Bircan Kolbaşı

• PhD
• Research Assistant at Istanbul Medipol University

Background: Endometrial cancer remains a significant health concern, with type 1 endometrial cancer characterized by aberrant expression of estrogen-dependent and mTOR pathway proteins. In this study, we evaluated the effects of two novel hydrazone derivatives against the Ishikawa cell line, a model for endometrial cancer. Methods: Two novel hydraz...

Purpose: This study aimed to examine the therapeutic effects of injection of conditioned medium of adipose-derived mesenchymal stem cells (ADMSC-CM) in a surgically created varicocele model in comparison with varicocelectomy. Materials and methods: Twenty-eight male Wistar Albino rats were randomly divided into four groups: sham group, varicocel...

This study aimed to investigate the effects of the calpain inhibitor N-Acetyl-Leu-Leu-norleucinal (ALLN) on neuroapoptotic cell damage caused by Copper Oxide Nanoparticles (CuO-NP) and exacerbation of damage through brain ischemia/reperfusion (I/R) in a rat model. Male Wistar Albino rats (n=80) were divided into eight groups: Control, I/R, CuO-NP,...

Background: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects. Objectives: Th...

Osteoarthritis (OA) is the most prevalent kind of joint disease, affecting millions of individuals worldwide. Allium sativum L. was used as a therapeutic agent in the microemulsion system against osteoarthritis due to allicin’s high antioxidant and anti-inflammatory effects. HPLC was used to evaluate the chemical components of the Allium sativum me...

There are various studies showing that oral supplements are shortening or facilitating effects on this process. Therefore, this study investigates the use of edible oils as supplements in the wound healing process. Of the 7 groups (control, Hypericum perforatum extracts in olive oil, olive, sesame, fish, black seed, sunflower), each has 8 Wistar Al...

Objective: Increasing evidence shows that three dimensional cell culture models better reflect the in vivo tumor microenvironment than two dimensional cell culture models. Co-culture models are ideal cell culture models for understanding the communication between cells and the in vivo microenvironment. Changes in expression levels of E-cadherin ar...

Aim: Studies on drugs or alternative therapies are still the main treatment options for PNI. In this study, we aimed to research the effects of PBM and OT on nerve repair in a rat sciatic injury model. Material and Methods: 29 Wistar albino rats were divided into four groups: control (n = 2), sham (n = 9), OT (n = 9) and PBM (n = 9). After 30 days...

Due to its high mobility, hip joint plays a crucial role in executing many movements such as standing, sitting, running, crouching. The distribution of mechanoreceptors and neural elements in anatomical structures that provide stabilization of the hip joint is important in determining the optimal surgical incision site for the hip joint stabilizers...

Mesenchymal stem cells (MSCs) are highly capable of self-renewal and differentiation. They can be isolated from a variety of sources such as adipose tissue, bone marrow, umbilical cord, tooth pulp and can be cultured under in vitro conditions. MSCs have anti-inflammatory, anti-apoptotic, angiogenic, immunomodulatory and many more therapeutic effect...

Research question Does chronic stress affect the key proteins and sperm parameters of the blood–testis barrier (BTB)? Design C57Bl/6 mice were divided into two groups: a non-treated control group and a chronic unpredictable stress (CUS) applied group. The stress status of the animals was confirmed with behavioural tests. Histopathologic evaluation...

Purpose Radiotherapy, chemotherapy, various tumors and invasive surgery can result in ejaculatory dysfunction and testicular insufficiency. Sperm cryopreservation is the only method which can provide a baby for couples. Cryopreservation freezes tissues and cells, allowing them to be stored for future use by stopping all biological activities. Cryop...

Elastofibroma dorsi (EFD) is a rare, benign, soft tissue tumor with an unclear pathogenesis, typically localized to the subscapular region. It occurs within the periscapular area between the ribs and dorsal chest wall muscles. Repetitive microtrauma by friction between the lower part of the scapula and the thoracic wall may cause reactive hyperprol...

We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and limonene were applied topically to the wounds once daily, separately or together, for 10 days. Tissue sections from the wounds we...

Regeneration is defined as tissue renewal and functional restoration process of the damaged parts of the body after an injury. Ambystoma mexicanum, commonly named the Axolotl, is one of the unique vertebrates, which has a remarkable ability to regenerate their extremities following the amputation. Although the process of regeneration includes sever...

Adult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar tissue formation. However, unlike mammals, adult salamanders repair the wounds by regeneration compared to scarring. To elucidate...

Peripheral nerve injuries are encountered frequently in clinical practice. In nerve repair, an end-to-end suture is the preferable choice of treatment. However, where primary closure is not possible, the defect is to be repaired with a nerve graft. A total of 21 female Wistar rats weighing 230 to 290 g were used in the study. They were classified i...