Bing Li

Imperial College London | Imperial · Faculty of Medicine

The imperative development of planar on‐chip micro‐batteries featuring high‐capacity electrodes and environmentally safer, cost‐effective, and stable systems is crucial for powering forthcoming miniaturized systems‐on‐chip smart devices. However, research in the area of high‐stability micro‐batteries is limited due to the complex fabrication proces...

Aqueous rechargeable zinc‐ion batteries (ZIBs) are increasingly recognized as promising energy storage systems for mini‐grid and mini‐off‐grid applications due to their advantageous characteristics such as high safety, affordability, and considerable theoretical capacity. However, the long‐term cycling performance of ZIBs is hampered by challenges...

Accurate assessment of neurological disease through monitoring of biomarkers has been made possible using the antibody‐based assays. But these assays suffer from expensive development of antibody probes, reliance on complicated equipments, and high maintenance costs. Here, using the novel reduced graphene oxide/polydopamine‐molecularly imprinted po...

Safe, accurate, and reliable analysis of urinary biomarkers is clinically important for the early detection and monitoring the progression of chronic kidney disease (CKD), as it becomes one of the...

Creatinine is an important biomarker for the diagnosis of chronic kidney disease (CKD). Recently, it has been reported that the concentration of salivary creatinine correlates well with the concentration of serum creatinine, which makes the former useful for the development of non-invasive and point-of-care (POC) detection for CKD diagnosis. Howeve...

Cholesterol detection needs to be carried out to detect early symptoms of dangerous diseases such as heart disease. The process of detecting cholesterol in the human blood requires a sensitive detection tool in order to produce accurate values. This paper reports the performance of chitosan thin films modified with reduced graphene oxide (rGO) and...

The high-performance miniaturized micro-supercapacitors exhibit great potential due to their inherent properties of high-power density, fast charge–discharge rates, long cycle life, and wide working temperature range. However, there is a need to further enhance the energy density of micro-supercapacitors. In this study, we investigate a hybrid elec...

Chronic kidney disease (CKD) is one of the most serious non‐communicable diseases affecting the population. In the early‐stages patients have no obvious symptoms, until it becomes life‐threatening leading end‐stage kidney failure. Therefore, it is important to early diagnose CKD to allow therapeutic interventions and progression monitoring. Here, a...

Precise manipulation of flexible surgical tools is crucial in minimally invasive surgical procedures, necessitating a miniature and flexible robotic probe that can precisely direct the surgical instruments. In this work, we developed a polymer-based robotic fiber with a thermal actuation mechanism by local heating along the sides of a single fiber....

Chitosan coatings could effectively increase the biostability and biocompatibility of biomaterials while maintaining their structural integrity. In this study, electrospun fibrous polyhydroxybutyrate (PHB) membranes were pre-treated with potassium hydroxide (KOH) or hydrogen peroxide (H2O2) and then modified with dopamine (DA) and glutaraldehyde (G...

While recent advances in cryo-EM, coupled with single particle analysis, have the potential to allow structure determination in a near-native state from vanishingly few individual particles, this vision has yet to be realised in practise. Requirements for particle numbers that currently far exceed the theoretical lower limits, challenges with the p...

While recent advances in cryogenic electron microscopy coupled with single particle analysis have the potential to allow structure determination in a near-native state from vanishingly few individual particles, this vision has yet to be realised in practise. Requirements for particle numbers that currently far exceed the theoretical lower limits, c...

Technologies that rely on the fundamental principle of thermal expansion have demonstrated high-precision, a growing demand in fields driven by miniaturization. However, scalable production of high aspect ratio devices that harness this capability while facilitating flexibility in design and functionality remains a challenge. We employed the high-t...

Recent technological advances in micro-robotics have demonstrated their immense potential for biomedical applications. Emerging micro-robots have versatile sensing systems, flexible locomotion and dexterous manipulation capabilities that can significantly contribute to the healthcare system. Despite the appreciated and tangible benefits of medical...

The detection of ions is essential for a wide range of applications including biomedical diagnosis, and environmental monitoring among others. However, current ion sensors are based on thick sensing films (∼100 µm), requiring time-consuming preparations, and they have a limit to their sensitivity of 59 mV.Log [C]⁻¹. Consequently, these sensors cann...

Accurate and reliable analysis of creatinine is clinically important for the early detection and monitoring of patients with kidney disease. We report a novel graphene nanoplatelet (GNP)/polydopamine (PDA)-molecularly imprinted polymer (MIP) biosensor for the ultra-trace detection of creatinine in a range of body fluids. Dopamine hydrochloride (DA)...

Graphene field-effect transistor (GFET) biosensors exhibit high sensitivity due to a large surface-to-volume ratio and the high sensitivity of the Fermi level to the presence of charged biomolecules near the surface. For most reported GFET biosensors, bulky external reference electrodes are used which prevent their full-scale chip integration and c...

Silicon is a promising alternative anode material in lithium-ion batteries as it has a higher theoretical specific capacity than the commercial graphite-based anodes. Within this work, a new multicoated composite material was fabricated through a simple, non-vacuum, and economical aerosol-assisted chemical deposition. This eco-friendly preparation...

A simple, non-vacuum aerosol-assisted chemical deposition (AACD) method was developed for the deposition of a homogeneous composite film of graphene nanoplatelets and nano silicon. The multicoated composite anode (with 10...

Accurate, reliable, and cost-effective immunosensors are clinically important for the early diagnosis and monitoring of the progressive diseases, and multiplexed sensing is a promising strategy for the next generation of diagnostics. This strategy allows for the simultaneous detection and quantification of multiple biomarkers with significantly enh...

Glial fibrillary acidic protein (GFAP) is a discriminative blood biomarker for many neurological diseases, such as traumatic brain injury. Detection of GFAP in buffer solutions using biosensors has been demonstrated, but accurate quantification of GFAP in patient samples has not been reported, yet in urgent need. Herein, we demonstrate a robust on-...

The detection of food adulterants and toxicants can prevent a large variety of adverse health conditions for the global population. Through the process of rapid sensing enabled by deploying novel and robust sensors, the food industry can assist in the detection of adulterants and toxicants at trace levels. Sensor platforms which exploit graphene-ba...

Up to now, the reproducibility and stability of graphene-based electrochemical sensors have represented an obstacle to the development of practical biosensing techniques. In this paper we report a cost-effective and highly reproducible graphene-based electrochemical sensing platform to monitor the kinetic conformational change of amyloidogenic prot...

Real-time monitoring of intrabody pressures can benefit from the use of miniaturized force sensors during surgical interventions or for the recovery period thereafter. Herein, we present a force sensor made of P(VDF-TrFE) with simple fabrication process that has been integrated into the tip of a medical catheter for intraluminal pressure monitoring...

Accurate detection of blood biomarkers related to neurodegenerative diseases could provide a shortcut to identifying early stage patients before the onset of symptoms. The specificity, selectivity and operational requirements of the current technologies, however, preclude their use in the primary clinical setting for early detection. Graphene, an e...

Short notes - nano imaging

When flexible electronic materials are combined with micro 3D printing fabrication, it presents new applications for medical wearable biosensors and devices. This paper introduces a novel carbon nanotube-coated force sensor, successfully combining the advantages of flexible conductive nanomaterials and the versatility of two photon polymerization t...

Axons with staggered microtubules cross-linked by tau protein possess a remarkable mechanical balance of high specific stiffness and toughness. Owing to their viscoelastic nature, axons exhibit stress rate-dependent mechanical behavior, which is relevant to their selective vulnerability to damage in traumatic brain injury. A Kelvin–Voigt viscoelast...

The functionalities offered by single-molecule electrical junctions have yet to be translated into monolayer or few-layer molecular films, where effective and reproducible electrical contact represents one of the challenging bottlenecks. Here we take a significant step in this direction by demonstrating that excellent electrical contact can be made...

Nature is a great source of inspiration for the development of solutions for biomedical problems. We present a novel biosensor design utilizing two-photon polymerisation and graphene to fabricate an enhanced biosensing platform for the detection of motile bacteria. A cage comprising venous valve-inspired directional micro-structure is fabricated ar...

We use a contactless microwave dielectric resonator gas sensing platform to study the adsorption dynamics of NO2 gas present in air onto a graphene surface. The use of microwaves removes the need for metal contacts that would otherwise be necessary for traditional conductivity measurements, and therefore allows non-invasive determination of NO2 con...

Owing to its viscoelastic nature, tendon exhibits stress rate-dependent breaking and stiffness function. A Kelvin-Voigt viscoelastic shear lag model is proposed to illustrate the micromechanical behavior of the tendon under dynamic tensile conditions. Theoretical closed-form expressions are derived to predict the deformation and stress transfer bet...

We report a non-contact CVD graphene gas sensing method that utilises a high Q microwave dielectric resonator perturbation technique. A graphene sample is coupled to the evanescent field of a dielectric resonator whereupon nitrogen dioxide (NO2), a p-doping gas, is detected by monitoring the change in the linewidth and frequency of the resonant mod...

The development of microfabrication techniques compatible with scalable production processes of semiconductor industry is of crucial importance for the technological exploitation of graphene. We report here a novel technique for the photolithographic fabrication of back-gated field-effect transistor immunosensors using chemical vapor deposited (CVD...

A graphene/electrochemically reduced graphene oxide/polyallylamine electrode was developed to enhance its electrocatalytical activity for the reduction of hydrogen peroxide. Graphene oxide was coated and immobilized on top of a pristine graphene electrode via π-π bonding. Polyallylamine was then immobilized onto the surface of graphene oxide via co...

A novel printed graphene electrode modified with electrochemically reduced graphene oxide was developed for the detection of a specific oligonucleotide sequence. The graphene oxide was immobilized onto the surface of a graphene electrode via π-π bonds and electrochemical reduction of graphene oxide was achieved by cyclic voltammetry. A much higher...

Here, the authors report on a novel shielding technique for the fabrication of electrical contacts on exfoliated graphene by sputtering and lift-off process. The technique solves this problem by removing unwanted gold film in patterning contacts and reduces the high contact resistivity typically found in sputtered devices ranging from 260 to 940 kΩ...

We report measurement of the radio-frequency (RF) transport electromagnetic properties of chemical vapour deposition (CVD) graphene over the DC to 110 MHz frequency range at room temperature. Graphene on Si/SiO2 substrate was mounted in a shielded four terminal-pair (4TP) adaptor which enabled direct connection to a calibrated precision impedance a...

Here we review commonly used techniques for the production of large area and high quality graphene to meet the requirements of industrial applications, including epitaxial growth on SiC, chemical vapour deposition (CVD) on transition metals and growth from solid carbon source. The review makes a comparison of the growth mechanisms, quality (such as...

Here we demonstrate the growth of transfer-free graphene on SiO2 insulator substrates from sputtered carbon and metal layers with rapid thermal processing in the same evacuation. It was found that graphene always grows atop the stack and in close contact with the Ni. Raman spectra typical of high quality exfoliated monolayer graphene were obtained...

Graphene is a highly promising material for numerous potential applications, ranging from electronics and photonics to sensors and composites [1-2]. To exploit these applications at an industrial level requires large scale growth of high quality graphene on device compatible substrates. To date, this has mainly been achieved via chemical vapour dep...