Binu V S

Binu V S
National Institute of Mental Health and Neuro Sciences | NIMHANS · Department of Biostatistics

M.Sc (Statistics) & PhD
Associate Professor of Biostatistics, NIMHANS, Bengaluru, India

About

91
Publications
29,210
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2,542
Citations
Citations since 2016
43 Research Items
1764 Citations
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300

Publications

Publications (91)
Article
Background: Child marriage is a breach of the basic fundamental rights of a child and is a major concern for policy makers in many countries. Objective: The present study intended to identify the direct and indirect socio-demographic factors associated with child marriage among 15–17 years old girls in India. Participants and setting: The study use...
Article
Introduction: One of the stringent assumptions about covariates in the Cox hazard and Logistic regression modelling is that they should be independent. Incorporating correlated covariates as such into the model might distort the precision of the estimates due to multicollinearity. One way to deal with multicollinearity is by using Principal Compone...
Article
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Background: The fertility problem inventory (FPI) is one of the most widely used measures that tap the diverse psychological problems faced by infertile couples. Research on translated versions of FPI has also reflected its high clinical significance. Aim: This research aimed to explore the psychometric properties and the clinical validity of th...
Article
Abstract Background IL-33/ST2 immune axis plays crucial roles in infection and immunity. A dysregulated IL-33/ST2 axis can induce autoimmune reaction and inflammatory responses. Guillain-Barré Syndrome (GBS) is an acute peripheral neuropathy, mostly caused by post-infection autoimmunity. The role of IL-33/ST2 axis is not known in GBS. This study ai...
Article
Guillain‐Barré Syndrome (GBS) is the commonest postinfectious polyradiculopathy. Though genetic background of the host seems to play an important role in the susceptibility to GBS, genes conferring major risk are not yet known. Dysregulation of Toll‐like receptor (TLR) molecules exacerbates immune‐inflammatory responses and the genetic variations w...
Research
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https://www.sciencedirect.com/science/article/abs/pii/S2212420921006774 https://doi.org/10.1016/j.ijdrr.2021.102716
Article
Background Adaptation is a process of adjusting to the current or expected climate change. The varied adverse outcomes enable people towards necessary adaptation. People living in disaster-prone areas go through a relatively higher frequency of emergencies and exigencies. Gradually people learn to cope with stress and over a while, they develop var...
Article
Background In clinical setting, to answer a research question, very often more than one outcome variables are used which are statistically correlated. Univariate analysis approach, which is commonly used in such context, violates the assumption of independence for correlated variables, while multivariate approach could give more robust and precise...
Article
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Schizophrenia is a complex neuropsychiatric disorder, influenced by a combined action of genes and environmental factors. The neurodevelopmental origin is one of the most widely recognized etiological models of this heterogeneous disorder. Environmental factors, especially infections during gestation, appear to be a major risk determinant of neurod...
Article
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Background Data can be missing when a survey fails to collect information from certain regions due to feasibility issues, which can impose problems while performing spatial analysis. Objective The present study aims to estimate missing aggregate level public health spatial data by utilizing the information from neighbouring regions and accounting...
Article
Introduction Antibodies against ganglioside complexes (GSCs) are associated with various clinical features and subtypes of Guillain Barré syndrome (GBS). Methods One‐hundred patients were evaluated for antibodies to GSCs formed by combination of GM1, GM2, GD1a, GD1b, GT1b and GQ1b using manual enzyme linked immuno‐sorbent assay (ELISA). Results T...
Article
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Background and aim Photobiomodulation is an emerging therapy for Diabetic peripheral neuropathy (DPN) of which the management is still a dilemma for clinicians. Elevated Neuron Specific Enolase (NSE) is associated with neuropathy. We aimed this study to assess the effect of Low Level Laser Therapy (LLLT) on Serum Neuron Specific Enolase in Type II...
Article
Background: Cancer care is physically and psychologically challenging both for care recipients and caregivers. Caregiving in cancer is an area that needs urgent attention in India. Much of caregiving literature in India is limited to mental illnesses. This study thus examines the perceptions and practices of psychological caregiving among caregive...
Article
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Though often used in cardiac intensive monitoring set up, simultaneous evaluation of several variables like CVP, PCWP, SVV and hTEE for fluid volume resuscitation (especially when capillary permeability is major problem than cardiac performance)is a major challenge in many ICU setups. Therefore, repetitive determination of blood volume by trivalent...
Article
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Introduction: Involuntary childlessness is a distressing condition that has considerable social implications in developing nations. Aim: The present study aims to investigate the less known sociocultural determinants of infertility stress in patients undergoing assisted conception and reproductive treatments. Methods: This cross-sectional research...
Article
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Background: Emotional response to infertility is mediated by numerous interrelated psychological variables such as personality, health perceptions, cognitive appraisals, coping, and social support. While men and women respond to infertility differently, illness cognitions are a vital component of their emotional adjustment. The aim of this study is...
Article
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Losing a much-awaited pregnancy and an unborn child, time and again is known to be a painful experience in recurrent miscarriage or pregnancy loss (RPL). Literature on psychological consequences of RPL is abundant. Nonetheless, application of psychological intervention in RPL remains to be an overlooked area. Using a repeated measures design and st...
Article
Objective: To explore the factors associated with social isolation among older people using the data from Building Knowledge Base on Population Ageing in India (BKPAI) survey. Methods: Multiple logistic regression and classification and regression tree (CART) analysis were used to identify the factors associated with social isolation using data...
Article
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Rationale: Pancreatic cancer is associated with poor prognosis with a 5-year survival rate of less than 6%. Approximately 90% of pancreatic cancer patients harbor somatic mutations in the KRAS gene. Multiple lines of evidence suggest a persistent activation of STAT3 in KRAS-driven oncogenesis contributing to desmoplasia and gemcitabine resistance....
Article
Full-text available
Introduction Involuntary childlessness is a distressing condition that has considerable social implications in developing nations. Aim The present study aims to investigate the less known sociocultural determinants of infertility stress in patients undergoing assisted conception and reproductive treatments. Methods This cross-sectional research w...
Article
Full-text available
Background Emotional response to infertility is mediated by numerous interrelated psychological variables such as personality, health perceptions, cognitive appraisals, coping, and social support. While men and women respond to infertility differently, illness cognitions are a vital component of their emotional adjustment. The aim of this study is...
Article
Full-text available
Background: Infant mortality rate (IMR) is globally identified by the policymakers as the marker of health of a population. Objectives: This study aimed to detect the change in hotspots of IMR in Indian states from the year 2000 to 2012, identify hotspots of IMR at district level in selected states from each of the six regions of India and deter...
Article
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Background: Hot-spot detection of Maternal Mortality Ratio (MMR) can assist in identifying the exact geographic location of regions that need urgent attention. Aims &Objectives: To detect hot-spots of MMR at district level in the selected nine states of India and the observed pattern was further correlated with hot-spots of certain known risk facto...
Article
Purpose: Ocular injuries in children are a major under-recognized cause of ocular morbidity and can be prevented by identifying the etiology and implementing measures to prevent these injuries. This study intends to assess the visual outcome and ocular survival in paediatric ocular trauma. Design: A descriptive study set in a tertiary care teaching...
Article
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Colorectal cancer is currently the third leading cause of cancer related deaths. There is considerable interest in using dietary intervention strategies to prevent chronic diseases including cancer. Cardamonin is a spice derived nutraceutical and herein, for the first time we evaluated the therapeutic benefits of cardamonin in Azoxymethane (AOM) in...
Article
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Objective: To determine the association between certain socio-demographic and life style factors with colorectal cancer.Methods: This case-control study was conducted using a pre-designed questionnaire among 100 incident colorectal cancer patients and 200 unmatched controls attending a tertiary care hospital in southern Karnataka. Cases and the con...
Article
Introduction: As per the WHO estimates in 2013, about 289,000 women died of complications related to pregnancy or childbirth. The present study aimed at assessing the status of birth preparedness (BP) and complication readiness (CR) among rural pregnant women and its correlates in coastal Karnataka in Southern India. Methods: This cross-sectional s...
Article
Aim: To evaluate the effectiveness of a Nurse Navigator Programme on anxiety, psychological distress and quality of life in people with breast cancer. Background: Breast cancer is the most frequently detected malignancy and a major cause of cancer death among women around the world. The lengthy course of illness from initial diagnosis to treatme...
Article
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Background Being infertile comes as an overwhelming realization for couples trying to conceive. In consideration of rising rates of infertility worldwide, clinicians in India have also begun exploring this field for new possibilities, development and research. The purpose of this study was to estimate the proportion and predictors of infertility sp...
Article
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Background: Stress associated with fishing is known to trigger consumption of alcohol and tobacco among fishermen. This study aimed to assess the prevalence of tobacco and alcohol consumption among fishermen in Udupi Taluk in the state of Karnataka, India, and to study associations with health status and job stress. Materials and Methods: The study...
Article
In complementary DNA (cDNA) microarray experiments, the measurement of interest is signal intensity ratio of spots. Each spot have four types of pixel intensities namely red foreground, green foreground, red background and green background. The uncertainty associated with the intensity ratio of a spot depends on the correlations between intensities...
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Background Maternal morbidities are considered a leading contributor to the burden of disease among women. Especially, if postpartum morbidities are left untreated, this can cause a negative impact on the quality of life. The study was conducted to determine the proportion and types of postpartum morbidities among women visiting government health f...
Article
APML is a highly curable hematological malignancy which is treated with differentiation agents and chemotherapy. The morbidity caused by chemotherapy in the treatment of APML is a great cause of concern. We treated 12 patients with newly diagnosed APML with single agent arsenic trioxide between 2010 and 2014 irrespective of risk stratification. Out...
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Background: According to the existing literature on infertility, stress appears to be inevitably associated with infertility diagnosis and treatment in sub-fertile individuals. The epidemiological data on the prevalence and predictors of infertility-specific stress in cultural specific scenario are scarce. The objective of the present study was to...
Article
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Measurement of physical activity in epidemiological studies requires tools which are reliable, valid and culturally relevant. We attempted to develop a physical activity questionnaire (PAQ) that would measure physical activity in various domains over a year and which would be valid for use in adults of different age groups with varying levels of ac...
Article
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Spatial autocorrelation measures the spatial dependency of observations that quantifies the degree of spatial clustering or dispersion in the values of a variable measured across a set of locations. There are two types of spatial autocorrelation measures such as global measures and local measures. In this article we are giving an overview of Moran’...
Article
We sought to evaluate the contribution of various modifiable risk factors to the partial population attributable risk (PARp) for diabetes in an Asian Indian population. Of a cohort of 3589 individuals, representative of Chennai, India, followed up after a period of ten years, we analyzed data from 1376 individuals who were free of diabetes at basel...
Article
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To assess proportion of adolescents perceiving their body image as normal and to study association between body shape, self-esteem and body mass index; each with body image perception. A cross sectional study was conducted among pre university college (PUC) students of Udupi taluk. A total of 550 students in the age group of 15-19y were randomly se...
Article
There is little data on the incidence rates of diabetes and prediabetes (dysglycemia) in Asian Indians. This article presents the incidence of diabetes and prediabetes and the predictors of progression in a population-based Asian Indian cohort. Data on progression to diabetes and prediabetes from 1,376 individuals, a subset of 2,207 of the Chennai...
Article
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Although tobacco deaths rarely make headlines, tobacco kills one person every six seconds. Tobacco kills a third to half of all people who use it, on average 15 years prematurely. To study the risk of oral cancer associated with gutka consumption and other tobacco products. (1) To find the association between gutka consumption and oral cancer. (2)...
Article
Microarray experiments are used to measure gene expression levels of thousands of genes at a time. The image analysis has an important role in the microarray data analysis and has potential impact on the identification of differentially expressed genes. Segmentation is one of the important processes in image analysis. The current paper attempts to...
Article
In a cDNA microarray experiment, the final measurement is intensity ratio at a spot in the microarray chip. The objective of the present study is to estimate the uncertainty associated with the final intensity ratio at each spot in cDNA microarray chips and also to explore the role of pixel intensity correlations in statistical inferences of gene e...
Article
The aim of the research was to develop and standardize a scale to assess patient's perception on physician's practices while prescribing for radiological examinations. The study data was collected from May 2013 to January 2014 in Udupi district. The questionnaire for the study was generated based on literature reviews. To assess content expert vali...
Article
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Background: Blood volume measurement though important in management of critically ill-patients is not routinely estimated in clinical practice owing to labour intensive, intricate and time consuming nature of existing methods. Aims: The aim was to compare blood volume estimations using trivalent chromium [51Cr(III)] and standard Evans blue dye (EB...
Article
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A health science researcher may sometimes wonder "why statistical methods are so important in research?" Simple answer is that, statistical methods are used throughout a study that includes planning, designing, collecting data, analyzing and drawing meaningful interpretation and report the findings. Hence, it is important that a researcher knows th...
Conference Paper
Applications of spatial data analytical techniques has increased in the last few years in almost all fields. Some of the applications are decision making in regional governance, to maintain law and order, disaster prediction and many more. The main objective of this paper is to study the influence of neighbouring states in the growth of regional ec...
Article
Regional cancer epidemiology is an important basis for determining the priorities for cancer control in different countries worldwide. There is no reliable information about the pattern of head and neck cancer in western Nepal and hence an attempt was here made to evaluate the situation based on hospital data, which provide the only source in the w...
Article
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As preventing cancer with the help of a vaccine is a comparatively new concept, awareness and education about it will have important implication in the implementation of this strategy. Present explorative questionnaire based survey included 618 MBBS students for final analysis. Majority of participants (89.6%) were well aware of the preventable nat...
Data
Questionnaire which was used as the survey instrument during the study. (DOC)
Data
Questionnaire S1 with response scoring system used for analyzing the data. (DOC)
Article
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Objective: We hypothesized that a single value of leukocyte count, on admission might be a helpful predictor to prognosticate the clinical outcome and plan the management (early delivery versus conservative management) in patients presenting with pre term pre-labour rupture of membranes (PPROM). Result: Based on the score cut off for the total leuk...
Article
Microarray experiments are used to measure gene expression levels of thousands of genes simultaneously. In cDNA microarray experiments, the measurement of interest is average of red to green signal intensity ratio at each spot that gives the expression level of a particular gene in a diseased sample compared to normal. The intensity ratio for a giv...
Article
Background: A consideration of the future specialization interests of undergraduate medical students might help to understand the needs of higher medical education and future manpower availability for healthcare. Methods: A cross-sectional study was conducted among 373 undergraduate students of a medical college in southern India using a self-ad...
Article
The purpose of this study was to assess the attitudes of undergraduate medical students towards the objective structured practical examination (OSPE) in Forensic Medicine, in a medical college in Nepal. Participants included 59 undergraduate medical students of the 7th semester. Findings indicated that the OSPE was an acceptable tool considering th...
Article
Background: The major part of demand for blood in India has been meeting through voluntary blood donations. The healthy, active and receptive huge student population is potential blood donors to meet safe blood requirements. However, there is a paucity of studies on awareness and attitude among health science students on voluntary blood donation. O...
Article
Smokeless tobacco is found to be as addictive and harmful as smoking but have not been explored into, especially among youth. This study was conducted to find the prevalence of tobacco chewing among college students in Nepal and the factors that have influence over their use. A cross-sectional study with a self-administered questionnaire. Five coll...