Bing Wang

Bing Wang
Charles Sturt University · School of Agricultural, Environmental and Veterinary Sciences

Ph.D. M.D. RegNutr.

About

79
Publications
32,715
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Introduction
Professor Bing Wang, received her Medical degree from Tianjin Medical University, China and Ph.D. in Nutrition Science from the University of Sydney, Australia. She led Nutritional Neurodevelopment Research programs in academia and industry before joining Charles Sturt University in Dec 2012. Her research program focuses on to elucidate the molecular basis of how nutrient components alter metabolic responses important in neurodevelopment and cognitive function from fetus to late life, and to translate the basic science discoveries to applications.
Education
August 1998 - May 2001
The University of Sydney
Field of study
  • Nutrition Science
January 1978 - December 1982
Tianjin Medical University
Field of study
  • Medicine

Publications

Publications (79)
Article
Full-text available
Propose To design a set of brain templates for postnatal piglet brains based on high-resolution T1-weighted imaging for voxel-based morphometric analysis. Materials and Methods Using a 3.0 T MR scanner, a population-based whole brain template was developed by averaging forty T1 images in the brains of postnatal piglets at 38 days of age. The templ...
Article
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Sialic acids (Sias) are acidic monosaccharides and red meat is a notable dietary source of Sia for humans. Among the Sias, N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) play multiple roles in immunity and brain cognition. On the other hand, N-glycolylneuraminic acid (Neu5Gc) is a non-human Sia capa...
Article
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Chitosan oligosaccharide (COS) is derived through deacetylation of chitin from crustacean shells. Previous studies reported the benefits of COS to gut microbiota, immunity and health of host species. In this study, 120 pregnant composite ewes were subdivided into treatment and control groups in duplicate. COS was supplemented via a loose lick to pr...
Article
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Background: Milk fat globule membrane (MFGM), natural to breast milk, is essential for neonatal development, but lacking from standard infant formulas. Objectives: To evaluate the safety and tolerability of MFGM supplementation in formula for infants 0 to 12 months. Methods: In a prospective, multicentre, double-blind, randomized trial, health...
Preprint
Full-text available
Background: Milk fat globule membrane (MFGM), natural to breast milk, is essential for neonatal development, but lacking from standard infant formulas Objectives: To evaluate the safety and tolerability of MFGM supplementation in formula for infants 0 to 12 months. Methods: In a prospective, multicentre, double-blind, randomized trial, healthy term...
Article
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Background and objectives: Human milk fat globule membrane (MFGM) has multifunctional health benefits. We evaluated neurodevelopment and growth of healthy term infants fed bovine milk-derived MFGM-enriched formula (MF) over 12 months. Methods and study design: A prospective, multi-center, double-blind, randomized trial was conducted in Fuzhou, C...
Article
Full-text available
Swine are one of the most important agricultural species for human food production. Given the significant disease challenges confronting commercial pig farming systems, introduction of a new feed additive that can enhance animal performance by improving growth and immune status represents a major opportunity. One such candidate is sialic acid (Sia)...
Article
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Background and objectives: Human milk fat globule membrane (MFGM) has multifunctional health benefits. We evaluated neurodevelopment and growth of healthy term infants fed bovine milk-derived MFGM-enriched formula (MF) over 12 months. Methods and study design: A prospective, multi-center, double-blind, randomized trial was conducted in Fuzhou, Chi...
Article
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Scope Lactoferrin (Lf), a sialylated milk glycoprotein promotes early neurodevelopment and cognition. Functional concentrations of Lf, however, remain unknown. Our objective was to determine the concentration‐dependency of Lf on genes associated with neurodevelopment and cognition in neonatal piglets. Methods and results Piglets were given milk re...
Article
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Human milk oligosaccharides (HMOs) are the third most abundant solid component after lactose and lipids of breast milk. All mammal milk contains soluble oligosaccharides, including neutral milk oligosaccharides (NMOs) without sialic acid (Sia) moieties and acidic oligosaccharides or sialylated milk oligosaccharides (SMOs) with Sia residues at the e...
Article
Full-text available
The profitability of milk production in the developing world varies widely among farming systems. This results from poor animal productivity and an inefficient marketing-chain structure in which farmers seldom profit from their dairying activities. The lack of chilling facilities for milk storage and the need to adulterate the raw product along the...
Article
13 Red meat-derived sialic acid (Sia), N-glycolylneuraminic acid (Neu5Gc), promotes the risk of carcinoma 14 and inflammation. Expression in skeletal muscle and organs across animal species remains unknown. 15 We measured Neu5Gc in skeletal muscle and organ tissues from nine species using UHPLC and found 16 that: (1) neu5Gc concentration in skeleta...
Article
Full-text available
Objectives To molecular characterize the expression levels of lactoferrin receptor (LfR) in different regions of brain and its response to lactoferrin (LF) intervention in piglets. Methods 3-day-old male piglets were randomly allocated to groups (Grp) 1 fed milk replacer supplemented with LF 1.1 g/L (n = 16) and Grp 2 0.06 g/L (n = 16) as control....
Article
Full-text available
Lactoferrin (LF), a sialylated iron-binding glycoprotein, has numerous vital physiological functions including immunomodulation and protection against a large group of microorganisms, improving neurodevelopment, health, growth performance, and milk production. Lactoferrin occurs in human milk at a higher concentration compared with bovine milk, but...
Article
Full-text available
Chitosan oligosaccharides (COS) are the hydrolyzed product of chitosan and have multifunctional health benefits. The objective of this study was to elucidate the effect of COS as a dietary supplement to gilts on their productivity and health, and that of their litters. Gilts were randomly assigned to either a treatment (n = 30) or control group (n...
Article
Full-text available
Sialylated milk oligosaccharides (SMOs) have a multifunctional health benefit, yet the molecular details underlying their potential role in modulating intestinal maturation remains unknown. To test the hypothesis that sialyllactose (SL) may mediate intestinal maturation and function through controlling neuronal function, studies were carried out wh...
Article
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Background: Human milk contains high concentrations and diversity of sialylated oligosaccharides that have multifunctional health benefits, however, their potential role in optimizing neurodevelopment remains unknown. Objective: To investigate the effect of sialylated milk oligosaccharides (SMOS) intervention on neurotransmitters and brain metaboli...
Article
Full-text available
Lactoferrin (LF) is a sialylated iron-binding glycoprotein, occurring in several biological secretions like milk, saliva, and seminal fluids and is a major component of a mammalian innate immune system. It plays multiple protective roles against large group of microorganisms and performs anti-inflammatory and anti-cancer activities. The concentrati...
Article
Full-text available
Optimal nutrition is important after preterm birth to facilitate normal brain development. Human milk is rich in sialic acid and preterm infants may benefit from supplementing formula with sialyllactose to support neurodevelopment. Using pigs as models, we hypothesized that sialyllactose supplementation improves brain development after preterm birt...
Article
Full-text available
The profitability of milk production in the developing world varies widely among farming systems. This results from poor animal productivity and an inefficient marketing-chain structure in which farmers seldom profit from their dairying activities. The lack of chilling facilities for milk storage and the need to adulterate the raw product along the...
Article
Full-text available
Milk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior new-born growth in litters from m...
Article
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Scope: A recent study revealed the accumulation of gut microbiota-produced acetate (GMPA) led to insulin over-secretion and obesity symptom. To further develop this scientific point, effect of resistant starch (RS) or exogenous acetate carried by RS (RSA) in the gut on metabolic syndrome is investigated using diet-induced obese rats. Methods and...
Article
Full-text available
Lactoferrin (LF), a sialylated iron-binding glycoprotein, performs multiple beneficial functions including modulating immunity and improves neurodevelopment, health and growth performance. Maternal LF intervention for gilts (first parity sows) on the performance of gilts and their offspring remains unknown. In the current study gilts were fed with...
Data
Breed information of the experimental gilts of treatment and control group. (DOCX)
Data
Total no of gilts from each breed line for the lactoferrin and control group. (DOCX)
Data
Nutritional composition of commercial pig feed. (DOCX)
Data
Information on the litter size of the farrowing gilts of lactoferrin and control group before and after cross-fostering. (DOCX)
Article
Full-text available
Recent studies have shown a relationship between the level of the sialic acid (Sia), N-glycolylneuraminic acid (Neu5Gc) in red meat and its risk in cancer, cardiovascular and inflammatory diseases. Unresolved is the Sia concentration in different organs of piglets during development. Our aim was to determine the level of free and conjugated forms o...
Article
Full-text available
Polysialic acid plays a key role in cancer metastasis and neurodevelopment. Our aim was to determine the developmental gene expression profiles for the two polysialyltransferases ST 8Sia II and ST8Sia IV, NCAM, SynCAM1, Neuropilin-2 (NRP2) and their polysialylated cognate glycans in different regions of the piglet brain during postnatal development...
Article
Full-text available
Recent studies have shown a relationship between the level of the sialic acid (Sia), N-glycolylneuraminic acid (Neu5Gc) in red meat and its risk in cancer, cardiovascular and inflammatory diseases. Unresolved is the Sia concentration in different organs of piglets during development. Our aim was to determine the level of free and conjugated forms o...
Article
Full-text available
Sialic acids (Sia) are key monosaccharide constituents of sialylated glycoproteins (Sia-GP), human sialylated milk oligosaccharide (Sia-MOS), and gangliosides. Human milk sialylated glycoconjugates (Sia-GC) are bioactive compounds known to act as prebiotics and promote neurodevelopment, immune function, and gut maturation in newborns. Only limited...
Article
Lactoferrin is a sialic acid-rich, iron-binding milk glycoprotein, known to have multifunctional health benefits, including its ability to modulate immune function and facilitate iron absorption, as well as its antibacterial and antiinflammatory actions. Human milk contains significantly higher lactoferrin levels than bovine milk at the same stages...
Article
Full-text available
The two mammalian α2,8-polysialyltransferases (polyST's), ST8Sia II (STX) and ST8Sia IV (PST), catalyze synthesis of the α2-8-linked polysialic acid (polySia) glycans on neural cell adhesion molecules (NCAMs). The objective of this study was to clone the coding sequence of the piglet ST8Sia II and determine the mRNA expression levels of ST8Sia II,...
Article
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An elevated level of the free deaminated Sia, KDN, was first discovered in human ovarian cancers (OC), suggesting that KDN may be an oncodevelopmental antigen (Inoue et al. 1998). To determine if this unexpected finding was unique to OC, we developed a LC-MS/MS glycomic approach to quantitatively determine the level of free and conjugated forms of...
Article
Full-text available
Lactoferrin (Lf) is a sialic acid (Sia)-rich, iron-binding milk glycoprotein that has multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. To test the hypothesis that Lf may function to improve neurodevelopment and cognition, the diet of postnatal piglets was supplemented with Lf from days 3 to 38....
Article
Full-text available
The molecular mechanisms underlying how dietary lactoferrin (Lf) impacts gut development and maturation and protects against early weaning diarrhea are not well understood. In this study, we supplemented postnatal piglets with an Lf at a dose level of 155 and 285 mg/kg/day from 3 to 38 days following birth. Our findings show that the high dose of L...
Article
Background: Lactoferrin (Lf) is an iron‐binding, sialylated glycoprotein prevalent in milk, and known to have multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. Objective: To determine the functional effect and underlying molecular biochemical mechanism of milk lactoferrin on early brain developme...
Article
Full-text available
Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementation with bLf on IUGR-induced sequelae, including inadequate growth and altered cerebral devel...
Article
Full-text available
Red meat and dairy products contain high sialic acid (Sia) levels, but the metabolic fate and health impact in children remain unknown. The aims of the present study were to quantify the levels of urinary Sia N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic acid (Neu5Gc) and ketodeoxynonulosonic acid (KDN) and to determine their relationship...
Article
Full-text available
Background Optimal nutrition for lactating mothers is importance for mother and infants’ health and well-being. We determined the nutrient intake and dietary changes during the first 3-month of lactation, and its potential effect on health and disease risk. Method Personal interviews were conducted to collect a 24h diet recall questionnaire from 1...
Article
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The early stages of neurodevelopment in infants are crucial for establishing neural structures and synaptic connections that influence brain biochemistry well into adulthood. This postnatal period of rapid neural growth is of critical importance for cell migration, neurite outgrowth, synaptic plasticity, and axon fasciculation. These processes thus...
Article
Background Lactoferrin (Lf), an iron‐binding glycoprotein containing terminal sialic acid residues, is secreted in milk. Lf is synthesized in brains of both humans suffering from Alzheimer's dementia, and in the mouse model of Parkinson's disease, suggesting that Lf may play a role in neurodegenerative diseases. Objective To investigate the neurop...
Conference Paper
Full-text available
Sulfated glycolipids (SGs) and glycosaminoglycans (GAGs) present on the surface of colonic, vaginal epithelial and neuroglial cells bind to HIV GP120, suggesting that these glycoconjugates may have a role in HIV infection. The main goal of this work was to test the ability of the human milk glycoconjugates (SGs and GAGs) to inhibit the infection of...
Article
Full-text available
Sialic acids are a family of nine-carbon carboxylated monosaccharides, KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) is the third member of the family of sialic acids. Recent biochemical and molecular biological studies on biosynthesis of KDN established that KDN is synthesized de novo from Mannose, it occurs widely among vertebrates and ba...
Conference Paper
Full-text available
In utero exposure to synthetic glucocorticoids mimics maternal stress and the clinical situation when glucocorticoids are administered to pregnant women at risk of premature delivery. Rat model of glucocorticoids exposure during gestation has been shown to cause reduction in brain weight, hypomyelination, and a delay in the differentiation of brain...
Conference Paper
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Background: In rats, in utero exposure to dexamethasone mimics gestational stress and showed reduction in brain weight and myelination. At postnatal day 7 (P7), in vivo 1H-MRS showed alterations of cerebral metabolism in cortex and hippocampus, suggesting impairment of brain structure, energy metabolism and neurotransmitter. Lactoferrin (Lf) an iro...
Article
Full-text available
The rapid growth of infant brains places an exceptionally high demand on the supply of nutrients from the diet, particularly for preterm in-fants. Sialic acid (Sia) is an essential component of brain gangliosides and the polysialic acid (polySia) chains that modify neural cell adhe-sion molecules (NCAM). Sia levels are high in human breast milk, pr...
Article
Full-text available
The gastrointestinal tract of mammals contains a complex microbial community that influences numerous aspects of health and development. It is postulated that establishment of this community during early life has long-term consequences on the health status of adults. Potential influences on colonization are expected to include environmental microbe...
Article
α-Amino (2-alkynylphenyl) methylphosphonate, which was generated from 2-alkynyl benzaldehyde, amine, and diethyl phosphate, reacted with aryl iodide at room temperature in the presence of catalytic amount of Pd2(dba)3 and DABCO in acetone, leading to the desired isoindol-1-ylphosphonate derivatives in good to excellent yields.
Article
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The UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (Gne) gene encodes a key bifunctional enzyme important in initiating and regulating sialic acid (Sia) synthesis. Sia is commonly expressed as a terminal (non-reducing) sugar residue on oligosaccharide side chains on cell surface glycoconjugates where it mediates many carbohydrate re...
Article
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Sialic acid, a key component of both human milk oligosaccharides and neural tissues, may be a conditional nutrient during periods of rapid brain growth. We tested the hypothesis that variations in the sialic acid content of a formula milk would influence early learning behavior and gene expression of enzymes involved in sialic acid metabolism in pi...
Article
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Sialic acid (N-acetylneuraminic acid), a component of gangliosides and sialylglycoproteins, may be a conditional nutrient in early life because endogenous synthesis is limited. The aim of this study was to investigate the metabolic fate of intravenously administrated N-acetylneuraminic acid-6-14C (sialic acid) in piglets. Three-day-old male domesti...
Article
Background -Sialic acid (Sia) is a family of 9-carbon sugars usually expressed as terminal residues on mammalian glycoconjugates. They play a key role in neural growth, development and function, cell signalling and recovery of injured neuronal tissues. N-acetylneuraminic acid (Neu5Ac) is the predominant Sia in humans, while most mammalian tissues c...
Article
Full-text available
Background: Sia, a key component of both human milk oligosaccharides and neural tissues, is involved in growth and development of neuronal function, signalling and recovery of injured neuronal tissues. Objective: To examine the influence of dietary Sia supplementation on the gene expression profile & identify brain development and cognition genes i...
Article
Full-text available
ST8Sia IV (polysialyltransferase IV gene) encodes a key enzyme that is required for polysialic acid synthesis. Polysialic acid is a component of the neural cell adhesion molecule and is necessary for synaptic plasticity of neural cells. We characterized 5.3 kb of pig ST8Sia IV cDNA and determined its expression profile in different organs. In hippo...
Article
Full-text available
The rapid brain growth of infants places exceptionally high demands on the supply of nutrients from the diet. Human milk is the best source of food for brain growth and cognition. One of nature's richest sources of sialic acid, a vital component of brain gangliosides and the building block of polysialic acid (PSA) on neural cell adhesion molecule (...
Article
Full-text available
The concentration of sialic acid in brain gangliosides and glycoproteins has been linked to learning ability in animal studies. Human milk is a rich source of sialic acid-containing oligosaccharides and is a potential source of exogenous sialic acid. The aim of the study was to compare the sialic acid concentration in the brain frontal cortex of br...
Article
Full-text available
Sialic acids are a family of nine-carbon acidic monosaccharides that occur naturally at the end of sugar chains attached to the surfaces of cells and soluble proteins. In the human body, the highest concentration of sialic acid (as N-acetylneuraminic acid) occurs in the brain where it participates as an integral part of ganglioside structure in syn...
Article
Full-text available
Using reverse-phase HPLC after pyridylamination, we quantified the concentrations of major neutral oligosaccharides in the milk of sixteen Japanese women collected at 4, 10, 30 and 100 d postpartum. In colostrum and mature milk (30 d lactation), lacto-N-fucopentaose (LNFP) I was the most abundant oligosaccharide, followed by 2'-fucosyllactose (2'-F...