable synthesis of nanoparticles (NPs) is a crucial aspect in the area of green nanotechnology. The known conventional routes for the production of NPs are complicated, noxious, expensive and not safer to human and environment. To overcome these threats, natural precursors such...
Article
Full-text available
Realizing myxobacteria as a potential source of antimicrobial metabolites, we pursued research to isolate myxobacteria showing antimicrobial properties. We have successfully isolated three strains (NR-1, NR-2, NR-3) using the Escherichia coli baiting technique. These isolates showed typical myxobacterial growth characteristics. Phylogenetic analysi...
Article
Full-text available
Objectives: The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anemia (SCA), and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (...
Article
Full-text available
Background: Urinary tract infection (UTI) is one of the frequently diagnosed infectious diseases which is caused mainly by Escherichia coli. E. coli confers resistance against the two major classes of antibiotics due to the production of extended spectrum β-lactamase enzymes (ESBL), biofilm, etc. Biofilm produced by uropathogenic E. coli (UPEC) pr...
Preprint
Objectives: The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anaemia (SCA) and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (A...
Preprint
Objectives: The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anaemia (SCA) and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (A...
Preprint
Objectives: The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anaemia (SCA) and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (A...
Preprint
Objectives: The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anaemia (SCA) and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (A...
Article
The concentration of carbon dioxide (CO2) has risen continuously in atmosphere due to human induced activities, and has been considered the predominant cause of global climate change. Paulowina tomentosa Steud. (P. tomentosa), a multipurpose tree is popular around global market for its timber and its potential role in CO2 sequestration. In this stu...
Article
Full-text available
p>The concentration of carbon dioxide (CO<sub>2</sub>) has risen continuously in atmosphere due to human induced activities, and has been considered the predominant cause of global climate change. Paulowina tomentosa Steud. ( P. tomentosa ), a multipurpose tree is popular around global market for its timber and its potential role in CO<sub>2</sub>...
Article
Full-text available
The concentration of carbon dioxide (CO 2 ) has risen continuously in atmosphere due to human induced activities, and has been considered the predominant cause of global climate change. Paulowina tomentosa Steud. ( P. toment osa ), a multipurpose tree is popular around global market for its timber and its potential role in CO 2 sequestration. I...
Article
Full-text available
Paulownia tomentosa Steud is a fast growing multipurpose tree. In vitro propagation using nodal explants of P. tomentosa was performed by manipulating amount of cytokinin and auxin in culture media. Shoot bud proliferation from explants were assessed in Murashige and Skoog (MS) medium supplemented with various amounts of hormones such as a) 0.5-2.5...
Data
Full-text available
The elaborated steps for the isolation and processing of the plant materials are covered in Supplementary Material. The antibiotic resistance pattern of tested bacteria is shown in Supplemental Table 1. The MIC values were determined by microbroth dilution method using 96-well plates (detailed procedure is in Supplementary Material). The MDR and no...
Article
Full-text available
Limited information is available regarding AmpC β-lactamase (ABL)-producing Enterobacteriaceae compared to extended-spectrum β-lactamase-producing enterobacteria. Since ABL-producing organisms are often resistant to multiple antimicrobial agents, therapeutic options against these pathogens are limited. Among 230 clinical Enterobacteriaceae isolates...
Article
Full-text available
Results: Experiments in Governing If you had just been elected to your nation’s highest office, what would you say in your inaugural address? What is the greatest challenge facing your country, and how would you use science to address it? In October, we asked young scientists to envision this scenario and send us their speeches. We heard from more...
Article
Full-text available
Results: Big Ideas: In July 2012, we asked young scientists to describe the one big idea in their field that they wish every non-scientist understood. Why? We heard from nearly 200 readers. A sample of the best responses can be found below. In the 5 October 2012 issue, we ran excerpts from 17 of the many interesting responses we received. Below,...

Questions and Answers

Question & Answers (14)
Question
81
There are some enzymes such as amylase, alpha-glucosidase, etc., which can be considered for the drug development of diabetes. And these are available commercially, no need to express and purify. Please let me know, if there are other such enzymes.
Question
I know some protocols, but I need the most suitable protocol that might be suitable for Nepal where limited chemicals and equipments are available and without kit (or with kit but should be cheaper than other method).

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