Bintug Ozturk

Ege University · Department of Pharmaceutical Botany

An environmentally friendly unreported rapid and simple reverse-phase high-performance thin-layer chromatography (RP-HPTLC) has been designed for the simultaneous determination of bioactive sesquiterpene coumarins feselol and samarcandin in the methanol extract of five Ferula species. The method was developed using glass plates coated with RP-18 si...

Peppermint (Mentha x piperita L.) plant was grown in this study using different mineral fertilizers combinations. Effects of fertilizer treatments on green and drug herb yields, herb essential nutrients (N, P, K, Ca, Na, Mg, Fe, Zn, Mn, Cu), essential oil yield, essential oil components (menthol, menthone, 1,8 cineole and menthofuran) and non-essen...

ABSTRACT Background: Many members of the genus Ferula are used in traditional medicine as aphrodisiac. Objectives: The aim of this study is to confirm the aphrodisiac potential of Ferula drudeana Korovin as listed in the Turkish traditional medicine and to isolate the active metabolites using male rats. Materials and Methods: The CHCl3 soluble frac...

Essential oil of Vitex agnus-castus’ leaves was analysed GC and GC-MS. The oil was predominantly rich in 1,8-cineole (24.38 %), sabinene (22.77 %), trans-β-farnesene (8.50 %), α-pinene (7.14 %), β-caryophyllene (6.49 %) and 1-terpinen-4-ol (5.23 %). In the phytotoxicity assay, the highest concentration of the oil (40 µL) completely inhibited the ge...

The objective of the present study was to examine the effect of potassium (K) fertilization and soil texture on total yield (1st and 2nd cuttings) and yield components of sweet basil (Ocimum basilicum L.) A greenhouse pot experiment was conducted in a completely randomized statistical design. Basil growth was examined in two different textured soil...

In the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to estimate the potential in vitro antioxidant effect of the methanol extracts of Ferula durdeana Korovin (F. durdeana) and Ferula huber-morathii Peşmen (F. huber-morathii). The antidiabetic activity of both extracts was evaluated in streptozotocin (...

The present study was carried to explore the potential antihyperglycemic and antihyperlipidemic activity of Ferula assa-foetida L. and Ferula tenuissima Hub-Mor & Pesmen extracts in streptozotocin (STZ) induced diabetic rats. Furthermore, phytochemical screening, in vitro antioxidant activity and acute toxicity study of both plants were performed....

The essential oil of Cotinus coggyria Scop.' leaves was found to be rich in α-pinene (43.1%), limonene (21.3%) and β-myrcene (8.5%). In the antimicrobial screening, essential oil was notably active on Staphylococcus aureus ATCC 29213, S. aureus ATCC BAA-977, Candida albicans ATCC 14053 and C. parapsilosis ATCC 22019 using the disc diffusion and vol...

In the present work three subspecies of Helichrysum plicatum DC. (Helichrysum plicatum DC. subsp. plicatum, Helichrysum plicatum DC. subsp. polyphillum (Ledeb) P.H.Davis & Kupicha and Helichrysum plicatum DC. subsp. isauricum Parolly) were investigated for the essential oil chemical compositions. The volatiles were obtained by conventional hydrodis...

Essential oil (EO) was hydrodistillated using a Clevenger-type apparatus and chemically determined using gas chromatography (GC) and GC/mass spectrometry. The analysis of the EO from the leaves of the Pistacia terebinthus has indicated that -pinene (19.97%), sabinene (15.43%), -pinene (8.57%) and terpinen-4-ol (9.65%) are the major compounds of the...

AIM: The aim of this study is to present a key map for evolution to virtual herbarium based on IZEF (Izmir, Ege University Faculty of Pharmacy Herbarium)- the first virtual herbarium of Turkey and to express the important role of virtual herbariums on researchs about plant sourced new medicinal lead molecules. METHOD: Data and images of 6000 herbar...

In this study, green herb and drug herb yields of basil (Ocimum basilicum L.) grown in organic and conventional farming systems were examined. Primary plant nutrients, total essential oil contents (%), and essential oil components were investigated as well. In the conventional system, nutrient inputs included 15.15.15 and monopotassium phosphate (M...

Essential oil (EO) was hydrodistillated using a Clevenger-type apparatus and chemically determined using gas chromatography (GC) and GC/mass spectrom-etry. The analysis of the EO from the leaves of the Pistacia terebinthus has indicated that a-pinene (19.97%), sabinene (15.43%), b-pinene (8.57%) and terpinen-4-ol (9.65%) are the major compounds of...

Helichrysum unicapitatum S.G. Şenol, Ö. Seçmen & B. Öztürk (Asteraceae) is described and illustrated from the SW province of Anatolia, Turkey. It grows on crys-talline calcareous rocks between Evran Tepe and Karababa Tepe (1800–2300 m), situ-ated within the Denizli Babadağ (Cadmus) Mountain Range. Helichrysum compactum seems to be its closest relat...

The aim of the current study was to investigate the protective effects of essential oils, used in traditional Turkish food and medicine, prepared from two Ziziphora. subspecies against H2O2-induced oxidative damage in human erythrocytes. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities, and effects of lipid pe...

DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalyzing the concerted breakage and rejoining of DNA strands during normal cellular growth. During the past few years, there has been considerable pharmacological interest in these enzymes because the inhibitors of DNA topoisomerases represent a m...

The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of the essential oil of Satureja thymbra. L. (Lamiaceae). Antinociceptive activity of the essential oil was measured by the formalin test in mice and by the light tail-flick and hot-plate methods in rats. The paw-edema test was performed in rats to evaluat...

DNA topoisomerases are important targets for cancer chemotherapy. We investigated the effects of a methanolic extract of Helichrysum pamphylicum on mammalian DNA topoisomerase I via in vitro plasmid supercoil relaxation assays. The extracts manifested a considerable inhibition of the enzyme's activity in a dose-dependent manner. We also performed a...

The essential oil of Turkish endemic Ziziphora taurica subsp. cleonioides aerial parts was found to contain (+)-pulegone (81.86%), limonene (4.48%) and piperitenone (2.30%) activity. The essential oil showed relevant antioxidant activity.

The aim of the present study was to explore the probable antiinflammatory effect of Hypericum triquetrifolium Turra. in a rat model of carrageenan induced inflammation. Male Wistar rats were treated intraperitoneally with 0.4% dimethylsulphoxide (DMSO) (as control group) and H. triquetrifolium extract (25, 50, 60 mg/kg), 30 min before 0.1 ml 1% car...

The aim of the present study was to investigate the antinociceptive activity of Hypericum triquetrifolium Turra. extract. The lyophilized extract was administered to male Swiss mice. Formalin paw test and tail flick tests were used for the evaluation of the antinociceptive activity. Plant extract (10, 25, 50 and 60 mg kg(-1), i.p.) (n = 16-24 for e...