Biljana Bozin

Biljana Bozin
University of Novi Sad · Center for Medical and Pharmaceutical Investigations and Quality Control, Department of Pharmacy

PhD in Biochemistry

About

94
Publications
37,195
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
4,939
Citations
Additional affiliations
October 2019 - March 2020
University of Novi Sad, Faculty of Medicine
Position
  • Professor (Full)
October 2019 - present
Univerzitet u Novom Sadu
Position
  • Professor (Full)

Publications

Publications (94)
Article
Full-text available
Mastitis is considered to be one of the most important diseases of dairy cows in terms of health, production, and economy. Being the most common cause of antibiotic consumption in dairy cows, treatment of this disease is one of the biggest challenges in the veterinary profession as an increasing number of pathogens develop resistance to antibiotics...
Article
Full-text available
Although oral ulcers represent one of the most frequent oral mucosal diseases, the available treatment is not sufficient to provide complete ulcer recovery without side-effects. Therefore, the aim of our study was to prepare a mucoadhesive oral gel based on Galium verum ethanol extract (GVL gel) and reveal its healing effects in the model of aphtho...
Conference Paper
Full-text available
Heat-not-burn tobacco products (HNB) are electronic devices that heat processed tobacco instead of combusting and have been marketed by the tobacco industry as a less harmful alternative to conventional cigarettes. Here we conducted a literature review of the differences in chemical composition among aerosols of conventional cigarettes, electro...
Article
The phytochemical analysis of the investigated Immortelle essential oil revealed the presence of monoterpenes and sesquiterpenes as major components that might be efficient as a wound healing potential agent. The present study aimed to develop an ointment based on the Immortelle essential oil and investigate its wound healing effects on excision wo...
Article
The alcohol-attributable mortality is an important issue in South-Eastern Europe, whereby consumption of homemade spirits is stated to be one of the leading causes. Presence of harmful volatiles in spirits in Serbia was investigated in 26 recorded and 127 unrecorded fruit spirits, collected in 2020 and analysed using GC-FID methods. Statistical ana...
Article
Full-text available
Mastitis is one of the most common and costly diseases affecting dairy cows worldwide. Since antibiotic resistance has become a global threat to both animal and human health, it is becoming more urgent to continuously search for new therapeutical alternatives for the control and treatment of bovine mastitis. Hence, our research aimed to test the th...
Article
Full-text available
Mastitis represents a heavy burden for the dairy sector worldwide with high economic and animal welfare impact. Antibiotic treatment is an important component of mastitis control programs. However, emergence and transfer of antimicrobial-resistant (AMR) bacteria is becoming a growing concern. Therefore, the development of novel agents is required f...
Article
Full-text available
As proper wound management is crucial to reducing morbidity and improving quality of life, this study evaluated for the first time the wound healing potential of H. italicum essential oil (HIEO) prepared in the form of ointment and gel in streptozotocin-induced diabetic wound models in rats. After creating full-thickness cutaneous wounds, forty-eig...
Article
Full-text available
Multiple positive effects that forests have on human health and overall well-being have been reported widely in the literature. Still, multiple elements of this relationship remain unidentified and unexplained. In this study, the composition of leaf volatile organic compounds (BVOCs) content in three common coniferous species: the Austrian pine (Pi...
Article
Full-text available
Traditional medicinal plants are used as an additional form of type 2 diabetes therapy in which oxidative stress is one of the progression factors. The aim of the study was the evaluation of antihyperglycemic and antioxidant potential of tea mixture registered as food and marketed for treatment of type 2 diabetes mellitus. Chemical profiling of the...
Article
The latest report on tetrahydrocannabinol (THC) exposure assessment performed by European Food Safety Authority showed that THC levels in certain food categories are high. However, the performed study included uncertainties regarding occurrence data and hemp-food consumption patterns. The aim of the present study was to quantify the levels of “tota...
Article
Full-text available
Bovine mastitis is the most widespread and economically important disease worldwide. The present study aimed to determine bioactive compounds in two essential oils (EOs) from wild (Thymus serpyllum) and common thyme (Thymus vulgaris) and to assess the antioxidant potential as well as antibacterial efficacy of the EOs against mastitis-associated bac...
Article
Medicinal plants have many beneficial effects on human health. Garlic (Allium sativum, Alliaceae) is one of the most famous herbal species, used for various diseases and conditions. Unfortunately, garlic is also associated with adverse effects, including cutaneous manifestations. In this review, burn injuries caused by application of raw garlic are...
Article
Full-text available
: It is considered that different plant organic compounds, known as phytoncides are creditable for positive effects of Forest therapy on human health. Ongoing pandemic has also put these compounds in research focus considering potential use for novel corona virus treatment. This research was conducted in order to examine the potential of Tilia cord...
Article
Rosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae) plant species. It is considered responsible for a wide spectrum of biological and pharmacological activities of plants containing this compound. The aim of the current review is to present the fate of rosmarinic acid inside the human body, explained through pharmacok...
Article
Full-text available
St. John’s wort has been used for centuries in traditional medicine of many cultures, and nowadays it is well-known as a clinically important antidepressant drug. Considering the rising market demand for Hyperici herba, quality control of crude drug is of paramount importance. In this paper we performed HPLC-DAD chemical profiling of St. John’s wor...
Article
The aim of the present study was chemical characterization of the savory (Satureja kitaibelii, Lamiaceae) extract, evaluation of its antioxidant potential and time-dependent monitoring of oxidative degradation parameters in sunflower and olive oil with added savory during storage and during the heating process. The savory extract was preliminary an...
Article
Introduction Human in vivo models of skin damage were often used in research of cutaneous disorders. The most commonly used models were tape‐stripping as mechanical, sodium lauryl sulphate‐induced irritation as chemical and ultraviolet radiation as physical damage model. In regard to differences between models, they were expected to have different...
Article
Mints are the most popular economic and traditional herbs. The aim of this paper was chemical characterization of volatile compounds from wild populations of Mentha aquatica , M . arvensis , M . longifolia , M . microphylla, M . pulegium , M . spicata , M . × dumetorum , M . × gentillis and M . × verticillata , as well as cultivated samples of M ....
Conference Paper
Full-text available
In vitro and in vivo researches of cinnamon indicate the high medical potential of this widely used spice. Significant effects are antimicrobial, antiinflammatory, the effect on lowering cholesterol levels and lowering blood glucose levels. It is also an ingredient in various dietary supplements intended for coronary disease and diabetes prevention...
Article
In this study, 48 herbal based products (41 for the pediatric population) were analyzed for the presence of ethanol and residual solvents. Ethanol was not detected in only 12% of the products designed for infants or toddlers aged under 2, and not quantified in only 5 of 14 'alcohol free' products. Actual content was higher than labeled in six out o...
Article
Objective Gastrointestinal (GI) disorders are estimated to be frequent among general population. Various types of traditional and complementary therapies, primarily phytotherapy, can be used for prevention and treatment of many diseases and conditions, including GI complaints. Thus, the aim of this study was to investigate the patterns of use of me...
Article
Objective: Besides conventional drugs, various vaginal disorders are often treated with complementary and alternative medicines. Different natural products are often used in treatment of genital infections. The aim is to present a case of treatment of vaginal infection with a garlic clove. Methods: A detailed interview was conducted with the sub...
Article
Full-text available
Oxidative stress has been associated with cervical cancer. Our aim was to examine lipid peroxidation and the extent of oxidative stress in women diagnosed with different stages of cervical cancer in order to evaluate its potential role in the evolution of cancer. We measured the concentration of thiobarbituric acid reactive substances, activities o...
Article
Full-text available
Introduction. Horehound (Marrubium vulgare, Lamiaceae) is a widely used plant in traditional medicine used for prevention and treatment of various diseases. High content of phenolic compounds makes it a significant source of natural antioxidants. The aim of this research was to examine in vitro antioxidant properties and anticholinesterase activity...
Article
Constant search for new drugs with antiviral properties often extends to products of natural origin. Lamiaceae is one of the most important herbal families, well known for various biological and medicinal effects of a variety of aromatic spices, including thyme, mint, oregano, basil, sage, savory, rosemary, self-heal, hyssop, lemon balm and many ot...
Article
Full-text available
St. John’s wort is a widely used medicinal plant. The quality of herbal drug, which is in most of the cases collected from nature, varies. Therefore, the aim of the present study was detailed chemical characterization of Hypericum perforatum subsp. perforatum samples collected in close time intervals during flowering and fruitification with the pur...
Article
Full-text available
Many studies have refuted the opinion that urban floras are poor in total species number and characterized primarily by neophytes. Also, it has been proved that urban flora differs from its surroundings, and at the same time reflects its richness. Our study focused on urban flora, structure and similarities, and the possible correlation with the ur...
Article
Full-text available
Many studies have refuted the opinion that urban floras are poor in total species number and characterized primarily by neophytes. Also, it has been proved that urban flora differs from its surroundings, and at the same time reflects its richness. Our study focused on urban flora, structure and similarities, and the possible correlation with the ur...
Article
Full-text available
Reynoutria japonica is on the IUCN list of the Worlds' 100 worst invasive species, but it is also, especially its rhißome, an integral part of traditional Chinese medicine. The objective of this study was to determine the amount of selected phenolic compounds in rhißome, stems, leaves and inflorescence methanol extracts of this plant, their antioxi...
Article
Full-text available
The roles of the pharmacist were transformed throughout the history and modern pharmacist as we know now beside providing products and playing in optimization of medicines has a crucial role in ensuring the efficacy and safety of applied drugs. A better life quality, global health and safety is the major goal of the 21st century and to achieve that...
Article
Full-text available
Ornithogalum umbellatum L. is a widely distributed species in Europe, that exhibit considerable variability at ecological, morpho-anatomical, and karyological level. Previous reports of the chemical investigations among Ornithogalum species indicate significant diversity of the secondary metabolites, as well. Knowing that environment affects the ph...
Article
The application of chemometric approaches in the comparison of the activity and the chemical composition of essential oils of 10 aromatic Lamiaceae species (Melissa officinalis, Mentha piperita, Mentha aquatica, Mentha longifolia, Ocimum basilicum, Origanum vulgare, Rosmarinus officinalis, Salvia officinalis, Salvia nemorosa, and Thymus vulgaris) i...
Article
Full-text available
The genus Hypericum includes over 500 widely distributed species. The main representative is St. John’s wort (Hypericum perforatum L. (1753), Hypericaceae), the only approved biological source of Hyperici herba by WHO and EMEA monographs. It is frequently used in the form of oil macerate for treatment of burns, scars, eczema and gastrointestinal di...
Chapter
Full-text available
Medicinal plants have a long tradition of use in folk and conventional medicine. In recent years numerous studies confirm various bioactivities of natural products, among them antibacterial activity. Natural antibacterial agents such are essential oils and isolated compounds now represent a notable source for pharmaceutical and food industry and ar...
Article
Aniseed (Pimpinella anisum L., Apiaceae) and its essential oil (EO) have been widely used. Because there are some data about the impact of aniseed EO on drug effects, this survey aimed to assess the potential of pharmacokinetic herb-drug interaction between aniseed EO and acetaminophen and caffeine in mice. The chemical analysis (gas chromatography...
Article
Thyme (Thymus vulgaris L., Lamiaceae) is, among numerous representatives of genus Thymus, the commonly used and cultivated species worldwide. This is mainly due to the presence of essential oil which has a number of notable and scientifically confirmed biological activities. However, the amount of thyme essential oil in the leaves is very low (0.8-...
Article
The genus Ganoderma includes about 80 species growing on cut or rotten trees. The most commonly used species is Ganoderma ludicum. Biomolecules responsible for the health benefits of Ganoderma are polysaccharides with an immunostimulative effect and triterpenes with a cytotoxic action. For more than 2000 years, it has been used traditionally in the...
Chapter
Full-text available
The genus Hypericum L. (Hypericaceae) comprises around 500 species divided in 36 sections. From ancient times, the common St. John’s wort (Hypericum perforatum L.) was often used in traditional pharmacy and medicine, and as important source of traditional drugs was, subjected to wide spectra of researches. Summarised data assured several clinical i...
Article
Full-text available
In this study, chemical composition, antioxidant and antibacterial activities of thyme and oregano essential oils, thymol and carvacrol, as well as their possible synergism were investigated. For chemical profiling of essential oils, GC-MS analysis was performed. Antioxidant capacity was assessed throughout neutralisation of DPPH and OH radicals. F...
Article
The aims of study were to examine the antibacterial potential of two commercial essential oils (EOs) from coriander (Coriandrum sativum L.) and thyme (Thymus vulgaris L.) against vaginal clinical strains of bacteria and yeast and their chemical composition. Antimicrobial activities of commercial essential oils were determined using macro-diffusion...
Article
Full-text available
Numerous traditional and clinically approved indications have created constant raise of demand for Hyperici herba in the world. However, the quality of the plant material depends on the plant source and abiotic factors of the habitats. The scope of the research was to find out whether other Hypericum species have similar chemical characteristics fo...
Article
The chemical composition and antioxidant properties of the essential oil and EtOH extract of immortelle (Helichrysum italicum (Roth) G.Don subsp. italicum, Asteraceae) collected in Montenegro were evaluated. The essential oil was characterized by GC/MS analysis, and the content of total phenolics and flavonoids in the EtOH extract was determined us...
Article
Full-text available
Background/Aim. Tea and coffee are one of the most widely consumed beverages in the world due to their beneficial health effects which are largely associated with their phenolic compounds composition, including chlorogenic acid. The main aim of this study was to determine 5-caffeoylquinic acid (5-CQA), as one of the major classes of chlorogenic aci...
Article
Full-text available
The effect of ELF-EMF on DNA through changes in antioxidative enzyme activities has not been sufficiently explored yet. The aim of this study was to determine ELF-EMF effect on antioxidative enzymes in cancer cell line and genotoxic potential on normal human lymphocytes. K562 cells were exposed to 50 Hz ELF-EMF (40 μT, 100 μT; 3 h, 24 h) and spectr...
Article
Abstract Essential oils from oregano (Origanum vulgare L.), mint (Mentha piperita L.), fennel (Foeniculum vulgare Mill.), and pine (Abies alba Mill.) needles and cones, and their active substances thymol, carvacrol, menthol, and anisaldehyde were tested for antifungal activity against Penicillium verrucosum. The lowest minimal inhibitory concentrat...
Article
Full-text available
The metabolic syndrome (MetS) is a polygenic multifactorial metabolic disorder with strong socioeconomic influence. MetS has became a worldwide epidemic, that directly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The human apoE gene, coding Apolipoprotein E, has three common polymorphisms in human population: e2, e3 a...
Article
The objectives of this study were to define the phenolic profile, antioxidant, anti-inflammatory and cytotoxic properties of edible Allium flavum subsp. flavum (small yellow onion), which has never been comprehensively examined before. The presence and content of 44 phenolic compounds in methanol extracts of A. flavum were investigated by LC-MS/MS,...
Article
The present study was designed to define the phenolic and terpene profile, antioxidant and anti-inflammatory activity of methanol extracts and essential oils of the leaves and seed cones of Juniperus foetidissima species, on which there has been little previous research. The content of 44 phenolics in extracts was determined using LC–MS/MS. A compa...
Article
Full-text available
The study shows the influence of the origin of plant material and biological source on the in vitro antioxidant (neutralization of DPPH and OH radical, nitric oxide, and inhibition of lipid peroxidation) and anticholinesterase activity of chemically characterized and quantified ethanol extracts of ten St. John's wort samples. The investigated sampl...
Article
Background: The use of herbal medicines and herbal dietary supplements in Serbia is very common and many patients consume herbal preparations with conventional drug therapy. Objective: The aim of this survey was to evaluate the consumers' awareness of herbal remedies and the safety of herbal dietary supplements, their attitude towards combining...
Article
The content and chemical composition of Mentha aquatica L. (Lamiaceae) essential oil during three phenophases (before flowering, flowering and after flowering) was compared. Quantities of the essential oils were determined according to the European Pharmacopoeia 4ed 12 and chemical profiles by GC-MS. The highest content of the essential oil was fou...
Article
Anise (Pimpinella anisum L.; Apiaceae) and its essential oil have been widely used in folk medicine, pharmacy and food industry. Since there are some data about the impact of anise on functions of central nervous system (CNS), the issue of possible interactions with drugs acting in CNS should be considered. This survey aimed to examine the influenc...
Article
The appearance of common and self-initiative usage of various herbal preparations in everyday practice and life imposes the question of possible interactions with drugs. This survey examined the influence of acute and chronic peppermint oil (PO--Mentha × piperita L., Lamiaceae; prepared as emulsion for oral use) on pentobarbitone-induced sleeping t...
Conference Paper
While many Apiaceae species are well-investigated and have long-standing application in cuisine and traditional medicine, the most of species are considered weeds and their chemical composition and bioactivity is unknown. The purpose of this work is to provide insight into chemical profile of selected species from tribe Scandiceae, wild-growing in...
Article
In this study we tried to determine if the activities of the primary antioxidant enzymes are detectable in amniotic fluid and if they can be used as early biomarkers of complications in pregnancy connected with bacterial vaginosis. This was a prospective study in which amniotic fluid was taken between 16 and 19 weeks of gestation. 161 pregnant wome...
Article
Members of the genus Allium have been used and cultured for thousands of years for their medicinal properties and characteristic flavor. Only two species of genus Allium (A. sativum L. and A. cepa L.) are well researched, while data on chemical composition and biological activities of other species, including Allium melanantherum Panc. (subgen. All...
Article
In this study, we tried to determine whether the activities of the primary antioxidant enzymes are detectable in amniotic fluid and whether they can be used as early biomarkers of complications in pregnancy such as pregnancy-induced hypertension (PIH), gestational diabetes mellitus (GDM), and bacterial vaginosis. This was a prospective study in whi...
Article
Contact sensitivity is a type of hypersensitivity which results in an immune response after contact of the skin or mucous membranes with various environmental substances. During the past two decades, the Allergy Department of the Clinic of Dermatovenereology Diseases in Novi Sad, has examined patients who were referred with a suspicion of contact s...
Article
Essential oils from air-dried leaves and verticillasters of Nepeta nuda ssp. nuda from Greece were analyzed by means of gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. The dominant constituent in the verticillaster oils was 4aα,7α,7aß-nepetalactone (75.7%). The main metabolites of the leaf oil were 1,8-cineol...
Article
Essential oils of Coriandrum sativum L. and Carum carvi L. fruits were analyzed by gas chromatography-mass spectrometry and assayed for their in vitro and in vivo antioxidant activity and hepatoprotective effect against carbon tetrachloride (CCl(4)) damage. The in vitro antioxidant activity was evaluated as a free radical scavenging capacity (RSC),...