Bindu Kalesan

Bindu Kalesan
Boston University | BU · Department of Medicine

PhD, MPH

About

141
Publications
15,646
Reads
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8,760
Citations
Additional affiliations
September 2015 - present
Boston University
Position
  • Director of Evan's Center for Clinical Translational Epidemiology and CER
September 2014 - present
Columbia University
Position
  • Research Assistant
September 2014 - present
Gun Violence Survivors Foundation, United States
Position
  • Vice President
Description
  • http://gvsfoundation.org/

Publications

Publications (141)
Article
Objectives Despite published guidelines and data for Medicare patients, it is uncertain how younger patients with intermittent claudication (IC) are treated. Additionally, the degree to which treatment patterns have changed over time with the expansion of endovascular interventions and outpatient centers is unclear. Our goal was to characterize IC...
Article
Background Rural counties in the United States have higher firearm suicide rates and opioid overdoses than urban counties. We sought to determine whether rural counties can be grouped based on these “diseases of despair.” Methods Age-adjusted firearm suicide death rates per 100,000; drug-related death rates per 100,000; homicide rate per 100,000,...
Article
Background Age- and intent-related differences in the burden and costs of firearm injury treated in emergency departments are not well-documented. Methods We performed a serial cross-sectional study of the Healthcare Cost and Utilization Program Nationwide Emergency Department Survey from 2006 to 2016. We used International Classification of Disea...
Article
Objectives: Length of stay (LOS) after carotid endarterectomy (CEA) and stenting (CAS) for asymptomatic disease is utilized as a quality measure and affects hospital operating margins. Patient-level Medicaid status has traditionally been associated with longer hospital LOS. Our goal was to assess the association between hospital-level Medicaid pre...
Article
Background: . Hospitalized self-inflicted firearm injuries have not been extensively studied, particularly regarding clinical diagnoses at the index admission. The objective of this study was to discover the diagnostic phenotypes (DPs) or clusters of hospitalized self-inflicted firearm injuries. Methods: . Using Nationwide Inpatient Sample data...
Article
Background Violent trauma has lasting psychological impacts. Our institution's Community Violence Response Team (CVRT) offers mental health services to trauma victims. We characterized implementation and determined factors associated with utilization by pediatric survivors of interpersonal violence-related penetrating trauma. Methods Analysis incl...
Article
Objective Firearm injuries have traditionally been associated with worse outcomes compared with other types of penetrating trauma. Lower extremity trauma with vascular injury is a common presentation at many centers. Our goal was to compare firearm and non-firearm lower extremity penetrating injuries requiring vascular repair. Methods We analyzed...
Article
Full-text available
Background Firearm-related death rates and years of potential life lost (YPLL) vary widely between population subgroups and states. However, changes or inflections in temporal trends within subgroups and states are not fully documented. We assessed temporal patterns and inflections in the rates of firearm deaths and %YPLL due to firearms for overal...
Article
Full-text available
Background: Pre-operative stress testing is widely used to evaluate patients for non-cardiac surgeries. However, its value in predicting peri-operative mortality is uncertain. The objective of this study is to assess the type and quality of available evidence in a comprehensive and statistically rigorous evaluation regarding the effectiveness of p...
Data
Video S2. Transitioning choropleth map showing spatiotemporal changes in mortality rates due to atrial fibrillation, 1990–2015 (best viewed with Windows Media Player).
Data
Table S1. Summary of Nationwide Inpatient Sample States, 1988–2015 Data S1. Age standardization. Table S2. Creating Weights Using 2000 Population Table S3. Age Standardization of Overall Heart Failure Mortality Rate Table S4. Age Standardization of Overall Heart Failure Mortality Rate Among Men Data S2. Differentiating causes of death: primary...
Data
Video S1. Transitioning chloropleth map showing spatiotemporal changes in the mortality rates due to heart failure, 1990–2015 (best viewed with Windows Media Player).
Article
Full-text available
Objective To determine whether restrictiveness-permissiveness of state gun laws or gun ownership are associated with mass shootings in the US. Design Cross sectional time series. Setting and population US gun owners from 1998-2015. Exposure An annual rating between 0 (completely restrictive) and 100 (completely permissive) for the gun laws of al...
Data
Infographic: Guns, Laws, and Mass Shootings
Data
Supplementary materials: Supplementary figure 1
Article
Full-text available
Background National conversation has justifiably been concerned with firearm-related deaths and much less attention has been paid to the consequences of surviving a firearm injury. We assessed the risk of hospital readmission, length of stay (LOS) during hospitalization, and costs within 90-days after surviving an index firearm injury and compared...
Article
Understanding the life years lost by assault and suicide due to firearms among white and black Americans can help us understand the race-specific and intent-specific firearm mortality burden and inform prevention programmes. The objective was to assess national and race-specific life expectancy loss related to firearms in the USA due to assault and...
Article
Perinatal depression/anxiety is considered the most underdiagnosed pregnancy complication in the US and is associated with poor maternal and fetal outcomes. However, despite its prevalence, most women who present with depressive symptoms are not screened and do not receive adequate treatment. We examined the clinical co-diagnosis of depression and/...
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Full-text available
Background Patients with atrial fibrillation (AF) are at risk for both thromboembolic and bleeding complications. While the risk for thromboembolism is higher among women with AF than men, the sex‐related differences in post‐discharge outcomes after hospitalization is not clearly understood. Methods We conducted a retrospective cohort study using...
Article
Background Firearm injuries can be morbid and potentially have high resource utilization. Historically, trauma and vascular surgery patients are at higher risk for readmissions. Our goal was to assess the risk for readmission among patients undergoing vascular repair after a firearm injury. Methods The National Readmission Database was queried fro...
Article
Full-text available
Purpose Globally, the age-standardised prevalence of type 2 diabetes mellitus (T2DM) has nearly doubled from 1980 to 2014, rising from 4.7% to 8.5% with an estimated 422 million adults living with the chronic disease. The MULTI sTUdy Diabetes rEsearch (MULTITUDE) consortium was recently established to harmonise data from 17 independent cohort studi...
Article
Background Suicides are of growing public health concern in the United States. Although the demographics of firearm suicides are well established, the sex and age differences in the role that life circumstances play in the risk for firearm suicide are not known. Methods We used suicide deaths from the National Violent Death Reporting System from 2...
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Full-text available
Dietary protein may help prevent age-related declines in strength and functional capacity. This study examines the independent relation between dietary protein and longitudinal changes in physical functioning among Framingham Offspring Study adults from Exams 5 (1991-1995) to 8 (2005-2008). Protein intakes were derived from three-day diet records d...
Article
Full-text available
The majority of the burden of firearm injury in the United States is on men as compared to women. There is limited evidence regarding sex differences in short-term hospitalization outcomes after surviving firearm injury. The risk of cardiovascular and all-cause hospital readmission, length of stay (LOS), and costs within 180 days after surviving an...
Article
Objective: The care of patients undergoing thoracic endovascular aortic repair (TEVAR) can be resource intensive, which can be driven by readmissions. Our objective was to characterize index readmissions at 30, 90, and 180 days after TEVAR. Methods: A retrospective analysis of the Nationwide Readmissions Database was performed for patients who u...
Article
Depression and anxiety are common among patients who have a major cardiovascular event. However, despite their frequency, there is a lack of evidence regarding the relationship between depression and/or anxiety and receiving revascularization in ST-elevation myocardial infarction (STEMI) hospitalizations. Using data from the Nationwide Inpatient Sa...
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Full-text available
Background Non-fatal firearm injuries constitute approximately 70% of all firearm trauma injuries in the United States. Patterns of severity of these injuries are poorly understood. We analyzed the overall, age-, sex- and intent-specific temporal trends in the injury severity of firearm hospitalizations from 1993 to 2014. Methods We assessed tempo...
Article
Full-text available
Objectives: To examine the relation of "shall-issue" laws, in which permits must be issued if requisite criteria are met; "may-issue" laws, which give law enforcement officials wide discretion over whether to issue concealed firearm carry permits or not; and homicide rates. Methods: We compared homicide rates in shall-issue and may-issue states...
Article
Background: To prevent intimate partner homicide (IPH), some states have adopted laws restricting firearm possession by intimate partner violence (IPV) offenders. "Possession" laws prohibit the possession of firearms by these offenders. "Relinquishment" laws prohibit firearm possession and also explicitly require offenders to surrender their firea...
Chapter
Cardiovascular diseases represent the most frequent cause of mortality in women, and the mortality from cardiovascular disease remained higher in women than men during the last three decades [1, 2]. Since the year 2000, however, there has been a marked reduction in cardiovascular mortality in both men and women [2]. This has been associated with im...
Article
Background: The complex association between socioeconomic status (SES) and depressive symptoms is not entirely understood and the existing literature does not address the relationship between early-life SES and later-life depression from a life-course perspective, incorporating mediating events. Methods: Using data from the Wisconsin Longitudina...
Article
Full-text available
Introduction: Firearm violence injures or kills 100,000 Americans each year. This paper applies the Host-Agent-Vector-Environment model to this issue. Research on firearm violence tends to focus on two elements-the host (i.e., victims of firearm violence) and the environment (i.e., gun policies)-but little attention has been paid to the agent (the...
Article
Full-text available
Objectives: To describe a new database containing detailed annual information on firearm-related laws in place in each of the 50 US states from 1991 to 2016 and to summarize key trends in firearm-related laws during this time period. Methods: Using Thomson Reuters Westlaw data to access historical state statutes and session laws, we developed a...
Article
Purpose: We examined the socio-demographic distribution of gun deaths across 3143 counties in 50 United States' states to understand the spatial patterns and correlates of high and low gun deaths. Methods: We used aggregate counts of gun deaths and population in all counties from 1999 to 2013 from the Centers for Disease Control and Prevention's...
Article
Investigating firearm injury trends over the past decade, we examined temporal trends overall and according to race/ethnicity and intent in fatal and nonfatal firearm injuries (FFIs and NFIs) in United States during 2001-2013. Counts of FFIs and estimated counts of NFIs were obtained from the Centers for Disease Control and Prevention's Web-based I...
Article
Background Data on the factors associated with school shootings in the USA are limited. The public conversation has often suggested several factors that may be linked to these events, however with little empirical support. Aiming to fill this gap, we describe the characteristics of school shooting incidents in the USA between 2013 and 2015 and expl...
Article
(Abstracted from Lancet 2016;387:1847–1855) Firearm violence and firearm mortality are a cause for concern in the USA. Several laws, including the Brady Law, child-access prevention laws, and stand-your-ground laws have been enacted in different states to address gun violence.
Article
We thank all authors for their interest in our paper;1 four main critiques are raised. First, Schell and Morral suggest that bootstrapping to recalculate standard error and confidence intervals would be appropriate in this context. We disagree. Bootstrapping is more appropriate under the assumption that observations are from an independent and iden...
Article
Full-text available
Objectives: To determine the temporal patterns and the difference in trends by race/ethnicity of pediatric firearm hospitalizations (FH) among those aged 15 years or younger in the United States. Methods: Data on pediatric FH was retrieved from the Nationwide Inpatient Sample between 1998 and 2011 (n = 16,998,470) using external cause of injury...
Article
Background: In an effort to reduce firearm mortality rates in the USA, US states have enacted a range of firearm laws to either strengthen or deregulate the existing main federal gun control law, the Brady Law. We set out to determine the independent association of different firearm laws with overall firearm mortality, homicide firearm mortality,...
Article
Although firearm-related homicide-suicides and firearm-related suicides are tragic and catastrophic events, there is increasing evidence that the two events have different precipitants and that understanding these precipitants may help prevention efforts. We aimed to assess the role of interpersonal conflict (IPC) and recent crises in firearm-relat...
Article
Full-text available
Background Human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) is an aggressive form of breast cancer and is historically associated with poor outcomes compared with HER2-negative MBC. Since 1998, four drugs have been globally approved for the targeted treatment of HER2-positive MBC. Additional advances in patien...
Article
Purpose: To better understand the effects of race and/or ethnicity and neighborhood poverty on pediatric firearm injuries in the United States, we compared overall and intent-specific firearm hospitalizations (FH) with those of pedestrian motor vehicle crash hospitalizations (PMVH). Methods: We used Nationwide Inpatient Sample data (1998-2011) a...
Article
Full-text available
We assessed gun ownership rates in 2013 across the USA and the association between exposure to a social gun culture and gun ownership. We used data from a nationally representative sample of 4000 US adults, from 50 states and District of Columbia, aged >18 years to assess gun ownership and social gun culture performed in October 2013. State-level f...
Article
Toxicity due to treatment causes a negative impact on quality of life in breast cancer survivors. Hot flash symptoms, described as intense sensations of heat, sweating and flushing occur in more than 50 % of breast cancer patients taking tamoxifen. We hypothesized that venlafaxine, a selective-norepinephrine reuptake inhibitor drug, was effective f...
Article
Firearm injuries are a major health problem contributing to significant morbidity and mortality. Depression is associated with increased risk of adverse health outcomes in trauma patients and those hospitalized for serious disorders. We examined the relation between preexisting depression and adverse hospital outcomes and related injury severity am...
Article
It has been well-established that patient self-testing (PST) of INR using home monitoring devices increasesthe average therapeutic time, as well as patient satisfaction. Long-term anticoagulation therapy with warfarin is used in patients with continuous-flow LVAD (CF-LVAD) to minimize the occurrence of thromboembolic events; however, PST devices ha...
Article
Hybrid percutaneous coronary intervention offers an alternative method of revascularization for high-risk surgical populations. We report the outcomes of a single-stage hybrid strategy in valvular cardiac surgery and explore its effects on operative risk and bleeding. In a hybrid operating room, 26 patients underwent hybrid surgery consisting of fe...
Article
Refractory cardiogenic shock (RCS) is associated with significant morbidity and mortality, and current mainstays of medical therapy appear inadequate. Veno-arterial extracorporeal membrane membranous oxygenation (VA-ECMO) represents an increasingly accepted therapy for RCS. Demographics, past medical history, pre-operative characteristics, outcomes...
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Full-text available
Mathematical models of disease progression predict disease outcomes and are useful epidemiological tools for planners and evaluators of health interventions. The 𝖱 package gems is a tool that simulates disease progression in patients and predicts the effect of different interventions on patient outcome. Disease progression is represented by a serie...
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Full-text available
Anemia and renal impairment are important co-morbidities among patients with coronary artery disease undergoing Percutaneous Coronary Intervention (PCI). Disease progression to eventual death can be understood as the combined effect of baseline characteristics and intermediate outcomes. Using data from a prospective cohort study, we investigated cl...
Article
Acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) remains associated with significant mortality despite the widespread application of early revascularization strategies. Recent evidence suggests that the use of intra-aortic balloon pump (IABP) counterpulsation does not improve mortality in this cohort of patients. We summarize...
Article
Background: Right heart failure (RHF) is an unresolved issue during continuous-flow left ventricular assist device (LVAD) support. There are scarce data about post-transplant outcomes in patients complicated with late RHF during LVAD support. Objective: To assess whether development of late RHF during LVAD support adversely affected post-transplant...
Article
Background: Long-term anticoagulation therapy with warfarin is used in pts. with continuous-flow LVAD (CF-LVAD) to minimize the occurrence of thromboembolic events. Patient self-testing (PST) of INR with home monitoring devices has been shown to improve time within therapeutic INR range as well as patient satisfaction in other settings. However, PS...
Article
Background: Staphylococcus aureus remains a leading cause of IE, but it is unknown whether S. aureus is associated with more severe infections or worsened outcomes compared to other bacterial organisms. The primary purpose of this study was to compare the clinical characteristics and mortality in S. aureus (SA) versus non-S. aureus (NSA) IE patient...
Article
Objectives Recent advances in technology and improved patient management have enabled the use of mechanical circulatory support for unexpected long-term periods. Improved long-term outcomes may facilitate the use of device therapy as an alternative to heart transplantation. However, there are scarce data about the long-term outcomes of continuous-f...
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Full-text available
Background Renal impairment (RI) is associated with impaired prognosis in patients with coronary artery disease. Clinical and angiographic outcomes of patients undergoing percutaneous coronary intervention (PCI) with the use of drug-eluting stents (DES) in this patient population are not well established. Methods We pooled individual data for 5,01...
Article
Full-text available
Objectives To document overall, racial, ethnic and intent-specific spatiotemporal trends of firearm-related fatality rates (FRF rates) in the USA. Design Cross-sectional study per year from 2000 to 2010. Setting USA. Participants Aggregate count of all people in the USA from 2000 to 2010. Outcome measures Data from the Web-based Injury Statistics Q...