Bilgin Kaygisiz

Eskisehir Osmangazi University, Medical School, Eskisehir,Turkey · Department of Medical Pharmacology

Background/aim: Cisplatin (CIS) is an effective antineoplastic agent used in the treatment of several cancer types. Peripheral neuropathy is a major dose-limiting side-effect in CIS therapy. Cannabinoids may alleviate this painful side effect. This study investigated the analgesic effects of anandamide (AN) on CIS-induced peripheral neuropathy, in...

Objective Acetylcholinesterase inhibitors are the focus of interest in the management of schizophrenia. We aimed to investigate the effects of acute galangin administration, a flavonoid compound with acetylcholinesterase inhibiting activity, on schizophrenia-associated cognitive deficits in rats and schizophrenia models in mice. Methods Apomorphin...

Objectives: Safe and effective drugs are still lacking for many pain therapies. In recent years, growing interest has been devoted thus on herbal drugs as an option to identify new pain killers. Based on this, extensive researches are carried out on Verbascum L. genus due to its therapeutic potency on pain and inflammation therapy. In this study, a...

Objective: In this study, the aim is to observe changes induced by dehydroepiandrosterone (DHEA) and resveratrol (RES) in diminished ovarian follicles that was induced by 4-vinylcyclohexenediepoxide (VCD). Materials and methods: Twenty four Wistar albino female rats were divided into 3 groups: control, DHEA and RES. Unilateral oophorectomy was p...

Background: Galangin, a flavonoid compound with acetylcholinesterase inhibitory activity, may improve cognitive functions by enhancing cholinergic transmission. Objectives: We aimed to investigate the effects of galangin on spatial memory impairment in rats. Methods: The effects of galangin (50 and 100 mg/kg) and reference anti-dementia drug d...

Objective: Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory pain. We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-α (TNF-α) and interleukine-1β...

Background: Chemerin is a novel chemoattractant adipokine, expressed in cardiovascular system and its receptor has also been detected in epicardial adipose tissue. Aims: The objective of this research is to determine the effects of chemerin on the cardiac parameters and gene expressions, in isolated perfused rat heart. Study design: Animal exp...

Objective: Statins, or 3-hydroxyl-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, which are potent inhibitors of cholesterol synthesis, are widely used in the treatment of hypercholesterolaemia and prevention of coronary artery diseases. Evidence from clinical trials also show other beneficial actions of statins unrelated to their chole...

Cisplatin is a widely used antineoplastic agent in the treatment of various cancers. Peripheral neuropathy is a well‐known side effect of cisplatin and has potential to result in limiting and/or reducing the dose, decreasing the quality of life. Thus, effective treatments are needed. Agmatine is an endogenous neuromodulator that has been shown to e...

Pregabalin, a drug used in epilepsy, anxiety, neuropathic pain is reported to have analgesic effects in inflammatory pain. We aimed to investigate whether pregabalin have gastric side effects and to compare with a non steroidal antiinflammatory drug (NSAID) in rats. The effects of pregabalin on antioxidant levels, which are suggested to protect aga...

Background: Cisplatin (CIS) is an effective antineoplastic agent used in treatment of several cancer types. However, peripheral neuropathy is a major side-effect seen in most of patients. Cannabinoids are known to have a potential analgesic effect. The aim was to investigate the antinociceptive effects of chronic administration of anandamide (AN),...

Objective: It was suggested that prostaglandins which are synthesized by cyclooxygenase (COX) enzymes contribute to the actions of angiotensin-converting enzyme (ACE) inhibition and angiotensin AT1 receptor antagonism and there is an interaction between ACE signaling pathway and COX enzymes. We aim to investigate the role of COX enzymes in the effe...

Resveratrol (RES), a polyphenolic compound, was reported to have protective effect against convulsions. The effects of resveratrol alone or in combination with low-dose antiepileptics against pentylenetetrazole (PTZ)-induced seizures and its histological effects in brain regions were investigated. Mice were divided into 8 groups: Control, RES (75m...

Background: Calcium homeostasis is considered to be important in antineoplastic as well as in neurotoxic adverse effects of cisplatin. Aims: This study aimed to investigate the role of Ca2+ in cisplatin neurotoxicity in cultured rat dorsal root ganglia (DRG) cells. Study Design: Cell culture study. Methods: DRG cells prepared from 1-day old Sp...

We aimed to investigate the effects and mechanisms of action of p-nonylphenol(p-NP) on uterine contractility in rats. The uterine tissues of female Sprague Dawley rats in diestrus were bathed in isolated organ bath. The effects of vehicle alone (0.1% ethanol), the positive control 17-β-E2 (10(-5) M) and p-NP (10(-9) M, 10(-8) M, 10(-7) M, 10(-6) M)...

Pregabalin, a potent anticonvulsant agent, is used in treatment-resistant epileptic patients. It is reported that pregabalin also has analgesic effect in different pain syndromes. However, there is limited data on its antinociceptive mechanisms of action. We aimed to investigate the central and peripheral antinociceptive effects of pregabalin and t...

Background: Gabapentin, a third-generation antiepileptic drug, is a structural analogue of γ-aminobutyric acid, which is an important mediator of central nervous system. There is clinical data indicating its effectiveness in the treatment of psychiatric illnesses such as bipolar disorder and anxiety disorders. Objectives: We aimed to investigate...

Background: Intracellular calcium contributes to the development of affective disorders. Also, calcium channel inhibitors influence the activity of many neurotransmitters and exert antidepressant and anxiolytic properties. Objectives: The aim of this study was to examine the effects of sertraline on anxiety and depressive behaviors and the role...

Objectives: Des-Arg9-bradykinin and bradykinin-potentiating peptide C (BPPC) may contribute to the regulation of cardiovascular function. Therefore, we studied effects of these peptides on coronary perfusion pressure (CPP), heart rate, left ventricular developed pressure (LVDP) and maximum rate of increase of left ventricular pressure (+dP/dtmax)....

The management of Parkinson's Disease Psychosis (PDP) is a challenge requiring to diminish antiparkinson treatment or to use classical antipsychotics which worsen motor symptoms. Second generation antipsychotics are current interest to treat PDP. This study aims to examine the effects of ziprasidone, an atypical antipsychotic agent, on locomotor ac...

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclo...

The aim of this study is to investigate the antidepressant and anxiolytic effects of simvastatin in rats. Sixty-four male adult (8-9 weeks old) Sprague-Dawley rats (200-250 g) were used. The forced swimming test and the elevated plus maze test were used for testing the antidepressant and anxiolytic effects. Eight groups were formed: control (saline...

Objective: The aim of this study was to examine the effects of chronic administration of ziprasidone, an atypical antipsychotic drug, on experimental models of psychosis and the role of nimodipine, a dihydropyridine calcium channel blocker, on these effects in mice. Methods: Experimental models of psychosis were studied in mice. Amphetamine-induced...

In this study, calcium antagonistic activity of sixteen hexahydroquinoline derivatives have been elucidated in rat ileum and rat thorasic aorta. In the studies on isolated rat ileum, it has been observed that all compounds showed meaningfull activity. In rat thorasic aorta studies, compound 3a has been found more active than nicardipine.